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| 1 | Hepatitis C virus syndrome: A constellation of organ-and non-organ specific autoimmune disorders, B-cell nonHodgkin's lymphoma, and cancer显示文摘The clinical course of chronic hepatitis C virus(HCV)infection is characterized by possible development of both liver and extrahepatic disorders. The tropism of HCV for the lymphoid tissue is responsible for several immune-mediated disorders; a poly-oligoclonal B-lymphocyte expansion, commonly observed in a high proportion of patients with HCV infection, are responsible for the production of different autoantibodies and immune-complexes, such as mixed cryoglobulins. These serological alterations may characterize a variety of autoimmune or neoplastic diseases. Cryoglobulinemic vasculitis due to small-vessel deposition of circulating mixed cryoglobulins is the prototype of HCV-driven immune-mediated and lymphoproliferative disorders; interestingly, in some cases the disease may evolve to frank malignant lymphoma. In addition, HCV shows an oncogenic potential as suggested by several clinicoepidemiological and laboratory studies; in addition to hepatocellular carcinoma that represents the most frequent HCV-related malignancy, a causative role of HCV has been largely demonstrated in a significant percentage of patients with isolated B-cells nonHodgkin's lymphomas. The same virus may be also involved in the pathogenesis of papillary thyroid cancer, a rare neoplastic condition that may complicate HCVrelated thyroid involvement. Patients with HCV infection are frequently asymptomatic or may develop only hepatic alteration, while a limited but clinically relevant number can develop one or more autoimmune and/or neoplastic disorders. Given the large variability of their prevalence among patients' populations from different countries, it is possible to hypothesize a potential role of other co-factors, i.e., genetic and/or environmental, in the pathogenesis of HCV-related extra-hepatic diseases. | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Michele Colaci Poupak Fallahi Alessia Piluso Alessandro Antonelli Anna Linda Zignego | 2015 | World Journal of Hepatology2015，7，3： | 11 |
| 2 | Hepatitis C virus infection and type 1 and type 2 diabetes mellitus显示文摘Hepatitis C virus(HCV) infection and diabetes mellitus are two major public health problems that cause devastating health and financial burdens worldwide. Diabetes can be classified into two major types: type 1 diabetes mellitus(T1DM) and T2 DM. T2 DM is a common endocrine disorder that encompasses multifactorial mechanisms, and T1 DM is an immunologically mediated disease. Many epidemiological studies have shown an association between T2 DM and chronic hepatitis C(CHC) infection. The processes through which CHC is associated with T2 DM seem to involve direct viral effects, insulin resistance, proinflammatory cytokines, chemokines, and other immunemediated mechanisms. Few data have been reported on the association of CHC and T1 DM and reports on the potential association between T1 DM and acute HCV infection are even rarer. A small number of studies indicate that interferon-α therapy can stimulate pancreatic autoim-munity and in certain cases lead to the development of T1 DM. Diabetes and CHC have important interactions. Diabetic CHC patients have an increased risk of developing cirrhosis and hepatocellular carcinoma compared with nondiabetic CHC subjects. However, clinical trials on HCV-positive patients have reported improvements in glucose metabolism after antiviral treatment. Further studies are needed to improve prevention policies and to foster adequate and cost-effec-tive programmes for the surveillance and treatment of diabetic CHC patients. | Alessandro Antonelli Silvia Martina Ferrari Dilia Giuggioli Andrea Di Domenicantonio Ilaria Ruffilli Alda Corrado Silvia Fabiani Santino Marchi Clodoveo Ferri Ele Ferrannini Poupak Fallahi | 2014 | World Journal of Diabetes2014，5，5： | 7 |
