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| 1 | Intraductal papillary neoplasm of the bile ducts: A case report and literature review显示文摘Intraductal papillary neoplasm of the bile duct(IPNB) is a rare bile duct neoplasm mostly found in far eastern nations where hepatolithiasis and clonorchiasis infections are endemic. In western countries,it is very rare and the etiology is unknown. In this article,we report the first IPNB patient we encountered in our clinic and a literature review. The patient is a 38-yearold female with a history of choledocholithiasis who presented with obstructive jaundice. She was found to have a papillary mass at the junction of the right hepatic duct and common hepatic duct with six masses in the liver parenchyma. The immunophenotypic and histologic features of the tumor are consistent with IPNB,gastric subtype. The patient had a partial hepatectomy and has been receiving palliative chemotherapy. In a search of Pub Med database,we collected 354 IPNB patients reported in 22 articles. In these patients,52.8% were from Japan and 27.7% were from western countries including the United States(11.0%). The age of the patients ranged from 35 to 80 years old with an average of 64.6. Male/female ratio was 1.5. Macroscopically,57.5% of the tumors were in the left lobe and 29.5% were in the right lobe. The average size of the tumor were 4.2 cm at the time of diagnosis. Histologically,pancreato-biliary subtype accounted for 41.8%,intestinal 28.0%,gastric 13.5% and oncocytic 16%. An invasive component is most often present in the pancreato-biliary and gastric subtypes. Despite recent advanced technologies,diagnosis of IPNB is still challenging,especially in western countries due to its rarity. Defined clinicopathologic features are in demand for the accurate diagnosis and proper treatment. | Yaohong Tan Clara Milikowski Yanelba Toribio Adam Singer Claudia P Rojas Monica T Garcia-Buitrago | 2015 | World Journal of Gastroenterology2015，21，43： | 19 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Conformational comparion in the snake toxin family显示文摘 | Roberto J F Clara P Mirtha J | 1996 | Int J Peptide Protein Res1996，47，： | 1 |
| 4 | Journal of Colloid and Interface Science显示文摘 | Clara P Sonia P Ana R | 2007 | 316:5702007，316，： | 1 |
| 5 | Cost and benefit analysis of routine varicella vaccination in German Children 显示文摘 | Beutels P Clara G Tormans E | 1996 | JID1996，174，3： | 1 |
| 6 | Growth inhibition by gamma rays affects lipids and fatty acids in garlic sprouts during storage显示文摘 | Mónica B. Pérez Marta I. Avelda?o Clara A. Croci | 2007 | Postharvest Biology and Technology2007，，2： | 1 |
| 7 | Identification of relevant micropollutants in Austrian municipal wastewater and their behaviour during wastewater treatment显示文摘 | CLARA M WINDHOFER G WEILGONY P | 2012 | Chemosphere2012，87，11： | 1 |
| 8 | Postoperative pain management: epidural analgesia 显示文摘 | Gianferrari P Voholina M Clara ME | 2003 | Minerva Chir2003，58，6： | 1 |
| 9 | A novel cell-based microfluidic multichannel setup-impact of hydrodynamics and surface characteristics on the bioadhesion of polystyrene micro- spheres 显示文摘 | WANG X Y CLARA P FRANZ G | 2013 | Colloids and Surfaces B: Biointerfaces2013，102，： | 1 |
| 10 | Sufentanil vs morphine combined with ropivacaine for thoracic epidural analgesia in major abdominal surgery显示文摘 | Gianferrari P Clara M E Borghi B | 2001 | Minerva Anestesiol2001，67，9： | 1 |
| 11 | Risk factors for intubation as a guide for noninvasive ventilation in patients with severe acute cardiogenic pulmonary edema显示文摘 | Josep Masip Joaquim Páez Montserrat Merino Sandra Parejo Francisco Vecilla Clara Riera Araceli Ríos Joan Sabater Josep Ballús J. Padró | 2003 | Intensive Care Medicine2003，，11： | 1 |
| 12 | Comparative analysis of rice MADS-box genes expressed during flower development显示文摘 | Nilla Pelucchi Fabio Fornara Cristina Favalli Simona Masiero Clara Lago Enrico M. Pè Lucia Colombo Martin M. Kater | 2002 | Sexual Plant Reproduction2002，，3： | 1 |
| 13 | Approximate k-closest-pairs in large high dimensional data sets显示文摘 | Fabrizio A Clara P | 2005 | Journal of Mathematical Modelling and Algorithms Springer Netherlands2005，4，2： | 1 |
| 14 | Idiosyncratic risk matters 显示文摘 | Goyal A Santa Clara P | 2003 | The Journal of Finance2003，58，3： | 1 |
| 15 | Effect of cholecystokinin-A receptor blockade on postprandial insulinaemia and gastric emptying in humans显示文摘 | Hidalgo L Clara P Estorch M | 2002 | Neurogastroenterol Motil2002，14，5： | 1 |
| 16 | Appraisal of the Horse Creek air injection project performance 显示文摘 | Clara C Zelenko V Schirmer P | 1998 | SPE 49519-MS1998，，： | 1 |
| 17 | Headspace solid -phase micro -extraction and gas chromatography-ion trap tandem mass spectrometry method for butyhin analysis in sediments: Optimization and validation显示文摘 | Pedro N Carvalho Luiz F Pinto M Clara P Basto | 2007 | Microchemical journal2007，87，2： | 1 |
| 18 | There is a risk -return trade - off after all 显示文摘 | Ghysels E Santa - Clara P Valkanov R | 2005 | Journal of Financial Economics2005，76，3： | 1 |
| 19 | Are chemical compounds import for soybean resistance to Anticarsia gemmatalis 显示文摘 | Giorla C P Clara B H Flavio M | 2005 | Journal of Chemical Ecology2005，31，： | 1 |
| 20 | On the interaction between imperfect compliance and technology adoption: Taxes versus trad- able emissions permits 显示文摘 | Clara P Jessica C | 2010 | Journal of Regulatory Econo- my2010，38，： | 1 |
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