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| 1 | Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells显示文摘Spermatogonial 干细胞(SSC ) 能在移植以后生产众多的男配偶子进接受者睾丸,介绍为基因治疗和修改基因的动物的连续生产的一条珍贵途径。然而, SSC 的成功的基因操作被限制了,部分由于复杂性和当前可得到的基因编辑技术的低效率。这里,我们证明有效基因修正能用 CRISPR-Cas9 系统被介绍进 SSC。我们使用了 CRISPR-Cas9 系统变异在 SCC 的 EGFP transgene 或内长的 Crygc 基因。变异的 SSC 在移植以后经历了精子发生进不肥沃的老鼠睾丸的生精的小管。圆 spermatids 被产生并且在进成熟卵母细胞的注射以后,支持了显示相应变异的显型的异质接合的后代的生产。而且,在 Crygc 的一个引起疾病的变化(在 SSC 先存在的 Crygc −/−) 能乐意地到加入的 CRISPR-Cas9-induced nonhomologous 结束(NHEJ ) 或指导相同的修理(HDR ) 被修理,导致没有是的离开目标修正的证据带改正的基因的 SSC 线由整个染色体的定序出现。用从这些线产生的圆 spermatids 的授精在 100% 的效率与改正的显型产生了后代。我们的结果表明有效基因由 CRISPR-Cas9 系统在老鼠 SSC 编辑,并且提供在 SSC 经由基因修正治好基因疾病的原则的证明。 | Yuxuan Wu Hai Zhou Xiaoying Fan Ying Zhang Man Zhang Yinghua Wang Zhenfei Xie Meizhu Bai Qi Yin Dan Liang Wei Tang Jiaoyang Liao Chikai Zhou Wujuan Liu Ping Zhu Hongshan Guo Hong Pan Chunlian Wu Huijuan Shi Ligang Wu Fuchou Tang Jinsong Li | 2015 | Cell Research2015，25，1： | 37 |
| 2 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 3 | Effect of vitamin E succinate on expression of TGF-β_1, c-Jun and JNK1 in human gastric cancer SGC-7901 cells显示文摘INTRODUCTIONVitamin E succinate (RRR-α-Tocopheryl Succinate,VES), a derivative of natural vitamin E, is acompound esterified by succinic acid and 6-hydroxyl-α-tocopheryl. | Kun Wu Bai He Liu Dan Yang Zhao Yan Zhao Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150001, Heilongjiang Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 17 |
| 4 | Associations of plasma homocysteine and high-sensitivity C-reactive protein levels with arterial stiffness in Chinese population: a community-based study显示文摘背景动脉的僵硬与年龄增加并且是也与传统的心血管的风险 factors.Little 联系了在学习是与动脉的僵硬调查血浆 homocysteine 和 hs-CRP 层次的协会在里面的礼品的中国 community.The 目的对与动脉的僵硬的 homocysteine 和高敏感的C反应的蛋白质( hs-CRP )的关系被知道我们联系了的基于社区的 cohort.Methods homocysteine 和 hs-CRP 铺平到动脉的 stiffne | FENG Sheng-qiang YE Ping LUO Lei-ming XIAO Wen-kai BAI Yong-yi FENG Dan LIU De-jun WU Hong-mei XU Ru-yi BAI Jie | 2012 | Chinese Medical Journal2012，，1： | 12 |
| 5 | Characteristics of the crustal magnetic anomaly and regional tectonics in the Qinghai-Tibet Plateau and the adjacent areas显示文摘Study of the characteristics of the crustal magnetic anomaly in the Qinghai-Tibet Plateau and the adjacent areas helps better understand the lithospheric structure and evolution, as well as the regional geodynamic processes. Here we analyze the distribution laws of the crustal magnetic anomaly and its vertical gradient, the decay characteristics of the anomaly, the contributions from different wavelength bands to the anomaly, and the relationship between the anomaly and the crustal regional tectonics in the plateau and nearby, based on a new and higher degree geomagnetic model NGDC-EMM-720-V3 constructed from the surface, aeromagnetic, marine and satellite survey data. The results reveal that the positive and negative anomalies in the Qinghai-Tibet Plateau are weak, while those of the surrounding areas are strong. The boundary agrees well with the border of the plateau regional tectonics. The anomaly is nearly east-west in the central and western plateau, arc-shaped in the southwestern and eastern, and nearly north-south in the southeastern, consistent with the tectonic trends. There are strong negative anomaly foci in the east and west syntaxis, whereas no significant differences exist among the Cenozoic blocks in the plateau interior. No direct correspondence exists between the anomaly and the crustal depth. On the background of a weak magnetic anomaly in the plateau, relatively stronger short wavelength fields from the shallower crust are overlapped in the Lhasa, Qilian, Qaidam, and Sichuan-Yunnan rhombic blocks. A strong negative anomaly in the east-west direction is distributed along the Himalayas, mainly caused by the middle and long wavelength bands in the deep and central crust. The magnetic structural layers are stable in the Sichuan and Tarim basins. The anomalies at different altitudes over the southern plateau vary strongly, showing a drastic variation in the magnetic structure from the deep crust to the shallow crust. | KANG GuoFa GAO GuoMing BAI ChunHua SHAO Dan FENG LiLi | 2012 | Science China Earth Sciences2012，55，6： | 11 |
