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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | The chromosome-level quality genome provides insights into the evolution of the biosynthesis genes for aroma compounds of Osmanthus fragrans显示文摘Sweet osmanthus(Osmanthus fragrans)is a very popular ornamental tree species throughout Southeast Asia and USA particularly for its extremely fragrant aroma.We constructed a chromosome-level reference genome of O.fragrans to assist in studies of the evolution,genetic diversity,and molecular mechanism of aroma development.A total of over 118 Gb of polished reads was produced from HiSeq(45.1 Gb)and PacBio Sequel(73.35 Gb),giving 100×depth coverage for long reads.The combination of Illumina-short reads,PacBio-long reads,and Hi-C data produced the final chromosome quality genome of O.fragrans with a genome size of 727 Mb and a heterozygosity of 1.45%.The genome was annotated using de novo and homology comparison and further refined with transcriptome data.The genome of O.fragrans was predicted to have 45,542 genes,of which 95.68%were functionally annotated.Genome annotation found 49.35%as the repetitive sequences,with long terminal repeats(LTR)being the richest(28.94%).Genome evolution analysis indicated the evidence of whole-genome duplication 15 million years ago,which contributed to the current content of 45,242 genes.Metabolic analysis revealed that linalool,a monoterpene is the main aroma compound.Based on the genome and transcriptome,we further demonstrated the direct connection between terpene synthases(TPSs)and the rich aromatic molecules in O.fragrans.We identified three new flower-specific TPS genes,of which the expression coincided with the production of linalool.Our results suggest that the high number of TPS genes and the flower tissue-and stage-specific TPS genes expressions might drive the strong unique aroma production of O.fragrans. | Xiulian Yang Yuanzheng Yue Haiyan Li Wenjie Ding Gongwei Chen Tingting Shi Junhao Chen Min S.Park Fei Chen Lianggui Wang | 2018 | Horticulture Research2018，5，1： | 16 |
| 3 | OTOTOXIC EFFECTS OF CARBOPLATIN IN ORGANOTYPIC CULTURES IN CHINCHILLAS AND RATS | DING Dalian JIANG Haiyan FU Yong Richard SALVI Shinichi SOMEYA Masaru TANOKURA | 2012 | Journal of Otology2012，7，2： | 14 |
| 4 | Tensile properties of high strength cast Mg alloys at room temperature:A review显示文摘As most Mg alloy products are now produced by a casting process,the development of high strength cast Mg alloys can promote their further applications and has already become one of the hot research areas of Mg alloys.The present paper reviews the strengthening mechanisms,tensile properties and modification results of commercial high strength cast Mg alloys;as well as the development of Mg-Gd,Mg-Nd and Mg-Sn based alloys.It concludes that precipitation strengthening is the most important strengthening mechanism in high strength cast Mg alloys,which contributes more than 60%of yield strength in solution&peak-aged(T6)cast Mg alloys.For the yield strength,the alloys follow the sequence of Mg-Gd(Y)-Ag>Mg-Gd(Y)-Zn>Mg-Gd-Y/Sm/Nd>Mg-Y-Nd(WE series)>ZK61>Mg-Nd>AZ91>Mg-Sn.Mg-Gd(Y)-Ag based alloys are the strongest cast Mg alloys at present,followed by Mg-Gd(Y)-Zn based alloys.The high yield strengths of Mg-Gd(Y)-Ag and Mg-Gd(Y)-Zn cast alloys are due to the co-precipitation of basal and prismatic meta-stable phases. | Fu Penghuai Peng Liming Jiang Haiyan Ding Wenjiang Zhai Chunquan | 2014 | China Foundry2014，11，4： | 12 |
