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| 1 | MicroRNAs and Type 2 Diabetes/Obesity显示文摘MicroRNAs 属于广泛地在调整象类型 2 糖尿病(T2D ) 和肥胖的致病那样的许多生理的过程被含有的小非编码的 RNA 的一个最新识别的班。Microarray 研究在糖尿病、肥胖的模型在胰岛素目标纸巾加亮 miRNA 表示的改变的侧面。新兴的证据建议 miRNAs 在胰岛素生产,分泌物和行动,以及在葡萄糖动态平衡和 adipocyte 区别的多样的方面起重要作用。织物特定的 miRNAs 的鉴定在 T2D 和肥胖含有可能为为早诊断和肥胖相关的医药复杂并发症的治疗学的干预的有效策略的未来发展有用。 | Mustafa Abdo Saif Dehwah Aimin Xu Qingyang Huang | 2012 | Journal of Genetics and Genomics2012，39，1： | 20 |
| 2 | Dissecting and Enhancing the Contributions of High-Molecular-Weight Glutenin Subunits to Dough Functionality and Bread Quality显示文摘Dear Editor, Seed storage proteins (SSPs) are frequently important determinants of crop quality traits (Shewry and Casey,1999).Dissecting and enhancing the genetic contributions of individual SSPs to their target traits are essential for effectively improving crop quality attributes.However,such a task is often difficult to accomplish,because SSPs are frequently expressed from multigene families and exhibit strong allelic variation.Consequently,detailed knowledge of the function of individual SSPs in crop quality trait is still limited.This scenario is well illustrated by high-molecular-weight glutenin subunits (HMWGSs),a complex family of SSPs that are involved in wheat enduse quality through affecting dough functionality (Békés,2012;Rasheed et al.,2014). | Yiwen Li Xuefi An Ran Yang Xiaomin Guo Guidong Yue Renchun Fan Bin Li Zhensheng Li Kunpu Zhang Zhenying Dong Luyan Zhang Jiankang Wang Xu Jia Hong-Qing Ling Aimin Zhang Xiangqi Zhang Daowen Wang | 2015 | Molecular Plant2015，8，2： | 9 |
| 3 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 4 | A high resolution lithospheric magnetic field model over China显示文摘CHAMP satellite data and ground-based magnetic observations are used and combined to map the lithospheric magnetic field over China by means of the revised spherical cap harmonic analysis(R-SHCA)modeling technique.The magnetic field is described to a spatial resolution of 150 km at the mean Earth’s radius,which represents a good compromise between the resolutions afforded by surface and satellite data.We compare the magnetic anomalies modeled at the regional scale with composite regions containing large-scale of tectonic structures.These regions,including the Tarim Basin and the Tibetan Plateau,are correlated with regional magnetic anomalies at satellite altitude but contain a significant number of small-scale and complex magnetic structures at the mean Earth’s radius.These magnetic anomalies are globally consistent with the known geological features in China but also offer a way to delineate the contours of the geological blocks and to discuss the connection between magnetic anomalies and the heat flow distribution in this region. | OU JiaMing DU AiMin E.THBAULT XU WenYao TIAN XiaoBo ZHANG TieLong | 2013 | Science China Earth Sciences2013，56，10： | 7 |
| 5 | Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment?显示文摘Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. Physical exercise has been long recognized for its therapeutic effects on depressive disorders, although knowledge of the underlying mechanisms remains limited. Suppressed hippocampal neurogenesis in adult brains has been regarded, at least partly, contributive to depression, whereas physical exercise that restores neurogenesis accordingly exerts the anti-depressive action. Several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. Here, we briefly review these novel findings and discuss the possibility of counteracting depression by modulating adiponectin signaling in the hippocampus with interventions including physical exercise and administration of pharmacological agents. | Suk Yu Yau Ang Li Aimin Xu Kwok-fai So | 2015 | Neural Regeneration Research2015，10，1： | 7 |
