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| 1 | NIR-induced highly sensitive detection of latent finger- marks by NaYF4:Yb,Er upconversion nanoparticles in a dry powder state显示文摘通常在犯罪场面发现 fingermarks 的大多数是潜伏的并且,这样为检测潜伏的 fingermarks 的一个有效方法是很重要的。然而,传统的发展中技术有象低察觉敏感,高背景干扰,复杂操作,和高毒性那样的缺点。处理这挑战,我们采用了荧光灯 NaYF 4:Yb,Er upconversion nanoparticles (UCNP ) 它能发荧光可见的光什么时候由 980 nm 使对人安全的在红外线附近的光激动,到污点,各种各样的底层上的潜伏的 fingermarks 出现。 UCNP 成功地被用作一篇小说荧光灯为有包括非渗入的材料(玻璃,大理石,铝合金表,不锈钢表,铝陪衬,和塑料卡片)的各种各样的底层上的高敏感,低背景,高效率,和低毒性的潜伏的 fingermarks 的察觉的标签,渗入半的材料(地板皮革,陶器的瓦,木头地板,和油漆木头),和象报纸的各种各样的类型那样的渗透的材料。这个工作证明 UCNP 是一万用荧光灯为几乎任何东西上的 fingermarks 的灵巧的察觉的标签材料,在法庭的科学启用他们的实际应用。 | Meng Wang Ming Li Mingying Yang Xiaomei Zhang Aoyang Yu Ye Zhu Penghe Qiu Chuanbin Mao | 2015 | Nano Research2015，8，6： | 20 |
| 2 | Distribution and health risk assessment of organochlorine pesticides(OCPs) in industrial site soils:A case study of urban renewal in Beijing,China显示文摘A field survey was conducted in a contaminated industrial site of southern Beijing,China to investigate the contents and distribution of the organochlorine pesticides(α-,β-,γ-,δ-HCH,p,p-DDT,p,p-DDE,p,p-DDD and o,p-DDT) in the profiles of soil,and a health risk assessment was carried out with CalTOX multimedia exposure model.Results showed that mean concentrations of total hexachlorocyclohexane isomers(HCHs) and total dichlorodiphenyltrichloroethane isomers(DDXs) in soils were in the range of 13.20-148.71 mg/kg,and 3.02-67.43 mg/kg,respectively.Organochlorine pesticides(OCPs) content peaked in the surface and declined in soil profile with depth.The amounts of HCHs in three profiles of soil were larger than DDXs.Composition analysis indicated that there was a trend of degradation of OCPs in the site,but the mean of HCHs and DDXs concentration were over the state warning standard limit(HCHs,0.50 mg/kg;DDXs,0.50 mg/kg).According to current land use development,health risk assessment with CalTOX and Monte Carlo analysis showed that health risks mainly came from two exposure pathways:dermal uptake and inhalation,and the total risk values all exceeded the general acceptable health risk value(10-6).The sensitivity analysis indicated that five parameters significantly contributed to total risk. | YANG Wenrui,WANG Rusong,ZHOU Chuanbin,LI FengState key laboratory of Urban and Regional Ecology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China. | 2009 | Journal of Environmental Sciences2009，21，3： | 14 |
| 3 | BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair显示文摘Calvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells(MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and repair. Abnormal function of osteogenic cells or diminished MSCs within the cranial suture can lead to skull defects, such as craniosynostosis. Despite the important function of each of these cell types within the cranial suture, we have limited knowledge about the role that crosstalk between them may play in regulating calvarial bone homeostasis and injury repair. Here we show that suture MSCs give rise to osteoprogenitors that show active bone morphogenetic protein(BMP) signalling and depend on BMP-mediated Indian hedgehog(IHH) signalling to balance osteogenesis and osteoclastogenesis activity. IHH signalling and receptor activator of nuclear factor kappa-Β ligand(RANKL) may function synergistically to promote the differentiation and resorption activity of osteoclasts. Loss of Bmpr1a in MSCs leads to downregulation of hedgehog(Hh) signalling and diminished cranial sutures. Significantly, activation of Hh signalling