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| 1 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 2 | miRNA expression profile in human osteosarcoma: Role of miR-1 and miR-133bin proliferation and cell cycle control显示文摘 | Chiara Novello Laura Pazzaglia Chiara Cingolani Amalia Conti Irene Quattrini Maria Manara Mauro Tognon Piero Picci Maria Benassi | 2013 | International Journal of Oncology2013，，2： | 2 |
| 3 | Age estimation in children by measurement of open apices in teeth 显示文摘 | Cameriere R Ferrante L Cingolani M | 2006 | Int J Legal Med2006，120，1： | 1 |
| 4 | Plant functional traits,herbivore selectivity and response to sheep grazing in Patagonian steppe grasslands显示文摘 | Cingolani AM Posse G Collantes MB | | 0，，： | 1 |
| 5 | Increased systolic performance with diastolic dysfunction in adult spontaneously hypertensive rats显示文摘 | Cingolani OH Yang X-P Cavasin MA | 2003 | Hypertension2003，41，： | 1 |
| 6 | Cardioprotective effect of beta-3adrenergic receptor agonism:role of neuronal nitric oxide synthase显示文摘 | Niu X Watts VL Cingolani OH | 2012 | J Am Coll Cardiol2012，59，22： | 1 |
| 7 | 查看详情显示文摘 | Anni M Manna L Cingolani R Valerini D. Cretí A.Lomascolo M | | 0，，18： | 1 |
| 8 | Usefulness of monitoring HIV drug resistance and adherence in individuals failing highly active antiretroviral therapy: a randomized study (ARGENTA) 显示文摘 | Cingolani A Antinori A Rizzo MG | 2002 | AIDS2002，16，3： | 1 |
| 9 | Cross-resistance among nonnucleoside reverse transcriptase inhibitors limits recycling efavirenz after nevirapine failure显示文摘 | Antinori A Zaccarelli M Cingolani A | 2002 | AIDS Res Hum Retroviruses2002，18，12： | 1 |
| 10 | miRNA expression profile in human osteosarcoma:role of miR-1 and miR-133b in proliferation and cell cycle control显示文摘 | Novello C Pazzaglia L Cingolani C | 2013 | Int J Oncol2013，42，： | 1 |
| 11 | Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction显示文摘 | Liu YH Carretero OA Cingolani OH | 2005 | Am J Physiol2005，289，6： | 1 |
| 12 | Regression of hypertensive myocardial fibrosis by Na /H exchange inhibition显示文摘 | CINGOLANI H E REBOLLEDO 0 R PORTIANSKY E L | 2003 | Hypertension2003，41，2： | 1 |
| 13 | Optimizing scale-up fermentation processes显示文摘 | Thiry M Cingolani D | 2002 | TRENDS in Biotechnology2002，20，3： | 1 |
| 14 | Angiotensin II stimulates cardiac L-type Ca^2+ current by a Ca^2+ and protein kinase C-dependent mechanism 显示文摘 | AIELLO E A CINGOLANI H E | 2001 | Am J Physiol Heart Circ Physiol2001，280，4： | 1 |
| 15 | Tailoring of nanocrystal sizes in CdSe films prepared by chemical deposition显示文摘 | TROJANEK F CINGOLANI R CANNOLETTA D | 2000 | Journal of Crystal Growth2000，209，4： | 1 |
| 16 | Epstein-Barr virus infection is predictive of CNS involvement in systemic AIDS-related non-Hodgkin's lymphomas显示文摘 | Cingolani A Gastaldi R Fassone L | 2000 | J Clin Oncol2000，18，19： | 1 |
| 17 | The effect of xanthine oxidase inhibition upon ejection fraction in heart failure patients: La Plata Study 显示文摘 | Cingolani H E Plastino J A Escudero E M | 2006 | J Card Fail2006，12，7： | 1 |
| 18 | Reduction of cardiac fibrosis decreases systolic performance without affecting diastolic function in hypertensive rats显示文摘 | Cingolani OH Yang XP Liu YH | 2004 | Hypertension2004，43，： | 1 |
| 19 | Circ Stretch-induced alkalinization of feline papillary muscle: An autocrine-paracrine system显示文摘 | Cingolani HE Alvarez BV | 1998 | Circ Res1998，83，8： | 1 |
| 20 | Is stuning prevented by ischemic preconditioning显示文摘 | Mosca SM Gelpi RJ Milei J Fernandez AG Cingolani HE | 1998 | Mol Cell Biochem1998，186，： | 1 |
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