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| 1 | Biological properties and clinical applications of berberine显示文摘Berberine,an isoquinoline alkaloid isolated from the Chinese herb Coptis chinens is and other Berber is plants,has a wide range of pharmacological properties.Berberine can be used to treat many diseases,such as cancer and digestive,metabolic,cardiovascular,and neurological diseases.Berberine has protective capacities in digestive diseases.It can inhibit toxins and bacteria,including Helicobac terpylo riprotect the intestinal epithelial barrier from injury,and ameliorate liver injury.Berberine also inhibits the proliferation of various types of cancer cells and impedes invasion and metastasis.Recent evidence has confirmed that berberine improves the efficacy and safety of chemoradiotherapies.In addition,berberine regulates glycometabolism and lipid metabolism,improves energy expenditure,reduces body weight,and alleviates nonalcoholic fatty liver disease.Berberine also improves cardiovascular hemodynamics,suppresses ischemic arrhythmias,attenuates the development of atherosclerosis,and reduces hypertension.Berberine shows potent neuroprotective effects,including antioxidative,antiapoptotic,and anti-ischemic.Furthermore,berberine exerts protective effects against other diseases.The mechanisms of its functions have been extensively explored,but much remains to be clarified.This article summarizes the main pharmacological actions of berberine and its mechanisms in cancer and digestive,metabolic,cardiovascular,and neurological diseases. | Danyang Song Jianyu Hao Daiming Fan | 2020 | Frontiers of Medicine2020，14，5： | 30 |
| 2 | Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes显示文摘Multifunctional nanoparticles combining diagnostic and therapeutic agents into a single platform make cancer theranostics possible and have attracted wide interests in the field. In this study, a multifunctional nanocomposite based on dextran and superparamagnetic iron oxide nanoparticles(SPIO) was prepared for drug delivery and magnetic resonance imaging(MRI). Amphiphilic dextran was synthesized by grafting stearyl acid onto the carbohydrate backbone, and micelle was formed by the resulted amphiphilic dextran with low critical micelle concentration at 1.8 mg L-1. Doxorubicin(DOX) and a cluster of the manganese-doped iron oxide nanoparticles(Mn-SPIO)nanocrystals were then coencapsulated successfully inside the core of dextran micelles, resulting in nanocomposites with diameter at about 100 nm. Cell culture experiments demonstrated the potential of these Mn-SPIO/DOX nanocomposites as an effective multifunctional nanoplatform for the delivery of anticancer drug DOX with a loading content(DLC) of 16 %. Confocal laser scanning microscopyreveals that the Mn-SPIO/DOX had excellent internalization ability against MCF-7/Adr cells after 2-h labeling compared with free DOXáHCl. Under a 3.0-T MRI scanner, Mn-SPIO/DOX nanocomposite-labeled cells in gelatin phantom show much darker images than the control. Their transverse relaxation(T2) rate is also significantly higher than that of the control cells(33.9 versus 2.3 s-1). Our result offers an effective strategy to treat MCF-7/Adr at optimized low dosages with imaging capability. | Bingbing Lin Hongying Su Rongrong Jin Danyang Li Changqiang Wu Xin Jiang Chunchao Xia Qiyong Gong Bin Song Hua Ai | 2015 | Science Bulletin2015，60，14： | 6 |
| 3 | Multiple active components synergistically driven heteroatom-doped porous carbon as high-performance counter electrode in dye-sensitized solar cells显示文摘A facile template-free in situ self-activation approach for the multiple active components synergistically driven porous carbon was presented via a feasible annealing process.The biomass-derived carbon without additional activation reagents was fabricated using K-rich pomelo peel(PP)as the carbon source,which possesses a high electric conductivity where abundant functional hetero-metal atoms are doped into the carbon framework that playing the role of catalytic graphitization.The K^+that exists within the biomass can induce self-activation during pyrolysis apart from the activating gases during the pyrolysis process.The resulting electrocatalyst of PP-850(PP was pyrolyzed at 850°C in an N_2atmosphere)with abundant heteroatoms possesses a higher power conversion efficiency(PCE)of 7.81%as the counter electrode(CE)of dye-sensitized