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| 1 | Comparison of Histological, Microbiological, and Molecular Methods in Diagnosis of Patients with TBLN Having Different Anti-TB Treatment Background显示文摘Objective The influence of anti-tuberculosis(TB) treatment history on tuberculous lymphadenitis(TBLN) diagnosis is unclear. Therefore, this study aims to evaluate the diagnostic methods, including histology, microbiology, and molecular tests, used for TBLN. Methods In this study, suspected patients with TBLN and having different anti-TB treatment background were enrolled. All the samples were tested simultaneously by histology, Ziehl-Neelsen(ZN) staining, mycobacterial culture(culture), Xpert MTB/RIF(xpert), real-time PCR, and high-resolution melting curve PCR(HRM). Thereafter, the performance of these methods on samples with different anti-TB treatment background was assessed. Results In our study, 89 patients were prospectively included 82 patients with TBLN and 7 with other diseases. The overall sensitivities of Xpert, real-time PCR, histology, ZN staining, and culture were 86.6%, 69.5%, 58.5%, 43.9%, and 22.0%, respectively. The anti-TB treatment history revealed dramatic influences on the sensitivity of culture(P < 0.0001). In fact, the treatment that lasted over 3 months also influenced the sensitivity of Xpert(P < 0.05). However, the treatment history did not affect the performance of remaining tests(P > 0.05). For rifampicin drug susceptibility test(DST), the anti-TB treatment showed only significant influence on the success rate of culture DST(P = 0.001), but not on those of Xpert and HRM tests(P > 0.05). Conclusion Other tests as well as culture should be considered for patients with TBLN having retreatment history or over 1-month treatment to avoid false negative results. | CHE Nan Ying HUANG Shao Jun MA Yan HAN Yi LIU Zi Chen ZHANG Chen MU Jing ZHAO Dan QU Yang ZHANG Hai Qing LIU Zhi Dong XU Shao Fa | 2017 | Biomedical and Environmental Sciences2017，30，6： | 6 |
| 2 | Norovirus Infection and Histo-blood Group Antigens in Children Hospitalized with Diarrhea in Lulong and Chenzhou in China显示文摘Norovirus(No V)is a pathogen that commonly causes viral diarrhea in children.Studies indicate that No V recognizes human histo-blood group antigens(HBGAs)as cell attachment factors.In order to explore the correlation between of No V infection and HBGAs,a cross-sectional study was conducted in children less than five years old who were hospitalized with diarrhea in two areas of China between November 2014 and February 2015. | SUN Xiao Man YAN Xiao Feng HE Zhi Gang Li Jing Xin GUO Ni Jun XU Zi Qian JIN Miao LI Dan Di ZHOU Yong Kang XIE Guang Cheng Pang Li Li ZHANG Qing LIU Na DUAN Zhao Jun | 2016 | Biomedical and Environmental Sciences2016，29，4： | 3 |
| 3 | Cis-2-dodecenoic Acid Mediates Its Synergistic Effect with Triazoles by Interfering with Efflux Pumps in Fluconazole-resistant Candida albicans显示文摘Objective To evaluate the synergy of the Burkholderia signaling molecule cis-2-dodecenoic acid(BDSF) and fluconazole(FLU) or itraconazole(ITRA) against two azole-resistant C. albicans clinical isolates in vitro and in vivo. Methods Minimum inhibitory concentrations(MICs) of antibiotics against two azole-resistant C. albicans were measured by the checkerboard technique, E-test, and time-kill assay. In vivo antifungal synergy testing was performed on mice. Analysis of the relative gene expression levels of the strains was conducted by quantitative reverse-transcription polymerase chain reaction(qR T-PCR). Results BDSF showed highly synergistic effects in combination with FLU or ITRA with a fractional inhibitory concentration index of ≤ 0.08. BDSF was not cytotoxic to normal human foreskin fibroblast cells at concentrations of up to 300 μg/mL. The qR T-PCR results showed that the combination of BDSF and FLU/ITRA significantly