| 5 | Insights into Cronobacter sakazakii Biofilm Formation and Control Strategies in the Food Industry显示文摘Cronobacter sakazakii(C.sakazakii)is a foodborne opportunistic pathogen that can cause life-threatening invasive diseases,such as necrotizing enterocolitis,meningitis,and sepsis in infants.The potential risk of C.sakazakii contamination of powdered infant formula(PIF)is an issue that has attracted considerable attention from manufacturers,regulators,and consumers.C.sakazakii biofilms on the surfaces of equipment and in diverse food-production environments constitute a mode of cell growth that protects the pathogen from hostile environments,and are an important source of persistent contamination of food products.Bacterial biofilms are difficult to remove due to their resistant properties.Conventional cleaning and sterilizing procedures may be insufficient for biofilm control,and may lead to further biofilm development and dispersal.Consequently,novel control strategies are being developed,such as nanotechnology-based delivery systems,interspecies interactions,antimicrobial molecules of microbial origin,natural extracts,and phages.This review focuses on describing the mechanisms underlying the biofilm formation and behavior of C.sakazakii and discussing potential control strategies. | Na Ling Stephen Forsythe Qingping Wu Yu Ding Jumei Zhang Haiyan Zeng | 2020 | Engineering2020，6，4： | 10 |
| 6 | OTOTOXIC MODEL OF OXALIPLATIN AND PROTECTION FROM NICOTINAMIDE ADENINE DINUCLEOTIDE显示文摘Oxaliplatin,an anticancer drug commonly used to treat colorectal cancer and other tumors,has a number of serious side effects,most notably neuropathy and ototoxicity.To gain insights into its ototoxic profile,oxaliplatin was applied to rat cochlear organ cultures.Consistent with it neurotoxic propensity,oxaliplatin selectively damaged nerve fibers at a very low dose 1μM.In contrast,the dose required to damage hair cells and spiral ganglion neurons was 50 fold higher(50μM).Oxailiplatin-induced cochlear lesions initially increased with dose,but unexpectedly decreased at very high doses.This non-linear dose response could be related to depressed oxaliplatin uptake via active transport mechanisms.Previous studies have demonstrated that axonal degeneration involves biologically active processes which can be greatly attenuated by nicotinamide adenine dinucleotide(NAD+).To determine if NAD+would protect spiral ganglion axons and the hair cells from oxaliplatin damage,cochlear cultures were treated with oxaliplatin alone at doses of 10μM or 50μM respectively as controls or combined with 20 mM NAD+.Treatment with 10μM oxaliplatin for 48 hours resulted in minor damage to auditory nerve fibers,but spared cochlear hair cells.However,when cochlear cultures were treated with 10μM oxaliplatin plus 20 mM NAD+,most auditory nerve fibers were intact.50μM oxaliplatin destroyed most of spiral ganglion neurons and cochlear hair cells with apoptotic characteristics of cell fragmentations.However,50μM oxaliplatin plus 20 mM NAD+treatment greatly reduced neuronal degenerations and hair cell missing.The results suggested that NAD+provides significant protection against oxaliplatin-induced neurotoxicity and ototoxicity,which may be due to its actions of antioxidant,antiapoptosis,and energy supply. | DING Dalian JIANG Haiyan FU Yong LI Yongqi Richard Salvi Shinichi Someya Masaru Tanokura | 2013 | Journal of Otology2013，8，1： | 9 |
| 7 | Development of a new method for analyzing free aluminum ions(Al^(3+)) in seafood using HPLC-ICP-MS显示文摘This paper presents a novel method for simultaneous online examination of free aluminum ions(Al3+)in seafood,using solidphase extraction and high-performance liquid chromatography online with inductively coupled plasma mass spectrometry(SPEHPLC-ICP-MS),without post-column reaction.The optimum conditions for chromatographic separation of Al3+were achieved using an IonPac CS5A analytical column with an IonPac CG5A guard column.The mobile phase consisted of 0.040 mol/L LiOH,0.0060 mol/L 2,6-pyridinedicarboxylic acid,and 0.090 mol/L CH3COOH(pH 4.7).The free Al3+ions in seafood were extracted by shaking with the mobile phase at 70°C for 2 h.SPE was conducted using an Oasis MCX,3cc/60 mg,30μm column,which was activated and equilibrated with 2 mL of methanol and 4 mL of deionized water before use.HCl(0.075 mol/L,2 mL)was used to wash inorganic Al from the SPE column.The standard recoveries of Al3+were all above 89%and the relative standard deviations were all below 5%.The proposed method was successfully used for the examination of Al3+in seafood samples,and the results were similar to those obtained using the static equilibrium method. | SHANG DeRong ZHAO YanFang ZHAI YuXiu NING JinSong DING HaiYan SHENG XiaoFeng | 2013 | Chinese Science Bulletin2013，58，35： | 8 |