partially restores suture morphology in Bmpr1a mutant mice, suggesting the functional importance of BMP-mediated Hh signalling in regulating suture tissue homeostasis. Furthermore, there is an increased number of CD200+ cells in Bmpr1a mutant mice, which may also contribute to the inhibited osteoclast activity in the sutures of mutant mice. Finally, suture MSCs require BMPmediated Hh signalling during the repair of calvarial bone defects after injury. Collectively, our studies reveal the molecular and cellular mechanisms governing cell–cell interactions within the cranial suture that regulate calvarial bone homeostasis and repair. | Yuxing Guo Yuan Yuan Ling Wu Thach-Vu Ho Junjun Jing Hideki Sugii Jingyuan Li Xia Han Jifan Feng Chuanbin Guo Yang Chai | 2018 | Bone Research2018，6，4： | 12 |
| 4 | Influence of physical properties of carrier on the performance of dry powder inhalers显示文摘Dry powder inhalers(DPIs) offer distinct advantages as a means of pulmonary drug delivery and have attracted much attention in the field of pharmaceutical science. DPIs commonly contain micronized drug particles which, because of their cohesiveness and strong propensity to aggregate, have poor aerosolization performance. Thus carriers with a larger particle size are added to address this problem. However, the performance of DPIs is profoundly influenced by the physical properties of the carrier, particularly their particle size, morphology/shape and surface roughness. Because these factors are interdependent, it is difficult to completely understand how they individually influence DPI performance.The purpose of this review is to summarize and illuminate how these factors affect drug–carrier interaction and influence the performance of DPIs. | Tingting Peng Shiqi Lin Boyi Niu Xinyi Wang Ying Huang Xuejuan Zhang Ge Li Xin Pan Chuanbin Wu | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 8 |
| 5 | Development of composite PLGA microspheres containing exenatide-encapsulated lecithin nanoparticles for sustained drug release显示文摘This study aimed to prepare poly(D, L-lactic-co-glycolic acid) microspheres(PLGA-Ms)by a modified solid-in-oil-in-water(S/O/W) multi-emulsion technique in order to achieve sustained release with reduced initial burst and maintain efficient drug concentration for a prolonged period of time. Composite PLGA microspheres containing exenatideencapsulated lecithin nanoparticles(Ex-NPs-PLGA-Ms) were obtained by initial fabrication of exenatide-loaded lecithin nanoparticles(Ex-NPs) via the alcohol injection method,followed by encapsulation of Ex-NPs into PLGA microspheres. Compared to Ms prepared by the conventional water-in-oil-in-water(W/O/W) technique(Ex-PLGA-Ms), Ex-NPs-PLGAMs showed a more uniform particle size distribution, reduced initial burst release, and sustained release for over 60 d in vitro. Cytotoxicity studies showed that Ms prepared by both techniques had superior biocompatibility without causing any detectable cytotoxicity.In pharmacokinetic studies, the effective drug concentration was maintained for over 30 d following a single subcutaneous injection of two types of Ms formulation in rats, potentially prolonging the therapeutic action of Ex. In addition, administration of Ex-NPs-PLGA-Ms resulted in a more smooth plasma concentration-time profile with a higher area under the curve(AUC) compared to that of Ex-PLGA-Ms. Overall, Ex-NPs-PLGA-Ms prepared by the novel S/O/W method could be a promising sustained drug release system with reduced initial burst release and prolonged therapeutic efficacy. | Ni Dong Chune Zhu Junhuang Jiang Di Huang Xing Li Guilan Quan Yang Liu Wen Tan Xin Pan Chuanbin Wu | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 7 |