solar cells(DSCs)compared with the CEs calcinated at other temperatures and a similar PCE with Pt counterpart(8.24%)based on the liquid I_3^-/I^-electrolyte.The better electrocatalytic performance is attributed to the synergistic effect between self-activation and the co-doping of nitrogen,sulfur and phosphorus all together in a carbon matrix.Due to the feasibility of large-scale production,rich heteroatom doping,the PP-derived carbon,which simplifies the procedure and decreases the cost,has a potential application for an alternative electrocatalyst for high-performance photovoltaic devices. | Hongyu Jing Danyang Wu Suxia Liang Xuedan Song Yonglin An Ce Hao Yantao Shi | 2019 | Journal of Energy Chemistry2019，28，4： | 2 |
| 4 | Boosting High-Rate Zinc-Storage Performance by the Rational Design of Mn_(2)O_(3) Nanoporous Architecture Cathode显示文摘Manganese oxides are regarded as one of the most promising cathode materials in rechargeable aqueous Zn-ion batteries(ZIBs)because of the low price and high security.However,the practical application of Mn2O3 in ZIBs is still plagued by the low specific capacity and poor rate capability.Herein,highly crystalline Mn2O3 materials with interconnected mesostructures and controllable pore sizes are obtained via a ligand-assisted self-assembly process and used as high-performance electrode materials for reversible aqueous ZIBs.The coordination degree between Mn2+and citric acid ligand plays a crucial role in the formation of the mesostructure,and the pore sizes can be easily tuned from 3.2 to 7.3 nm.Ascribed to the unique feature of nanoporous architectures,excellent zinc-storage performance can be achieved in ZIBs during charge/discharge processes.The Mn2O3 electrode exhibits high reversible capacity(233 mAh g−1 at 0.3 A g−1),superior rate capability(162 mAh g−1 retains at 3.08 A g−1)and remarkable cycling durability over 3000 cycles at a high current rate of 3.08 A g−1.Moreover,the corresponding electrode reaction mechanism is studied in depth according to a series of analytical methods.These results suggest that rational design of the nanoporous architecture for electrode materials can effectively improve the battery performance. | Danyang Feng Tu‑Nan Gao Ling Zhang Bingkun Guo Shuyan Song Zhen‑An Qiao Sheng Dai | 2020 | Nano-Micro Letters2020，12，1： | 2 |
| 5 | Silencing of ER-resident oxidoreductase PDIA3 inhibits malignant biological behaviors of multidrug-resistant gastric cancer显示文摘Glycosylation is a common posttranslational modification of proteins,which plays a role in the malignant transformation,growth,progression,chemoresistance,and immune response of tumors.Disulfide isomerase family A3(PDIA3)specifically acts on newly synthesized glycoproteins to promote the correct folding of sugar chains.Studies have shown that PDIA3 participates in multidrug-resistant gastric cancer(MDR-GC).In this study,we performed western blot analysis and immunohistochemistry to identify PDIA3 expression.Cell proliferation was assessed by CCK-8 assay.Transwell assays were used to detect the migration and invasion abilities of cells.Immunoprecipitation coupled to mass spectrometry(IP-MS)analysis was employed to identify PDIA3-interacting proteins and the associated pathways in MDR-GC cells.Glycoprotein interactions and translocation were detected by immunofluorescence assay.The results showed that PDIA3 knockdown significantly inhibited the proliferation,invasion,and migration abilities of MDR-GC cells.Kyoto Encyclopedia of Genes and Genomes analysis of the IP-MS results showed that PDIA3 was closely associated with focal adhesion pathways in MDR-GC cells.Additionally,important components of focal adhesion pathways,including fibronectin-1(FN1)and integrinα5(ITGA5),were identified as pivotal PDIA3-binding glycoproteins.Knockdown of PDIA3 altered the cellular locations of FN1 and ITGA5,leading to abnormal accumulation.In conclusion,our results suggest that knockdown of PDIA3 inhibited the malignant behaviors of MDR-GC cells and influenced the translocation of FN1 and ITGA5. | Danyang Song Meng Guo Kaichu Wu Jianyu Hao Yongzhan Nie Daiming Fan | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 2 |
