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| 1 | Autoimmune liver serology:Current diagnostic and clinical challenges显示文摘Liver-related autoantibodies are crucial for the correct diagnosis and classification of autoimmune liver diseas-es(AiLD),namely autoimmune hepatitis types 1 and 2(AIH-1 and 2),primary biliary cirrhosis(PBC),and the sclerosing cholangitis variants in adults and children.AIH-1 is specified by anti-nuclear antibody(ANA) and smooth muscle antibody(SMA).AIH-2 is specified by antibody to liver kidney microsomal antigen type-1(anti-LKM1) and anti-liver cytosol type 1(anti-LC1).SMA,ANA and anti-LKM antibodies can be present in de-novo AIH following liver transplantation.PBC is specified by antimitochondrial antibodies(AMA) react-ing with enzymes of the 2-oxo-acid dehydrogenase complexes(chiefly pyruvate dehydrogenase complex E2 subunit) and disease-specific ANA mainly react-ing with nuclear pore gp210 and nuclear body sp100.Sclerosing cholangitis presents as at least two variants,first the classical primary sclerosing cholangitis(PSC) mostly affecting adult men wherein the only(and non-specific) reactivity is an atypical perinuclear antineutro-phil cytoplasmic antibody(p-ANCA),also termed peri-nuclear anti-neutrophil nuclear antibodies(p-ANNA) and second the childhood disease called autoimmune sclerosing cholangitis(ASC) with serological features resembling those of type 1 AIH.Liver diagnostic serol-ogy is a fast-expanding area of investigation as new purified and recombinant autoantigens,and automatedtechnologies such as ELISAs and bead assays,become available to complement(or even compete with) tradi-tional immunofluorescence procedures.We survey for the first time global trends in quality assurance impact-ing as it does on(1) manufacturers/purveyors of kits and reagents,(2) diagnostic service laboratories that fulfill clinicians' requirements,and(3) the end-user,the physician providing patient care,who must properly interpret test results in the overall clinical context. | Dimitrios P Bogdanos Diego Vergani Pietro Invernizzi Ian R Mackay | 2008 | World Journal of Gastroenterology2008，14，21： | 40 |
| 2 | Viral hepatitis update: Progress and perspectives显示文摘Viral hepatitis,secondary to infection with hepatitis A,B,C,D,and E viruses,are a major public health problem and an important cause of morbidity and mortality.Despite the huge medical advances achieved in recent years,there are still points of conflict concerning the pathogenesis,immune response,development of new and more effective vaccines,therapies,and treatment.This review focuses on the most important research topics that deal with issues that are currently being solved,those that remain to be solved,and future research directions.For hepatitis A virus we will address epidemiology,molecular surveillance,new susceptible populations as well as environmental and food detections.In the case of hepatitis B virus,we will discuss host factors related to disease,diagnosis,therapy,and vaccine improvement.On hepatitis C virus,we will focus on pathogenesis,immune response,direct action antivirals treatment in the context of solid organ transplantation,issues related to hepatocellular carcinoma development,direct action antivirals resistance due to selection of resistanceassociated variants,and vaccination.Regarding hepatitis D virus,we describe diagnostic methodology,pathogenesis,and therapy.Finally,for hepatitis E virus,we will address epidemiology(including new emerging species),diagnosis,clinical aspects,treatment,the development of a vaccine,and environmental surveillance. | María B Pisano Cecilia G Giadans Diego M Flichman Viviana E Ré María V Preciado Pamela Valva | 2021 | World Journal of Gastroenterology2021，27，26： | 8 |
| 3 | Diagnostic and therapeutic challenges of gastrointestinal angiodysplasias: A critical review and view points显示文摘Gastrointestinal angiodysplasias (GIADs), also called angioectasias, are the most frequent vascular lesions. Its precise prevalence is unknown since most of them are asymptomatic. However, the incidence may be increasing since GIADs affect individuals aged more than 60 years and population life expectancy is globally increasing worldwide. They are responsible of about 5% to 10% of all gastrointestinal bleeding (GIB) cases. Most GIADs are placed in small bowel, where are the cause of 50 to 60% of obscure GIB diagnosed with video capsule endoscopy. They may be the cause of