| 6 | Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair显示文摘Treatment of large bone defects derived from bone tumor surgery is typically performed in multiple separate operations,such as hyperthermia to extinguish residual malignant cells or implanting bioactive materials to initiate apatite remineralization for tissue repair;it is very challenging to combine these functions into a material.Herein,we report the first photothermal(PT)effect in bismuth(Bi)-doped glasses.On the basis of this discovery,we have developed a new type of Bi-doped bioactive glass that integrates both functions,thus reducing the number of treatment cycles.We demonstrate that Bi-doped bioglasses(BGs)provide high PT efficiency,potentially facilitating photoinduced hyperthermia and bioactivity to allow bone tissue remineralization.The PT effect of Bi-doped BGs can be effectively controlled by managing radiative and non-radiative processes of the active Bi species by quenching photoluminescence(PL)or depolymerizing glass networks.In vitro studies demonstrate that such glasses are biocompatible to tumor and normal cells and that they can promote osteogenic cell proliferation,differentiation,and mineralization.Upon illumination with near-infrared(NIR)light,the bioglass(BG)can efficiently kill bone tumor cells,as demonstrated via in vitro and in vivo experiments.This indicates excellent potential for the integration of multiple functions within the new materials,which will aid in the development and application of novel biomaterials. | Liping Wang Nicholas J.Long Lihua Li Yao Lu Mei Li Jiangkun Cao Yu Zhang Qinyuan Zhang Shanhui Xu Zhongmin Yang Chuanbin Mao Mingying Peng | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 7 | Impact of particle size and pH on protein corona formation of solid lipid nanoparticles:A proof-of-concept study显示文摘When nanoparticles were introduced into the biological media,the protein corona would be formed,which endowed the nanoparticles with new bio-identities.Thus,controlling protein corona formation is critical to in vivo therapeutic effect.Controlling the particle size is the most feasible method during design,and the infuence of media pH which varies with disease condition is quite important.The impact of particle size and pH on bovine serum albumin(BSA)corona formation of solid lipid nanoparticles(SLNs)was studied here.The BSA corona formation of SLNs with increasing particle size(120-480 nm)in pH 6.0 and 7.4 was investigated.Multiple techniques were employed for visualization study,conformational structure study and mechanism study,etc.'BSA corona-caused aggregation'of SLN2-3 was revealed in pH 6.0 while the dispersed state of SLNs was maintained in pH 7.4,which signifcantly affected the secondary structure of BSA and cell uptake of SLNs.The main interaction was driven by van der Waals force plus hydrogen bonding in p H 7.4,while by electrostatic attraction in pH 6.0,and size-dependent adsorption was confrmed.This study provides a systematic insight to the understanding of protein corona formation of SLNs. | Wenhao Wang Zhengwei Huang Yanbei Li Wenhua Wang Jiayu Shi Fangqin Fu Ying Huang Xin Pan Chuanbin Wu | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 3 |
