|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Isolation and characterisation of human gingival margin-derived STRO-1/MACS^+ and MACS^-cell populations显示文摘Recently,gingival margin-derived stem/progenitor cells isolated via STRO-1/magnetic activated cell sorting(MACS) showed remarkable periodontal regenerative potential in vivo.As a second-stage investigation,the present study's aim was to perform in vitro characterisation and comparison of the stem/progenitor cell characteristics of sorted STRO-1-positive(MACS^+) and STRO-1-negative(MACS^-) cell populations from the human free gingival margin.Cells were isolated from the free gingiva using a minimally invasive technique and were magnetically sorted using anti-STRO-1 antibodies.Subsequently,the MACS^+ and MACS^- cell fractions were characterized by flow cytometry for expression of CD14,CD34,CD45,CD73,CD90,CD105,CD146/MUC18 and STRO-1.Colony-forming unit(CFU) and multilineage differentiation potential were assayed for both cell fractions.Mineralisation marker expression was examined using real-time polymerase chain reaction(PCR).MACS^+ and MACS- cell fractions showed plastic adherence.MACS^+ cells,in contrast to MACS- cells,showed all of the predefined mesenchymal stem/progenitor cell characteristics and a significantly higher number of CFUs(P<0.01).More than 95%of MACS^+ cells expressed CD105,CD90 and CD73;lacked the haematopoietic markers CD45,CD34 and CD14,and expressed STRO-1 and CD146/MUC18.MACS- cells showed a different surface marker expression profile,with almost no expression of CD14 or STRO-1,and more than 95%of these cells expressed CD73,CD90 and CD146/MUC18,as well as the haematopoietic markers CD34 and CD45 and CD105.MACS^+ cells could be differentiated along osteoblastic,adipocytic and chondroblastic lineages.In contrast,MACS- cells demonstrated slight osteogenic potential.Unstimulated MACS^+ cells showed significantly higher expression of collagen I(P<0.05) and collagen III(P<0.01),whereas MACS^- cells demonstrated higher expression of osteonectin(P<0.05;MannWhitney).The present study is the first to compare gingival MACS^+ and MACS- cell populations demonstrating that MACS^+ cells,in contrast to MACS- cells,harbour stem/progenitor cell characteristics.This study also validates the effectiveness of the STRO-l/MACS^+technique for the isolation of gingival stem/progenitor cells.Human free gingival margin-derived STRO-1/MACS^+ cells are a unique renewable source of multipotent stem/progenitor cells. | Karim M Fawzy El-Sayed Sebastian Paris Christian Graetz Neemat Kassem Mohamed Mekhemar Hendrick Ungefroren Fred Fndrich Christof Drfer | 2015 | International Journal of Oral Science2015，7，2： | 6 |
| 3 | Nasal Carriage as a Source of Staphylococcus aureus Bacteremia显示文摘 | Christof VE Karsten B Konstanze M | 2001 | N Engl J Med2001，344，： | 1 |
| 4 | SQP Methods for Solving Optimal Control Problems with Control & State Constraints Adjoit Variables, Sensitivity Analysis and Real-time Eontxol 显示文摘 | Christof B Helmut M | 2000 | Journal of Computationaland Applied Mathematics2000，120，1： | 1 |
| 5 | Sociocultural Integration in Mergers and Acquisitions: Unresolved Paradoxes and Directions for Future Research显示文摘 | Günter K. Stahl Duncan N. Angwin Philippe Very Emanuel Gomes Yaakov Weber Shlomo Yedidia Tarba Niels Noorderhaven Haim Benyamini Dave Bouckenooghe Samia Chreim Muriel Durand Mélanie E. Hassett Gary Kokk Mark E. Mendenhall Nicola Mirc Christof Miska Kathle | 2013 | Thunderbird Int’l Bus Rev2013，，4： | 1 |
| 6 | Relation between the molecular structure and the efficiency of superabsorbent poly- mer (SAP) as concrete admixture to mitigate autogenousshrinkage显示文摘 | Christof S Viktor M Michaela G | 2012 | Cement and Concrete Research2012，，42： | 1 |
| 7 | Myosin-V is a mechanical racket显示文摘 | Christof J Gebhardt M Anabel EM | 2006 | Proc Natl Acad Sci2006，103，： | 1 |
