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| 1 | Prediction of genetic value for sweet cherry fruit maturity among environments using a 6K SNP array显示文摘The timing of fruit maturity is an important trait in sweet cherry production and breeding.Phenotypic variation for phenology of fruit maturity in sweet cherry appears to be under strong genetic control,but that control might be complicated by phenotypic instability across environments.Although such genotype-by-environment interaction(G×E)is a common phenomenon in crop plants,knowledge about it is lacking for fruit maturity timing and other sweet cherry traits.In this study,1673 genome-wide SNP markers were used to estimate genomic relationships among 597 weakly pedigree-connected individuals evaluated over two seasons at three locations in Europe and one location in the USA,thus sampling eight‘environments’.The combined dataset enabled a single meta-analysis to investigate the environmental stability of genomic predictions.Linkage disequilibrium among marker loci declined rapidly with physical distance,and ordination of the relationship matrix suggested no strong structure among germplasm.The most parsimonious G×E model allowed heterogeneous genetic variance and pairwise covariances among environments.Narrow-sense genomic heritability was very high(0.60–0.83),as was accuracy of predicted breeding values(>0.62).Average correlation of additive effects among environments was high(0.96)and breeding values were highly correlated across locations.Results indicated that genomic models can be used in cherry to accurately predict date of fruit maturity for untested individuals in new environments.Limited G×E for this trait indicated that phenotypes of individuals will be stable across similar environments.Equivalent analyses for other sweet cherry traits,for which multiple years of data are commonly available among breeders and cultivar testers,would be informative for predicting performance of elite selections and cultivars in new environments. | Craig M.Hardner Ben J.Hayes Satish Kumar Stijn Vanderzande Lichun Cai Julia Piaskowski JoséQuero-Garcia JoséAntonio Campoy Teresa Barreneche Daniela Giovannini Alessandro Liverani Gérard Charlot Miguel Villamil-Castro Nnadozie Oraguzie Cameron P.Peace | 2019 | Horticulture Research2019，6，1： | 5 |
| 2 | Apple whole genome sequences:recent advances and new prospects显示文摘In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for apple.Over the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued crop.Causal gene identities for phenotypes of fundamental and practical interest can today be discovered much more rapidly.Genome-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and pedigrees.High-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for breeders.We understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild relatives.The WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple production.This review includes examples of basic and practical breakthroughs and challenges in using the apple WGSs.Recommendations for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple. | Cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro Fazio Hisayo Yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande | 2019 | Horticulture Research2019，6，1： | 3 |
| 3 | RosBREED:bridging the chasm between discovery and application to enable DNA-informed breeding in rosaceous crops显示文摘The Rosaceae crop family(including almond,apple,apricot,blackberry,peach,pear,plum,raspberry,rose,strawberry,sweet cherry,and sour cherry)provides vital contributions to human well-being and is economically significant across the U.S.In 2003,industry stakeholder initiatives prioritized the utilization of genomics,genetics,and breeding to develop new cultivars exhibiting both disease resistance and superior horticultural quality.However,rosaceous crop breeders lacked certain knowledge and tools to fully implement DNA-informed breeding—a“chasm”existed between existing genomics and genetic information and the application of this knowledge in breeding.The RosBREED project(“Ros”signifying a Rosaceae genomics,genetics,and breeding community initiative,and“BREED”,indicating the core focus on breeding programs),addressed this challenge through a comprehensive and coordinated 10-year effort funded by the USDA-NIFA Specialty Crop Research Initiative.RosBREED was designed to enable the routine application of modern genomics and genetics technologies in U.S.rosaceous crop breeding programs,thereby enhancing their efficiency and effectiveness in delivering cultivars with producer-required disease resistances and market-essential horticultural quality.This review presents a synopsis of the approach,deliverables,and impacts of