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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Theory of stimula- ted Raman scattering cancellation in wavelength-division- ultiplexed systems via spectral inversion 显示文摘 | Alexandra G G Demetrios N C Jean T | 1999 | Photonics Technology Letters1999，11，10： | 1 |
| 3 | CYP1A1,CYP19,and GSTM1 polymorphisms increase the risk of endometriosis显示文摘 | DEMETRIOS A A GEORGIOS E K ANASTASIA G G | 2003 | Fertil Steril2003，79，1： | 1 |
| 4 | Developing Web-based learning scenarios using the IMS learning design 显示文摘 | Demetrios G Sampson Pythagoras Karampiperis Panayiotis Zervas | 2005 | The ASK-LDT Environment2005，3807，： | 1 |
| 5 | A citywide prehospital protocol increases access to stroke thrombolysis in toronto 显示文摘 | David J G Lance H R Demetrios J S et O1 | 2009 | Stroke2009，40，： | 1 |
| 6 | Beitrage zur Pilzflora von Missouri显示文摘 | Demetrio C H | | Hedwigia0，24，： | 1 |
| 7 | Overdispersion: models and estimation显示文摘 | HINDE J DEMETRIO C G B | 1998 | Computational Statistics and Data Analysis1998，27，2： | 1 |
| 8 | Duality in reconstruction systems显示文摘 | Pedro G M Mariano A R Demetrio S | 2012 | Linear Algebra Appl2012，436，： | 1 |
| 9 | Control charts for the toxicity ot finished water-Modeling the structure of toxicity显示文摘 | Eleni M S Demetrios E K Spyridon K G | 2007 | Water Research2007，41，12： | 1 |
| 10 | A Score Test for Testing a Zero - inflated Poisson Regression Model Against Zero - inflated Negative Alternatives显示文摘 | Ridout M Hinde J Demetrio C G B | 2001 | Biometrics2001，，57： | 1 |
| 11 | Correlation of ovary and leaf spermidine andspermine content with the alternate bearing habit of olive显示文摘 | Odora S P Demetrios G V | 2005 | Journal of PlantPhysiology2005，，： | 1 |
| 12 | A Score test for testing a zero-inflated poisson regression model against zero-inflated negative binomial alternatives显示文摘 | RIDOUT M HINDE J DEMETRIO C G B | 2001 | Biometrics2001，57，： | 1 |
| 13 | Screening patients with chest pain in the emergency department using electron beam tomography:A follow up study显示文摘 | Demetrios G Budoff MJ Kaufer E | 2001 | J Am Coll Cardiol2001，38，： | 1 |
| 14 | Evidence of trans-Atlantic movement and natal homing of bluefin tuna from stable isotopes in otoliths 显示文摘 | ROOKER J SECOR D DEMETRIO G | 2008 | Marine Ecology Progress Series2008，368，： | 1 |
| 15 | Passive tracking of a maneuvering target: An Adaptive approach显示文摘 | SOKRATIS K K ASSIMAKIS K L DEMETRIOS G L | 1994 | IEEE Trans Signal Processing1994，42，7： | 1 |
| 16 | Tailoring supported ionic liquid membranes for the selective separation of transesterification reaction compounds显示文摘 | Antonia P. de los Ríos Francisco J. Hernández-Fernández Hugo Presa Demetrio Gómez Gloria Víllora | 2008 | Journal of Membrane Science2008，，1： | 1 |
| 17 | On the importance of the nature of the ionic liquids in the selective simultaneous separation of the substrates and products of a transesterification reaction through supported ionic liquid membranes显示文摘 | Antonia P. de los Ríos Francisco J. Hernández-Fernández Francisca Tomás-Alonso Manuel Rubio Demetrio Gómez Gloria Víllora | 2007 | Journal of Membrane Science2007，，2： | 1 |
| 18 | Organic and nitrogen removal in a two- stage biological contactor treating municipal wastewater 显示文摘 | Demetrios N Hiras Ioannis D Manariotis Sotirios G Grigoropoulos | 2004 | Bioresource Technology2004，93，1： | 1 |
| 19 | Doppler echocardiographic prediction of pulmonary arterial hypertension in congenital heart di-seases显示文摘 | Demetrio K Stanley J Goldber G | 1984 | Am J Cardiol1984，53，4： | 1 |
| 20 | Ascore Test for Testing Aze-ro-Inflated Poisson Regression Model Against Zero-Inflated Nega-tive Binomial Altematives显示文摘 | RidoutM Hinde I Demetrio G G B | 2001 | Biometrics2001，，57： | 1 |
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