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	题名	作者	年代	出处	被引量
1	Metformin revisited: Does this regulator of AMP-activated protein kinase secondarily affect bone metabolism and prevent diabetic osteopathy?显示文摘Patients with long-term type 1 and type 2 diabetes mellitus(DM) can develop skeletal complications or 'diabetic osteopathy'. These include osteopenia, osteoporosis and an increased incidence of low-stress fractures. In this context, it is important to evaluate whether current anti-diabetic treatments can secondarily affect bone metabolism. Adenosine monophosphateactivated protein kinase(AMPK) modulates multiple metabolic pathways and acts as a sensor of the cellular energy status; recent evidence suggests a critical role for AMPK in bone homeostasis. In addition, AMPK activation is believed to mediate most clinical effects of the insulin-sensitizer metformin. Over the past decade, several research groups have investigated the effects of metformin on bone, providing a considerable body of pre-clinical(in vitro, ex vivo and in vivo) as well as clinical evidence for an anabolic action of metformin on bone. However, two caveats should be kept in mind when considering metformin treatment for a patient with type 2 DM at risk for diabetic osteopathy. In the first place, metformin should probably not be considered an antiosteoporotic drug; it is an insulin sensitizer with proven macrovascular benefits that can secondarily improve bone metabolism in the context of DM. Secondly, we are still awaiting the results of randomized placebo-controlled studies in humans that evaluate the effects of metformin on bone metabolism as a primary endpoint.	Antonio Desmond McCarthy Ana María Cortizo Claudia Sedlinsky	2016	World Journal of Diabetes2016，7，6：	9
2	Supercritical fluid extraction and high -performance liquid chromatography -fluorescence detection method for pelycyclic aromatic hydrocarbons investigation in vegetable oil显示文摘	Lage Yusty M A Cortizo Davina J L	2005	Food Control2005，16，：	1
3	Development of a mechanical device for concealing underground urban solid residual containers显示文摘	DI'AZ R V SIERRA J M CORTIZO J L	2005	Materials and Design2005，26，：	1
4	Comparison of three single-phase PLL algorithms for UPS applications显示文摘	Santos Filho R M Seixas P F Cortizo P C	2008	IEEE Transactions on Industrial Electronics2008，55，8：	1
5	Insulin-deficient diabetes-induced bone microarchitecture alterations are associated with a decrease in the osteogenic potential of bone marrow progenitor cells: Preventive effects of metformin显示文摘	María José Tolosa Sara Rocío Chuguransky Claudia Sedlinsky León Schurman Antonio Desmond McCarthy María Silvina Molinuevo Ana María Cortizo	2013	Diabetes Research and Clinical Practice2013，，2：	1
6	Small-signal stability for parallel-connected inverters in stand-alone AC supply systems显示文摘	Ernane Antonio Lves Coelho Porfirio Cabaleiro Cortizo Pedro Francisco Donoso Garcia	2002	IEEE Transaction on industrial electronics2002，38，2：	1
7	Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture显示文摘	Cortizo A M Sedlinsky C McCarthy A D Blanco A Schurman L	2006	Eur J Pharmacol2006，536，：	1
8	Small-signal stability for parallel-connected inverters in stand-alone AC supply systems显示文摘	Ernane Antonio Alves Coelho Porfirio Cabaleiro Cortizo Pedro Francisco Donoso Garcia	2002	IEEE Trans on Industry applications2002，38，2：	1
9	Effect of the Thermal Degradation of SBS Copolymers During the Ageing of Modified Asphalts显示文摘	Cortizo M S Larsen D O Bianchetto H	2004	Polymer Degradation and Stability2004，86，：	1
10	Synthesis of a new vanadyl (IV) complex with trehalose (TreVO): insulin- mimetic activities in osteoblast-like cells in culture显示文摘	Barrio D A Williams P A M Cortizo A M	2003	Journal of Biological Inorganic Chemistry2003，8，4：	1
11	Metformin prevents anti-osteogenic in vivo and ex vivo effects of rosiglitazone in rats显示文摘	Claudia Sedlinsky María Silvina Molinuevo Ana María Cortizo María José Tolosa Juan Ignacio Felice María Laura Sbaraglini Leon Schurman Antonio Desmond McCarthy	2011	European Journal of Pharmacology2011，，3：	1
12	Effect of advanced glycation endproducts on the secretion of insulin-like growth factor-I and its binding proteins: role in osteoblast development显示文摘	McCarthy AD Etcheverry SB Cortizo AM	2001	Acta Diabetol2001，38，3：	1
13	Effect of the thermal degradation of SBS copolymers during the ageing of modified asphalts显示文摘	CORTIZO M S LARSEN D O BIANCHETTO H	2004	Polymer Degradation and Stability2004，86，2：	1
14	Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture显示文摘	Cortizo A M Sedlinsky C McC arthy A D	2006	Eur J Pharmacol2006，536，12：	1
15	Characterization of chitin from Illex argentinus squid pen 显示文摘	M Susana Cortizo Carla F Bergho Jose Luis Alessandrini	2008	Carbohydrate Polymers2008，74，5：	1
16	Metallic dental material biocompatibility in osteoblasdike cells: Correlation with metal ion rel ease显示文摘	Cortizo MC De Mele MF Cortizo AM	2004	Biol Trace Elem Res2004，100，2：	1
17	Comparison of three single-phase PLL algorithms forUPS applications显示文摘	Santos Filho R M Seixas P F Cortizo P C	2006	IEEE Trans on IndustrialElectronics2006，55，8：	1
18	Comparison of three single-phase PLL algorithms forUPS applications显示文摘	FILHO R M S SEIXAS P F CORTIZO P C	2008	IEEE Trans on IndustrialElectronics2008，55，8：	1
19	Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture显示文摘	Cortizo AM Sedlinsky C McCarthy AD	2006	Eur J Pharmacol2006，536，12：	1
20	A Three-phase Line-interactive UPS System Implementation with Series-parallel Active Power-line Conditioning Capabilites显示文摘	S A Oliverira da Silva P Donoso Garcia P C Cortizo	2001	IEEE2001，，：	1

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