| 6 | The First Case of Asymptomatic Infection of COVID-19-Kashgar Prefecture, Xinjiang Uygur Autonomous Region, China, October, 2020显示文摘On October 24,2020,a 17-year-old female was detected as having an asymptomatic infection of coronavirus disease 2019(COVID-19)during a regular nucleic acid test in Kashgar Prefecture,Xinjiang Uygur Autonomous Region.She was then transferred to a local designated hospital for medical observation.The patient lived in Shufu County of Kashgar Prefecture and worked in a local garment factory.On the afternoon of October 24 after she was diagnosed as positive,a total of 831 persons in the garment factory were tested and the results were all negative.Afterwards,16 close contacts and 406 of close contacts of close contacts were also tested,and 137 were positive and had asymptomatic infections. | Ji Wang Jun Zhao Xiang Zhao Zhenguo Gao Yang Song Xin Ma Kai Nie Aimin Xu Mahemuti Ling Zhang Wenbo Xu Yan Cui | 2020 | China CDC weekly2020，2，45： | 6 |
| 7 | Design System of the Two-step Gear Reducer on Case-based Reasoning显示文摘The design of the two-step gear reducer is a tedious and time-consuming process.For the purpose of improving the efficiency and intelligence of design process,case-based reasoning(CBR) technology was applied to the design of the two-step gear reducer.Firstly,the current design method for the two-step gear reducer was analyzed and the principle of CBR was described.Secondly,according to the characteristics of the reducer,three key technologies of CBR were studied and the corresponding methods were provided,which are as follows:(a) an object-oriented knowledge representation method,(b) a retrieval method combining the nearest neighbor with the induction indexing,and(c) a case adaptation algorithm combining the revision based on rule with artificial revision.Also,for the purpose of improving the credibility of case retrieval,a new method for determining the weights of characteristics and a similarity formula were presented,which is a combinatorial weighting method with the analytic hierarchy process(AHP) and roughness set theory.Lastly,according to the above analytic results,a design system of the two-step gear reducer on CBR was developed by VC++,UG and Access 2003.A new method for the design of the two-step gear reducer is provided in this study.If the foregoing developed system is applied to design the two-step gear reducer,design efficiency is improved,which enables the designer to release from the tedious design process of the gear reducer so as to put more efforts on innovative design.The study result fully reflects the feasibility and validity of CBR technology in the process of the design of the mechanical parts. | JI Aimin HUANG Quansheng XU Huanmin CHEN Zhengming | 2009 | Chinese Journal of Mechanical Engineering2009，22，5： | 6 |
| 8 | GGDEF and EAL proteins play different roles in the control of Sinorhizobium melUoti growth, motility, exopolysaccharide production, and competitive nodulation on host alfalfa显示文摘一个新细菌的第二等的送信人,二度 --(3,5 ) 周期的二聚的 guanosine monophosphate (c-di-GMP ) ,通常被综合或由包含的蛋白质分解了 GGDEF 或 glutamatealanineleucine (EAL ) 领域。因为 c-di-GMP 和他们的基因的 cyclase 或 phosphodiesterase 根据已知的 genomic DNA 序列在几乎所有细菌之中是分布式的,他们经常行动。然而, GGDEF 和 EAL 基因的系统的鉴定在 rhizobia 仍然保持不清楚,与兼容的荚交往到的土壤细菌形成修理氮的小瘤。在这研究, 19 通常认为的 GGDEF 和 EAL 基因在模型根瘤菌被识别, Sinorhizobium meliloti,由生物信息的分析(编码 5 GGDEF 蛋白质和 EAL 双域蛋白质) 。14 基因的空异种通过系统的 plasmid 插入被构造。所有 14 基因异种在最小的中等、有缺点的活动性显示出缺乏的生长,并且 11 基因异种生产了更多的 exopolysaccharide 并且在主人工厂上显示了更少的竞争生节,苜蓿。我们的结果建议 GGDEF 和 EAL 蛋白质可以在 S 的控制起不同作用。meliloti 生理学,尽管他们包含保存催化(GGDEF 或 EAL ) 领域。我们发现也暗示了那 c-di-GMP 可以在在这根瘤菌和它的主人之间的相互作用起一个重要作用种建立有效共生。 | Yiwen Wang Ji Xu Aimin Chen Yanzhang Wang Jiabi Zhu Guanqiao Yu Ling Xu Li Luo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，6： | 5 |
