|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 2 | Rheological and physical differences between foam and emulsion fracturing fluids显示文摘 | Blauer R E Phillips A M Craig D P | 1988 | SPE18214 MS1988，，： | 1 |
| 3 | An empirical analysis of the product - process matrix 显示文摘 | Safizadeh M H Ritzman L P Sharma D Craig W | 1996 | Management Science1996，42，11： | 1 |
| 4 | Levels of stress and health practices of wives of alcoholics显示文摘 | Montgomery P Craig D | 1990 | Canadian Journal of Nursing Research1990，22，2： | 1 |
| 5 | Barriers to Swift, Even Flow in the Internal Supply Chain of Perioperative Surgical Services De- partment: A Case Study显示文摘 | FREDENDALL L D CRAIG J B FOWLER P J etal | 2009 | Decision Sciences2009，40，2： | 1 |
| 6 | The relevance of the amorphous state to pharmaceutical dosage forms: Glassy drugs and freeze dried systems 显示文摘 | CRAIG D Q M ROYALL P G KETT V L HOPTON M L | 1999 | International Journal of Pharmaceutics1999，179，2： | 1 |
| 7 | Infection of SCID mice with Mycobacterium leprae and control with antigen-activated 'immune'human peripheral blood mononuclear cells 显示文摘 | Craig L E Spelman J P Strandverg J D | 1995 | Inection and Immunity1995，63，3： | 1 |
| 8 | Pigmented villonodular synovitis of the knee:average five-year follow-up of arthroscopic treatment显示文摘 | Rauh P B Bernard J Craig D M | 2002 | J South Orthop Assoc2002，11，2： | 1 |
| 9 | An Epidemiological and Ecological Study of Human Alveolar Echinococcosis Transmission in South Gansu,China显示文摘 | Craig P S Giraudoux P Shi D | 2000 | Acta Tropica2000，77，： | 1 |
| 10 | Modeling wave-enhanced turbulence in the ocean surface layer显示文摘 | Craig P D Banner M L | 1994 | J Phys Oceanogr1994，24，： | 1 |
| 11 | Temporal and spatial patterns of gene expression in skeletal muscles in re-sponse to swim training in adult zebrafish(Danio rerio)显示文摘 | LeMoine C M R Craig P M Julie K D | | 0，，： | 1 |
| 12 | Elevated insular gluta- mate in fibromyalgia is associated with experimental pain显示文摘 | Harris R E Sundgren P C Craig A D | 2009 | Ar- thritis Rheum2009，60，10： | 1 |
| 13 | Vinculin retains focal contact localization after mutational disruption of tail domain binding to PIP2-containing bilayers 显示文摘 | Johnson R P Cohen D M Craig S W | 2000 | Mol Biol Cell2000，11，： | 1 |
| 14 | A prognostic index for ductal carcinoma in situ 显示文摘 | Lagios M D Craig P H | 1996 | Cancer1996，77，： | 1 |
| 15 | The effect of processing variables on the physical characteristics of non-ionic surfactant vesicles ( niosomes ) formed abexadecyl diglycerol ether 显示文摘 | Arunothayanum P Bernard M S Craig D Q M | 2000 | Int J Pharm2000，201，： | 1 |
| 16 | Mixing chemical reaction and flowfield development in ducted rockets显示文摘 | S P Vanka F D Stull and R R Craig | 1986 | Journal of Propulsion1986，，12： | 1 |
| 17 | The effect of processing variables on the physical characteristics of non-ionic surfactant vesicles(niosomes)formed from a hexadecyl diglycerol ether显示文摘 | ARUNOTHAYANUN P BERNARD M S CRAIG D Q M | 2000 | Int J Pharm2000，201，： | 1 |
| 18 | Enabling and measuring electronic customer relationship management readiness显示文摘 | Jutla D Craig J Bodorik P | 2001 | Organizational Systems and Technologies Track2001，1120，： | 1 |
| 19 | Peer Involvement in Bullying:Insights and Challenges for Intervention显示文摘 | O'Connell P Pepler D Craig W | | 0，，22： | 1 |
| 20 | Red blood cell mass and plasma volume changes in manned space flight显示文摘 | Craig L Fischer M D Johnson P C | 1992 | JAMA1992，200，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员