| 6 | Studies on the overexpression of the soybean GmNHX1 in Lotus corniculatus: The reduced Na^+ level is the basis of the increased salt tolerance显示文摘The full length cDNA coding for a novel vacuolar Na+/H+ antiporter (GmNHX1) was cloned from soybean and determined to consist of 2591 bp with a 5′-untranslated region of 464 bp, an open reading frame (ORF) of 1641 bp, and a 3′-untrans- lated region of 486 bp. The deduced protein se- quence contains 546 aa with the typical characters of the vacuolar Na+/H+ antiporters, and shares high similarity with that of AtNHX1, OsNHX1 and AgNHX1. The soybean genome showed a single copy of the GmNHX1 gene. Northern blot analysis demonstrated that the expression of the GmNHX1 was tissue-spe- cific, increased by ABA treatment, NaCl, KCl, LiCl and dehydration stress, and lower in leaves but higher in roots and hypocotyls of salt-tolerant than salt-sensitive cultivars. The GmNHX1 was overex- pressed under the control of a tandem cauliflower mosaic virus (CaMV) 35S promoter in the model le- guminous plant Lotus corniculatus L. and conferred salt-tolerance of the transgenic plants. Measure- ments of Na+ and K+ contents in both roots and shoots demonstrated that the plantlets of GmNHX1- overexpressing lines had lower Na+ and K+ content, and higher K+/Na+ ratio than the controlled lines that were transformed with the empty vector, which indi- cates that the salt-tolerance conferred by GmNHX1 is closely related with decreased accumulation of Na+ in the transgenic plants. | SUN Yanxiang WANG Dan BAI Yanling WANG Ningning WANG Yong | 2006 | Chinese Science Bulletin2006，51，11： | 10 |
| 7 | Association of IL-17 polymorphisms with gastric cancer risk in Asian populations显示文摘AIM: To investigate associations between the IL-17 rs2275913 G>A and rs763780 T>C polymorphisms and susceptibility to gastric cancer in Asian populations. METHODS: We reviewed studies published up to 2014 on IL-17 polymorphisms with gastric cancer susceptibility systematically. Relevant articles were identified in the MEDLINE, Science Citation Index, Cochrane Library, Pub Med, EMBASE, CINAHL and Current Contents Index databases. We used version 12.0 STATA statistical software to evaluate the statistical data. Two reviewers abstracted the data independently. Odds ratios(ORs) and 95% confidence intervals(95%CIs) were calculated. RESULTS: Seven independent, case-control studies were chosen for the meta-analysis, which included 3210 gastric cancer patients and 3889 healthy controls. The overall estimation showed a positive association between the IL-17 rs2275913 G>A polymorphism and the occurrence of gastric cancer for five genetic models(all P < 0.05) and similar results were observed for the IL-17 rs763780 T>C variation with four genetic models(all P < 0.05), but not for the dominant model(P > 0.05). Subgroup analysis by country revealed that the rs2275913 G>A and rs763780 T>C polymorphisms may be the main risk factor for gastric cancer in Chinese and Japanese populations. CONCLUSION: The IL-17 gene may be significantly correlated with gastric cancer risk in Asian populations, especially those carrying the rs2275913 G>A and rs763780 T>C polymorphisms. | Zi-Wen Long Hong-Mei Yu Ya-Nong Wang Dan Liu Yan-Zhi Chen Yu-Xia Zhao Lu Bai | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 8 | Paired associated magnetic stimulation promotes neural repair in the rat middle cerebral artery occlusion model of stroke显示文摘Paired associative stimulation has been used in stroke patients as an innovative recovery treatment.However,the mechanisms underlying the therapeutic effectiveness of paired associative stimulation on neurological function remain unclear.In this study,rats were randomly divided into middle cerebral occlusion model(MCAO)and paired associated magnetic stimulation(PAMS)groups.The MCAO rat model was