RosBREED,highlighting synergistic global collaborations and future needs.Enabling technologies and tools developed are described,including genome-wide scanning platforms and DNA diagnostic tests.Examples of DNA-informed breeding use by project participants are presented for all breeding stages,including pre-breeding for disease resistance,parental and seedling selection,and elite selection advancement.The chasm is now bridged,accelerating rosaceous crop genetic improvement. | Amy F.Iezzoni Jim McFerson James Luby Ksenija Gasic Vance Whitaker Nahla Bassil Chengyan Yue Karina Gallardo Vicki McCracken Michael Coe Craig Hardner Jason D.Zurn Stan Hokanson Eric van de Weg Sook Jung Dorrie Main Cassia da Silva Linge Stijn Vanderzande Thomas M.Davis Lise L.Mahoney Chad Finn Cameron Peace | 2020 | Horticulture Research2020，7，1： | 2 |
| 4 | Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication显示文摘 | Nai-Yun Hsu Olha Ilnytska Georgiy Belov Marianita Santiana Ying-Han Chen Peter M. Takvorian Cyrilla Pau Hilde van der Schaar Neerja Kaushik-Basu Tamas Balla Craig E. Cameron Ellie Ehrenfeld Frank J.M. van Kuppeveld Nihal Altan-Bonnet | 2010 | Cell2010，，5： | 1 |
| 5 | Zinc-deficiency-induced retinal dysfunction in Crohn’s disease显示文摘 | Dr. Craig J. McClain MD Le-Chu Su PhD Howard Gilbert MD Douglas Cameron MD | 1983 | Digestive Diseases and Sciences1983，，1： | 1 |
| 6 | Modeling of genetic gain for single traits from marker-assisted seedling selection in clonally propagated crops显示文摘Seedling selection identifies superior seedlings as candidate cultivars based on predicted genetic potential for traits of interest.Traditionally,genetic potential is determined by phenotypic evaluation.With the availability of DNA tests for some agronomically important traits,breeders have the opportunity to include DNA information in their seedling selection operations—known as marker-assisted seedling selection.A major challenge in deploying marker-assisted seedling selection in clonally propagated crops is a lack of knowledge in genetic gain achievable from alternative strategies.Existing models based on additive effects considering seed-propagated crops are not directly relevant for seedling selection of clonally propagated crops,as clonal propagation captures all genetic effects,not just additive.This study modeled genetic gain from traditional and various marker-based seedling selection strategies on a single trait basis through analytical derivation and stochastic simulation,based on a generalized seedling selection scheme of clonally propagated crops.Various trait-test scenarios with a range of broad-sense heritability and proportion of genotypic variance explained by DNA markers were simulated for two populations with different segregation patterns.Both derived and simulated results indicated that marker-based strategies tended to achieve higher genetic gain than phenotypic seedling selection for a trait where the proportion of genotypic variance explained by marker information was greater than the broad-sense heritability.Results from this study provides guidance in optimizing genetic gain from seedling selection for single traits where DNA tests providing marker information are available. | Sushan Ru Craig Hardner Patrick A Carter Kate Evans Dorrie Main Cameron Peace | 2016 | Horticulture Research2016，3，1： | 1 |
| 7 | Multiple-digit periungual Bowen's disease:a novel treatment approach with radiotherapy显示文摘 | Hunt WT Cameron A Craig P | 2013 | Clin Exp Dermatol2013，38，8： | 1 |
| 8 | Consensus-Derived Practice Standards Plan for Complicated Kaposiform Hemangioendothelioma显示文摘 | Beth A. Drolet Cameron C. Trenor Leonardo R. Brand?o Yvonne E. Chiu Robert H. Chun Roshni Dasgupta Maria C. Garzon Adrienne M. Hammill Craig M. Johnson Brook Tlougan Francine Blei Michèle David Ravindhra Elluru Ilona J. Frieden Sheila F. Friedlander Ionel | 2013 | The Journal of Pediatrics2013，，1： | 1 |
| 9 | Ribvirin' s antiviral mechanism of action: lethal mutagenesis? 显示文摘 | Shane Crotty Craig Cameron Raul Andino | 2002 | J Mol Med2002，80，2： | 1 |
| 10 | Multisociety (AATS, ACCF, SCAI, and STS) expert consensus statement: Operator and institutional requirements for transcatheter valve repair and replacement, part 1: Transcatheter aortic valve replacement显示文摘 | Carl L. Tommaso R. Morton Bolman Ted Feldman Joseph Bavaria Michael A. Acker Gabriel Aldea Duke E. Cameron Larry S. Dean Dave Fullerton Ziyad M. Hijazi Eric Horlick D. Craig Miller Marc R. Moon Richard Ringel Carlos E. Ruiz Alfredo Trento Bonnie H. Weiner | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，： | 1 |
