|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 2 | Longitudinal study of children with perinatal braindamage in whom early neurohabilitation was applied: Pre- liminary report显示文摘 | Harmony T Barrera Resendiz J Juarez Colin M E | 2015 | Neurosci Lett2015，611，： | 1 |
| 3 | Murine Denys - Drash syndrome: evi dence of podocyte de - differentiation and systemic mediation of glomerul - oselerosis 显示文摘 | Charles E P Stewart F Colin G M | 2003 | Human Molecular Genetics2003，12，18： | 1 |
| 4 | Seismic travehime analysis for azimuthally anisotropic media:Theory and experiment显示文摘 | Colin M S Daniel A E | 1997 | Geophysics1997，62，5： | 1 |
| 5 | Recombinant forms of Gerbich blood group antigens:expression and purification显示文摘 | Jaskiewicz E Czerwinski M Colin Y | 2002 | Transfus Clin Biol2002，9，2： | 1 |
| 6 | Resistin up-regulates fractalkine expression in human endothelial cells lack of addictive effect with TNF-alpha显示文摘 | Manduteanu I Dragomir E Colin M | | 0，，01： | 1 |
| 7 | Screening and confirmatory determination of ractopamine residues in calves treated with growth promoting does of the β-agonist 显示文摘 | Christopher T E Colin S T Car J M Arts | 1998 | Analyst1998，123，： | 1 |
| 8 | Management of depression in the elderly by general practitioners: Attitude stoaging and factor safecting practice 显示文摘 | COLINS E KATONA C ORRE M | 1995 | Family Health Care1995，12，： | 1 |
| 9 | Effect of a nutritionalintervention on body composition, clinical status, and quality of life inpatients with heart failure显示文摘 | Colin R E Castillo M L Orea T A | 2004 | Nutrition2004，20，10： | 1 |
| 10 | Treating cancer with sonodynamic therapy: a review 显示文摘 | David C Conor M E Colin F | 2015 | International Journal of Hyperthermia the Official Journal of European Society for Hyperthermic Oncology North American Hyperthermia Group2015，31，2： | 1 |
| 11 | The B^3∑- state of the SO radical显示文摘 | Ching-ping Liu Nicola L E Colin M Western | 2006 | J Mol Spectrosc2006，，238： | 1 |
| 12 | Consequences of vitamin D receptor gene polymorphisms for growth inhibition of cultured human peripheral blood mononuclear cells by 1, 25-dihydroxyvitamin D3 显示文摘 | Colin E M Weel A E Uitterlinden A G | 2000 | Clin Endocrinol (Oxf)2000，52，2： | 1 |
| 13 | Protein-ligand binding affinity by nonequilibrium free en- ergy methods显示文摘 | Benjamin P C Sebastien F Colin M E | 2008 | Journal of Physical Chemistry B2008，112，14： | 1 |
| 14 | Metallic layers added by plasma on polyethylene显示文摘 | Cruz G J Olayo M G Colin E | 2009 | Progress in Organic Coatings2009，，64： | 1 |
| 15 | Pregnancy and birth after assisted reproduction显示文摘 | Colin J S N Panzzi M E G | 2002 | Reproductive BioMedicine Online2002，5，1： | 1 |
| 16 | Linking microbial community structure and function to seasonal differences in soil moisture and temperature in a Chihuahua desert grassland显示文摘 | Colin W B Veronica A M Nancy E M | 2009 | Microbial Ecology2009，58，： | 1 |
| 17 | The establishment of Aceratoneuromyia indica (Hymenoptera: Eulophidae) in three biogeographical regions of Argentina显示文摘 | Ovruski S M Schliserman P de Coil O R Penaloza C Orono L E Colin C | 2006 | Florida Entomologist2006，89，2： | 1 |
| 18 | Late Holocene intermediate water variability in the northeastern Atlantic as recorded by deep-sea corals显示文摘 | COPARD K COLIN C HENDERSON G M SCHOLTEN J DOUVILLE E SICRE M A FRANK N | 2012 | Earth and Planetary ScienceLetters2012，313，： | 1 |
| 19 | Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype influences vertebral fracture risk 显示文摘 | Colin E M Uitterlinden A G Meurs J B | 2003 | Clin Endocrinol Metab2003，88，8： | 1 |
| 20 | Aptamer-conjugated nanoparticles for selective collection and detection of cancer cells 显示文摘 | Joshua K H Joshua E S Colin D M | 2006 | Analytical chemistry2006，78，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员