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| 1 | Molecular mechanisms of liver ischemia reperfusion injury:Insights from transgenic knockout models显示文摘Ischemia reperfusion injury is a major obstacle in liver resection and liver transplantation surgery.Understanding the mechanisms of liver ischemia reperfusion injury(IRI) and developing strategies to counteract this injury will therefore reduce acute complications in hepatic resection and transplantation,as well as expanding the potential pool of usable donor grafts.The initial liver injury is initiated by reactive oxygen species which cause direct cellular injury and also activate a cascade of molecular mediators leading to microvascular changes,increased apoptosis and acute inflammatory changes with increased hepatocyte necrosis.Some adaptive pathways are activated during reperfusion that reduce the reperfusion injury.IRI involves a complex interplay between neutrophils,natural killer T-cells cells,CD4+ T cell subtypes,cytokines,nitric oxide synthases,haem oxygenase-1,survival kinases such as the signal transducer and activator of transcription,Phosphatidylinositol 3-kinases/Akt and nuclear factor κβ pathways.Transgenic animals,particularly genetic knockout models,have become a powerful tool at elucidating mechanisms of liver ischaemia reperfusion injury and are complementary to pharmacological studies.Targeted disruption of the protein at the genetic level is more specific and maintained than pharmacological inhibitors or stimulants of the same protein.This article reviews the evidence from knockout models of liver IRI about the cellular and molecular mechanisms underlying liver IRI. | Gourab Datta Barry J Fuller Brian R Davidson | 2013 | World Journal of Gastroenterology2013，19，11： | 50 |
| 2 | Reactive oxygen intermediates target CC (MT) 6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation 显示文摘 | Datta R Taneja N Sukhatme V P | 1993 | Proc Natl Acad Sci U S A1993，90，6： | 2 |
| 3 | Ionizing radiation activates transcription of the EGR gene via CArG elements显示文摘 | Datta R Rubin E Sukhatme V P | 1992 | Proc Natl Acad Sci U S A1992，89，10： | 2 |
| 4 | The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase显示文摘 | Thomas F Franke Sung-Il Yang Tung O Chan Ketaki Datta Andrius Kazlauskas Deborah K Morrison David R Kaplan Philip N Tsichlis | 1995 | Cell1995，，5： | 2 |
| 5 | Elastic wave propagation in laminated composite plates 显示文摘 | Karunasena W M Bratton R L Datta S K | 1990 | ASME J Eng Mat Tech1990，113，： | 2 |
| 6 | Transcription-dependent and-independent control of neuronal survival by the PI3K-Akt signaling pathway显示文摘 | Brunet A Datta S R Greenberg M E | 2001 | Curr Opin Neurobiol2001，11，3： | 1 |
| 7 | Evolution and soil entrapment of nitrogen gases formed by denitrification in flooded soil 显示文摘 | Samson M I Buresh R J De Datta S K | 1990 | Soil Science and Plant Nutrition1990，36，： | 1 |
| 8 | Direct power of grid-connected wound rotor induction machine without rotor position sensors显示文摘 | Datta R Ranganathan V T | 2001 | IEEE Transactions of Power Electronics2001，16，3： | 1 |
| 9 | Seismic risk analysis of modified fan type cable stayed bridges 显示文摘 | Khan R A Datta T K Ahrnad S | 2006 | Engineering Structures2006，28，9： | 1 |
| 10 | Image retrieval:ideas,influences,and trends of the new age显示文摘 | Datta R Joshi D Li J | 2008 | ACM ComputingSurveys2008，40，2： | 1 |
| 11 | Containment of herbicide resistance through genetic engineering of the chloroplast genome显示文摘 | Daniell H Datta R Varma S Gray S.Lee S.B | | 0，，： | 1 |
| 12 | Enzyme immobilization: an overview on techniques and support materials显示文摘 | Datta S Christena L R Rajaram Y R S | 2013 | 3 Biotech2013，3，1： | 1 |
| 13 | Technological and economical potential of poly lactic acid and lactic acid derivatives 显示文摘 | DATTA R | 1995 | FEMS Microbiology Reviews1995，16，： | 1 |
| 14 | Seimic Behaviour of Base Isolated Buildings: A State of the Art Rview显示文摘 | Jangid R S Datta T K | 1995 | Structures and Buildings1995，110，2： | 1 |
| 15 | Identi- fication of the V600D mutation in Exon 15 of the BRAF onto gene in congenital,benign Langerhans cell histiocyto- sis显示文摘 | Kansal R Quintainilla-Martinez L Datta V | 2013 | Genes Chromosomes Cancer2013，52，1： | 1 |
| 16 | Postoperative beta radiation treatment of pterygium显示文摘 | Datta R | 1983 | Int J Radiat Oncol Biol Phys1983，9，： | 1 |
| 17 | Vibration and stability behavior of laminated composite curved panels with cutout under partial in-plane loads 显示文摘 | KUMAR L R DATTA P K PRABHAKARA D L | 2005 | International Journal of Structural Stability and Dynamics2005，5，1： | 1 |
| 18 | Semi-empirical approach to optimise the quantity of drying aids required to spray dry sugar-rich foods显示文摘 | Bhandari BR Datta N Crook R | 1997 | Dry Technology1997，15，10： | 1 |
| 19 | Modeling the heating uniformity contributed by a rotating turntable in microwave ovens显示文摘 | Geedipalli S S R Rakesh V Datta A K | 2007 | Journal ofFoodEngineering2007，82，： | 1 |
| 20 | 显示文摘 | Fishtik I Alexander A Datta R | 2000 | Int J Hydrogen Energy2000，25，： | 1 |
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