fatal severe bleeding episodes;nevertheless, recurrent overt or occult bleeding episodes requiring repeated expensive treatments and disturbing patient’s quality-of-life are more frequently observed. Diagnosis and treatment of GIADs (particularly those placed in small bowel) are a great challenge due to insidious disease behavior, inaccessibility to affected sites and limitations of available diagnostic procedures. Hemorrhagic causality out of the actively bleeding lesions detected by diagnostic procedures may be difficult to establish. No treatment guidelines are currently available, so there is a high variability in the management of these patients. In this review, the epidemiology and pathophysiology of GIADs and the status in the diagnosis and treatment, with special emphasis on small bowel angiodysplasias based on multiple publications, are critically discussed. In addition, a classification of GIADs based on their endoscopic characteristics is proposed. Finally, some aspects that need to be clarified in future research studies are highlighted. | Diego García-Compeán ángel N Del Cueto-Aguilera Alan R Jiménez-Rodríguez José A González-González Héctor J Maldonado-Garza | 2019 | World Journal of Gastroenterology2019，25，21： | 5 |
| 4 | Oxygen related sediment microfabries in modern 'black shales', Gulf of California, Mexico显示文摘 | Diego T D Douglas R G | 1999 | Journal of Foraminifera Research1999，29，4： | 1 |
| 5 | System Oriented Har-monic-Balance Algorithms for Circuit-Level Simulation 显示文摘 | Vittorio R Diego M Franco M | 2011 | Computer- Aided Design of Integrated Circuits and Sys-tems IEEE Transactions2011，30，2： | 1 |
| 6 | Functional modulation of the transient outward current Ito by KCNE β-subunits and regional distribution in human non-failing and failing hearts显示文摘 | Susanne R Diego C Eva MG | | 0，，： | 1 |
| 7 | Evaluation of a blocking ELISA using monoclonal antibodies for the detection of porcine epidemic diarrhea virus and its antibodies 显示文摘 | Carvajal A Lanza I Diego R | 1995 | J Vet Diagn Invest1995，7，： | 1 |
| 8 | Solid waste management of a chemical-looping combustion plant using Cu-based oxygen carriers显示文摘 | Labiano F G Gayan P Adanez de Diego L Forero C R | 2007 | Environment Science Technology2007，41，6： | 1 |
| 9 | Four-dimensional SAR imaging for height estimation and monitoring of single and double scatterers显示文摘 | Gianfranco F Diego R and Serafino F | 2009 | IEEE Transactions on Geoscience and Remote Sensing2009，47，1： | 1 |
| 10 | Effects of supercritical carbon dioxide on waste banana peels for heavy metal removal显示文摘 | Juliana Q A Rodrigo B R Diego T S | 2011 | The Journal of Supercritical Fluids2011，58，： | 1 |
| 11 | Evaluation ot a blocking ELISA using monoclonal antibodies for the detection of porcine epidemic diarrhea virus and its antibodies显示文摘 | Carvaial A Lanza I Diego R | 1995 | Vet Diagn Invest1995，7，1： | 1 |
| 12 | Supercritical fluid extraction of fish oil from fish by - products : a compari- son with other methods 显示文摘 | Rodriguez N R Diego S M Behran S | 2012 | Food Engineering2012，，109： | 1 |
| 13 | A meta- analysis of bees' responses to anthropogenic disturbance显示文摘 | Winfree R Aguilar R Diego P V | 2009 | Ecology2009，90，8： | 1 |
| 14 | Analysis of harmonics in power systems using the wavelet packet transform显示文摘 | Barros J Diego R I | 2008 | IEEE Transactions on Instrumentation and Measurement2008，57，1： | 1 |
| 15 | A neuro-immune mode for discriminating and visualizing anomalies显示文摘 | Fabio A.G Juan C G Diego A R | | 0，，03： | 1 |
| 16 | Treatment and posttreatment effects of mandibular cervical headgear followed by fixed appliances in Class Ⅲ malocclusion显示文摘 | DIEGO R DAVID A GIOVANNI O | 2008 | Am J Orthod Dentofacial Orthnp2008，133，3： | 1 |
| 17 | Efficiently combining positions and normals for precise 3D geometry显示文摘 | Diego N Szymon R James D | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
| 18 | Influence of the pile shape on wind erosion CFD emission simulation 显示文摘 | TORANO J A RODRIGUEZ R DIEGO I | 2007 | Applied Mathematical Modelling2007，31，11： | 1 |
| 19 | Mapping wound-response genes involved in post-harvest physiological deterio-ration(PPD)of cassava(Manihot esculenta Crantz)显示文摘 | DIEGO F C KIM R EMMANUEL O | 2002 | Euphytica2002，128，： | 1 |
| 20 | Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males显示文摘 | Di Diego J M Cordeiro J M Goodrow R J | | 0，，15： | 1 |
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