| 3 | Hepatitis C virus-related lymphoproliferative disorders:An overview显示文摘Hepatitis C virus (HCV) is a global health problem affecting 3% of the world’s population (about 180 million) and a cause of both hepatic and extrahepatic diseases. B-cell lymphoproliferative disorders, whose prototype is mixed cryoglobulinemia, represent the most closely related as well as the most investigated HCV- related extrahepatic disorder. The association between extrahepatic (lymphoma) as well as hepatic malignancies (hepatocellular carcinoma) has justified the inclusion of HCV among human cancer viruses. HCV-associated manifestations also include porphyria cutanea tarda, lichen planus, nephropathies, thyreopathies, sicca syndrome, idiopathic pulmonary fibrosis, diabetes, chronic polyarthritis, sexual dysfunctions, cardiopathy/ atherosclerosis, and psychopathological disorders. A pathogenetic link between HCV virus and some lymphoproliferative disorders was confirmed by their responsiveness to antiviral therapy, which is now considered the first choice treatment. The aim of the present paper is to provide an overview of extrahepatic manifestations of HCV infection with particular attention to B-cell lymphoproliferative disorders. Available pathogenetic hypotheses and suggestions about the most appropriate, currently available, therapeutic approaches will also be discussed. | Anna Linda Zignego Carlo Giannini Clodoveo Ferri | 2007 | World Journal of Gastroenterology2007，13，17： | 5 |
| 4 | Cytokines and HCV-Related Disorders显示文摘 | Poupak Fallahi Clodoveo Ferri Silvia Martina Ferrari Alda Corrado Domenico Sansonno Alessandro Antonelli Jürg Schifferli | 2012 | Clinical and Developmental Immunology2012，，： | 1 |
| 5 | Genetic map- ping of polyphenol oxidase in tetraploid wheat显示文摘 | Simeone R Pasqualone A Clodoveo M L | 2002 | Cell Mol Biol- ogy Letters2002，7，： | 1 |
| 6 | Genetic mapping of polyphenol oxidase in tetraploid wheat 显示文摘 | Simeone R Pasqualone A Clodoveo M L | 2002 | Cellular Molecular Biology Letters2002，7，： | 1 |
| 7 | Thyroid disorders in chronic hepatitis C显示文摘 | Alessando A Clodoveo F Alessandro P | | Am J Med 200 10，117，1： | 1 |
| 8 | Thyroid disorders in chronic hepatitis C显示文摘 | ALESSANDRO ANTONELLI CLODOVEO FERRI ALESSANDRO PAMPANA | 2004 | The American Journal of Medicine2004，117，1： | 1 |
| 9 | Immunopathogenesis of HCV-related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia显示文摘 | Alessandro Antonelli Clodoveo Ferri Silvia Martina Ferrari Michele Colaci Poupak Fallahi | 2008 | Autoimmunity Reviews2008，，1： | 1 |
| 10 | B-cells and mixed cryoglobulinemia显示文摘 | Clodoveo Ferri Alessandro Antonelli Maria Teresa Mascia Marco Sebastiani Poupak Fallahi Daniela Ferrari Marco Giunti Stefano A. Pileri Anna Linda Zignego | 2007 | Autoimmunity Reviews2007，，2： | 1 |
| 11 | Immunopathogenesis of HCV-related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia显示文摘 | Alessandro Antonelli Clodoveo Ferri Silvia Martina Ferrari Michele Colaci Poupak Fallahi | 2008 | Autoimmunity Reviews2008，，1： | 1 |
| 12 | Mixed cryoglobulinemia显示文摘 | Clodoveo Ferri | | 0，，： | 1 |
| 13 | B-cells and mixed cryoglobulinemia显示文摘 | Clodoveo Ferri Alessandro Antonelli Maria Teresa Mascia Marco Sebastiani Poupak Fallahi Daniela Ferrari Marco Giunti Stefano A. Pileri Anna Linda Zignego | 2007 | Autoimmunity Reviews2007，，2： | 1 |
| 14 | Ultrasound-assisted extraction of virgin olive oil to improve the process efficiency显示文摘 | CLODOVEO M L DURANTE V LA NOTTE D | 2013 | Eur J Lipid Sci Tech2013，，115： | 1 |
| 15 | Cryoglobulinemic vasculitis显示文摘 | Clodoveo Ferri Maria Teresa Mascia | 2006 | Current Opinion in Rheumatology2006，，1： | 1 |
| 16 | Mixed cryoglobulinemia: demographic, clinical, and serologic features and survival in 231 patients显示文摘 | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Massimiliano Cazzato Giovanni Longombardo Alessandro Antonelli Rodolfo Puccini Claudio Michelassi Anna Linda Zignego | 2004 | Seminars in Arthritis and Rheumatism2004，，6： | 1 |
| 17 | Mixed cryoglobulinemia: demographic, clinical, and serologic features and survival in 231 patients显示文摘 | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Massimiliano Cazzato Giovanni Longombardo Alessandro Antonelli Rodolfo Puccini Claudio Michelassi Anna Linda Zignego | 2004 | Seminars in Arthritis and Rheumatism2004，，6： | 1 |
| 18 | Thyroid disorders in chronic hepatitis C显示文摘 | Alessandro Antonelli Clodoveo Ferri Alessandro Pampana Poupak Fallahi Claudia Nesti Martina Pasquini Santino Marchi Ele Ferrannini | 2004 | The American Journal of Medicine2004，，1： | 1 |
| 19 | Ultrasound-assisted extraction of virgin olive oil to improve the process efficiency显示文摘 | CLODOVEO M L DURANTE V LA NOTTE D | 2013 | Eur J Lipid Sci Tech2013，，115： | 1 |
| 20 | Genetic map- ping of polyphenol oxidase in tetraploid wheat 显示文摘 | Simeone R Pasqualone A Clodoveo M L | 2002 | Cellular & Molecular Biology Letters2002，7，： | 1 |
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