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| 1 | Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study显示文摘 | Christopher D. Williams Joel Stengel Michael I. Asike Dawn M. Torres Janet Shaw Maricela Contreras Cristy L. Landt Stephen A. Harrison | 2011 | Gastroenterology2011，，1： | 20 |
| 2 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 3 | Cancer and age related colonic crypt deficiencies in cytochrome c oxidase Ⅰ显示文摘AIM: To investigate whether defi ciency of expressionof cytochrome c oxidase I (CcOI) in colonic crypts is associated with colon cancer.METHODS: The pattern and level of expression of CcOI in non-neoplastic colonic crypts,and in dysplastic tissues,was assessed using standard immunohis-tochemical methods.Biopsies were obtained from individuals undergoing colonoscopies for screening purposes or for a medically indicated reason.Tissue samples were also obtained from surgical colonic resections.Samples from resections were taken from colonic mucosa 1 and 10 cm from tumors and from the tumors themselves.Samples were evaluated for frequency of crypts with reduced or absent expression of CcOI.In most crypts the loss was apparent throughout the entire crypt,while in a small minority the loss was segmental.The strong immunoreactivity using this monoclonal antibody makes the scoring unambiguous.The percent of crypts with reduced or absent expression of CcOI or (infrequent) segmented loss of expression was then calculated.Data analyses were performed using SPSS statistical package 17.0.RESULTS: The average frequency of CcOI deficient crypts (CcOI-DC) is low in individuals between 20 and 39 years of age,with 0.48% ± 0.40% CcOI-DC for women and 1.80% ± 0.35% for men.CcOI-DC increases after age 40 years,so that between the ages of 40 and 44 years the average frequency of CcOI- DC goes up to 5.89% ± 0.84% in women and 2.15% ± 1.27% in men.By 80-84 years of age,the average frequency of CcOI-DC goes up in women to 15.77% ± 0.97% and in men to 22.6% ± 0.65%.The increases in CcOI-DC from ages 40-44 years compared to 80-84 years in women and men are significantly different with P < 0.01.For women over age 60 years,deficiency of CcOI expression is greater in those women who have had a cancer in their colon.The frequency of CcOI-DC,measured in men,increased in tissues adjacent to colon cancer,being 4.03% ± 0.27% in individuals free of neoplasia in the age range 55-64 yearsand 14.13% ± 0.35% in resected histologically normal tissue of men with cancer in the same age range,P < 0.001.Similar signifi cant differences were noted in older age ranges.The frequency of CcOI-DC crypts in the cecum and sigmoid colon of an individual are signifi cantly correlated,with an R2 = 0.414 for women and R2 = 0.528 for men,P < 0.001.This suggests that the factors determining the level of CcOI deficiency act throughout the colon.Most defective crypts are in clusters of two or more,a likely consequence of crypt fission.In the non-neoplastic margins of cancers,crypts are frequently defi cient for CcOI,and such crypts may appear in large clusters,some containing more than 100 defi cient crypts.CcOI defi ciency is also apparent in colon cancers and sometimes involves a large section of the tumor.Overall,CcOI deficient cells can be visualized in segments of crypts,in whole crypts that increase in frequency with age,in crypts undergoing f ission,in clusters of crypts where the clusters increase in size with age,in increased frequency near tumors,in large clusters in the intimate margins of tumors,and in the tumors themselves.There is no clear dividing line between early stages that can be considered aspects of aging and later stages that can be considered aspects of the progression to cancer.This ambiguity may re ect a rather general situation leading to adult cancer where the early stages of cellular change appear to be relatively innocuous features of the aging process but over decades may evolve into malignancy.CONCLUSION: CcOI defi cient crypts increase in frequency with age,and clusters of defi cient crypts are associated with,and may give rise to,colon cancer. | Carol Bernstein Alexander Facista Huy Nguyen Beryl Zaitlin Nadia Hassounah Cristy Loustaunau Claire Margaret Payne Bhaskar Banerjee Steve Goldschmid V Liana Tsikitis Robert Krouse Harris Bernstein | 2010 | World Journal of Gastrointestinal Oncology2010，2，12： | 5 |