| 6 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 7 | Thermocline Model for Estimating Argo Sea Surface Temperature Thermocline Model for Estimating Argo Sea Surface Temperature显示文摘Argo has become an important constituent of the global ocean observation system.However,due to the lack of sea surface measurements from most Argo profiles,the application of Argo data is still limited.In this study,a thermocline model was constructed based on three key thermocline parameters,i.e,thermocline upper depth,the thermocline bottom depth,and thermocline temperature gradient.Following the model,we estimated the sea surface temperature of Argo profiles by providing the relationship between sea surface and subsurface temperature.We tested the effectiveness of our proposed model using statistical analysis and by comparing the sea surface temperature with the results obtained from traditional methods and in situ observations in the Pacific Ocean.The root mean square errors of results obtained from thermocline model were found to be significantly reduced compared to the extrapolation results and satellite retrieved temperature results.The correlation coefficient between the estimation result and in situ observation was 0.967.Argo surface temperature,estimated by the thermocline model,has been theoretically proved to be reliable.Thus,our model generates theoretically feasible data present the mesoscale phenomenon in more detail.Overall,this study compensates for the lack surface observation of Argo,and provides a new tool to establish complete Argo data sets. | Chunling Zhang Mengli Zhang Zhenfeng Wang Song Hu Danyang Wang Shenglong Yang | 2022 | Sustainable Marine Structures2022，4，1： | 1 |
| 8 | Promoter and coding sequence diversity of CsCCD1 may contribute to the differential accumulation of floralβ-ionone in fresh tea leaves显示文摘The carotenoid-derived volatileβ-ionone makes an important contribution to tea fragrance.Here,we qualitatively and quantitatively analysed 15 carotenoids in tea leaves of 13 cultivars by UHPLC-APCI-MS/MS.The 13 cultivars were divided into two groups by PCA(Principal Component Analysis)clustering analysis of their carotenoid content,and OPLS-DA(Orthogonal projections to latent structures)indicated that the levels ofβ-carotene(VIP=2.89)and lutein(VIP=2.30)were responsible for much of the variation between the two groups.Interestingly,theβ-carotene toβ-ionone conversion rates in Group 1 were higher than in Group 2,while theβ-carotene content was significantly lower in Group 1 than in Group 2.Theβ-ionone content was significantly higher in Group 1.Pearson Correlation Coefficient calculation between the transcription level of candidate genes(CsCCD1 and CsCCD4)and the accumulation ofβ-ionone indicated that CsCCD1 may involve in the formation ofβ-ionone in 13 cultivars.Prokaryotic expression and in vitro enzyme activity assays showed that‘Chuanhuang 1’had an amino acid mutation in carotenoid cleavage dioxygenases 1(CsCCD1)compared with‘Shuchazao’,resulting in a significantly higherβ-ionone content in‘Chuanhuang 1’.Sequence analysis showed that‘Chuanhuang 1’and‘Huangdan’had different CsCCD1 promoter sequences,leading to significantly higher CsCCD1 expression andβ-ionone accumulation in‘Chuanhuang 1’.These results indicated that the promoter and coding sequence diversity of CsCCD1 might contribute to the differential accumulation ofβ-ionone in different tea cultivars. | Jingming Wang Mingyue Zhao Ting Gao Yingying Feng Feiquan Wang Yuting Pan Jieyang Jin Tingting Jing Mengqian Lu Mengting Zhang Danyang Guo Xiaochun Wan Wilfried Schwab Chuankui Song | 2023 | Horticultural Plant Journal2023，9，4： | 1 |
| 9 | Grain carbon emission transfer and its spatiotemporal shifts based on the increasing supply-demand separation in China over the past three decades显示文摘The food system is one of the major sources of anthropogenic greenhouse gas(GHG)emissions.The impact of emission transfer due to the separation between food production and consumption within the context of carbon neutrality remains unclear.In this study,we constructed an emission inventory for three types of grains at the production stage of their life cycle and then analysed the spatiotemporal evolution characteristics of the grain supply and demand.With the use of a spatial equilibrium model,we simulated the spatial distribution flow of the different types of grains from 1990 to 2018 and calculated the resulting GHG emission transfer efficiency.The main results include the following:(1)The imbalance between the grain supply and demand intensified,which was mainly reflected in the distance between the geographic centre of the grain supply and consumption increasing 3.2 times,and thus,the self-sufficiency decreased.