| 8 | Self-assembled Nanostructures Based on DNA:Towards the Development of Nanobiotechnology显示文摘 | | 2000 | Current Opinion in Chemical Biology2000，4，6： | 1 |
| 9 | Competing dissociation channels in the photolysis of S2Clz at 235 nm显示文摘 | Einfeld T S Christof M Gerieke K H | 2002 | J Cbem Phys2002，117，9： | 1 |
| 10 | Capsid protein- mediated recruitment of host DnaJ-Like proteins is required forPotato virus Y infection in Tobacco plants显示文摘 | Daniel H Annette T M Christof D | 2007 | Journal of Virology2007，81，11： | 1 |
| 11 | SQP-methods for solving optimal control problems with control and state constraints adjoint variables:sensitivity analysis and real-time eontr显示文摘 | Christof B Helmut M | 2000 | Journal of Computational and Applied Mathematics2000，120，1： | 1 |
| 12 | Accuracy of dual - source CT in the characterisation of non - calcified plaque : use of a colour - coded analysis compared with virtual histology intravascular ultrasound显示文摘 | HARALD B CHRISTOF B HEUSCHMID M | 2009 | Br J Radiol2009，82，982： | 1 |
| 13 | Diagnostic value of pelvic examination,ultrasound,and Serum CA125 in postmenopausal women with a pelvic mass:An International Multicenter Study显示文摘 | PETER KENEMANS CHRISTOF SOHN | 1994 | Cancer1994，74，： | 1 |
| 14 | Potential Distribution of Dengue Fever Under Scenarios of Climate Change and Economic Development显示文摘 | Christofer ?str?m Joacim Rockl?v Simon Hales Andreas Béguin Valerie Louis Rainer Sauerborn | 2013 | EcoHealth2013，，4： | 1 |
| 15 | Integra- tion of retroviral vectors显示文摘 | GABRIEL R SCHMIDT M Christof von Kalle | 2012 | Current Opinion in Immu- nology2012，24，5： | 1 |
| 16 | α-Purothionin, a new wheat allergen associated with severe allergy显示文摘 | Sandra Pahr Claudia Constantin Nikolaos G. Papadopoulos Stavroula Giavi Mika M?kel? Anna Pelkonen Christof Ebner Adriano Mari Sandra Scheiblhofer Josef Thalhamer Michael Kundi Susanne Vrtala Irene Mittermann Rudolf Valenta | 2013 | The Journal of Allergy and Clinical Immunology2013，，： | 1 |
| 17 | Myosin-V isl a mechanical racket显示文摘 | Christof J Gebhardt M Anabel EM | 2006 | Proc Natl Acad Sci2006，103，： | 1 |
| 18 | Global Regulatory Impaet ofClpP Protease of Staphylococcus aureus on Regulons Involved inVirulence,Oxidative Stress Response,Autolysis,and DNA Repair显示文摘 | Antje M Franziska A Christof R | 2006 | J Bacteriol2006，188，16： | 1 |
| 19 | Relation between the molecular structure and the efficiency of superabsorbent polymers (SAP) as concrete admixture to mitigate autogenous shrinkage 显示文摘 | Christof S Viktor M Michaela G | 2012 | Cement and Concrete Research2012，，42： | 1 |
| 20 | Fluctuating temperature modifies heat-mortality association around the globe显示文摘Studies have investigated the effects of heat and temperature variability(TV)on mortality.However,few assessed whether TV modifies the heat-mortality association.Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries.TV was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures. | Yao Wu Bo Wen Shanshan Li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana Maria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahmad Ben Armstrong Bertil Forsberg CarmenÍñiguez Caroline Ameling César De la Cruz Valencia ChristoferÅström Danny Houthuijs Do Van Dung Dominic Royé Ene Indermitte Eric Lavigne Fatemeh Mayvaneh Fiorella Acquaotta Francesca de’Donato Francesco Sera Gabriel Carrasco-Escobar Haidong Kan Hans Orru Ho Kim Iulian-Horia Holobaca Jan Kyselý Joana Madureira Joel Schwartz Klea Katsouyanni Magali Hurtado-Diaz Martina SRagettli Masahiro Hashizume Mathilde Pascal Micheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola Michelozzi Patrick Goodman Paulo Hilario Nascimento Saldiva Rosana Abrutzky Samuel Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Yasushi Honda Michelle L.Bell Yuming Guo | 2022 | The Innovation2022，3，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员