| 4 | Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study显示文摘 | Christopher D. Williams Joel Stengel Michael I. Asike Dawn M. Torres Janet Shaw Maricela Contreras Cristy L. Landt Stephen A. Harrison | 2011 | Gastroenterology2011，，1： | 5 |
| 5 | 1282名驾驶员焦虑水平与危险驾驶关系研究显示文摘目的探讨驾驶员焦虑水平与危险驾驶行为的关系。方法采用问卷调查法,分别使用贝克焦虑量表与Dula危险驾驶行为量表(DDDI-Dula Dangerous Driving Index)对1 282名驾驶员的焦虑水平与危险驾驶行为进行了评价并研究分析两者之间的相关性;对不同焦虑水平驾驶员的危险行为进行方差分析及秩和检验。结果(1)焦虑总分与危险驾驶量表总分以及三个子量表分数呈显著性正相关(P<0.01),(2)由方差分析和秩和检验显示,处于不同焦虑水平的驾驶员其危险驾驶行为在以下方面存在不同(P<0.05):DDDI总分、负面情绪驾驶、攻击性驾驶、危险驾驶、过去2周中尾随的数量、过去两周中阻碍其他车辆驾驶的数量、过去2周中超速且超过限速15英里/时的次数、过去两周中闯红灯的数量,过去两周内超速驶入应停车减速的区域的次数、过去3年中驾驶肇事次数以及过去一年中影响下驾驶的次数。结论驾驶员的焦虑水平可以影响危险驾驶行为,危险驾驶行为与高焦虑水平具有一定关系。 | 孙舒放 Chris S. Dula Cristi L. Adams | 2009 | 广东医学2009，30，10： | 4 |
| 6 | Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration显示文摘 | Wolfram Goessling Trista E. North Sabine Loewer Allegra M. Lord Sang Lee Cristi L. Stoick-Cooper Gilbert Weidinger Mark Puder George Q. Daley Randall T. Moon Leonard I. Zon | 2009 | Cell2009，，6： | 2 |
| 7 | Novel diet-related mouse model of colon cancer parallels human colon cancer显示文摘AIM:To investigate the close parallels between our novel diet-related mouse model of colon cancer and human colon cancer.METHODS:Twenty-two wild-type female mice(ages 6-8 wk)were fed the standard control diet(AIN-93G)and an additional 22 female mice(ages 6-8 wk)were fed the control diet supplemented with 0.2%deoxycho-lic acid[diet+deoxycholic acid(DOC)]for 10 mo.Tu-mors occurred in the colons of mice fed diet+DOC and showed progression to colon cancer[adenocarcinoma(AC)].This progression is through the stages of tubular adenoma(TA),TA with high grade dysplasia or ad-enoma with sessile serrated morphology,intramucosal AC,AC stage T1,and AC stage T2.The mouse tumors were compared to human tumors at the same stages by histopathological analysis.Sections of the small and large intestines of mice and humans were evaluated for glandular architecture,cellular and nuclear morphology including cellular orientation,cellular and nuclear atyp-ia,pleomorphism,mitotic activity,frequency of goblet cells,crypt architecture,ulceration,penetration of crypts through the muscularis mucosa and presence of malignant crypts in the muscularis propria.In addition,preserved colonic tissues from genetically similar male mice,obtained from a prior experiment,were analyzed by immunohistochemistry.The male mice had been fed the control diet or diet+DOC.Four molecular markers were evaluated:8-OH-dG,DNA repair protein ERCC1,autophagy protein beclin-1 and the nuclear location of beta-catenin in the stem cell region of crypts.Also,male mice fed diet+DOC plus 0.007%chlorogenic acid(diet+DOC+CGA)were evaluated for ERCC1,beclin-1 and nuclear location of beta-catenin.RESULTS:Humans with high levels of diet-relatedDOC in their colons are at a substantially increased riskof developing colon cancer.The mice fed diet+DOChad levels of DOC in their colons comparable to that ofhumans on a high fat diet.The 22 mice without addedDOC in their diet had no colonic tumors while 20 ofthe 22 mice(91%)fed diet+DOC developed colonictumors.Furthermore,the tumors in 10 of these mice(45%of mice)included an adenocarcinoma.All micewere free of cancers of the small intestine.Histopatho-logically,the colonic tumor types in the mice werevirtually identical to those in humans.In humans,char-acteristic aberrant changes in molecular markers can be detected both in field defects surrounding cancers(from which cancers arise)and within cancers.In thecolonic tissues of mice fed diet+DOC similar changesin biomarkers appeared to occur.Thus,8-OH-dG wasincreased,DNA repair protein ERCC1 was decreased,autophagy protein beclin-1 was increased and,in thestem cell region at the base of crypts there was sub-stantial nuclear localization of beta-catenin as well asincreased cytoplasmic beta-catenin.However,in micefed diet+DOC+CGA(with reduced frequency ofcancer)and evaluated for ERCC1,beclin-1,and beta-catenin in the stem cell region of crypts,mouse tissueshowed amelioration of the aberrancies,suggestingthat chlorogenic acid is protective at the molecular levelagainst colon cancer.This is the first diet-related modelof colon cancer that closely parallels