(2)The total emission transfer TET of rice and wheat decreased because of the increase in the intra-regional supply,while that of maize gradually increased due to the increase in the inter-regional supply.(3)Overall,grain trade improved the carbon efficiency of grain production in China.The trade efficiency of crops varied,with wheat and maize leading to overall effective carbon reductions,while the carbon transfer efficiency of rice from trade was relatively low.(4)The carbon footprint of grain production in China's provinces exhibited a downward trend,but due to the intensified separation between the grain supply and demand,certain major grain-producing areas achieved inefficient carbon increases.Therefore,we suggest further optimization of the spatial structure of planting and breeding,strengthening of the grain supply in the region,and enhancement in the optimization of the low-carbon production structure and adjustment of cultivated land use combined with regional governance strategies.The application of these measures could contribute to achieving dual-carbon goals. | Xinxian QI Xianjin HUANG Yaya SONG Danyang WANG Tianze ZHONG Zemiao LIU | 2023 | Science China Earth Sciences2023，66，5： | 0 |
| 10 | The Use of Graphene-Based Earphones in Wireless Communication显示文摘Graphene-based materials have attracted much attention in recent years. Many researchers have demonstrated prototypes using graphene-based materials, but few specific applications have appeared. Graphenebased acoustic devices have become a popular topic. This paper describes a novel method to fabricate graphenebased earphones by laser scribing. The earphones have been used in wireless communication systems. A wireless communication system was built based on an ARM board. Voice from a mobile phone was transmitted to a graphene-based earphone. The output sound had a similar wave envelope to that of the input; some differences were introduced by the DC bias added to the driving circuit of the graphene-based earphone. The graphene-based earphone was demonstrated to have a great potential in wireless communication. | Luqi Tao Song Jiang Cheng Li He Tian Ningqin Deng Danyang Wang Yi Yang Tian-Ling Ren | 2015 | Tsinghua Science and Technology2015，20，3： | 0 |
| 11 | Volatile compound-mediated plant-plant interactions under stress with the tea plant as a model显示文摘Plants respond to environmental stimuli via the release of volatile organic compounds(VOCs),and neighboring plants constantly monitor and respond to these VOCs with great sensitivity and discrimination.This sensing can trigger increased plant fitness and reduce future plant damage through the priming of their own defenses.The defense mechanism in neighboring plants can either be induced by activation of the regulatory or transcriptional machinery,or it can be delayed by the absorption and storage of VOCs for the generation of an appropriate response later.Despite much research,many key questions remain on the role of VOCs in interplant communication and plant fitness.Here we review recent research on the VOCs induced by biotic(i.e.insects and pathogens)and abiotic(i.e.cold,drought,and salt)stresses,and elucidate the biosynthesis of stress-induced VOCs in tea plants.Our focus is on the role of stress-induced VOCs in complex ecological environments.Particularly,the roles of VOCs under abiotic stress are highlighted.Finally,we discuss pertinent questions and future research directions for advancing our understanding of plant interactions via VOCs. | Jieyang Jin Mingyue Zhao Tingting Jing Mengting Zhang Mengqian Lu Guomeng Yu Jingming Wang Danyang Guo Yuting Pan Timothy D.Hoffmann Wilfried Schwab Chuankui Song | 2023 | Horticulture Research2023，10，9： | 0 |