| 9 | Enhancing Genetic Gain through Genomic Selection: From Livestock to Plants显示文摘Although long-term genetic gain has been achieved through increasing use of modern breeding methods and technologies,the rate of genetic gain needs to be accelerated to meet humanity’s demand for agricultural products.In this regard,genomic selection(GS)has been considered most promising for genetic improvement of the complex traits controlled by many genes each with minor effects.Livestock scientists pioneered GS application largely due to livestock’s significantly higher individual values and the greater reduction in generation interval that can be achieved in GS.Large-scale application of GS in plants can be achieved by refining field management to improve heritability estimation and prediction accuracy and developing optimum GS models with the consideration of genotype-by-environment interaction and non-additive effects,along with significant cost reduction.Moreover,it would be more effective to integrate GS with other breeding tools and platforms for accelerating the breeding process and thereby further enhancing genetic gain.In addition,establishing an open-source breeding network and developing transdisciplinary approaches would be essential in enhancing breeding efficiency for small-and medium-sized enterprises and agricultural research systems in developing countries.New strategies centered on GS for enhancing genetic gain need to be developed. | Yunbi Xu Xiaogang Liu Junjie Fu Hongwu Wang Jiankang Wang Changling Huang Boddupalli MPrasanna Michael SOlsen Guoying Wang Aimin Zhang | 2020 | Plant Communications2020，1，1： | 4 |
| 10 | The FGF21-adiponectin axis in controlling energy and vascular homeostasis显示文摘Whole-body energy metabolism and cardiovascular homeostasis are tightly controlled processes that involve highly coordinated crosstalk among distal organs.This is mainly achieved by a large number of hormones released from each organ.Among them,fibroblast growth factor 21(FGF21)and adiponectin have recently gained considerable attention,since both of them possess multiple profound protective effects against a myriad of cardio-metabolic disorders.Despite their distinct structuresand production sites,these two hormones share striking functional similarity.This dichotomy is recently reconciled by the demonstration of the FGF21-adiponectin axis.In adipocytes,both transcription and secretion of adiponectin are strongly induced by FGF21,which is partially dependent on PPARg activity.Furthermore,the glucose-lowering,lipid-clearing,and anti-atherosclerotic functions of FGF21 are diminished in adiponectin-null mice,suggesting that adiponectin serves as an obligatory mediator of FGF21-elicited metabolic and vascular benefits.However,in both animals and human subjects with obesity,circulating FGF21 levels are increased whereas plasma adiponectin concentrations are reduced,perhaps due to FGF21 resistance,suggesting that dysfunctional FGF21-adiponectin axis is an important contributor to the pathogenesis of obesity-related cardio-metabolic syndrome.The FGF21-adiponectin axis protects against a cluster of cardio-metabolic disorders via mediating multi-organ communications,and is a promising target for therapeutic interventions of these chronic diseases. | Xiaoyan Hui Tianshi Feng Qing Liu Yuan Gao Aimin Xu | 2016 | Journal of Molecular Cell Biology2016，8，2： | 4 |
| 11 | CXCR4-guided liposomes regulating hypoxic and immunosuppressive microenvironment for sorafenib-resistant tumor treatment显示文摘Clinical sorafenib treatment could activate C-X-C receptor type 4(CXCR4)/stromal source factor-1α(SDF-1α)axis to aggravate intra-tumoral hypoxia of hepatocellular carcinoma(HCC),which further leads to progression,invasion,metastasis,and immunosuppression of tumors and in return causes resistance to sorafenib therapy.Therefore,a multi-functional oxygen delivery nanoplatform was rationally constructed based on an oxygen-saturated perfluorohexane(PFH)-cored liposome,with the CXCR4 antagonist LFC131 peptides modifying on the surface to simultaneously deliver sorafenib and the CSF1/CSF1R inhibitor PLX3397(named PFH@LSLP)for sorafenib-resistant HCC treatment.The PFH@LSLP was developed to overcome sorafenib resistance by syner-gistic effects of the