| 8 | 18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs显示文摘Hepatic stellate cells(HSCs)are essential drivers of fibrogenesis.Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis.18beta-glycyrrhetinic acid(18b-GA)is a natural compound that exists widely in herbal medicines,such as Glycyrrhiza uralensis Fisch,which is used for treating multiple liver diseases,especially in Asia.In the present study,we demonstrated that 18b-GA decreased hepatic fibrosis by inducing the apoptosis in activated HSCs.18b-GA inhibited the expression of a-smooth muscle actin and collagen type Ⅰ alpha-1.Using a chemoproteomic approach derived from activity-based protein profiling,together with cellular thermal shift assay and surface plasmon resonance,we found that 18b-GA covalently targeted peroxiredoxin 1(PRDX1)and peroxiredoxin 2(PRDX2)proteins via binding to active cysteine residues and thereby inhibited their enzymatic activities.18b-GA induced the elevation of reactive oxygen species(ROS),resulting in the apoptosis of activated HSCs.PRDX1 knockdown also led to ROS-mediated apoptosis in activated HSCs.Collectively,our findings revealed the target proteins and molecular mechanisms of 18b-GA in ameliorating hepatic fibrosis,highlighting the future development of 18b-GA as a novel therapeutic drug for hepatic fibrosis. | Qian Zhang Piao Luo Liuhai Zheng Jiayun Chen Junzhe Zhang Huan Tang Dandan Liu Xueling He Qiaoli Shi Liwei Gu Jiahao Li Qiuyan Guo Chuanbin Yang Yin Kwan Wong Fei Xia Jigang Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，4： | 3 |
| 9 | Nontoxic virus nanofibers improve the detection sensitivity for the anti-p53 antibody, a biomarker in cancer patients显示文摘在浆液的 anti-p53 抗体的存在是为癌症的 biomarker。然而,它的高敏感察觉仍然是在癌症诊断的一个问题。处理这挑战,我们使用了 fd 噬菌体,对人安全的细菌特定的病毒 nanofiber 那能被以一种无差错的方式感染主人细菌大量生产,并且遗传上设计了它显示能够在它的方面墙上认出并且捕获 anti-p53 抗体的肽。我们作为一根俘获探针采用了结果的噬菌体 nanofibers 开发连接酶的 immunosorbent 试金(ELISA ) 的一个修改版本方法,称为的 phage-ELISA。我们为 anti-p53 抗体的察觉把它比作传统的 ELISA 方法, p53-ELISA,哪个使用 recombinant 捕获 anti-p53 的野类型的 p53 蛋白质抗体。我们使用了 phage-ELISA 与恶意的肿瘤的各种各样的类型在 316 个病人的一个试验性的组检测 anti-p53 抗体。我们发现 17.7% 的察觉率(56 个积极盒子) 被 phage-ELISA 完成,它为 p53-ELISA (65 个积极盒子) 比得上 20.6% 的察觉率。然而,当噬菌体和 p53 被联合为 phage/p53-ELISA 形成捕获抗体的探针时, 30.4% 的察觉率(96 个积极盒子) 被完成。我们的工作证明由于由噬菌体 nanofibers 和 p53 的 anti-p53 抗体的联合俘获, phage/p53-ELISA 与癌症的各种各样的类型在病人为 anti-p53 抗体完成了最高诊断的精确性和察觉效率。我们的工作建议那 nanofibers 和抗原的联合,哪个俘获抗体,能导致增加的察觉敏感,它为在生命科学,临床的药,和环境科学的应用是有用的。 | Pengtao Pan Yicun Wang Ye Zhu Xiang Gao Zhigang Ju Penghe Qiu Li Wang Chuanbin Mao | 2015 | Nano Research2015，8，11： | 3 |
| 10 | Mapping the elastic properties of two-dimensional MoS_(2) via bimodal atomic force microscopy and finite element simulation显示文摘Elasticity is a fundamental mechanical property of two-dimensional(2D)materials,and is critical for their application as well as for strain engineering.However,accurate measurement of the elastic modulus of 2D materials remains a challenge,and the conventional suspension method suffers from a number of drawbacks.In this work,we demonstrate a method to map the in-plane Young’s modulus of mono-and bi-layer MoS_(2) on a substrate with high spatial resolution.Bimodal atomic force microscopy is used to accurately map the effective spring constant between the microscope tip and sample,and a finite element method is developed to quantitatively account for the effect of substrate stiffness on deformation.Using these methods,the in-plane Young’s modulus of monolayer MoS_(2) can be decoupled from the substrate and determined as 265±13 GPa,broadly consistent with previous reports though with substantially smaller uncertainty.It is also found that the elasticity of mono-and bi-layer MoS_(2) cannot be differentiated,which is confirmed by the first principles calculations.This method provides a convenient,robust and accurate means to map the in-plane Young’s modulus of 2D materials on a substrate. | Yuhao Li Chuanbin Yu Yingye Gan Peng Jiang Junxi Yu Yun Ou Dai-Feng Zou Cheng Huang Jiahong Wang Tingting Jia Qian Luo Xue-Feng Yu Huijuan Zhao Cun-Fa Gao Jiangyu Li | 2018 | npj Computational Materials2018，，1： | 3 |
