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| 1 | HIV entry inhibitors: a new generation of antiretroviral drugs显示文摘爱滋病是目前对待能,并且病人们能由于高度活跃的 antiretroviral 治疗(HAART ) 的成功有好预后,但是它仍然不可医好或可防止。HAART 的高毒性,和药抵抗的出现增加命令继续研究进新策略和干预。在进主机房间的 HIV 附件和入口的理解的可观的进步为讲道理地设计防碍这进程的代理人建议了新可能性。为临床的使用的熔化禁止者 enfuvirtide (Fuzeon ) 的赞同和介绍在爱滋病治疗学表明一个新时代。这里,我们考察病毒使用完成房间入口的关键步,它在现出症状之前的潜、临床的发展阶段作为潜在的目标,和混合物应得注意,报导了有效地禁止房间入口。 | Elias KRAMBOVITIS Filippos PORICHIS Demetrios A SPANDIDOS | 2005 | Acta Pharmacologica Sinica2005，26，10： | 4 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Distribution of endocrine disruptors in the Llobregat River basin (Catalonia,NE Spmn)显示文摘 | Raquel Céspedes Sílvia Lacorte Demetrio Raldúa | 2005 | Chemosphere2005，61，11： | 1 |
| 4 | Method development for the determination of anthocyanins in red wines by high-performance liquid chromatography and classification of German red wines by means of multivariate statistical methods显示文摘 | Ba?lint Berente Demetrio De la Calle Garc??a Manfred Reichenba' cher edc | 2000 | Journal of Chromatography A2000，，871： | 1 |
| 5 | Pilot survey of a broad range of priority pollutants in sediment and fish from the Ebro river basin (NE Spain)显示文摘 | Silvia Lacorte Demetrio Raldúa Elena Martínez Alicia Navarro Sergi Diez Josep M. Bayona Damià Barceló | 2005 | Environmental Pollution2005，，3： | 1 |
| 6 | Frequent genetic alterations at the microsatellite level in cytologic sputum samples of patients with idiopathic pulmonary fibrosis显示文摘 | Dimitris A George S Demetrios A | 2000 | Am J Respir Crit Care Med2000，162，： | 1 |
| 7 | CYP1A1,CYP19,and GSTM1 polymorphisms increase the risk of endometriosis显示文摘 | DEMETRIOS A A GEORGIOS E K ANASTASIA G G | 2003 | Fertil Steril2003，79，1： | 1 |
| 8 | Pancreaticoduodenectomy: a rare procedure for the management of complex pancreaticoduodenal injuries显示文摘 | Juan A Asensio Patrizio Petrone Gustavo Roldán Eric Kuncir Demetrios Demetriades | 2003 | Journal of the American College of Surgeons2003，，6： | 1 |
| 9 | Slag Cleaning: The Chilean Copper Smeher Experience 显示文摘 | Demetrio S Ahumada J Duran M A Mast E Rojas U | 2000 | JOM2000，52，8： | 1 |
| 10 | Pathogenetic mecha- nisms and treatment options for ophthalmic pterygium: trends and perspectives显示文摘 | Efstathios T Detorakis Demetrios A | 2009 | Internation Journal of Molecular Medicine2009，23，2： | 1 |
| 11 | Duality in reconstruction systems显示文摘 | Pedro G M Mariano A R Demetrio S | 2012 | Linear Algebra Appl2012，436，： | 1 |
| 12 | Study of conductivity of dEPDM rubber and PAni blends显示文摘 | DANIELA A A JOSE C M DEMETRIO A W S | 2007 | Macromolecular Symposia2007，，1： | 1 |
| 13 | The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation显示文摘 | Jesús Villar Jesús Blanco José Manuel A?ón Antonio Santos-Bouza Lluís Blanch Alfonso Ambrós Francisco Gandía Demetrio Carriedo Fernando Mosteiro Santiago Basaldúa Rosa Lidia Fernández Robert M. Kacmarek | 2011 | Intensive Care Medicine2011，，12： | 1 |
| 14 | Synthesis and antiproliferativeactivity of 3-amino-N-phenyl- 1H-indazole- 1- carboxamides 显示文摘 | Demetrio R Benedetta M Stella C A | 2009 | European Journal of Medicinal Chemistry2009，44，1： | 1 |
| 15 | Distribution of endocrine disruptors in the Llobregat River basin (Catalonia,NE Spain)显示文摘 | Raquel Ce'spedes Sílvia Lacorte Demetrio Raldúa | 2005 | Chemosphere2005，61，11： | 1 |
| 16 | Mathematical models for current, voltage, and coupling capacitor voltage transformers显示文摘 | Demetrios A Tziouvaras Peter McLaren George ALexander | 2000 | IEEE Transactions on Pow er Delivery2000，15，1： | 1 |
| 17 | Laser induced breakdown spectroscopy in art and archaeology显示文摘 | Demetrios A | 2001 | Applied Spectroscopy2001，55，6： | 1 |
| 18 | Therapeutic implications of chemokine-mediated pathways in atherosclerosis: realistic perspectives and utopias显示文摘动脉粥样硬化的致病上的当前的观点强烈在 atherosclerostic 损害的建立和前进支持煽动性的调停人的参与。调停 Chemokine 的机制是由与动脉的墙的细胞的部件安排外部血的煽动性的细胞的部件的相互作用的如此的过程的有势力管理者。在动脉粥样硬化支持 chemokine 小径的角色使 chemokine ligands 和他们的受体潜力变为治疗学的增加的证据指向。在下列评论,我们试图在动脉粥样硬化在尊重加亮 chemokines 和他们的受体的特殊结构、功能的特征到他们的角色,并且检验到什么可得到的程度,数据能在疾病管理惯例被用于。 | Stavros APOSTOLAKIS Virginia AMANATIDOU Demetrios A SPANDIDOS | 2010 | Acta Pharmacologica Sinica2010，31，9： | 1 |
| 19 | Mathematical models for current,voltage,and coupling capacitor voltage transformers显示文摘 | Demetrios A Tziouvaras Peter McLaren | 2000 | IEEE Trans on Power Delivery2000，15，1： | 1 |
| 20 | Management of pancreatic injuries显示文摘 | Juan A Asensio Demetrios D | 1999 | Current Problems in Surgery1999，36，5： | 1 |
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