inhibits the expression of the efflux pump genes CDR1 and MDR1 via suppression of the transcription factors TAC1 and MRR1, respectively, when compared with FLU or ITRA alone. No dramatic difference in the mR NA expression levels of ERG1, ERG11, and UPC2 was found, which indicates that the drug combinations do not significantly interfere with UPC2-mediated ergosterol levels. In vivo experiments revealed that combination therapy can be an effective therapeutic approach to treat candidiasis. Conclusion The synergistic effects of BDSF and azoles may be useful as an alternative approach to control azole-resistant Candida infections. | YANG Dong Liang HU Yan Ling YIN Zi Xin ZENG Gui Sheng LI Dan ZHANG Yu Qian XU Zhen Hua GUAN Xiao Ming WENG Li Xing WANG Lian Hui | 2019 | Biomedical and Environmental Sciences2019，32，3： | 2 |
| 4 | Diagnosis,treatment,and prevention of severe acute hepatitis of unknown etiology in children显示文摘Background Severe acute hepatitis of unknown etiology in children has recently exhibited a global trend of concentrated occurrence.This review aimed to summarize the current available information regarding the outbreak of severe acute hepatitis and introduce our hospital’s previous experiences with the diagnosis and treatment of severe acute hepatitis for reference.Data sources Websites including the UK Health Security Agency,European Centre for Disease Prevention and Control,CDC,WHO,and databases including PubMed/Medline,Cochrane Library,Embase and Web of Science were searched for articles on severe acute hepatitis in children.Results As of May 26,2022,a total of 650 cases have been reported in 33 countries;at least 38(6%)children required liver transplantation,and nine(1%)died.Cases are predominantly aged between 3 and 5 years old,and there are no epidemiological links among them.The common manifestations are jaundice,vomiting and pale stools.Adenovirus tested positive in most cases,and SARS-CoV-2 and other viruses were detected in a few cases,but virus particles were not found in liver tissue.Adenovirus immunohistochemistry showed immunoreactivity in the intrasinusoidal lumen from some liver samples.The hierarchical treatment includes symptomatic and supportive therapy,management of coagulation disorders and hepatic encephalopathy,artifcial liver support,and liver transplantation(approximately 6%–10%of cases require liver transplant).Conclusions The etiology of this severe acute hepatitis in children is not clear.The clinical features are severe acute hepatitis with signifcantly elevated liver enzymes.Clinicians need to be alert to children with hepatitis. | Ying‑Hu Chen Jin‑Gan Lou Zi‑Hao Yang Qing‑Jiang Chen Chun‑Zhen Hua Sheng Ye Chen‑Mei Zhang Jie Chen Zong‑Wei Huang Jin‑Dan Yu Zhi‑Gang Gao Qiang Shu | 2022 | World Journal of Pediatrics2022，18，8： | 2 |
| 5 | The effects of health Qigong Baduanjin on the prevention,treatment,and recovery of COVID‑19显示文摘To summarize the application and modern studies on health Qigong Baduanjin by domestic and foreign scholars,combined them with clinical practice of mobile hospital in Wuhan,we explore the prevention,treatment,and recovery of Baduanjin in the war against COVID‑19.On the basis of studying ancient classics,such as Huangdi’s Internal Classic,and the concrete exercise methods of Baduanjin,we propose three ideas:prevention before disease onset,promoting healing during illness,and strengthening the body after recovery.We aimed to give full play to Baduanjin in the battle against COVID‑19 to popularize correct prevention and health knowledge for the patients and the healthy as well as to provide a reference for medical workers to use Traditional Chinese Medicine to prevention and treatment. | Yi‑Zhen HAN Meng‑Wei FU Zi‑Jie CHEN Fei‑Hong REN Dan‑Dan XIE Jing‑Lei LI Si‑Yu ZHAO Qian SHEN | 2020 | Journal of Integrative Nursing2020，2，2： | 2 |