following 3 roles:1)the O_(2)-saturated PFH core could alleviate the tumor hypoxia by O_(2) supply;2)the LFC131 peptide recognized the hypoxia-related overexpressed CXCR4 and then blocked SDF-1α/CXCR4 axis to re-sensitize the HCC cells to sorafenib;3)PLX3397 activated the immune responses via inhibiting the CSF1/CSF1R pathway in TAMs,further enhanced CD8^(+)T cell infiltration to reverse immunosuppression in tumors.Antitumor performance on H22 tumor-bearing mice and HCC patient-derived tumor xenograft(PDX)model showed that PFH@LSLP could overcome sorafenib resistance by synergistic effect of hypoxia attenuation,resistance-related gene regulation,and immune-microenvironment modification. | Yuehua Wang Zhenjie Wang Fei Jia Qing Xu Zhilin Shu Junlin Deng Aimin Li Meng Yu Zhiqiang Yu | 2022 | Bioactive Materials2022，7，11： | 3 |
| 12 | Nightside field-aligned current during the April 6,2000 superstorm显示文摘Using the east-west geomagnetic disturbance fields observed from stations at mid-latitudes,we investigate the characteristics of field-aligned currents on the nightside during the April 6,2000 superstorm.The results indicate that there is an eastward disturbance on the nightside of Northern Hemisphere during the main phase of magnetic storm,while the interplanetary magnetic field(IMF)is continued southward.The positive disturbances in the postmidnight are larger than that in the premidnight.This suggests that upward field-aligned currents develop on the nightside,when the IMF is directed southward.The peak of upward fieldaligned currents is located in postmidnight,and it will be more obvious at substorm expansion.We get the conclusion that both partial ring current and region-2 field-aligned current shift to dusk sector.The upward region-2 current is decreased at substorm onset,and intensified after it.We also investigate the relationship between the upward field-aligned currents on the nightside and the auroral electrojets at high latitudes.It shows a good correspondence between region-2 current and the westward electrojet in the postmidnight.We suppose that they are both associated with the convection electric field. | WANG Yuan HONG MingHua CHEN GengXiong XU WenYao DU AiMin ZHAO XuDong LIU XiaoCan LUO Hao | 2010 | Chinese Science Bulletin2010，55，20： | 3 |
| 13 | On Stability of F-Gorenstein Flat Categories显示文摘为了基于公寓, Asadollahi 和 Salarian 调查 cohomology 理论,给了 F-Gorenstein 扁平的 R 模块,和这些模块的定义如果 R 是恰好协调的,确切完全是 Gorenstein。在这份报纸,我们得到 F-Gorenstein 扁平的 R 模块的一些性质并且建立 F-Gorenstein 扁平的范畴的稳定性。 | Jiangsheng Hu Aimin Xu | 2016 | Algebra Colloquium2016，23，2： | 3 |
| 14 | Adiponectin as a negative regulator in obesity-related mammary carcinogenesis显示文摘肥胖和它的联系疾病的流行在我们的社会上提出了巨大的保健影响。肥胖为许多严重医药条件是 maj 或风险因素,例如新陈代谢的症候群,类型 2 糖尿病和心血管的混乱等等。Inaddition,有癌症的肥胖的靠近的协会吸引了重要注意。包括胸,前列腺,子宫内膜,冒号和胆囊癌症,几肥胖相关的癌症有一个神经质的基础并且是生命风格相关。乳癌是最经常的癌症和在女人之中的癌症死亡的第二个领先的原因。在 pre- andpost-menopausal 年的过量脂肪过多是为乳癌的发展的一个独立风险因素,并且也与迟了阶段的疾病和差的预后被联系。 | Yu Wang | 2007 | Cell Research2007，17，4： | 3 |
| 15 | Energy budget of the magnetosphere-ionosphere system in solar Cycle 23显示文摘The energy budget of the magnetosphere-ionosphere (MI) system during 1998-2008 was examined by using Akasofu's epsilon function. The results showed that 1) the yearly average rate of solar wind energy input into the MI system was 4.51 GGJ (GGJ=1018 J), while the yearly average total dissipation was 4.30 GGJ; 2) the energy partitioning in the ring current and polar region was 56%:44%; 3) the energy input and dissipation processes continuously proceeded both in storm-substorm events and less disturbed intervals, suggesting the significant contribution of slow but long-lasting energy process during the less disturbance periods to the total energy budget. In addition, we found in this study an interesting phenomenon 'self-adjustment ability' of the MI system which behaves just like a water reservoir. During solar active years, the input energy is more than the dissipated energy, implying that a portion of the input energy is not immediately released, but is stored in the magnetosphere. On the other hand, during less active years, the dissipated energy is more than the input energy, implying that the previously stored energy makes up for the energy input shortage in this period. | XU WenYao DU AiMin | 2012 | Science China(Technological Sciences)2012，55，5： | 3 |
