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| 1 | Global Wheat Head Detection(GWHD)Dataset:A Large and Diverse Dataset of High-Resolution RGB-Labelled Images to Develop and Benchmark Wheat Head Detection Methods显示文摘The detection of wheat heads in plant images is an important task for estimating pertinent wheat traits including head population density and head characteristics such as health,size,maturity stage,and the presence of awns.Several studies have developed methods for wheat head detection from high-resolution RGB imagery based on machine learning algorithms.However,these methods have generally been calibrated and validated on limited datasets.High variability in observational conditions,genotypic differences,development stages,and head orientation makes wheat head detection a challenge for computer vision.Further,possible blurring due to motion or wind and overlap between heads for dense populations make this task even more complex.Through a joint international collaborative effort,we have built a large,diverse,and well-labelled dataset of wheat images,called the Global Wheat Head Detection(GWHD)dataset.It contains 4700 high-resolution RGB images and 190000 labelled wheat heads collected from several countries around the world at different growth stages with a wide range of genotypes.Guidelines for image acquisition,associating minimum metadata to respect FAIR principles,and consistent head labelling methods are proposed when developing new head detection datasets.The GWHD dataset is publicly available at http://gffzzef49fa24bca249bbhkno5xqf06w966xfw.ffgz.tsg.suse.edu.cn/and aimed at developing and benchmarking methods for wheat head detection. | Etienne David Simon Madec Pouria Sadeghi-Tehran Helge Aasen Bangyou Zheng Shouyang Liu Norbert Kirchgessner Goro Ishikawa Koichi Nagasawa Minhajul A.Badhon Curtis Pozniak Benoit de Solan Andreas Hund Scott C.Chapman Frédéric Baret Ian Stavness Wei Guo | 2020 | Plant Phenomics2020，2，1： | 13 |
| 2 | Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip [Invited]显示文摘There is a rapidly growing demand to use silicon and silicon nitride(Si3N4) integrated photonics for sensing applications, ranging from refractive index to spectroscopic sensing. By making use of advanced CMOS technology,complex miniaturized circuits can be easily realized on a large scale and at a low cost covering visible to mid-IR wavelengths. In this paper we present our recent work on the development of silicon and Si3N4-based photonic integrated circuits for various spectroscopic sensing applications. We report our findings on waveguide-based absorption, and Raman and surface enhanced Raman spectroscopy. Finally we report on-chip spectrometers and on-chip broadband light sources covering very near-IR to mid-IR wavelengths to realize fully integrated spectroscopic systems on a chip. | Ananth Z.Subramanian Eva Ryckeboer Ashim Dhakal Frédéric Peyskens Aditya Malik Bart Kuyken Haolan Zhao Shibnath Pathak Alfonso Ruocco Andreas De Groote Pieter Wuytens Daan Martens Francois Leo Weiqiang Xie Utsav Deepak Dave Muhammad Muneeb Pol Van Dorpe Joris Van Campenhout Wim Bogaerts Peter Bienstman Nicolas Le Thomas Dries Van Thourhout Zeger Hens Gunther Roelkens Roel Baets | 2015 | Photonics Research2015，3，5： | 7 |
| 3 | Effects of KRAS, BRAF, NRAS , and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis显示文摘 | Wendy De Roock Bart Claes David Bernasconi Jef De Schutter Bart Biesmans George Fountzilas Konstantine T Kalogeras Vassiliki Kotoula Demetris Papamichael Pierre Laurent-Puig Frédérique Penault-Llorca Philippe Rougier Bruno Vincenzi Daniele Santini Giusepp | 2010 | Lancet Oncology2010，，8： | 6 |