| 8 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 9 | Verification of Mutagen Function of Zeocin in Nannochloropsis oceanica Through Transcriptome Analysis显示文摘Zeocin can cause double strand breaks of DNA and thus is frequently used as a selective antibiotic of eukaryotic Sh ble transformants. In non-transformation system, Zeocin may function as a mutagen if not totally lethal. To verify such function of Zeocin, we mutated Nannochloropsis oceanica by increasing the concentration of Zeocin in medium gradually, and isolated a N. oceanica strain(single cell culture) which survived Zeocin up to 10.0μg mL^(-1). The Zeocin-tolerant strain entered the exponential growth phase later and grew slower than the wild strain. Transcriptome profiling showed that the Zeocin-tolerant N. oceanica strain survived Zeocin mainly by adapting(heritable), rather than acclimating(plastic) to Zeocin. Hence mutating N. oceanica with Zeocin was approved effective. Meanwhile, the physiological characteristics of this Zeocin-tolerant strain were demonstrated. As we proposed, N. oceanica tolerated Zeocin by strengthening its protein degradation and antioxidation. The genes controlling cell division and cellular response to stimuli may also have played important roles in the reduction of growth and the tolerance to Zeocin. Our findings evidenced that Zeocin can serve as an appropriate mutagen of microalgae. Creating variations through mutation with Zeocin may help to study the genetic basis of the traits of this monoploidy and asexual microalga, as well as improve its production. | LIN Genmei WANG Yamei GUO Li DING Haiyan HU Yongmei LIANG Sijie ZHANG Zhongyi YANG Guanpin | 2017 | Journal of Ocean University of China2017，16，3： | 5 |
| 10 | Pyrrolidine dithiocarbamate protects pancreatic β-cells from oxidative damage through regulation of FoxO1 activity in type 2 diabetes rats显示文摘Pyrrolidine dithiocarbamate (PDTC ) 罐头降低血葡萄糖水平并且在糖尿病的 rats.However 改进胰岛素敏感,在糖尿病的老鼠位于 PDTC 治疗的这效果下面的机制仍然保持不明确。在这研究,我们 PDTC 与 experimentaltype 在老鼠对胰腺的小岛房间的氧化损坏由授与保护的 evaluatedthe 机制 2 糖尿病 mellitus (DM ) 。在老鼠的 DM 被伴有单个 intraperitoneal (i.p ) 的长期的高脂肪的饮食得到 streptozotocin 的低剂量的注射。在 PDTC (50 mg/kg/day i.p ) 的一个 7 天的政府以后,血 glucoselevels 被测量,胰腺的纸巾为各种各样的生物化学、酶的 activitiesusing immunohistochemistry, immunofluorescence,和西方的污点技术的决心是镇定的。apoptotic 的百分比胰腺的小岛房间被流动 cytometry 检测。结果证明糖尿病的老鼠提高了血葡萄糖层次和 insulinresistance,随 malondialdehyde 内容, nitrotyrosine 生产,和可诱导的氮的 oxidesynthase 表示的增加伴随了。在 superoxide dismutase 和谷胱甘肽 peroxidase 活动的减少也在 DM 老鼠被观察,与提高的房间 apoptosis 达到顶点。PDTC 处理显著地减少了氧化损坏和房间 apoptosis,并且也通过下面调整的 FoxO1 acetylation 和建议的起来调整的原子 PDX-1 level.These 数据增加了胰岛素生产那 PDTC 能保护小岛房间免受氧化损坏的伤害并且在一个 DM 老鼠模型通过 regulationof PDX-1 和 FoxO1 改进胰岛素生产。 | Haiyan Ding Tienian Zhu Xiaomei Yin Jiankun Liu Lizhong Zhang Michel Bemier Ruijing Zhao | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 4 |
| 11 | Cisplatin-induced vestibular hair cell lesion-less damage at high doses显示文摘Cisplatin, a widely used anticancer drug, damages hair cells in cochlear organotypic cultures at low doses, but paradoxically causes little damage at high doses resulting in a U-shaped dose-response function. To determine if the cisplatin dose-response function for vestibular hair cells follows a similar pattern, we treated vestibular organotypic cultures with doses of cisplatin ranging from 10 to 1000 μM. Vestibular hair cell lesions progressively increased as the dose of cisplatin increased with maximum damage occurring around 50-100 μM, but the lesions progressively decreased at higher doses resulting in little hair cell loss at 1000 μM. The U-shaped doseresponse function for cisplatin-treated vestibular hair cells in culture appears to be regulated by copper transporters, Ctrl, ATP7A and ATP7B, that dose-dependently regulate the uptake, sequestration and extrusion of cisplatin. | Dalian Ding Haiyan Jiang Jianhui Zhang Xianrong Xu Weidong Qi Haibo Shi Shankai Yin Richard Salvi | 2018 | Journal of Otology2018，13，4： | 4 |