| 16 | Growth Mechanism,Modified Morphology and Optical Properties of Coral-like BaTiO_3 Architecture through CTAB Assisted Synthesis显示文摘Three-dimensional hierarchical structure coral-like BaTiO3 nanoparticles have been self-assembled by a facile one step hydrothermal method. Cetyltrimethyl ammonium bromide(CTAB),Ba(OH)2·8H2O and tetrabutyl titanate have been used as precursors. The prepared Ba TiO3 exhibits cubic perovskite phase at room temperature,and the coral-like architecture is a micro-nano hiberarchy consisted of dendrimer-like structure and trunk-like structure. By adjusting the hydrothermal duration and the precursor substances,a surfactant induced mechanism is proposed to understand the self-assembly process. UV-vis measurement demonstrates that the as-prepared Ba TiO3 nanoparticles exhibit dozens of times overwhelming absorptive character compared to the ordinary nanospheres at ultraviolet band,which is benefited from the coral-like porous framework. Moreover,halogen anions( F,Cl,Br,and I) have been chosen to adjust the coral-like Ba TiO3 physical properties. Results show the halogen doping produces distinct modulation effect on the grain size,UV-vis absorbance and photoluminescence properties of the materials. The coral-like BaTiO3 nanoparticle and its halogen modified ramifications offer significant opportunities to develop nano-laser devices,photon detectors,photocatalyst based on BaTiO3 perovskite materials. | Pengjun Zhao Lei Wang Liang Bian Jinbao Xu Aimin Chang Xinqian Xiong Fanglong Xu Jiaqi Zhang | 2015 | Journal of Materials Science & Technology2015，31，2： | 2 |
| 17 | Methylesterification of cell-wall pectin controls the diurnal flower-opening times in rice显示文摘Flowers are the core reproductive organ of plants, and flowering is essential for cross-pollination. Diurnal flower-opening time is thus a key trait influencing reproductive isolation, hybrid breeding, and thermostability in plants. However, the molecular mechanisms controlling this trait remain unknown. Here, we report that rice Diurnal Flower Opening Time 1 (DFOT1) modulates pectin methylesterase (PME) activity to regulate pectin methylesterification levels of the lodicule cell walls, which affect lodicule swelling to control diurnal flower-opening time. DFOT1 is specifically expressed in the lodicules, and its expression gradually increases with the approach to flowering but decreases with flowering. Importantly, a knockout of DFOT1 showed earlier diurnal flower opening. We demonstrate that DFOT1 interacts directly with multiple PMEs to promote their activity. Knockout of PME40 also resulted in early diurnal flower opening, whereas overexpression of PME42 delayed diurnal flower opening. Lower PME activity was observed to be associated with higher levels of pectin methylesterification and the softening of cell walls in lodicules, which contribute to the absorption of water by lodicules and cause them to swell, thus promoting early diurnal flower opening. Higher PME activity had the opposite effect. Collectively, our work uncovers a molecular mechanism underlying the regulation of diurnal flower-opening time in rice, which would help reduce the costs of hybrid breeding and improve the heat tolerance of flowering plants by avoiding higher temperatures at anthesis. | Mumei Wang Xiaopei Zhu Guoqing Peng Minglong Liu Shuqing Zhang Minghao Chen Shitang Liao Xiaoying Wei Peng Xu Xiyu Tan Fangping Li Zhichuan Li Li Deng Ziliang Luo Liya Zhu Shuai Zhao Dagang Jiang Jing Li Zhenlan Liu Xianrong Xie Shaokui Wang Aimin Wu Chuxiong Zhuang Hai Zhou | 2022 | Molecular Plant2022，15，6： | 2 |
