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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Muscle force and movement variability before and after total knee arthroplasty: A review显示文摘Variability in muscle force output and movement variability are important aspects of identifying individuals with mobility deficits, central nervous system impairments, and future risk of falling. This has been investigated in elderly healthy and impaired adults, as well as in adults with osteoarthritis(OA), but the question of whether the same correlations also apply to those who have undergone a surgical intervention such as total knee arthroplasty(TKA) is still being investigated. While there is a growing body of literature identifying potential rehabilitation targets for individuals who have undergone TKA, it is important to first understand the underlying post-operative impairments to more efficiently target functional deficits that may lead to improvedlong-term outcomes. The purpose of this article is to review the potential role of muscle force output and movement variability in TKA recipients. The narrative review relies on existing literature in elderly healthy and impaired individuals, as well as in those with OA before and following TKA. The variables that may predict longterm functional abilities and deficits are discussed in the context of existing literature in healthy older adults and older adults with OA and following TKA, as well as the role future research in this field may play in providing evidence-based data for improved rehabilitation targets. | Jessica W Smith Jesse C Christensen Robin L Marcus Paul C LaStayo | 2014 | World Journal of Orthopedics2014，5，2： | 3 |
| 3 | Characterization of the dissolved organic carbon in landfill leachatepolluted groundwater 显示文摘 | Christensen J B Jensen D L Gron C | 1998 | Wat Res1998，32，1： | 1 |
| 4 | Variation within isolates of Acremonium endophytes from perennial ryegrass显示文摘 | Christensen M J Latch G C M Tapper B A | 1991 | Mycology Research1991，95，： | 1 |
| 5 | Methane Yield in Source-sorted Organic Fraction of Municipal Solid Waste显示文摘 | Davidsson A Gruvberger C Christensen T H | 2007 | Waste Manage2007，27，： | 1 |
| 6 | Measurement of soil microbial biomass provides an early indication of chan- ges in total soil organic matter due to straw in corporation 显示文摘 | Powlson D S Brookes P C Christensen B | 1987 | Soil Biol Bioehem1987，19，： | 1 |
| 7 | Recent developments in inductively coupled plasma magnetic sector multiple collector mass spectrometry 显示文摘 | Halliday A N Lee D C Christensen J N Walder A J Freedman P A Jones C E Hall C M Yi W Teagle D | 1995 | Int J Mass Spec Ion Proc1995，，： | 1 |
| 8 | Ecopath with Ecosim:Methods,capabilities and limitations显示文摘 | Christensen V Walters C J | 2004 | Ecological Modelling2004，172，： | 1 |
| 9 | The rules of innovation显示文摘 | Christensen C M | 2002 | MIT Technology Review2002，21，： | 1 |
| 10 | A role for flavin monooxygenase-like enzymes in auxin biosynthesis显示文摘 | ZHAO Y CHRISTENSEN S K FANKHAUSER C | 2001 | Science2001，291，5502： | 1 |
| 11 | Customer power, strate- gic investment, and the failure of leading firms 显示文摘 | Christensen C M Bower J L | 1996 | Strategic Management Journal1996，17，3： | 1 |
| 12 | A global movement toward an ecosystem approach to management of marine resources显示文摘 | Sherman K Sissenwine M Christensen V Duda A Hempel G Ibe C Levin S Liuch-Belda D Matishov G McGlade J O'Toole M Switzinger S Serra R Skjoldat H-R Tang Q Thulin J Vandeweerd V Zwanenburg K | | 0，，： | 1 |
| 13 | The innovator's DNA 显示文摘 | DYER J H GREGERSEN H B CHRISTENSEN C M | 2009 | Harvard Business Review2009，87，12： | 1 |
| 14 | Reinventing your business model显示文摘 | JOHNSON M W CHRISTENSEN C M KAGERMANN H | 2008 | Harvard Business Review2008，86，12： | 1 |
| 15 | Catalyticasymmetric henry reactions-a simple approach to optically active β-nitro α-hydroxy esters 显示文摘 | Christensen C Juhl K Jorgensen K A | 2001 | Chem Commun2001，，： | 1 |
| 16 | Measurement of soil microbial biomass provides an early indication of changes in total soil organic matter due to straw incorporation显示文摘 | Powlson D S Brookes P C Christensen B T | 1987 | Soil Biology and Biochemistry1987，19，： | 1 |
| 17 | Using X-ray absorption near edge structure (XANES) spectroscopy to determine selenium oxidation states in animal mineral supplements and feeds显示文摘 | Christensen C R Cutler J N Christensen D A | 2004 | J Anita Sci2004，84，： | 1 |
| 18 | The great leap: driving innovation from the base of the pyramid 显示文摘 | Hart S L Christensen C M | 2002 | MIT Sloan Management Review2002，44，1： | 1 |
| 19 | Perturbations of Banach frames and atomic decompositions显示文摘 | Heil C | 1997 | Math Nathr1997，185，： | 1 |
| 20 | Disruptive Technologies:Catching the Wave显示文摘 | C M Christensen | 1995 | Harvard Business Review1995，，12： | 1 |
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