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| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 3 | High prevalence of hepatic steatosis and vascular thrombosis in COVID-19:A systematic review and meta-analysis of autopsy data显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)disease can frequently affect the liver.Data on hepatic histopathological findings in COVID-19 is scarce.AIM To characterize hepatic pathological findings in patients with COVID-19.METHODS We conducted a systematic review with meta-analysis registered on PROSPERO(CRD42020192813),following PRISMA guidelines.Eligible trials were those including patients of any age and COVID-19 diagnosis based on a molecular test.Histopathological reports from deceased COVID-19 patients undergoing autopsy or liver biopsy were reviewed.Articles including less than ten patients were excluded.Proportions were pooled using random-effects models.Q statistic and I2 were used to assess heterogeneity and levels of evidence,respectively.RESULTS We identified 18 studies from 7 countries;all were case reports and case series from autopsies.All the patients were over 15 years old,and 67.2%were male.We performed a meta-analysis of 5 studies,including 116 patients.Pooled prevalence estimates of liver histopathological findings were hepatic steatosis 55.1%[95%confidence interval(CI):46.2-63.8],congestion of hepatic sinuses 34.7%(95%CI:7.9-68.4),vascular thrombosis 29.4%(95%CI:0.4-87.2),fibrosis 20.5%(95%CI:0.6-57.9),Kupffer cell hyperplasia 13.5%(95%CI:0.6-54.3),portal inflammation 13.2%(95%CI:0.1-48.8),and lobular inflammation 11.6%(95%CI:0.3-35.7).We also identified the presence of venous outflow obstruction,phlebosclerosis of the portal vein,herniated portal vein,periportal abnormal vessels,hemophagocytosis,and necrosis.CONCLUSION We found a high prevalence of hepatic steatosis and vascular thrombosis as major histological liver features.Other frequent findings included portal and lobular inflammation and Kupffer cell hyperplasia or proliferation.Further studies are needed to establish the mechanisms and implications of these findings. | Luis Antonio Díaz Francisco Idalsoaga Macarena Cannistra Roberto Candia Daniel Cabrera Francisco Barrera Alejandro Soza Rondell Graham Arnoldo Riquelme Marco Arrese Michael D Leise Juan Pablo Arab | 2020 | World Journal of Gastroenterology2020，26，48： | 3 |
| 4 | An exosome pathway without an ESCRT显示文摘Exosome biogenesis occurs via multiple mechanisms,but how these pathways are controlled remains poorly understood.In a recent study published in Cell Research,Wei et al.identify Rab31 GTPase as a regulator of lipid-mediated exosome biogenesis independent of other commonly-recognized ESCRT and tetraspanin pathways.Exosomes are 30-150 nm vesicles that mediate intercellular crosstalk by transferring bioactive cargos in normal physiology and disease.Exosomes originate in the multivesicular body(MVB)of endosomes;inward membrane budding produces intraluminal vesicles(ILVs)contained within MVBs that carry membrane cargos and molecules from the surrounding cytoplasm.MVBs fuse with the plasma membrane,secreting ILVs as exosomes(Fig.1). | Candia M.Kenific Haiying Zhang David Lyden | 2021 | Cell Research2021，31，2： | 3 |
| 5 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 6 | Effects of unfractionated and low molecular weight heparins on platdet thromboxane biosynthesis'in vivo'显示文摘 | De Candia E Rocca B | 1994 | Thromb Haetmost1994，72，6： | 1 |
| 7 | Vascular endothelial growth factor plasma levels in patients with systematic lupus erythematosus and primarT antiphospholipid syndrome显示文摘 | Navarro C Candia L Silveria LH | 2002 | Lupus2002，11，1： | 1 |
| 8 | 显示文摘 | Sorensen O Villadsen J | 1984 | Bull Soc Chim Belg1984，93，： | 1 |
| 9 | One-year outcome after decompressive surgery for massive non-dominant hemispheric infraction显示文摘 | Carter BS Ogilvy CS Candia GJ | 1997 | Neurosurgery1997，40，6： | 1 |
| 10 | Immune-inflammato- ry activation in heart failure 显示文摘 | Candia AM Villacorta H Jr Mesquita ET | 2007 | Arqu-ivos Brasileiros de Cardio- logia2007，，3： | 1 |
| 11 | Mssbauer emission studies of calcined Co-Mo/Al2O3 catalysts: Catalytic significance of Co precursors显示文摘 | WIVEL C CLAUSEN B S CANDIA R | 1984 | J Catal1984，87，2： | 1 |
| 12 | Thrombin-induced platelet activation is inhibited by high-and low-molecular-weight heparin 显示文摘 | De Candia E De Cristofaro R Landolfi R | 1999 | Circulation1999，99，25： | 1 |
| 13 | Doppler evaluation of arterial complications of adult orthotopic liver transplantation显示文摘 | Vit A De Candia A Como G | 2003 | J Clin Ultrasound2003，31，7： | 1 |
| 14 | In situ Mossbauer emission spectroscopy studies of unsupported and supported sulfided Co-Mo hydrodesulfurization catalysts: evidence for and nature of a Co-Mo-S phase显示文摘 | Tops(ke H Clausen B S Candia R | 1981 | Catal1981，68，43： | 1 |
| 15 | Investigation of Platelet Aggregation Inhibitory Activity by Phenyl Amides and Esters of Piperidinecarboxylic Acids 显示文摘 | De Candia M Summo L Carrieri A | 2003 | Bioorg Med Chem2003，11，20： | 1 |
| 16 | Thrombin induced platelet activation is inhibited by high and low molecular weight heparin显示文摘 | De candia E De Cristofaro R Landolfi R | 1999 | Circulation1999，99，9： | 1 |
| 17 | Incidence and management of Complications of transsphenoidal operation for pituitary adenomas显示文摘 | Black PM Zervas NT Candia GL | 1987 | Nerosurgery1987，20，6： | 1 |
| 18 | Acutediarrhe in chil-dren population:detection of rtavirusel eetrphertypes显示文摘 | Candia N Parra G I ChireoM | 2003 | Acta Virol2003，47，3： | 1 |
| 19 | Dytlamo: Amazon's highly available key-value store显示文摘 | CANDIA G D HASTORUN D JAMPANJ M | 2007 | Operating systems review2007，41，6： | 1 |
| 20 | Regulatory T cells are lo- cally induced during intravaginal infection of mice with Neisseria gonor- rhoeae 显示文摘 | Imarai M Candia E Rodriguez-Tirado C | 2008 | Infect hnmun2008，76，12： | 1 |
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