| 4 | Innate and adaptive immune responses toward nanomedicines显示文摘Since the commercialization of the frst liposomes used for drug delivery,Doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological systems.Fundamental work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more effciently.While nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond cancer.In parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented speed.To rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune system.This review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions. | Iara Maíra de Oliveira Viana Sabrina Roussel Joan Defrêne Eliana Martins Lima Frédéric Barabé Nicolas Bertrand | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 5 | Differential colorectal carcinogenesis:Molecular basis and clinical relevance显示文摘Colorectal cancer(CCR) is one of the most frequent cancers in developed countries.It poses a major public health problem and there is renewed interest in understanding the basic principles of the molecular biology of colorectal cancer.It has been established that sporadic CCRs can arise from at least two different carcinogenic pathways.The traditional pathway,also called the suppressor or chromosomal instability pathway,follows the Fearon and Vogelstein model and shows mutation in classical oncogenes and tumour suppressor genes,such as K-ras,adenomatous polyposis coli,deleted in colorectal cancer,or p53.Alterations in the Wnt pathway are also very common in this type of tumour.The second main colorectal carcinogenesis pathway is the mutator pathway.This pathway is present in nearly 15% of all cases of sporadic colorectal cancer.It is characterized by the presence of mutations in the microsatellite sequences caused by a defect in the DNA mismatch repair genes,mostly in hMLH1 or hMSH2.These two pathways have clear molecular differences,which will be reviewed in this article,but they also present distinct histopathological features.More strikingly,their clinical behaviours are completely different,having the 'mutator' tumours a better outcome than the 'suppressor' tumours. | Alberto Morán Paloma Ortega Carmen de Juan Tamara Fernández-Marcelo Cristina Frías Andrés Sánchez-Pernaute Antonio José Torres Eduardo Díaz-Rubio Pilar Iniesta Manuel Benito | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 5 |
| 6 | High-Throughput Measurements of Stem Characteristics to Estimate Ear Density and Above-Ground Biomass显示文摘Total above-ground biomass at harvest and ear density are two important traits that characterize wheat genotypes.Two experiments were carried out in two different sites where several genotypes were grown under contrasted irrigation and nitrogen treatments.A high spatial resolution RGB camera was used to capture the residual stems standing straight after the cutting by the combine machine during harvest.It provided a ground spatial resolution better than 0.2 mm.A Faster Regional Convolutional Neural Network(Faster-RCNN)deep-learning model was first trained to identify the stems cross section.Results showed that the identification provided precision and recall close to 95%.Further,the balance between precision and recall allowed getting accurate estimates of the stem density with a relative RMSE close to 7%and robustness across the two experimental sites.The estimated stem density was also compared with the ear density measured in the field with traditional methods.A very high correlation was found with almost no bias,indicating that the stem density could be a good proxy of the ear density.The heritability/repeatability evaluated over 16 genotypes in one of the two experiments was slightly higher(80%)than that of the ear density(78%).The diameter of each stem was computed from the profile of gray values in the extracts of the stem cross section.Results show that the stem diameters follow a gamma distribution over eachmicroplot with an average diameter close to 2.0mm.Finally,the biovolume computed as the product of the average stem diameter,the stem density,and plant height is closely related to the above-ground biomass at harvest with a relative RMSE of 6%.Possible limitations of the findings and future applications are finally discussed. | Xiuliang Jin Simon Madec Dan Dutartre Benoit de Solan Alexis Comar Frédéric Baret | 2019 | Plant Phenomics2019，1，1： | 5 |
| 7 | Inheritance patterns of secondary symbionts during sexual reproduction of pea aphid biotypes显示文摘食草的昆虫经常怀有影响他们的生态学和进化的细菌的共生者。蚜虫招待应尽的 endosymbiont Buchnera,它为复制被要求,和其频率越过蚜虫人口变化的容许的共生者。这些似母亲播送了第二等的共生者特别地在豌豆蚜虫被学习了, Acyrthosiphon pisum,哪个港口穿上环境地依赖的效果的至少 8 不同细菌的种类(不数的 Buchnera ) 主人健康。特别地,这些共生者种类与豌豆蚜虫人口在特定的植物上喂被联系。尽管他们是继承的似母亲,这些细菌偶尔越过昆虫系被转移。如此的 nonmaternal 转移的一机制在性复制期间是到子孙的父亲的传播。迄今为止,第二等的共生者的传播在仅仅蚜虫系和 3 共生者种类的一把在蚜虫的性复制期间被调查了。更好描绘这个过程,我们通过包含属于 9 专业化主人的遗传因子型,和 117 个十字的 49 克隆的一个交叉实验在豌豆蚜虫的性复制期间调查了 7 共生者种类的继承模式。在子孙的共生者种类在从鸡蛋并且在以后的单性生殖的代孵化的 fundatrix 阶段与诊断质的 PCR 被检测。我们没发现共生者的父亲的传播的证实的案例到子孙,并且我们观察到特别共生者种(Serratia symbiotica ) 的母亲的传播是相当低效的。我们在尊重讨论这些观察到豌豆蚜虫的生态学。 | Jean Peccoud Joêl Bonhomme Frédérique Mahéo Manon de la Huerta Olivier Cosson Jean-Christophe Simon | 2014 | Insect Science2014，21，3： | 4 |