| 12 | Experimental and numerical studies of Ca(OH)_(2)/CaO dehydration process in a fixed-bed reactor for thermochemical energy storage显示文摘The Ca(OH)_(2)/CaO thermochemical energy storage(TCES)system based on calcium looping has received extensive attention owing to its high energy storage density,prolonged energy storage time,and environmental friendliness.The heat storage process of the Ca(OH)_(2)/CaO TCES system in a mixed heating reactor was evaluated in this study,by employing a combination of direct and indirect heating modes.The dehydration process was studied experimentally,and a numerical model was established and verified based on the experimental results.The dehydration behavior of 500 g of Ca(OH)_(2) powder was investigated in a fixed-bed reactor with mixed heating.The experimental and simulation results indicated that mixed heating causes combined centripetal and horizontal propulsion.Heat input is the main limiting factor in the heat storage process,because the radial advance of the reaction is hindered by the low thermal conductivity of the solid reactant particles.Heat transmission partitions were added to enhance the performance of the reactor.The performance of the modified reactor was compared with that of a conventional reactor.The radial heat transmission partitions in the modified reactor effectively enhance the energy storage rate and reduce the reaction time by 59.5%compared with the reactor without partitions. | Zhihao Zhang Danyang Song Hengxing Bao Xiang Ling Xiaogang Jin | 2023 | Chinese Journal of Chemical Engineering2023，62，10： | 0 |
| 13 | Climate change in the Hongliujing area of Lop Nur over the past 200 years revealed by the stable oxygen isotopes of Tamarix cones显示文摘The layers of Tamarix cones within sedimentary deposits in arid regions have significant chronological and paleoenvironmental implications.Here,we compare the δ^(18)O values of Tamarix cones in the Hongliujing area of Lop Nur with meteorological data for the Ruoqiang meteorological station for 1960-2019 AD.Linear regression analysis was used to reconstruct the average temperature for April and the precipitation for November in the Hongliujing area over the past 200 years.The results showed that the δ^(18)O values were significantly negatively correlated with the temperature for February,April,May,August,December,and with the annual mean temperature;significantly negatively correlated with the precipitation for February and April;significantly negatively correlated with the sunshine hours for March and May;significantly positively correlated with the sunshine hours for February,July,August,October,and December,and with the annual mean values;and significantly correlated with the relative humidity for April,July,August,September,October,and November,and with the annual mean values.Based on the δ^(18)O record of the past 200 years,the Hongliujing area experienced two warm-wet periods(1874-1932 and 2004-2019 AD)and two cold-dry periods(1832–1873 and 1933-2003 AD).Thus,the climate was characterized by alternating warm-wet and cold-dry conditions.Wavelet analysis revealed three main cycles:45 years,29 years,and 14 years. | Zhiguang LI Yaqing DONG Haoyu ZHANG Hongxiao SUN Danyang JIA Shikai SONG Yuanjie ZHAO | 2023 | Frontiers of Earth Science2023，17，4： | 0 |
| 14 | Conditioned medium for non-small cell lung cancer promotes proliferation and migration of human bone marrow mesenchymal stem cells显示文摘To verify the effects of chemokine 8(CXCL-8)secreted by non-small cell lung cancer cells(A549)on human bone marrow mesenchymal stem cells(hBMSC)movement,and analyzes the Akt pathway promotes the molecular mechanism of CXCL-8 in the hBMSC movement.The supernatants of A549 and human normal lung epithelial cells(BEAS-2B)supernatant were extracted,and then hBMSCs were cultured with these two supernatants.Establish control group,A549 supernatant(A549S)group,BEAS 2B supernatant(BEAS-2BS)group and A549S+Akt inhibitors group.The content of CXCL-8 in supernatant was detected by ELISA;the absorbance value(A value),apoptosis rate and cell migration rate of hBMSCs in each group were detected respectively by MTT assay,Annexin V-PI cell apoptosis assay and Transwell cell migration experiment.The expression of Akt and p-Akt in hBMSCs was detected by W estern blot. | Wang Lulu Shen Lei Jiang Yang Jin Haifeng Zhang Song Liu Danyang Li Yongtao | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 15 | Flow characteristics simulation of spiral coil reactor used in the thermochemical energy storage system显示文摘According to environmental and energy issues,renewable energy has been vigorously promoted.Now solar power is widely used in many areas but it is limited by the weather conditions and cannot work continuously.Heat storage is a considerable solution for this problem and thermochemical energy storage is the most promising way because of its great energy density and stability.However,this technology is not mature enough to be applied to the industry.The reactor is an important