| 12 | Effects of Zr,Ti and Sc additions on the microstructure and mechanical properties of Al-0.4Cu-0.14Si-0.05Mg-0.2Fe alloys显示文摘The evolution of microstructure and mechanical properties of Al-0.4 Cu-0.14 Si-0.05 Mg-0.2 Fe(wt.%)alloys, micro-alloyed with Zr, Ti and Sc, were investigated. The addition of 0.2%Zr to base alloy accelerates the precipitation of Si-rich nano-phase in α-Al matrix, which plays an important role in improving the mechanical properties of an alloy. The tensile strength increases from 102 MPa for the base alloy to 113 MPa for the Zr-modified alloy. Adding 0.2%Zr + 0.2%Ti to base alloy effectively refines a-Al grain size and accelerates the precipitation of Si and Cu elements, leading to heavy segregation at grain boundary.By further adding 0.2%Sc to Zr + Ti modified alloy, the segregation of Si and Cu elements is suppressed and more Si and Cu precipitates appeared in α-Al matrix. Accompanied with the formation of coherent Al_3Sc phase, the tensile strength increases from 108 MPa for the Zr + Ti modified alloy to 152 MPa for the Sc-modified alloy. Due to excellent thermal stability of Al_3Sc phase, the Sc-modified alloy exhibits obvious precipitation hardening behavior at 350℃, and the tensile strength increases to 203 MPa after holding at 350 ℃ for 200 h. | Jian Feng Bing Ye Lijie Zuo Ruijuan Qi Qudong Wang Haiyan Jiang Rong Huang Wenjiang Ding Jie Yao Chuntao Wang | 2018 | Journal of Materials Science & Technology2018，34，12： | 3 |
| 13 | Microstructure, tensile properties and creep behavior of Al-12Si-3.5Cu-2Ni-0.8Mg alloy produced by different casting technologies显示文摘The relationship between the as-cast microstructure and mechanical properties of the Al-12 Si-3.5 Cu-2 Ni-0.8 Mg alloys produced by permanent mold casting(PMC) and high pressure die casting(HPDC)is investigated. The alloys in both PMC and HPDC consist of Al, Si, Al_5 Cu_2 Mg_8 Si_6, Al_3 Cu Ni, and Al_7 Cu_4 Ni phase. However, the microstructure of the HPDC alloy is significantly refined. Compared to the PMC alloy,the ultimate tensile strength of the HPDC alloy is significantly increased from 244 MPa to 310 MPa, while the elongation shows a reverse trend at room temperature. At low stress and temperature range, slight variations of stress exponent and activation energy indicate that the minimum creep rate is controlled by the grain boundary creep. Then the minimum creep rate is higher for the specimen with the smaller grain size, where grain boundary creep is the dominant creep mechanism. At high stress region, the stress exponent for the PMC alloy and HPDC alloy is 5.18 and 3.07, respectively. The different stress exponents and activation energies measured at high stress and high temperature range indicates that the creep mechanism varies with the casting technologies. | Lijie Zuo Bing Ye Jian Feng Xiangyang Kong Haiyan Jiang Wenjiang Ding | 2018 | Journal of Materials Science & Technology2018，34，7： | 3 |
| 14 | Antioxidative stress-induced damage in cochlear explants显示文摘The imbalance of reactive oxygen species and antioxidants is considered to be an important factor in the cellular injury of the inner ear. At present, great attention has been placed on oxidative stress. However,little is known about fighting oxidative stress. In the current study, we evaluated antioxidant-induced cochlear damage by applying several different additional antioxidants. To determine whether excessive antioxidants can cause damage to cochlear cells, we treated cochlear explants with 50 m M M40403, a superoxide dismutase mimetic, 50 m M coenzyme Q-10, a vitamin-like antioxidant, or 50 m M d-methionine, an essential amino acid and the important antioxidant glutathione for 48 h. Control cochlear explants without the antioxidant treatment maintained their normal structures after incubation in the standard serum-free medium for 48 h, indicating the maintenance of the inherent oxidative and antioxidant balance in these cochlear explants. In contrast, M40403 and coenzyme Q-10-treated cochlear explants displayed significant hair cell damage together with slight damage to the auditory nerve fibers.Moreover, d-methiodine-treated explants exhibited severe damage to the surface structure of hair cells and the complete loss of the spiral ganglion neurons and their peripheral fibers. These results indicate that excessive antioxidants are detrimental to cochlear cells, suggesting that inappropriate dosages of antioxidant treatments can interrupt the balance of the inherent oxidative and antioxidant capacity in the cell. | Dalian Ding Jianghui Zhang Fang Liu Peng Li Weidong Qi Yazhi Xing Haibo Shi Haiyan Jiang Hong Sun Shankai Yin Richard Salvi | 2020 | Journal of Otology2020，15，1： | 3 |
