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| 1 | Lack of association between UGT1A7,UGT1A9,ARP,SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients显示文摘AIM: To investigate simultaneously UGT1A7, UGT1A9, ARP, SPINK and CFTR genes to verify whether genetic polymorphisms predispose to the development of pancreatic cancer (PC). METHODS: Genomic DNA of 61 pancreatic cancer patients and 105 healthy controls (HC) were analyzed. UGT1A7 genotyping was determined by PCR-RFLP analysis. Specific PCR and sequencing were used to analyze genetic variants of UGT1A9, ARP, SPINK1 and CFTR genes. RESULTS: Four different alleles (*1: WT; *2: N129K and R131K; *3: N129K, R131K, and W208R; and *4: W208R) in UGT1A7 and three different alleles (*1: WT; *4: Y242X; and *5: D256N) in UGT1A9 were detected. All UGT1A polymorphisms were observed at similar frequency in PC patients and HC. Seven different alleles in ARP were found in PC patients and HC at similar frequency. The SPINK1 mutations N34S and P55S occurred in five PC patients with a prevalence (4.1%) not significantly different from that observed (2.0%) in HC. The only CFTR ΔF508 mutation was recognized in three PC patients with a prevalence (4.9%) similar to HC. CONCLUSION: UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms are not associated with PC in Italian patients. | Ada Piepoli Annamaria Gentile Maria Rosa Valvano Daniela Barana Cristina Oliani Rosa Cotugno Michele Quitadamo Angelo Andriulli Francesco Perri | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 2 | A study of internet searches for medical information in dermatology patients:the patient-physician relationship显示文摘 | Orgaz-Molina J Cotugno M Giron-Prieto MS | 2015 | Actas Dermosifiliogr2015，106，6： | 1 |
| 3 | Ocular gene therapy: current progress and future prospects 显示文摘 | Colella P Cotugno G Attricchio A | 2009 | Trends Mol Med2009，15，1： | 1 |
| 4 | Promoter methylation correlates with reduced NDRG2 expression in advanced colon tumour 显示文摘 | Piepoli A Cotugno R Merla G | 2009 | BMC Med Genomies2009，2，： | 1 |
| 5 | BAG3 down-modu- lation sensitizes HPV18(+) HeLa cells to PEITC-induced apoptosis and restores p53 显示文摘 | Cotugno R Basile A Romano E | 2014 | Cancer left2014，354，2： | 1 |
| 6 | Clinical efficacy of bariatric surgery versus liraglutide in patients with type 2 diabetes and severeobesity:a 12-month retrospective evaluation显示文摘 | Cotugno M Nosso G Saldalamacchia G | 2015 | Acta Diabetol2015，52，2： | 1 |
| 7 | Comparison of a monoclonal antigen stool test (Hp StAR) with the ^(13)C-urea breath test in monitoring Helicobacter pylori eradication therapy显示文摘AIM: To evaluate the agreement between a mAb-based stool test (HP StAR) and the urea breath test (UBT) in monitoring (H pylori) infection after eradication therapy.METHODS: Patients with discordant results on UBT and Hp StAR underwent endoscopy with biopsies for rapid urease test, culture, and histology to confirm H pylori status.RESULTS: Among 250 patients (50±14 years), 240 (96.0%) had concordant UBT and Hp StAR tests with a significant correlation between DOB and A values (R = 0.87; P<0.0001).The remaining 10 (4.0%) patients had discordant tests (positive Hp StAR and negative UBT) with the Hp StAR inaccurate in five cases (false positive) and UBT inaccurate in the other five cases (false negative). The 'maximal expected' sensitivity, specificity, +PV, -PV, +LR, and -LR were 91%, 100%, 100%, 97.4%, ∞, and 8.2 respectively,for the UBT, and 100%, 97.4%, 91%, 100%, 38.8, and 0,respectively, for the Hp StAR. Overall accuracy for both tests was 98%.CONCLUSION: Both the UBT and the Hp StAR are equally accurate in monitoring H pylori infection. Nowadays,the choice of the 'best' non-invasive H pylori test in the post-treatment setting should be done not only in terms of diagnostic accuracy but also in view of cost and local facilities. | Francesco Perri Michele Quitadamo Rosalba Ricciardi Ada Piepoli Rosa Cotugno Annamaria Gentile Alberto Pilotto Angelo Andriulli | 2005 | World Journal of Gastroenterology2005，11，37： | 1 |
| 8 | Aberrant DNA methylation in non-neoplastic gastric mucosa of Helicobacter pylori infected patients and effect of eradication显示文摘 | Perri F Cotugno R Piepoli A | | 0，，07： | 1 |
| 9 | Inhibition of ocular neovascularization by hedgehog blockade 显示文摘 | Surace EM Balaggan KS Tessitore A Mussolino C Cotugno G Bonetti C | 2006 | Mol Ther2006，13，3： | 1 |
| 10 | Role of pharmacist counseling in preventing adverse drug events after hos- pitalization显示文摘 | SCHNLPPER J L KIRWIN J L COTUGNO M C | 2006 | Arch Intern Med2006，166，5： | 1 |
| 11 | Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence显示文摘 | F. Perri A. Piepoli C. Bonvicini A. Gentile M. Quitadamo M. Di Candia R. Cotugno F. Cattaneo M.R. Zagari L. Ricciardiello M. Gennarelli F. Bazzoli G.N. Ranzani A. Andriulli | 2005 | Cytokine2005，，5： | 1 |
| 12 | Role d pharmacist counseling in preventing adverse drug events after hospitalization显示文摘 | Schnipper JL Kirwin JL Cotugno MC | | 0，，05： | 1 |
| 13 | Promoter methylation correlates with reduced NDRG2 expression in advanced colon tumour 显示文摘 | Piepoli A Cotugno R Merla G | 2009 | BMC Med Genomics2009，，2： | 1 |
| 14 | Role of pharmacist counseling in preventing adverse drug events after hospitalization显示文摘 | Schnipper JL Kirwin JL Cotugno MC | 2006 | Arch Intern Med2006，166，5： | 1 |
| 15 | Inhibition of ocular neovascularization by hedgehog blockade 显示文摘 | Surace EM Balaggan KS Tessitore A Mussolino C Cotugno G Bonetti C | 2005 | Mol Ther2005，13，3： | 1 |
| 16 | Promoter methylation correlates with reduced NDRG2 expression in advanced colon turnout 显示文摘 | Ada Piepoli Rosa Cotugno Giuseppe | 2009 | BMC Medical Genomics2009，256，3： | 1 |
| 17 | Molecular interac- tions in and transport properties of densely cross-linked net- works: A time resolved FT-IR spectroscopy investigation of the epoxy/water system 显示文摘 | Cotugno S Mensitieri G Musto P | 2005 | Macromolecules2005，38，3： | 1 |
| 18 | Relationship lending, hierarchical distance and credit tightening: evidence from the fi- nancial crisis显示文摘 | COTUGNO M MONFERRA S SAMPAGNARO G | 2013 | Journal of Banking & Finance2013，37，5： | 1 |
| 19 | Promoter methylation correlates with reduced NDRG2 expression in advanced colon tumour显示文摘 | Piepoli A Cotugno R Merla G | 2009 | BMC Med Genomics2009，2，： | 1 |
| 20 | Role of pharmacist counseling in preventing adverse drug events after hospitalization显示文摘 | Schnipper JL Kirwin JL Cotugno MC | 2006 | Arch Intern Med2006，166，： | 1 |
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