| 6 | Different mechanisms of improving CH_(3)NH_(3)PbI_(3) perovskite solar cells brought by fluorinated or nitrogen doped graphdiyne显示文摘Fluorinated and nitrogen-doped graphdiyne(F/N-GDY)have been used in the active layer of perovskite solar cells(PSCs)for the first time.The introduction of heteroatoms turns out to be an effective method for boosted solar cells performance,which increases by 32.8%and 33.0%,better than the pristine or GDY doped PSCs.The enhanced performance can be attributed firstly to the superiority of F/N-GDY originated from the unique structure and optoelectronic properties of GDY.Then,both can further reduce surface defects and improve surface and bulk crystallinity than pristine GDY.What's more,efficiency increase caused by F-GDY is mainly attributed to the improvement of fill factor(FF),while the higher short-circuit current(Jsc)plays more important role by N-GDY doping.Most importantly,the detailed mechanism brought about by doping of F-GDY or N-GDY is expounded by systematical characterizations,especially the synchrotron radiation technique.Doping of F-GDY causes Pb and forms new Pb-F bonds between F-GDY and Pb ions.Doping of N-GDY or GDY brings about Pb(N-GDY doping induces more deviation than that of GDY due to the participation of imine N),improving its electron density and conductivity. | Huan Huang Bing Liu Dan Wang Rongli Cui Xihong Guo Ying Li Shouwei Zuo Zi Yin Huanhua Wang Jing Zhang Hui Yuan Lirong Zheng Baoyun Sun | 2022 | Nano Research2022，15，1： | 2 |
| 7 | Electrochemistry of hemoglobin entrapped in a nafion/nano-zno film on carbon ionic liquid electrode显示文摘 | SUN Wei ZHAI Zi Qin WANG Dan Dan | 2009 | Bioeleetrochemistry2009，74，2： | 1 |
| 8 | Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway显示文摘Spermatogenic dysfunction is one of the major secondary complications of diabetes;however,the underlying mechanisms remain ill-defined,and there is no available drug or strategy for the radical treatment of diabetic spermatogenic dysfunction.Therefore,the objective of this study is to investigate the protective effects of nicotinamide mononucleotide(NMN)on testicular spermatogenic function in streptozotocin(STZ)-induced diabetic mice.The results show that oral administration of NMN significantly increases the body and testis weight and the number of sperms.Moreover,the abnormal sperm count and the rate of sperm malformation are significantly decreased compared with the saline-treated diabetic mice.Histological analysis reveals that NMN treatment significantly increases the area and diameter of seminiferous tubules,accompanied by an increased number of spermatogenic cells and sperms.Immunohistochemistry and qRT-PCR results show that NMN increases Bcl-2 expression and decreases Bax expression in the testis.NMN also increases the protein expression of Vimentin and the mRNA expressions of WT1 and GATA4.In addition,qRT-PCR,western blot analysis and immunohistochemistry results also show that NMN increases the expressions of glycolysis-related rate-limiting enzymes including HK2,PKM2,and LDHA.In summary,this study demonstrates the protective effects of NMN on the testis in an STZ-induced diabetic mice model.NMN exerts its protective effects via reducing spermatogenic cell apoptosis by regulating glycolysis of Sertoli cells in diabetic mice.This study provides an experimental basis for the future clinical application of NMN in diabetes-induced spermatogenicdysfunction. | Duo Ma Linlin Hu Jinyuan Wang Min Luo Aihong Liang Xiaocan Lei Biyun Liao Meixiang Li Ming Xie Haicheng Li Yiwei Gong Dan Zi Xiangrun Li Xi Chen Xucai Liao | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 1 |
| 9 | Experimental study of effect of Ganyanping on fibrosis in rat liver 显示文摘 | TANG WX DAN ZI YAN HM el al | 2003 | World J Gastroenterol2003，9，6： | 1 |