| 11 | Solid lipid dispersion of calcitriol with enhanced dissolution and stability显示文摘Solid dispersion of calcitriol with lipophilic surfactants and triglycerides was developed by melt-mixing method to modify the release and enhance stability of the drug.The solid dispersions were characterized by differential scanning calorimetry(DSC),hot stage polarized optical microscopy(HSPM),infrared spectroscopy(FTIR)and stability studies.The solid dispersion significantly enhanced the stability of calcitriol,which could be attributed to the high antioxidant activity of the solid lipid dispersion.The rapid dissolution rate from the solid dispersion was attributed to the amorphous or solid solution state of drug with improved specific surface area and wettability than the drug crystals.Therefore,solid dispersion of calcitriol with D-a-tocopheryl polyethylene glycol 1000 succinate(TPGS)offers a good approach to modify the release and enhance stability of calcitriol.The influence of lipophilic solid dispersion on drug bioavailability needs further investigation. | Ting Yuan Lingzhen Qin Zhouhua Wang Jinyuan Nie Zhefei Guo Ge Li Chuanbin Wu | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，1： | 2 |
| 12 | Nontoxic engineered virus nanofibers as an efficient agent for the prevention and detection of fungal infection显示文摘Candida albicans (C。albicans ) 感染让高死亡在 immunocompromised 病人评价。由于当前的诊断系统的无效和对 candidiasis 的准许的疫苗的缺席, C 的预防。albicans 感染仍然是挑战。C。albicans 感染能被藏匿反的 aspartyl 朊酶评估并且阻止 2 抗体(anti-Sap2 IgG ) 和 Hsp90 抗体(anti-Hsp90 IgG ) 。在这研究,为诊断和 C 的预防的改进探索一个新代理人。albicans 感染,设计 fd 抗菌素,被认为对人安全的病毒 nanofiber,与二被设计并且准备能导致并且捕获 anti-Sap2 IgG 和 anti-Hsp90 IgG 的 epitopes。双显示的噬菌体作为一根新奇俘获探针被采用开发一个新连接酶的 immunosorbent 试金( ELISA )方法,它显著地 recombinant 蛋白质 Sap2 在被用作涂层抗原捕获特定的抗体( rSap2-ELISA )的 ELISA 和 recombinant 蛋白质 Hsp90 在被用作涂层抗原捕获特定的抗体( rHsp90-ELISA )的 ELISA 与那些相比改进了察觉率。另外, nanofibers 充当了一支潜在的疫苗使老鼠,以及 recombinant 蛋白质免疫,更高效地调停了体液、细胞的有免疫力的回答, C 的减少的层次。albicans 殖民,并且在 C 增加了幸存率。感染 albicans 的老鼠。因此,双显示的 nanofiber 被显示了是为保护对的一个强大的 bifunctional 代理人的噬菌体和临床的感染的敏感察觉,它有潜力广泛地在生命科学,临床的药,和环境科学被过去常。 | Yicun Wang Hongxi Shi Shuai Dong Yan Li Meng Wang Yanyan Huai Xintong Zhang Xi Chen Chuanbin Mao Xiang Gao Li Wang | 2018 | Nano Research2018，11，4： | 2 |
| 13 | Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology:Implications for Alzheimer's disease therapy显示文摘Alzheimer's disease(AD),characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates,is the most common neurodegenerative disorder with limited therapeutic agents.Autophagy plays a critical role in the degradation of phosphorylated Tau aggregates,and transcription factor EB(TFEB)is a master regulator of autophagy and lysosomal biogenesis.Thus,small-molecule autophagy enhancers targeting TFEB hold promise for AD therapy.Here,we found that celastrol,an active ingredient isolated from the root extracts of Tripterygium wilfordii(Lei Gong Teng in Chinese)enhanced TFEB-mediated autophagy and lysosomal biogenesis in vitro and in mouse brains.Importantly,celastrol reduced phosphorylated Tau aggregates and attenuated memory dysfunction and cognitive deficits in P301S Tau and 3xTg mice,two commonly used AD animal models.Mechanistical studies suggest that TFEB-mediated autophagy-lysosomal pathway is responsible