produced by middle cerebral artery embolization.The PAMS group received PAMS on days 3 to 20 post MCAO.The MCAO group received sham stimulation,three times every week.Within 18 days after ischemia,rats were subjected to behavioral experiments—the foot-fault test,the balance beam walking test,and the ladder walking test.Balance ability was improved on days 15 and 17,and the footfault rate was less in their affected limb on day 15 in the PAMS group compared with the MCAO group.Western blot assay showed that the expression levels of brain derived neurotrophic factor,glutamate receptor 2/3,postsynaptic density protein 95 and synapsin-1 were significantly increased in the PAMS group compared with the MCAO group in the ipsilateral sensorimotor cortex on day 21.Resting-state functional magnetic resonance imaging revealed that regional brain activities in the sensorimotor cortex were increased in the ipsilateral hemisphere,but decreased in the contralateral hemisphere on day 20.By finite element simulation,the electric field distribution showed a higher intensity,of approximately 0.4 A/m^2,in the ischemic cortex compared with the contralateral cortex in the template.Together,our findings show that PAMS upregulates neuroplasticity-related proteins,increases regional brain activity,and promotes functional recovery in the affected sensorimotor cortex in the rat MCAO model.The experiments were approved by the Institutional Animal Care and Use Committee of Fudan University,China(approval No.201802173 S)on March 3,2018. | Bei-Yao Gao Cheng-Cheng Sun Guo-Hua Xia Shao-Ting Zhou Ye Zhang Ye-Ran Mao Pei-Le Liu Ya Zheng Dan Zhao Xu-Tong Li Janie Xu Dong-Sheng Xu Yu-Long Bai | 2020 | Neural Regeneration Research2020，15，11： | 8 |
| 9 | Isotopic Compositions of Sulfur in the Jinshachang Lead–Zinc Deposit, Yunnan, China, and its Implication on the Formation of Sulfur-Bearing Minerals显示文摘The Jinshachang lead–zinc deposit is mainly hosted in the Upper Neoproterozoic carbonate rocks of the Dengying Group and located in the Sichuan–Yunnan–Guizhou(SYG) Pb–Zn–Ag multimetal mineralization area in China.Sulfides minerals including sphalerite,galena and pyrite postdate or coprecipitate with gangue mainly consisting of fluorite,quartz,and barite,making this deposit distinct from most lead–zinc deposits in the SYG.This deposit is controlled by tectonic structures,and most mineralization is located along or near faults zones.Emeishan basalts near the ore district might have contributed to the formation of orebodies.The δ34S values of sphalerite,galena,pyrite and barite were estimated to be 3.6‰–13.4‰,3.7‰–9.0‰,6.4‰ to 29.2‰ and 32.1‰–34.7‰,respectively.In view of the similar δ34S values of barite and sulfates being from the Cambrian strata,the sulfur of barite was likely derived from the Cambrian strata.The homogenization temperatures(T ≈ 134–383°C) of fluid inclusions were not suitable for reducing bacteria,therefore,the bacterial sulfate reduction could not have been an efficient path to generate reduced sulfur in this district.Although thermochemical sulfate reduction process had contributed to the production of reduced sulfur,it was not the main mechanism.Considering other aspects,it can be suggested that sulfur of sulfides should have been derived from magmatic activities.The δ34S values of sphalerite were found to be higher than those of coexisting galena.The equilibrium temperatures calculated by using the sulfur isotopic composition of mineral pairs matched well with the homogenization temperature of fluid inclusions,suggesting that the sulfur isotopic composition in ore-forming fluids had reached a partial equilibrium. | BAI Junhao HUANG Zhilong ZHU Dan YAN Zaifei ZHOU Jiaxi | 2013 | Acta Geologica Sinica(English Edition)2013，87，5： | 8 |