| 10 | Improvement of the SST γ-Re_(θt) transition model for flows along a curved hydrofoil显示文摘The transition in the boundary-layer flow affects the hydrodynamic performances of hydraulic machineries,as the key components in the ship propulsion system.The shear stress transfer(SST)γ-Re_(θt) transition model is an important prediction tool in the boundary layer simulation for hydrofoils.The present paper improves the prediction accuracy of the SST γ-Re_(θt) model for the boundary layers along a curved hydrofoil.The SST γ-Re_(θt) transition model for the flows along a curved hydrofoil is improved by introducing a correction to the transition onset Reynolds number Reθt.First,the transition onset locations for the flows along the hydrofoils of different curvatures are obtained by the large eddy simulation and by using the SST γ-Re_(θt) model.Then,the transition onset Reynolds numbers Reθt in the SST γ-Re_(θt) model is modified to ensure that the predicted boundary layer parameters are consistent with the large eddy simulation(LES)results.The correlation function between the curvature ratio and the modified transition onset Reynolds number is obtained and subsequently used as a correction function in the original SST γ-Re_(θt) model.Three test cases are used to evaluate the performance of the improved SST γ-Re_(θt) model.For the NACA0035 hydrofoil with a large curvature,the predicted results obtained by using the improved SST γ-Re_(θt) model are quite consistent with the experimental data,which indicates the advantages of the improved model in predicting the boundary layer transition along a hydrofoil.In the test cases of the NACA0016 hydrofoil with a mild curvature and the NACA66(mod)-312 hydrofoil,the prediction results of the improved model are in good agreement with the experimental results in terms of the wake region and the boundary layer parameters,which indicates that the improved SST γ-Re_(θt) model can serve as a powerful tool in the design and the optimization of hydraulic machineries such as the waterjet pumps or the naval propellers. | Chang-liang Ye Chao-yue Wang Dan Zi Yuan Tang Bart.P.M.van Esch Fu-jun Wan | 2021 | Journal of Hydrodynamics2021，33，3： | 1 |
| 11 | 显示文摘 | Yuan Xiao Zi Li Dan | 2002 | Electrochemistry Communications2002，4，2： | 1 |
| 12 | CircBAGE2(hsa_circ_0061259)regulates CCND1 and PDCD10 expression by functioning as an miR-103a-3p‘sponge’to alter the proliferation and apoptosis of prostate cancer cells显示文摘Objective The aim of the article is to explore the function of circBAGE2(hsa_circ_0061259)in prostate cancer(PCa)cells.Methods Sequencing results of circBAGE2 were verified by quantitative RT PCR(qRT-PCR)and Sanger sequencing.Agarose gel electrophoresis was used to detect the resistance of GAPDH,BAGE2,and circBAGE2 to RNase R and their expression as cDNA and gDNAin 22RV1 cells.The biological functions of circBAGE2 were investigated by CCK8 assay and flow cytometry in 22RV1 cells transfected with siRNAs.Multiple databases were used to predict the target binding sites between circRNAs,miRNAs,and mRNAs.Western blotting was used to detect the expression of CCND1 and PDCD10.Results CircBAGE2 was significantly upregulated in PCa samples and PCa cells compared to that in matched normal tissues and normal cells,and CircBAGE2 knockdown inhibits cell proliferation and promotes apoptosis.Downregulation of circBAGE2 compromised the expression of CCND1 and PDCD10.The 3’UTRs of CCND1 and PDCD10 were matched by miR-103a-3p,which shared binding sites with circBAGE2.Conclusion CircBAGE2 contributes to PCa progression by upregulating CCND1 and PDCD10 expression through its role as a‘sponge’of miR-103a-3p.CircBAGE2 may be a potential therapeutic target for PCa. | Chunlei Zhang Dan Liu Qinqin Tian Qi Yang Xiaoyuan Zi Yinghao Sun | 2021 | Oncology and Translational Medicine2021，7，5： | 1 |
| 13 | Kinematics and error analysis of cooperative cable parallel manipulators for multiple mobile cranes显示文摘 | Qian Sen Zi Bin Zhang Dan | 2014 | International Journal of Mechanics and Materials in Design2014，，10： | 1 |
