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| 1 | Clinical and epidemiological characteristics of norovirus gastroenteritis among hospitalized children in Lebanon显示文摘AIM To assess the burden of norovirus(No V) and to determine the diversity of circulating strains among hospitalized children in Lebanon. METHODS Stool samples were collected from children presenting with acute gastroenteritis to six major hospitals in Lebanon. A total of 739 eligible stool samples, testing negative for diarrhea caused by rotavirus as a possible viral pathogen, were collected between January 2011 and June 2013. A standardized questionnaire including demographic, epidemiological and clinical observations was used at the time of hospitalization of children presenting with diarrhea. Viral RNA was extracted from stool samples followed by reverse transcription polymerase chain reaction and nucleotide sequencing of a fragment of the viral protein 1 capsid gene. Multiple sequence alignments were carried out and phylogenetic trees were constructed using the MEGA 6 software.RESULTS Overall, 11.2% of stool samples collected from children aged < 5 years tested positive for No V genogroups Ⅰ(GⅠ) and Ⅱ(GⅡ). GⅡ accounted for 10.6% of the gastroenteritis cases with only five samples being positive for GⅠ(0.7%). The majority of hospitalized children showed symptoms of diarrhea, dehydration, vomiting and fever. Upon sequencing of positive samples and based on their clustering in the phylogenetic tree, 4/5 of GⅠ gastroenteritis cases were designated GⅠ.3 and one case as GⅠ.4. GⅡ.4 was predominantly detected in stool of our study participants(68%). We report a JB-15/KOR/2008 GⅡ.4 Apeldoorn 2008-like variant strain circulating in 2011; this strain was replaced between 2012 and 2013 by a variant sharing homology with the Sydney/NSW0514/2012/AUS GⅡ.4 Sydney 2012 and Sydney 2012/FRA GⅡ.4 strains. We also report the co-circulation of non-GⅡ.4 genotypes among hospitalized children. Our data show that No V gastroenteritis can occur throughout the year with the highest number of cases detected during the hot months.CONCLUSION The majority of No V-associated viral gastroenteritis cases among our participants are attributable to GⅡ.4, which is compatible with results reported worldwide. | Nada M Melhem Hassan Zaraket Khalil Kreidieh Zeinab Ali Moza Hammadi Soha Ghanem Farah Hajar Amjad Haidar Adlette Inati Mariam Rajab Hassan Fakhouri Bassam Ghanem Ghassan Baasiri Ghassan Dbaibo | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 2 | Neural prostheses for restoring functions lost after spinal cord injury显示文摘Spinal cord injury(SCI)is a debilitating condition that affects more than 2.5 million individuals worldwide(Thuret et al.,2006).In addition to its devastating effects on the individual,this disease is a heavy burden to the society in terms of | Marc Fakhoury | 2015 | Neural Regeneration Research2015，10，10： | 2 |
| 3 | Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thromhotic thrombocytopenic purpura:a study of ll cases显示文摘 | Fakhouri F Vemant JP Veyradier A | 2005 | Blood JT Blood2005，106，： | 1 |
| 4 | Effect of Fatty Acid Addition on the Properties of Biopolymer Films Based on Lipophilic Maize Starch and Gelatin 显示文摘 | F M FAKHOURI L C B FONTES L H INNOCENTINI- MEI | 2009 | Starch-Starke2009，，61： | 1 |
| 5 | Telomeric function of mammalian telomerases at short telomeres显示文摘 | Fakhoury J Marie-Egyptienne DT Londo?o-Val ejo JA | | 0，，： | 1 |
| 6 | Identification of Systems Containing Linear Dynamic and Static Nonlinear Elements 显示文摘 | Billings S A Fakhouri S Y | 1982 | Automatica1982，18，1： | 1 |
| 7 | Angiotension cn activates collagen gene through a mechanism involving the MAP/ ER kinase pathway显示文摘 | Tharaux PL Chatziantoniou C Fakhouri F | 2000 | Hypertension2000，36，3： | 1 |
| 8 | A new treatment for TTP显示文摘 | Fakhouri F Deroure B Hummel A | | Nephrol Dial Transplant0，21，： | 1 |
| 9 | Angiotensin Ⅱ activates collagen Ⅰ gene through a mechanism involving the MAP/ER kinase pathway显示文摘 | Tharaux P L Chatziantoniou C Fakhouri F | 2000 | Hypertension2000，36，3： | 1 |
| 10 | C3 glomerulopa- thy;a new classification显示文摘 | Fakhouri F Fremeaux-Bacchi V Nol LH | 2010 | Nat Rev Nephrol2010，6，8： | 1 |
| 11 | Insights from the use in clinical practice of Eculizumab in adult patients with atypical hemolytic uremic syndrome affecting the native kidneys: an analysis of 19 cases显示文摘 | Fakhouri F Delmas Y Provot F | 2014 | Am J Kidney Dis2014，63，1： | 1 |
| 12 | Isolation and identification of N-mercapto-4-formyl-carbostyril, an antibiotic produced by Pseudomonas fluorescens 显示文摘 | Fakhouri W Walker F Vogler B | 2001 | Phytochemistry2001，58，8： | 1 |
| 13 | Effectiveness of diazepam rectal gel in adults with acute repetitive seizures and prolonged seizures: A single-center experience 显示文摘 | Fakhoury T Chumley T Bensalem-Owen M | 2007 | Epilepsy Behavior2007，11，3： | 1 |
| 14 | Indirect comparison of once daily insulin detemir and glargine in reducing weight gain and hypoglycaemic episodes when administered in addition to conventional oral anti-diabetic therapy in patients with type-2 diabetes显示文摘 | Fakhoury W Lockhart I Kotchie RW | 2008 | Pharmacology2008，82，2： | 1 |
| 15 | Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura:a study of 11cases显示文摘 | Fakhouri F Vernant JP Veyradier A | 2005 | Blood2005，106，6： | 1 |
| 16 | Mc Carthy Specialist palliative carein nonmalignant disease显示文摘 | AddingtorrHall J Fakhoury W | 1998 | Palliat Med1998，12，6： | 1 |
| 17 | Generalized absence seizures wi th 10-15 Hz fast discharges显示文摘 | Fakhoury T Abou Khalil B | 1999 | Clin Neurophysiol1999，110，6： | 1 |
| 18 | Angiotensin Ⅱ activates collagen Ⅰ gene through a mechanism /nvolving the MAP/ ER kinase pathway显示文摘 | Tharanx PL Chatziantoniou C Fakhouri F | 2000 | Hypertension2000，36，11： | 1 |
| 19 | Enhancement of NMP degradation under UV light by nitrogen-doped TiOz thin films using a design of experiment 显示文摘 | Fakhouri H Smith W Pulpytel J etal | 2011 | J Nano-glectron Phys2011，3，1： | 1 |
| 20 | Laparoscopic right colon resection with intracorporeal anastomosis显示文摘 | Karen Chang Mathew Fakhoury Moshe Barnajian Cristi Tarta Roberto Bergamaschi | 2013 | Surgical Endoscopy2013，，5： | 1 |
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