| 10 | Vitamin D receptor gene polymorphisms and colorectal cancer risk:A systematic meta-analysis显示文摘AIM:To investigate the relationship between polymorphisms present in the vitamin D receptor(VDR) gene and colorectal cancer risk,a systematic meta-analysis of population-based studies was performed.METHODS:A total of 38 relevant reports published between January 1990 and August 2010 were identified,of which only 23 qualified for this meta-analysis based on our selection criteria.Five polymorphic variants of the VDR gene,including Cdx-2(intron 1e) and FokI(exon 2) present in the 5' region of the gene,and BsmI(intron 8),ApaI(intron 8),and TaqI(exon 9) sites present in the 3' untranslated region(UTR),were evaluated for possible associations with colorectalcancer risk.Review manager 4.2 was used to perform statistical analyses.RESULTS:In the meta-analysis performed,only the BsmI polymorphism was found to be associated with colorectal cancer risk.In particular,the BsmI B genotype was found to be related to an overall decrease in the risk for colorectal cancer [BB vs bb:odds ratio(OR) = 0.87,95% CI:0.80-0.94,P = 3 × 10-4;BB vs Bb + bb:OR = 0.90,95% CI:0.84-0.97,P = 5 × 10-4].Moreover,in subgroup analyses,the BsmI B genotype was significantly associated with colon cancer,and not rectal cancer.An absence of between-study heterogeneity was also observed.CONCLUSION:A meta-analysis of 23 published studies identified the BsmI polymorphism of the VDR gene to be associated with an increased risk of colon cancer. | Yong-Heng Bai Hong Lu, Dan Hong Cheng-Cheng Lin Zhen Yu Bi-Cheng Chen | 2012 | World Journal of Gastroenterology2012，18，14： | 7 |
| 11 | Effect of Acupuncture on Ovary Morphology and Function in DHEA-Induced Polycystic Ovary Syndrome Model Rats显示文摘Objective To investigate the effects of acupuncture on ovary morphology and function in dehydroepiandrosterone(DHEA)-induced polycystic ovary syndrome(PCOS)model rats.Methods A total of 40 adult female Wistar rats were randomly allocated to 4 groups by a random number table,including control,model,metformin and acupuncture groups,10 rats in each group.PCOS rat model was developed by injecting with DHEA(6 mg/100 g body weight)in 0.2 mL of oil subcutaneously.Electrical stimulation(2 Hz,3 mA)was applied to Guanyuan(CV 4),Zigong(EX-CA1)and Qihai(CV 6)acupoints for 30 min daily in the acupuncture group,and metformin(200 mg/kg)was given to rats in the metformin group,both once per day for 21 consecutive days,and rats in the normal group was fed with normal saline and fed regularly.After 21 days of administration,the rat blood samples were collected for detecting the reproductive hormonal levels[luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E2),progesterone(P),testosterone(T)]and inflammatory factors(visfatin,IL-6)analysis.Ovary tissue was used for histopathological analysis.Results Compared with the model group,rats in the acupuncture and metformin groups were significantly lower in weight gain,FSH,LH and T levels,and E2 and P levels significantly increased(alll P<0.05).Meanwhile,LH and FSH levels were significantly decreased,and P,T and E2 levels significantly increased in the acupuncture group,compared with the metformin group(P<0.05).Compared with the model group,IL-6 and visfatin levels were significantly decreased in the acupuncture and metformin groups(P<0.05).There were no significant differences in IL-6 and visfatin levels between the acupuncture and metformin groups(P>0.05).Ovarian diameter in the acupuncture and metformin groups were smaller than the model group(P<0.05).However,there were no significant differences in ovarian diameters between the acupuncture and metformin groups(P>0.05).Conclusion Acupuncture might improve ovary morphology and its function in DHEA-induced PCOS model rats. | LI Dan BAI Peng WU Jin-yang XIE Min ZHAO Rui-zhen WANG Zhong-peng QI Xiao-han | 2021 | Chinese Journal of Integrative Medicine2021，27，3： | 6 |