human progressionto colon cancer,both at the histomorphological level aswell as in its molecular profile.CONCLUSION:The diet-related mouse model of coloncancer parallels progression to colon cancer in humans,and should be uniquely useful in model studies of pre-vention and therapeutics. | Anil R Prasad Shilpa Prasad Huy Nguyen Alexaner Facista Cristy Lewis Beryl Zaitlin Harris Bernstein Carol Bernstein | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 8 | Histologic analysis of endometriomas: what the surgeon needs to know显示文摘 | Ludovico Muzii Antonella Bianchi Filippo Bellati Emanuela Cristi Milena Pernice Marzio A. Zullo Roberto Angioli Pierluigi Benedetti Panici | 2007 | Fertility and Sterility2007，，2： | 2 |
| 9 | The contagion effects of accounting restatements显示文摘 | Gleason Cristi A Jenkins N T and Johnson W B | 2008 | The Accounting Review2008，83，16： | 1 |
| 10 | Fuzzy logic data correlation approach in multi-sensor multi-target tracking systems 显示文摘 | A M Aziz M Tummlal R Cristi | 1999 | Signal Processing1999，76，2： | 1 |
| 11 | Microstructural evaluation of initial dissolution of aluminosilicate particles and formation of geopolymer material显示文摘The rheological behavior of microparticulate structures of geopolymers was studied.The materials were developed from alternative sources of aluminosilicate and were activated in different concentrations using 5,10,and 15M sodium hydroxide,and sodium silicate,which were added in a 2:1ratio (by volume).The solid constituents used were bottom ash/metakaolin and neat metakaolin in a 2:1blend. The theological characteristics were determined after 5min of homogenization and a subsequent curing of the pastes at room temperature for 28 days.The materials presented amorphous characteristics, which confirmed the formation of geopolymers.A thixotropic behavior was observed for all forrfiulations,except for bottom ash/metakaolin activated at 5M,which resulted in geopolymers with a lower intensity compared with those activated at 10 and 15M,High activator concentrations exhibited a proportional relationship for geopolymer ring growth,which resulted in a reduced structure mobility and, consequently,an increased viscosity and yield stress.The effects are more evident in the metakaolin samples,and are associated with the water content that is required for reaction.Samples that were activated with 10M sodium hydroxide presented a favorable workability and particle packing,in terms of the theological and structural aspects. | Rozineide A.Antunes Boca Santa Julia Cristie Kessler Cintia Soares Humberto Gracher Riella | 2018 | Particuology2018，16，6： | 1 |
| 12 | Tumour proliferation,angiogenesis,and ploidy status in human colon cancer显示文摘 | Cristi E Perrone G Todcano G | 2005 | J Clin Pathol2005，58，11： | 1 |
| 13 | Fuzzy logic data con'clarion approach in multi-sensor multi-target tracking systems 显示文摘 | Aziz A M Tummala M Cristi R | 1999 | Signal Processing (S0165-1684)1999，76，2： | 1 |
| 14 | Adaptive quatemion feedback regulation for eigenaxis rotations显示文摘 | Cristi R Burl J Russo N | 1994 | J of Guidance Control and Dynamics1994，17，6： | 1 |
| 15 | Laparoscopic right colon resection with intracorporeal anastomosis显示文摘 | Karen Chang Mathew Fakhoury Moshe Barnajian Cristi Tarta Roberto Bergamaschi | 2013 | Surgical Endoscopy2013，，5： | 1 |
| 16 | Adaptive sliding mode control of autonomous underwater vehicles in the dive plane显示文摘 | Cristi R Papoulias F A Healey A | 1990 | IEEE Journal of Oceanic Engineering1990，15，3： | 1 |
| 17 | Tumour proliferation, angiogenesis, and ploidy status in human colon cancer显示文摘 | Cristi E Perrone G Todcano G | 2005 | J Clin Pathol2005，58，11： | 1 |
| 18 | Adaptive Sliding Mode Control of Autonomous Underwater Vehicles in the Dive Plane显示文摘 | Cristi R Papoulias F A Healey A J | 1990 | IEEE Journal of Oceanic Engineering1990，15，3： | 1 |
| 19 | Absorption coefficient of bulk and thin film Cu20显示文摘 | Claudia Malerba FrancescoBiccari Cristy Leonor Azanza Ricardo | 2011 | Solar Energe Materials and Solar Cell2011，，： | 1 |
| 20 | The study of the oxidation of uranium by external and diffuse reflectance FTIR spectroscopy using remote-sensing and evacuable cell techniques显示文摘 | POWELL G L DOBBINS A G CRISTY S S | 1994 | SPIE1994，2089，： | 1 |
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