| 15 | Structural Variation Analysis of Mutated Nannochloropsis oceanica Caused by Zeocin Through Genome Re-Sequencing显示文摘Zeocin can cause double strand breaks of DNA and thus may be employed as a mutagen.In this study,two strains of Nannochloropsis oceanica,the wild and the Zeocin-tolerant strains,were re-sequenced to verify such function of Zeocin.The results showed that Zeocin can mutate the N.oceanica genome and cause the structural variation.Zeocin either swept away or selected the alleles of genes functioning in ubiquitin-mediated proteolysis,alpha-linolenic acid metabolism,ascorbate and aldarate metabolism,ribosome biogenesis,and circadian rhythm,indicating that N.oceanica may have adjusted its metabolic performances for protein,carbohydrate,and lipid,and changed its ribosome biosynthesis and living rhythm to survive in Zeocin containing medium.In addition,Zeocin caused mutation may have influenced the expression of a set of transcription factors.It was concluded that Zeocin effectively caused the structural variation of the genome of N.oceanica,and forced the microalgae to select out the alleles of a set of genes around these variations in order to adapt to Zeocin containing medium.Further studies on the genetic basis of the phenotypic adaptation of this haploid and asexual microalga and the application of Zeocin to its genetic improvement are very important. | LIN Genmei ZHANG Zhongyi GUO Li DING Haiyan YANG Guanpin | 2018 | Journal of Ocean University of China2018，17，5： | 3 |
| 16 | Pattern of hair cell loss and delayed peripheral neuron degeneration in inner ear by a high-dose intratympanic gentamicin显示文摘To gain insights into the ototoxic effects of aminoglycoside antibiotics(AmAn) and delayed peripheral ganglion neuron death in the inner ear.experimental animal models were widely used with several different approaches including AmAn systemic injections,combination treatment of AmAn and diuretics,or local application of AmAn.In these approaches,systemic AmAn treatment alone usually causes incomplete damage to hair cells in the inner ear.Co-administration of diuretic and AmAn can completely destroy the cochlear hair cells,but it is impossible to damage the vestibular system.Only the approach of AmAn local application can selectively eliminate most sensory hair cells in the inner ear.Therefore,AmAn local application is more suitable for studies for complete hair cell destructions in cochlear and vestibular system and the following delayed peripheral ganglion neuron death.In current studies,guinea pigs were unilaterally treated with a high concentration of gentamicin(GM,40 nig/ml) through the tympanic membrane into the middle ear cavity.Auditory functions and vestibular functions were measured before and after GM treatment.The loss of hair cells and delayed degeneration of ganglion neurons in both cochlear and vestibular system were quantified 30 days or 60 days after treatment.The results showed that both auditory and vestibular functions were completely abolished after GM treatment.The sensory hair cells were totally missing in the cochlea,and severely destroyed in vestibular end-organs.The delayed spiral ganglion neuron death 60 days after the deafening procedure was over 50%.However,no obvious pathological changes were observed in vestibular ganglion neurons 60 days post-treatment.These results indicated that a high concentration of gentamycin delivered to the middle ear cavity can destroy most sensory hair cells in the inner ear that subsequently causes the delayed spiral ganglion neuron degeneration.This model might be useful for studies of hair cell regenerations,delayed degeneration of peripheral auditory neurons,and/or vestibular compensation.In addition,a potential problem of ABR recording for unilateral deafness and issues about vestibular compensation are also discussed. | Jintao Yu Dalian Ding Fengjun Wang Haiyan Jiang Hong Sun Richard Salvi | 2014 | Journal of Otology2014，9，3： | 2 |