| 12 | Microstructure and properties of high emissivity coatings显示文摘A new coating on lining in industrial furnace for energy saving has been developed. Properties and microstructure of the coatings were revealed by emissivity instrument,X-ray diffraction (XRD),transmission electron microscope (TEM) and scanning electron microscope (SEM),respectively. The result indicates that the emissivity of coatings is higher than 0.90 and the thickness of coatings is about 200 μm. ZrO2,Cr2O3 and SiC in the coating benefit practical applications of coatings at high temperature with du-rable high emissivity and the continuous structure between the coatings and the substrate makes the coatings high cohesion and ex-cellent adhesion for both specimens with and without sintering at high temperature. Result from laboratory experiment shows that the heating speed of specimen with coating is higher than that of controlled specimen and the temperature increases 30°C during the heating. The average temperature drop of specimen with coatings has a 13.5% improvement in the cooling speed. The application of coatings on the checker brick in a blast furnace of 1750m3 indicates that the coating causes the blast temperature to an average in-crease of 28°C,reduces the fluctuation of blast temperature before the blowing-in and leads to a fuel saving of 10% approximately. | Zhigang Dan Daqiang Cang Huimin Zhou Hao Bai Yanbin Zong | 2008 | Journal of University of Science and Technology Beijing2008，15，5： | 6 |
| 13 | Hyperthyroid heart disease in pregnancy: Retrospective analysis of a case series and review of the literature显示文摘BACKGROUND Hyperthyroidism in pregnancy may pose a great threat to maternal and fetal health.The risk of hyperthyroid heart disease(HHD),even heart failure,is significantly elevated in pregnant women.AIM To investigate the clinical characteristics,prognosis,and therapy of HHD in pregnant women.METHODS We searched the patient registry data at West China Second University Hospital of Sichuan University in Chengdu,China,following the approval by the Ethics Committee.We retrospectively analyzed the clinical characteristics of pregnant women diagnosed with HHD.The medical records of women with HHD during pregnancy from January 2012 to December 2017 were obtained from the electronic medical records system.All the included patients were followed in outpatient clinics and by telephone interviews until October 2018.RESULTS A total of 155 patients were diagnosed with thyrotoxicosis,of whom six were diagnosed with HHD.Three of them had regular antenatal care.Two patients were complicated with acute heart failure attacks,and one of them had a stillbirth.Both of these patients had a long history of Graves’disease with poor treatment compliance.Treatments of precipitating factors such as the control of infection could relieve the symptoms and prolong gestation for a better prognosis.Hyperthyroid heart failure could be controlled with aggressive diuretics and management of the coexisting complications.Intense monitoring and timely anti-heart failure treatment were crucial in patients with severe cardiac damage.Our findings indicated the importance of regular antenatal care and treatment adherence in patients with hyperthyroidism.CONCLUSION The timely and accurate diagnosis of HHD and the implementation of effective management are important for a better prognosis in pregnant women with HHD.Improvement in patients’awareness of thyrotoxicosis is needed. | Dan Shan Yi Bai Qiu-He Chen Yu-Xia Wu Qian Chen Ya-Yi Hu | 2019 | World Journal of Clinical Cases2019，7，19： | 5 |
| 14 | Transport of Asian surface pollutants to the global stratosphere from the Tibetan Plateau region during the Asian summer monsoon显示文摘Due to its surrounding strong and deep Asian summer monsoon(ASM)circulation and active surface pollutant emissions,surface pollutants are transported to the stratosphere from the Tibetan Plateau region,which may have critical impacts on global climate through chemical,microphysical and radiative processes.This article reviews major recent advances in research regarding troposphere-stratosphere transport from the region of the Tibetan Plateau.Since the discovery of the total ozone valley over the Tibetan Plateau in summer from satellite observations in the early 1990s,new satellite-borne instruments have become operational and have provided significant new information on atmospheric composition.In addition,in situ measurements and model simulations are used to investigate deep convection and the ASM anticyclone,surface sources and pathways,atmospheric chemical transformations and the impact on global climate.Also challenges are discussed for further understanding critical questions on microphysics and microchemistry in clouds during the pathway to the global stratosphere over the Tibetan Plateau. | Jianchun Bian Dan Li Zhixuan Bai Qian Li Daren Lyu Xiuji Zhou | 2020 | National Science Review2020，7，3： | 5 |