| 18 | Endothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice显示文摘Endothelin-1 (ET-1 ) 为哺乳动物的开发和生活是必要的,但是它也在 pathophysiological 条件下面在增加的心血管的风险被含有。这研究的目的是在水管和瘦、肥胖的老鼠的肾的动脉在内皮细胞层依赖者和内皮细胞层无关的回答上决定 prepro-endothelin-1 基因的 endothelial overexpression 的影响。肥胖被 high-fat-diet (HFD ) 导致在有 prepro-endothelin-1 基因的 Tie-1 倡导者驱动的、内皮细胞层特定的 overexpression 的老鼠的消费(TET het ) 并且在里面野类型(WT ) 一个 C57BL/6N 背景上的同窝出生的人。等轴的紧张在戒指被测量(与内皮细胞层) 主动脉(A) ,颈动脉(CA ) 并且肠骨(IA ) 动脉象一样主要(MRA ) 并且部分肾(SRA ) 动脉;所有实验在 L 名字或 COX 禁止者 meclofenamate 的缺席或存在被进行。prostacyclin 和 thromboxane A2 的版本被 ELISA 测量。在 MRA, TET het 本身增加了收缩到 endothelin-1,但是反应响应血清素在 SRA 被减少;面对 L 名字在 SRA 到醋胆素然而并非胰岛素有也改进的松驰。HFD 本身扩充了收缩到 endothelin-1 (MRA ) 并且到 thromboxane prostanoid (TP ) 受体收缩筋 U46619 (CA, MRA ) 象到 isoproterenol (A) 的便于的松驰一样。HFD 和 TET het overexpression 增加了 MRA 和 SRA 的收缩到 vasoconstrictors 然而并非面对 meclofenamate;这联合也在 A 扩充了进一步的松驰到 isoproterenol。到在 IA 的 endothelin-1 的收缩被 endothelin 阻止 -- 受体对手 BQ-123 但是仅仅由 BQ-788 在肥胖的老鼠稀释了。COX-1 禁止者 FR122047 废除了 CA 的收缩到醋胆素。prostacyclin 的版本从肥胖的 TET het 老鼠并且由 FR122047 废除了。这些调查结果建议那 endothelial TET 在瘦动物的 het overexpression 在脉管的应答上有最小的效果。不管多么有肥胖的 comorbid, endothelin-1-modulated,调停 prostanoid 的肾的动脉的机能障碍变得明显。 | Oliver BARETELLA Sookja K CHUNG Aimin XU Paul M VANHOUTFE | 2017 | Acta Pharmacologica Sinica2017，38，4： | 2 |
| 19 | Investigation of the SA evolution by using the CHAOS-4 model over 1997–2013显示文摘The temporal and spatial evolution characteristics of the geomagnetic secular acceleration(SA) are investigated, based on CHAOS-4 core field model during the period of 1997–2013. The SA evolution on a short time scale is associated with the phenomenon of the geomagnetic jerk. More details of the global extent and the occurrence time of the successive jerks(the 1999, 2003, 2007, and 2011 jerks) are obtained. The location, size and reversed polarity pattern for the 1999 jerk are similar to those for the 2003 jerk in the Asian-Indian sector. While the 2007 and 2011 jerks mainly take place in the Atlantic sector. The direction and speed of the shift for the four jerks are different, identified by the occurrence time of the jerks. The zonal motions of the SA patches exhibit an oscillation pattern in the Asian-Indian sector, whereas a purely westward drifting pattern is along the equator in the Atlantic sector. It is believed that the shift of the jerks is related to the motion of SA-B_r patches observed at the core-mantle boundary(CMB). | OU JiaMing DU AiMin XU WenYao | 2016 | Science China Earth Sciences2016，59，5： | 2 |
| 20 | Intercellular and inter-organ crosstalk in browning of white adipose tissue:molecular mechanism and therapeutic complications显示文摘Adipose tissue(AT)is highly plastic and heterogeneous in response to environmental and nutritional changes.The development of heat-dissipating beige adipocytes in white AT(WAT)through a process known as browning(or beiging)has garnered much attention as a promising therapeutic strategy for obesity and its related metabolic complications.This is due to its inducibility in response to thermogenic stimulation and its association with improved metabolic health.WAT consists of adipocytes,nerves,vascular endothelial cells,various types of immune cells,adipocyte progenitor cells,and fibroblasts.These cells contribute to the formation of beige adipocytes through the release of protein factors that significantly influence browning capacity.In addition,inter-organ crosstalk is also important for beige adipocyte biogenesis.Here,we summarize recent findings on fat depot-specific differences,secretory factors participating in intercellular and inter-organ communications that regulate the recruitment of thermogenic beige adipocytes,as well as challenges in targeting beige adipocytes as a potential anti-obese therapy. | Lai Yee Cheong Aimin Xu | 2021 | Journal of Molecular Cell Biology2021，13，7： | 2 |
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