| 8 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 9 | Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial显示文摘 | Aimery de Gramont Eric Van Cutsem Hans-Joachim Schmoll Josep Tabernero Stephen Clarke Malcolm J Moore David Cunningham Thomas H Cartwright J Randolph Hecht Fernando Rivera Seock-Ah Im Gy?rgy Bodoky Ramon Salazar Frédérique Maindrault-Goebel Einat Shacham- | 2012 | Lancet Oncology2012，，12： | 3 |
| 10 | Efficacy and Safety of Tumor Necrosis Factor Antagonists in Crohn’s Disease: Meta-Analysis of Placebo-Controlled Trials显示文摘 | Laurent Peyrin–Biroulet Pierre Deltenre Nicolas de Suray Julien Branche William J. Sandborn Jean–Frédéric Colombel | 2008 | Clinical Gastroenterology and Hepatology2008，，6： | 3 |
| 11 | Implications of safety requirements for the treatment of THMC processes in geological disposal systems for radioactive waste显示文摘The mission of nuclear safety authorities in national radioactive waste disposal programmes is to ensure that people and the environment are protected against the hazards of ionising radiations emitted by the waste.It implies the establishment of safety requirements and the oversight of the activities of the waste management organisation in charge of implementing the programme.In Belgium,the safety requirements for geological disposal rest on the following principles:defence-in-depth,demonstrability and the radiation protection principles elaborated by the International Commission on Radiological Protection(ICRP).Applying these principles requires notably an appropriate identification and characterisation of the processes upon which the safety functions fulfilled by the disposal system rely and of the processes that may affect the system performance.Therefore,research and development(R&D)on safety-relevant thermo-hydro-mechanical-chemical(THMC)issues is important to build confidence in the safety assessment.This paper points out the key THMC processes that might influence radionuclide transport in a disposal system and its surrounding environment,considering the dynamic nature of these processes.Their nature and significance are expected to change according to prevailing internal and external conditions,which evolve from the repository construction phase to the whole heatingecooling cycle of decaying waste after closure.As these processes have a potential impact on safety,it is essential to identify and to understand them properly when developing a disposal concept to ensure compliance with relevant safety requirements.In particular,the investigation of THMC processes is needed to manage uncertainties.This includes the identification and characterisation of uncertainties as well as for the understanding of their safety-relevance.R&D may also be necessary to reduce uncertainties of which the magnitude does not allow demonstrating the safety of the disposal system. | Frédéric Bernier Frank Lemy Pierre De Cannière Valéry Detilleux | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，3： | 3 |
| 12 | A Hepatocellular Carcinoma 5-Gene Score Associated With Survival of Patients After Liver Resection显示文摘 | Jean–Charles Nault Aurélien De Reyniès Augusto Villanueva Julien Calderaro Sandra Rebouissou Gabrielle Couchy Thomas Decaens Dominique Franco Sandrine Imbeaud Francis Rousseau Daniel Azoulay Jean Saric Jean–Frédéric Blanc Charles Balabaud Paulette Bioulac | 2013 | Gastroenterology2013，，1： | 3 |
| 13 | Lactic acid bacteria as functional starter cultures for the food fermentation industry显示文摘 | Frédéric Leroy Luc De Vuyst | 2003 | Trends in Food Science & Technology2003，，2： | 2 |