| 14 | Deflection of cavitation bubble near the rigid wall with a gas-containing hole显示文摘The presence of a rigid wall causes a microjet of the cavitation bubble to collapse to move toward the wall,while a free surface does the opposite.When a rigid wall surface is combined with a free surface,it may affect the direction of the microjet.The motive of this study is to find out the influence of the dynamic behavior of a laser-induced bubble near the rigid wall with a gas-containing hole.Evolutions of the bubble at different distances from the gas-containing hole in the horizontal and vertical directions were recorded by a high-speed camera(2.3×10^(5) fps).When the bubble collapse near the boundary,the bubble will produce two situations:away from or toward the boundary.It focuses on the direction of the bubble,the oscillation period of a bubble,and reflection angle,and quantitative analysis of the results.It was found that the boundary not only changes the morphologic of the bubble and the overall direction of movement but also affects the oscillation period.In addition,it can control the deflection of the bubble. | Yu-rong Sun Qiang Zhong Zhi-feng Yao Dan Zi Ruo-fu Xiao Fu-jun Wang | 2023 | Journal of Hydrodynamics2023，35，2： | 1 |
| 15 | Distribution of Microbiota in Fine Particulate Matter Particles in Guangzhou, China显示文摘Objective High PM2.5 concentration is the main feature of increasing haze in developing states,but information on its microbial composition remains very limited.This study aimed to determine the composition of microbiota in PM2.5 in Guangzhou,a city located in the tropics in China.Methods In Guangzhou,from March 5th to 10th,2016,PM2.5 was collected in middle volume air samplers for 23 h daily.The 16 S rDNA V4 region of the PM2.5 sample extracted DNA was investigated using high-throughput sequence.Results Among the Guangzhou samples,Proteobacteria,Bacteroidetes,Firmicutes,Cyanobacteria,and Actinobacteria were the dominant microbiota accounting for more than 90%of the total microbiota,and Stenotrophomonas was the dominant gram-negative bacteria,accounting for 21.30%–23.57%.We examined the difference in bacterial distribution of PM2.5 between Beijing and Guangzhou at the genus level;Stenotrophomonas was found in both studies,but Escherichia was only detected in Guangzhou.Conclusion In conclusion,the diversity and specificity of microbial components in Guangzhou PM2.5 were studied,which may provide a basis for future pathogenicity research in the tropics. | DONG Shi Rui HAN Ya Jing WU Jing ZENG Cheng Li ZHU Ke Hui CHEN Xiao Jing LIU Yu Mei ZOU Xiao Qian ZHENG Shao Ling WEN Zi Hao LIU Dan Dan WANG Yao HUANG Xiu Xia DU Xiu Ben HAO Jian Lei WANG Huan Yu GUO Shu JING Chun Xia YANG Guang | 2020 | Biomedical and Environmental Sciences2020，33，5： | 1 |
| 16 | Gene Knockdown in Human Rhinovirus 1B Using 2′-OMe-modified si RNAs Results in the Reactivation of the Interferon Response显示文摘学习是调查 2-O-methylated (2-OMe ) 的击倒的效率的这的目的在人的鼻病毒 1B (HRV1B ) 上修改了小介入的 RNA (siRNAs ) 复制和干扰素反应。因此, 24 2-OMe-modified siRNAs 被设计指向 HRV1B。HRV1B 的 RNA 层次,像使用费的受体 3,黑瘤联系区别的基因 5, retinoic 酸可诱导的基因 -- 我,和干扰素在感染 HRV1B 的 HeLa 和 BEAS-2B 被决定有 2-OMe-modified siRNAs 的上皮的房间 transfected。结果表明所有 2-OMe-modified siRNAs 防碍 HRV1B 的复制在一房间特定并且 transfection 效率依赖者举止。像使用费的受体的病毒的激活 3,黑瘤联系区别的基因 5, retinoic 酸可诱导的基因 -- 我,和干扰素反应被检测。在结论,在这研究使用的 2-OMe-modified siRNAs 能防碍 HRV1B 复制,可能导致干扰素反应的复活。 | XIE Guang Cheng ZHANG Qing PANG Li Li LI Dan Di JIN Miao LI Hui Ying XU Zi Qian KONG Xiang Yu WANG Hong LU Shan DUAN Zhao Jun | 2016 | Biomedical and Environmental Sciences2016，29，2： | 1 |
