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| 1 | Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma显示文摘AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples.METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens: AFP, β-catenin, p53, CD44, MSH-2,MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups.RESULTS: Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nuclear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples.CONCLUSION: AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data onin vivo human tumors. | Dénes Grg János Regly-Mérei Sándor Paku László Kopper Péter Nagy | 2005 | World Journal of Gastroenterology2005，11，32： | 6 |
| 2 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 3 | Clustering sensors in wireless ad hoe networks operating in a threat environment显示文摘 | Patel D J Batta R Nagi R | 2005 | Operations Research2005，53，3： | 1 |
| 4 | Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hypermeability in angiogenesis 显示文摘 | Dvorak HF Nagy JA Feng D | 1999 | Curt Top Microbiol Immunol1999，23，7： | 1 |
| 5 | Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis显示文摘 | NAGY J A VASILE E FENG D | 2002 | J Exp Med2002，196，11： | 1 |
| 6 | Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor,histamine,and serotonin显示文摘 | Feng D Nagy AJ Hipp J | 1996 | J Exp Med1996，183，： | 1 |
| 7 | Mutiply attenuated lentiviral vector achieved efficient gene delivery in vivo显示文摘 | Zufferey R Nagy D Mandel RJ | 1997 | Nat Biotechnol1997，15，9： | 1 |
| 8 | Electrieal resistivity of concrete显示文摘 | WHOTING D A NAGI M A | 2003 | A Literature Review by PCA R & D Serial2003，，2457： | 1 |
| 9 | Cyclin D-cdk6 complex is targeted by P21 (WAF) in growth-arrested lymphoma cells显示文摘 | Tvrdik D Djaborkhel R Nagy A | 2002 | J Struct Biol2002，140，13： | 1 |
| 10 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 11 | Delineation of a carcinogenic Helicobacter pylori proteome 显示文摘 | Franco A T Friedman D B Nagy T A | 2009 | Mol Cell Proteomics2009，8，8： | 1 |
| 12 | Vascular permeability factor/ vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis显示文摘 | DVORAK H F NAGY J A FENG D | 1999 | Curr Top Microbiol Immunol1999，237，1： | 1 |
| 13 | First trimester ce sarean scar pregnancy evolving into placenta previa/accreta at term显示文摘 | Ben Nagi J Ofili Yebovi D Marsh M | 2005 | J Ultrasound Med2005，24，11： | 1 |
| 14 | The use of FISH and real-time PCR to monitor the biooxidation and cyanidation for gold and silver recovery from a mine tailings concentrate (Ticapampa,Peru) 显示文摘 | Schippers A Nagy A A Kock D | 2008 | Hydrometallurgy2008，94，14： | 1 |
| 15 | PIV study of the flow field generated by a saw tooth impeller显示文摘 | Unadkat H Rielly C D Nagy Z K | 2011 | Chemical Engineering Science2011，66，21： | 1 |
| 16 | Corrective osteotomies in malunions of the distal radius:do we get what we planned显示文摘 | von Campe A Nagy L Arbab D | 2006 | Clin Orthop Relat Res2006，450，： | 1 |
| 17 | A formation mechanism for catalytically grown helix-shaped graphite nanotubes显示文摘 | AMELINCKX S ZHANG X B BERNAERTS D ZHANG X F IVANOV V NAGY JB | 1994 | Science1994，265，： | 1 |
| 18 | 查看详情显示文摘 | Spevak W Nagy J O Charych D H | | 0，，： | 1 |
| 19 | The Gravitational Poten- tial and its Derivatives for the Prisrn显示文摘 | D Nagy G Papp J Benedek | 2000 | Journal of Ge- odesy2000，74，78： | 1 |
| 20 | Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus显示文摘 | Nagy G Koncz A Telarico T Fernandez D Ersek B Buzás E Perl A | | 0，，03： | 1 |
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