| 15 | Process Optimization and Reaction Mechanism of Removing Copper From an Fe-Rich Pyrite Cinder Using Chlorination Roasting显示文摘The aim is to remove copper from a pyrite cinder by optimizing the chlorination roasting process using response surface methodology (RSM) and the reaction mechanism of chlorination roasting based on thermodynamic calculation was discussed.A quadratic model was suggested by RSM to correlate the key parameters,namely,dosage of chlorinating agent,roasting temperature and roasting time to the copper volatilization ratio.The results indicate that the model is well consistent with the experimental data at a correlation coefficient (R2) of 0.95,and the dosage of chlorinating agent and roasting temperature both have significant effects on the copper volatilization ratio.However,a roasting temperature exceeding 1 170 ℃ decreases the volatilization ratio.The optimum conditions for removing copper from the cinder were identified as chlorinating agent dosage at 5%,roasting temperature at 1 155.10 ℃ and roasting time of 10 min; under such a condition,a copper volatilization ratio of 95.16% was achieved from the cinder.Thermodynamic calculation shows that SiO2 in the pellet plays a key role in the chlorine release from calcium chloride,and the chlorine release reactions cannot occur without it. | LIU Jian WEN Shu-ming CHEN Yu LIU Dan BAI Shao-jun WU Dan-dan | 2013 | Journal of Iron and Steel Research(International)2013，20，8： | 5 |
| 16 | Wind estimation around the shipwreck of Oriental Star based on field damage surveys and radar observations显示文摘Based on observational analyses and on-site ground and aerial damage surveys, this work aims to reveal the weather phenomena—especially the wind situation—when Oriental Star capsized in the Yangtze River on June 1, 2015.Results demonstrate that the cruise ship capsized when it encountered strong winds at speeds of at least 31 m s^(-1) near the apex of a bow echo embedded in a squall line. As suggested by the fallen trees within a 2-km radius around the wreck location,such strong winds were likely caused by microburst straight-line wind and/or embedded small vortices, rather than tornadoes. | Zhiyong Meng Dan Yao Lanqiang Bai Yongguang Zheng Ming Xue Xiaoling Zhang Kun Zhao Fuyou Tian Mingjun Wang | 2016 | Science Bulletin2016，61，4： | 5 |
| 17 | Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population显示文摘Intraocular pressure(IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10^(-7), and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10^(-8), including 4 previously reported loci: rs145063132(7 p21.2, ETV1/DGKB), rs548030386(7 q31.2, ST7 near CAV1/CAV2), rs7047871(9 p24.2, GLIS3), and rs2472494(9 q31.1, ABCA1/SLC44 A1). Of the 17 newly identified loci, five were reported to have ocular related phenotypes: PTCH2(rs7525308 in 1 p34.1), LRIF1/DRAM2(rs1282146 in 1 p13.3), COLEC11(rs201143466 in 2 p25.3),SPTBN1(rs4514918 in 2 p16.2), and CRK(rs11078446 in 17 p13.3). The genetic loci identified in this study not only increase our understanding of the genes involved in intraocular pressure but also provide important genetic markers to improve future genetic screening and drug discovery for intraocular pressure disorders. | Lulin Huang Yuhong Chen Ying Lin Pancy O.S.Tam Yilian Cheng Yi Shi Bo Gong Fang Lu Jialiang Yang Haixin Wang Yi Yin Yong Cao Dan Jiang Ling Zhong Bai Xue Jing Wang Fang Hao Dean-Yao Lee Chi-Pui Pang Xinghuai Sun Zhenglin Yang | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 18 | Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats显示文摘Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis(CP),but cortical modulation of painful CP remains elusive.Here,we examined the role of the anterior cingulate cortex(ACC)in the pathogenesis of abdominal hyperalgesia in a rat model of CP induced by intraductal administration of trinitrobenzene sulfonic acid(TNBS).TNBS treatment resulted in long-term abdominal hyperalgesia and anxiety in rats.Morphological data indicated that painful CP induced a significant increase in FOS-expressing neurons in the nucleus tractus solitarii(NTS)and ACC,and some FOS-expressing neurons in the NTS projected to the ACC.In addition,a larger portion of ascending fibers from the NTS innervated pyramidal neurons,the neural subpopulation primarily expressing FOS under the condition of painful CP,rather than GABAergic neurons within the ACC.CP rats showed increased expression of vesicular glutamate transporter 1,and increased membrane trafficking and phosphorylation of the N-methyl-D-aspartate receptor(NMDAR)subunit NR2B and theα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor(AMPAR)subunit GluR1 within the ACC.Microinjection of NMDAR and AMPAR antagonists into the ACC to block excitatory synaptic transmission significantly attenuated abdominal hyperalgesia in CP rats,which was similar to the analgesic effect of endomorphins injected into the ACC.Specifically inhibiting the excitability of ACC pyramidal cells via chemogenetics reduced both hyperalgesia and comorbid anxiety,whereas activating these neurons via optogenetics failed to aggravate hyperalgesia and anxiety in CP rats.Taken together,these findings provide neurocircuit,biochemical,and behavioral evidence for involvement of the ACC in hyperalgesia and anxiety in CP rats,as well as novel insights into the cortical modulation of painful CP,and highlights the ACC as a potential target for neuromodulatory interventions in the treatment of painful CP. | Dan Ren Jia-Ni Li Xin-Tong Qiu Fa-Ping Wan Zhen-Yu Wu Bo-Yuan Fan Ming-Ming Zhang Tao Chen Hui Li Yang Bai Yun-Qing Li | 2022 | Neuroscience Bulletin2022，38，4： | 4 |
| 19 | A state‑of‑the‑art review on rock seepage mechanism of water inrush disaster in coal mines显示文摘Water inrush is one of the most dangerous disasters in coal mining.Due to the large-scale mining and complicated hydrogeological conditions,thousands of deaths and huge economic losses have been caused by water inrush disasters in China.There are two main factors determining the occurrence of water inrush:water source and water-conducting pathway.Research on the formation mechanism of the water-conducting pathway is the main direction to prevent and control the water inrush,and the seepage mechanism of rock mass during the formation of the water-conducting pathway is the key for the research on the water inrush mechanism.This paper provides a state-of-the-art review of seepage mechanisms during water inrush from three aspects,i.e.,mechanisms of stress-seepage coupling,fow regime transformation and rock erosion.Through numerical methods and experimental analysis,the evolution law of stress and seepage felds in the process of water inrush is fully studied;the fuid movement characteristics under diferent fow regimes are clearly summarized;the law of particle initiation and migration in the process of water inrush is explored,and the efect of rock erosion on hydraulic and mechanical properties of the rock media is also studied.Finally,some limitations of current research are analyzed,and the suggestions for future research on water inrush are proposed in this review. | Dan Ma Hongyu Duan Jixiong Zhang Haibo Bai | 2022 | International Journal of Coal Science & Technology2022，9，4： | 4 |
| 20 | Effective and precise adenine base editing n mouse zygotes显示文摘 | Puping Liang Hongwei Sun Xiya Zhang Xiaowei Xie Jinran Zhang Yaofu Bai Xueling Ouyang Shengyao Zhi Yuanyan Xiong Wenbin Ma Dan Liu Junjiu Huang Zhou Songyang | 2018 | Protein & Cell2018，9，9： | 4 |
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