| 14 | Global Wheat Head Detection 2021:An Improved Dataset for Benchmarking Wheat Head Detection Methods显示文摘The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/institutions.With an associated competition hosted in Kaggle,GWHD_2020 has successfully attracted attention from both the computer vision and agricultural science communities.From this first experience,a few avenues for improvements have been identified regarding data size,head diversity,and label reliability.To address these issues,the 2020 dataset has been reexamined,relabeled,and complemented by adding 1722 images from 5 additional countries,allowing for 81,553 additional wheat heads.We now release in 2021 a new version of the Global Wheat Head Detection dataset,which is bigger,more diverse,and less noisy than the GWHD_2020 version. | Etienne David Mario Serouart Daniel Smith Simon Madec Kaaviya Velumani Shouyang Liu Xu Wang Francisco Pinto Shahameh Shafiee Izzat SATahir Hisashi Tsujimoto Shuhei Nasuda Bangyou Zheng Norbert Kirchgessner Helge Aasen Andreas Hund Pouria Sadhegi-Tehran Koichi Nagasawa Goro Ishikawa Sébastien Dandrifosse Alexis Carlier Benjamin Dumont Benoit Mercatoris Byron Evers Ken Kuroki Haozhou Wang Masanori Ishii Minhajul ABadhon Curtis Pozniak David Shaner LeBauer Morten Lillemo Jesse Poland Scott Chapman Benoit de Solan Frédéric Baret Ian Stavness Wei Guo | 2021 | Plant Phenomics2021，3，1： | 2 |
| 15 | Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer显示文摘Managing familial pancreatic cancer(FPC)is challenging for gastroenterologists,surgeons and oncologists.High-risk individuals(HRI)for pancreatic cancer(PC)(FPC or with germline mutations)are a heterogeneous group of subjects with a theoretical lifetime cumulative risk of PC over 5%.Screening is mainly based on annual magnetic resonance imaging(MRI)and endoscopic ultrasound(EUS).The goal of screening is to identify early-stage operable cancers or high-risk precancerous lesions(pancreatic intraepithelial neoplasia or intraductal papillary mucinous neoplasms with high-grade dysplasia).In the literature,target lesions are identified in 2%-5%of HRI who undergo screening.EUS appears to provide better identification of small solid lesions(0%-46%of HRI)and chronicpancreatitis-like parenchymal changes(14%-77%of HRI),while MRI is probably the best modality to identify small cystic lesions(13%-49%of HRI).There are no specific studies in HRI on the use of contrast-enhanced harmonic EUS.EUS can also be used to obtain tissue samples.Nevertheless,there is still limited evidence on the accuracy of imaging procedures used for screening or agreement on which patients to treat.The cost-effectiveness of screening is also unclear.Certain new EUS-related techniques,such as searching for DNA abnormalities or protein markers in pancreatic fluid,appear to be promising. | Diane Lorenzo Vinciane Rebours Frédérique Maire Maxime Palazzo Jean-Michel Gonzalez Marie-Pierre Vullierme Alain Aubert Pascal Hammel Philippe Lévy Louis de Mestier | 2019 | World Journal of Gastroenterology2019，25，34： | 2 |
| 16 | Trough levels and antibodies to infliximab may not predict response to intensification of infliximab therapy in patients with inflammatory bowel disease显示文摘 | Benjamin Pariente Guillaume Pineton de Chambrun Roman Krzysiek Marine Desroches Gauthier Louis Chiara De Cassan Clotilde Baudry Jean‐Marc Gornet Pierre Desreumaux Dominique Emilie Jean‐Frédéric Colombel Matthieu Allez | 2011 | Inflamm Bowel Dis2011，，7： | 2 |
| 17 | Animal models to test drugs with potential antidiabetic activity显示文摘 | T.S. Fr?de Y.S. Medeiros | 2007 | Journal of Ethnopharmacology2007，，2： | 2 |
| 18 | Acrylamide formation in fried potato products – Present and future, a critical review on mitigation strategies显示文摘 | Raquel Medeiros Vinci Frédéric Mestdagh Bruno De Meulenaer | 2011 | Food Chemistry2011，，4： | 2 |
| 19 | IL-2,its receptors,and bcl-2 and bax genes in normal,hyperplastic and carcinomatous human prostates:immunohistochemical comparative analysis显示文摘 | Royuela M De Miguel MP Bethencourt FR | 2000 | Growth Factors2000，18，： | 1 |
| 20 | Health risk assessment of dioxin emissions from municipal waste incinerators: the Neerlandquarter (Wilrijk, Belgium)显示文摘 | J Nouwen C Cornelis R De Fré M Wevers P Viaene C Mensink J Patyn L Verschaeve R Hooghe A Maes M Collier G Schoeters R Van Cleuvenbergen P Geuzens | 2001 | Chemosphere2001，，4： | 1 |
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