component in the thermochemical energy storage system where the charging and discharging process happens.In this paper,a spiral coil is proposed and used as a reactor in the thermochemical energy storage system.The advantages of the spiral coil include simple structure,small volume,and so on.To investigate the flow characteristics,the simulation was carried out based on energy-minimization multi-scale model(EMMS)and Eulerian two-phase model.CaCO_(3) particles were chosen as the reactants.Particle distribution was shown in the results.The gas initial velocity was set to 2 m·s^(-1),3 m·s^(-1),and 4 m·s^(-1).When the particles flowed in the coil,gravity,centrifugal force and drag force influenced their flow.With the Reynold numbers increasing,centrifugal and drag force got larger.Accumulation phenomenon existed in the coil and results showed with the gas velocity increasing,accumulation moved from the bottom to the outer wall of the coil.Besides,the accumulation phenomenon was stabilized whenφ>720°.Also due to the centrifugal force,a secondary flow formed,which means solid particles moved from the inside wall to the outside wall.This secondary flow could promote turbulence and mixing of particles and gas.In addition,when the particle volume fraction is reduced from 0.2 to 0.1,the accumulation at the bottom of the coil decreases,and the unevenness of the velocity distribution becomes larger. | Xiaoyi Chen Danyang Song Dong Zhang Xiaogang Jin Xiang Ling Dongren Liu | 2022 | Chinese Journal of Chemical Engineering2022，35，2： | 0 |
| 16 | Activation of G-protein-coupled receptor 39 reduces neuropathic pain in a rat model显示文摘Activated G-protein-coupled receptor 39(GPR39)has been shown to attenuate inflammation by interacting with sirtuin 1(SIRT1)and peroxisome proliferator-activated receptor-γcoactivator 1α(PGC-1α).However,whether GPR39 attenuates neuropathic pain remains unclear.In this study,we established a Sprague-Dawley rat model of spared nerve injury-induced neuropathic pain and found that GPR39 expression was significantly decreased in neurons and microglia in the spinal dorsal horn compared with sham-operated rats.Intrathecal injection of TC-G 1008,a specific agonist of GPR39,significantly alleviated mechanical allodynia in the rats with spared nerve injury,improved spinal cord mitochondrial biogenesis,and alleviated neuroinflammation.These changes were abolished by GPR39 small interfering RNA(siRNA),Ex-527(SIRT1 inhibitor),and PGC-1αsiRNA.Taken together,these findings show that GPR39 activation ameliorates mechanical allodynia by activating the SIRT1/PGC-1αpathway in rats with spared nerve injury. | Longqing Zhang Xi Tan Fanhe Song Danyang Li Jiayi Wu Shaojie Gao Jia Sun Daiqiang Liu Yaqun Zhou Wei Mei | 2024 | Neural Regeneration Research2024，19，3： | 0 |
| 17 | Adjacent Pt Nanoparticles and Sub-nanometer WO_(x)Clusters Determine Catalytic Isomerization of C_(7)H_(16)显示文摘Processes for the isomerization of light alkanes have been commercialized;however,the isomerization of paraffins(C_(n)H_(2n+2),n≥7)remains a challenge.On mesoporous tungsten-zirconia catalyst supported Pt catalysts(Pt/WZrOx),initial isomerization productivity of 5249 moli-C7/molPt/h was obtained for n-heptane reforming at 275°C and 5 bar of hydrogen. | Bin Zhang Wei Zhou Jie Zhang Zirui Gao Danyang Cheng Lipeng Tang Xingwu Liu Yueqin Song Chunyang Dong Yao Xu Jie Yan Mi Peng Huizhen Liu Mark Douthwaite Meng Wang Ding Ma | 2022 | CCS Chemistry2022，4，8： | 0 |
| 18 | Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity显示文摘血容器通常坚持说 stereotyped 腔直径和他们的稳定的结构为脉管的功能是关键的。然而,很,很少对控制容器直径的维护和 endothelial 房间的正直的分子的机制被知道。我们由一条化学遗传途径在 zebrafish 胚胎调查了这个问题。小分子图书馆用实时 Tg 被屏蔽(kdrl : GRCFP ) endothelial 房间是的转基因的在胚胎明确地用 GFP 标记的 zn1 。由在腔形成以后在胚胎的血容器的形态学和功能上分析混合物的效果, PP1,一个通常认为的 Src kinase 禁止者,明确地由打断 endothelial 房间正直减少脉管的腔尺寸作为有能力被识别。禁止的效果不由于因为象几个 VEGFR 禁止者一样的另一 Src 禁止者和 Src morpholino 没能生产类似的显型,表明抑制的 Src 或一般 VEGF。在介绍 22 代表性的哺乳动物的 kinases 的一块面板并且调查出版数据以后,我们选择了一些可能的新候选人。这些候选人 kinase 禁止者的 Combinational 分析证实 PP1 由禁止 VEGFR2 和地图 kinase 小径导致了 endothelial 倒塌。更重要地,二临床上同意的药 Dasatinib 和 Sunitinib 的组合使用生产了一样的显型。这是第一研究阐明用化学遗传控制 endothelial 完整的维护的小径来临,显示那 endothelial 正直被 VEGFR2 和地图 kinase 小径的联合行动控制。我们的结果也在循环系统上建议二 anticancer 药的联合的可能的副作用。 | Hanbing Zhong Danyang Wang Nan Wang Yesenia Rios Haigen Huang Song Li Xinrong Wu Shuo Lin | 2011 | Cell Research2011，21，7： | 0 |
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