| 17 | Effects of Gd Addition on the Microstructure and Tensile Properties of Mg–4Al–5RE Alloy Produced by Three Different Casting Methods显示文摘This work deals with the effect of 0.67 wt%Gd addition on the microstructure and tensile properties of Mg–4 Al–5 RE(where RE represents La–Ce mischmetal)alloy produced by sand casting(SC),permanent mold casting(PMC),and high-pressure die casting(HPDC).The results show that Gd addition could refine the grains,but its efficiency decreases by increasing the cooling rate due to the shifting from SC to PMC and finally to the HPDC method.Meanwhile,the acicular Al11 RE3 phase is modified into the short-rod or granular-like shape under the three casting conditions.Such refined and modified microstructures are due to the Al2(Gd,RE)phases,which act as the nucleation sites in both theα-Mg matrix and Al11 RE3 phase.Also,the weakening grain refinement effect in the increased cooling rates can be attributed to the narrow constitutional undercooling zone.After Gd addition,the 0.2%proof strength of the SC and PMC alloys increases by about 16.9%and 12.7%,respectively,while in the HPDC alloy,it decreases by about 5.9%.The main factor in the strength increment of the SC and PMC alloys is the grain boundary strengthening due to grain refinement which is proved by modeling the related mechanisms,whereas weak secondary phases and grain boundary strengthening mechanisms in the HPDC alloy lead to strength reduction.After Gd addition,the elongation to failure of the SC,PMC,and HPDC alloys is significantly enhanced by about 34.8%,20.2%,and 12.3%,respectively,due to the crack resistance nature of the modified short-rod/granular Al11(RE,Gd)3 phase compared to the acicular one. | Jie Wei Qudong Wang Li Zhang Mahmoud Ebrahimi Haiyan Jiang Wenjiang Ding | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，10： | 2 |
| 18 | Stability of superconducting Nd_(0.8)Sr_(0.2)NiO_(2) thin films显示文摘The discovery of superconducting states in the nickelate thin film with infinite-layer structure has paved a new way for studying unconventional superconductivity.So far,research in this field is still very limited due to difficulties in sample preparation.Here we report the successful preparation of the superconducting state of Nd_(0.8)Sr_(0.2)NiO_(2)thin film(T_(c)=8.0-11.1 K)and study the stability of such films in the ambient environment,water,and under electrochemical conditions.Our work demonstrates that the superconducting state of Nd_(0.8)Sr_(0.2)NiO_(2)is remarkably stable,which can last for at least 47-day continuous exposure to air at 20°C and 35%relative humidity.We also show that the superconductivity disappears after being immersed in de-ionized water at room temperature for 5 h.Surprisingly,it can also survive under ionic liquid gating conditions with an applied voltage of about 4 V,which is even more stable than conventional perovskite complex oxides. | Xiang Ding Shengchun Shen Huaqian Leng Minghui Xu Yan Zhao Junrui Zhao Xuelei Sui Xiaoqiang Wu Haiyan Xiao Xiaotao Zu Bing Huang Huiqian Luo Pu Yu Liang Qiao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，6： | 2 |
| 19 | Preparation of superhydrophobic silica film on Mg–Nd–Zn–Zr magnesium alloy with enhanced corrosion resistance by combining micro-arc oxidation and sol–gel method显示文摘 | Shaohua Wang Xingwu Guo Yijun Xie Lihua Liu Haiyan Yang Rongyu Zhu Jia Gong Liming Peng Wenjiang Ding | 2012 | Surface & Coatings Technology2012，，： | 2 |
| 20 | Effect and mechanism of tacrolimus on melanogenesis on A375 human melanoma cells显示文摘 | Huang Haiyan Wang Xiaoyan Ding Xiaolan Xu Qianxi Sonia Kay Hwang Wang Fang Du Juan Zhang Jianzhong | 2014 | Chinese Medical Journal2014，，16： | 2 |
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