| 17 | Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial显示文摘An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to enrollment.The participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or BBIBP-CorV.The primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating strains.Between May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV group.Interim results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or 2.For immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by BBIBP-CorV.Our findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages. | Nawal Al Kaabi Yun Kai Yang Yu Liang Ke Xu Xue Feng Zhang Yun Kang Yu Qin Jin Jun Wei Hou Jing Zhang Tian Yang Salah Hussein Mohamed Saif ElDein Ze Hua Lei Hao Zhang Shuai Shao Zhao Ming Liu Ning Liu Xiang Zheng Ji Guo Su Sen Sen Yang Xiangfeng Cong Yao Tan Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Fu Jie Shen Jin Juan Wu Zi Bo Han Li Fang Du Fang Tang Shi Chen Zhi Jing Ma Fan Zheng Ya Nan Hou Xin Yu Li Xin Li Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 18 | A new sesquiterpene from hairy root culture of Artemisia annua显示文摘A new sesquiterpene(Z)-7-acetoxy-methyl-11-methyl-3-methylenedodeca-1,6,10-triene(AMDT) was isolnted and identified from the methanol extract of the hairy root culture of Artemisia annua.The structure of AMDT was determined based on the analysis of spectroscopic data,notably of the 2D NMR spectra.This new compound showed cytotoxicity against human tumor cell lines 95-D and HeLa with IC50 values of 27.08 and 20.12μmol/L,respectively. | Dan Dan Zhai Jian Jiang Zhong | 2010 | Chinese Chemical Letters2010，21，5： | 0 |
| 19 | Four new sesquiterpene derivatives from Dendrobium findlayanum显示文摘Three new sesquiterpene glycosides with alloaromadendrane and ylangene-derived type aglycones,named dendrofindlayanosides A-C(1-3),one new cyclopacamphane type sesquiterpene named dendrofindlayanobilin A(4),together with five known compounds have been isolated from stems of Dendrobium findlayanum.Their structures were determined on the basis of spectroscopic and chemical methods. | YANG Dan CHENG Zhong-Quan ZI Cheng-Ting YANG Liu DONG Fa-Wu HU Jiang-Miao ZHOU Jun | 2019 | Chinese Journal of Natural Medicines2019，17，12： | 0 |
| 20 | Leaf Morphology Genes SRL1 and RENL1 Co-Regulate Cellulose Synthesis and Affect Rice Drought Tolerance显示文摘The morphological development of rice(Oryza sativa L.)leaves is closely related to plant architecture,physiological activities,and resistance.However,it is unclear whether there is a co-regulatory relationship between the morphological development of leaves and adaptation to drought environment.In this study,a drought-sensitive,roll-enhanced,and narrow-leaf mutant(renl1)was induced from a semi-rolled leaf mutant(srl1)by ethyl methane sulfonate(EMS),which was obtained from Nipponbare(NPB)through EMS.Map-based cloning and functional validation showed that RENL1 encodes a cellulose synthase,allelic to NRL1/OsCLSD4.The RENL1 mutation resulted in reduced vascular bundles,vesicular cells,cellulose,and hemicellulose contents in cell walls,diminishing the water-holding capacity of leaves.In addition,the root system of the renl1 mutant was poorly developed and its ability to scavenge reactive oxygen species(ROS)was decreased,leading to an increase in ROS after drought stress.Meanwhile,genetic results showed that RENL1 and SRL1 synergistically regulated cell wall components.Our results revealed a theoretical basis for further elucidating the molecular regulation mechanism of cellulose on rice drought tolerance,and provided a new genetic resource for enhancing the synergistic regulation network of plant type and stress resistance,thereby realizing simultaneous improvement of multiple traits in rice. | LIU Dan ZHAO Huibo WANG Zi’an XU Jing LIU Yiting WANG Jiajia CHEN Minmin LIU Xiong ZHANG Zhihai CEN Jiangsu ZHU Li HU Jiang REN Deyong GAO Zhenyu DONG Guojun ZHANG Qiang SHEN Lan LI Qing QIAN Qian HU Songping ZHANG Guangheng | 2024 | Rice science2024，31，1： | 0 |
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