| 11 | HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A–cyclophilin A interaction to cyclophilin inhibitors显示文摘 | Udayan Chatterji Precious Lim Michael D. Bobardt Stefan Wieland Daniel G. Cordek Gregoire Vuagniaux Francis Chisari Craig E. Cameron Paul Targett-Adams Tanya Parkinson Philippe A. Gallay | 2010 | Journal of Hepatology2010，，1： | 1 |
| 12 | Marked increase in type 1 diabetes mellitus incidence in children aged 0-14 yr in Victoria,Australia,from 1999 to 2002显示文摘 | Chong JW Craig ME Cameron FJ | | 0，，： | 1 |
| 13 | A prospective randomized study comparing stapled with handsewn esophagogastric anastomoses显示文摘 | Craig SR Walker WS Cameron EW | 1996 | J R Coll Surg Edinb1996，41，1： | 1 |
| 14 | Reliability and Validity of Canada's Physical Activity Monitor for Assessing Trends显示文摘 | CRAIG C L RUSSELL S J CAMERON C | 2002 | Med Sci Sports Exe2002，34，9： | 1 |
| 15 | A prospective randomized study comparing stapled with hand-sewn oe- sophagogastric anastomoses 显示文摘 | Craig SR Walker WS Cameron EWJ | 1996 | J R Coll Surg Edinb1996，41，1： | 1 |
| 16 | Marked increase in type 1 diabetes mellitus incidence in children aged 0- 14 yr in Victoria, Australia, from 1999 to 2002显示文摘 | Chong JW Craig ME Cameron FJ | 2007 | Pediatr Diabetes2007，8，2： | 1 |
| 17 | Scalp reconstructive flaps显示文摘Scalp reconstruction requires keen insight into underlying anatomy and surgical armamentarium.The reconstructive surgeon must consider a plethora of complexities to devise a safe and cosmetically maximized outcome.The purpose of this article is to review scalp reconstruction techniques and the current literature in the framework of the reconstructive ladder,with special emphasis on local flap consideration,design,and execution. | Craig Cameron Brawley Douglas Sidle | 2022 | Plastic and Aesthetic Research2022，9，1： | 0 |
| 18 | A randomized controlled trial of Promoting Physical Activity in Regional and Remote Cancer Survivors(PPARCS)显示文摘Background:Physical activity(PA)is important for cancer survivors.Trials of remotely delivered interventions are needed to assist in reaching under-served non-metropolitan cancer survivors.The objective of this study was to ascertain whether wearable technology,coupled with health coaching was effective in increasing PA in breast and colorectal cancer survivors living in regional and remote areas in Australia.Methods:Cancer survivors from 5 states were randomized to intervention and control arms.Intervention participants were given a Fitbit Charge 2TMand received up to 6 telephone health coaching sessions.Control participants received PA print materials.Accelerometer assessments at baseline and 12 weeks measured moderate-to-vigorous PA(MVPA),light PA,and sedentary behavior.Results:Eighty-seven participants were recruited(age=63±11 years;74(85%)female).There was a significant net improvement in MVPA of 49.8 min/week,favoring the intervention group(95%confidence interval(95%CI):13.6-86.1,p=0.007).There was also a net increase in MVPA bouts of 39.5 min/week(95%CI:11.9-67.1,p=0.005),favoring the intervention group.Both groups improved light PA and sedentary behavior,but there were no between-group differences.Conclusion:This’s the first study to demonstrate that,when compared to standard practice(i.e.,PA education),a wearable technology intervention coupled with distance-based health coaching,improves MVPA in non-metropolitan cancer survivors.The results display promise for the use of scalable interventions using smart wearable technology in conjunction with phone-based health coaching to foster increased PA in geographically disadvantaged cancer survivors. | Sarah J.Hardcastle Chloe Maxwell-Smith Vinicius Cavalheri Terry Boyle Marta Leyton Román Cameron Platell Michael Levitt Christobel Saunders Frank Sardelic Sophie Nightingale Jacob McCormick Craig Lynch Paul A.Cohen Max Bulsara Dana Hince | 2024 | Journal of Sport and Health Science2024，13，1： | 0 |
| 19 | GLOBAL GENOMIC PREDICTION IN HORTICULTURAL CROPS:PROMISES,PROGRESS,CHALLENGES AND OUTLOOK显示文摘Only when all contribute their firewood can they build up a big fire(众人拾柴火焰高).Horticultural crops are a major source of high value nutritious food,and new improved cultivars developed through breeding are required for sustainable production in the face of abiotic and biotic stresses,and to deliver novel,premium products to consumers.However,grower confidence in the performance of new germplasm,particularly across environmental variability,is important for commercial adoption and germplasm-environ-ment matching to optimize production. | Craig HARDNER Satish KUMAR Dorrie MAIN Cameron PEACE | 2021 | Frontiers of Agricultural Science and Engineering2021，8，2： | 0 |
| 20 | 就算不喜欢iPhoneX,也要学苹果的公关套路显示文摘1.化繁为简。如果你对苹果公司公关部门的任何一篇新闻稿进行阅读水平检测,那么它很可能会被判定为“4年级学生或以下”水平。任何一点行业术语、陈词滥调或是技术类的复杂词汇都会被删除。沟通内容越简单,就能接触到越多受众。 | Cameron Craig | 2017 | 中外管理2017，0，11： | 0 |
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