for phosphorylated Tau degradation in response to celastrol.Overall,our findings indicate that Celastrol is a novel TFEB activator that promotes the degradation of phosphorylated Tau aggregates and improves memory in AD animal models.Therefore,Celastrol shows potential as a novel agent for the treatment and/or prevention of AD and other tauopathies. | Chuanbin Yang Chengfu Su Ashok Iyaswamy Senthil Kumar Krishnamoorthi Zhou Zhu Sichang Yang Benjamin Chunkit Tong Jia Liu Sravan G.Sreenivasmurthy Xinjie Guan Yuxuan Kan Aston Jiaxi Wu Alexis Shiying Huang Jieqiong Tan Kingho Cheung Juxian Song Min Li | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 2 |
| 14 | Studies on the spray dried lactose as carrier for dry powder inhalation显示文摘The purpose of this study was to investigate the spray dried lactose as carrier for dry powder inhalation(DPI).The lactose particles were prepared by spray drying,then the particle size,shape and crystal form were characterized by laser diffraction,scanning electron microscopy(SEM),X-ray diffraction(XRD)and differential scanning calorimetry(DSC).The spray dried lactose particles were spherical and amorphous,but would transfer to crystal form when storage humidity was above 32%.Thus,the humidity of the storage environment should be controlled below 30%strictly in order to maintain the amorphous nature of spray dried lactose which is a great benefit to DPI development. | Linna Wu Xu Miao Ziyun Shan Ying Huang Lu Li Xin Pan Qinghe Yao Ge Li Chuanbin Wu | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，6： | 1 |
| 15 | 显示文摘 | Mao Chuanbin Li Hengde Cui Fuzhai | 1999 | Journal of Crystal Growth1999，206，： | 1 |
| 16 | The Functionalization of Titanium With EDTA to Induce Biomimetic Mineralization of Hydroxyapatite显示文摘 | Mao Chuanbin Li Hengde Cui Fuzhai | 1999 | J Mater Chem1999，，9： | 1 |
| 17 | Rapid identification of two-dimensional materials via machine learning assisted optic microscopy显示文摘A combination of Fresnel law and machine learning method is proposed to identify the layer counts of 2D materials.Three indexes,which are optical contrast,red-green-blue,total color difference,are presented to illustrate and simulate the visibility of 2D materials on Si/SiO_(2) substrate,and the machine learning algorithms,which are k-mean clustering and k-nearest neighbors,are employed to obtain thickness database of 2D material and test the optical images of 2D materials via red-green-blue index.The results show that this method can provide fast,accurate and large-area property of 2D material.With the combination of artificial intelligence and nanoscience,this machine learning assisted method eases the workload and promotes fundamental research of 2D materials. | Yuhao Li Yangyang Kong Jinlin Peng Chuanbin Yu Zhi Li Penghui Li Yunya Liu Cun-Fa Gao Rong Wu | 2019 | Journal of Materiomics2019，5，3： | 1 |
| 18 | Oriented growth of hydroxyapatite on (001) textured titanium with functionalized self-assembled silane monolayer as template 显示文摘 | Mao Chuanbin Li Hengde Cui Fuzhai | 1998 | J Mater Chem1998，8，： | 1 |
| 19 | Carbon-coated SnO 2 /graphene nanosheets as highly reversible anode materials for lithium ion batteries显示文摘 | Chaofeng Zhang Xing Peng Zaiping Guo Chuanbin Cai Zhixin Chen David Wexler Sean Li Huakun Liu | 2011 | Carbon2011，，5： | 1 |
| 20 | Iron/copper promoted oxidative homo - coupling reaction of terminal alkynes using air as the oxi- dam显示文摘 | Xu Meng Chuanbin Li Baochun Han Tiansheng Wang Baohua Chen | 2010 | Tetrahedron2010，66，23： | 1 |
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