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| 1 | Pilot study of atomoxetine in patients with Parkinson’s disease and dopa-unresponsive Freezing of Gait显示文摘Background:Freezing of gait(FoG)is a common and debilitating condition in Parkinson’s disease(PD)associated with executive dysfunction.A subtype of FoG does not respond to dopaminergic therapy and may be related to noradrenergic deficiency.This pilot study explores the effects of atomoxetine on gait in PD patients with dopaunresponsive FoG using a novel paradigm for objective gait assessment.Findings:Ten patients with PD and dopa-unresponsive FoG were enrolled in this eight-week open label pilot study.Assessments included an exploratory gait analysis protocol that quantified spatiotemporal parameters during straight-away walking and turning,while performing a dual task.Clinical,and subjective assessments of gait,quality of life,and safety were also administered.The primary outcome was a validated subjective assessment for FoG(FOG-Q).Atomoxetine was well tolerated,however,no significant change was observed in the primary outcome.The gait analysis protocol correlated well with clinical scales,but not with subjective assessments.DBS patients were more likely to increase gait velocity(p=0.033),and improved in other clinical assessments.Conclusions:Objective gait analysis protocols assessing gait while dual tasking are feasible and useful for this patient population,and may be superior correlates of FoG severity than subjective measures.These findings can inform future trials in this population. | Gonzalo J.Revuelta Aaron Embry Jordan J.Elm Chris Gregory Amy Delambo Steve Kautz Vanessa K.Hinson | 2015 | Translational Neurodegeneration2015，4，1： | 3 |
| 2 | Calculation of near-threshold O- photodetachment, including fine-structure effects 显示文摘 | Miecznik Gregory Greene Chris H | 1996 | Phys Rev A1996，53，： | 1 |
| 3 | Multiple Grating Simultaneously Formed in Holographic Polymer- dispered Liquid Crystal显示文摘 | Chris C Bowley Adam K Fontecchio Gregory P Crawfod | 2000 | Appl Phys Lett2000，76，： | 1 |
| 4 | Catheter ablation for atrial fibrillation in heart failure:untying the Gordian knot显示文摘Atrial fibrillation(AF) and heart failure(HF) are complex clinical entities that occur concomitantly in a significant population of patients, and their prevalence is rising in epidemic proportions. Traditionally, both rate and rhythm control strategies have been regarded as equivalent in the management of dysrhythmia in this AF-HF cohort with escalation of treatment largely guided by symptoms. Both disorders are involved in an elaborate pathophysiological interplay with shared cardiovascular risk factors that contribute to the development and sustenance of both AF and HF. Recent studies and continued development of evidence to support catheter ablation for AF has brought into question the traditional belief in equivalence between rate and rhythm control. Indeed, recent trials, in particular the CASTLE-AF(Catheter Ablation versus Standard Conventional Therapy in Patients with Left Ventricular Dysfunction and Atrial Fibrillation) study, suggest that catheter ablation for AF improves survival and rates of hospitalisation in patients with concomitant HF and AF, threatening a paradigm shift in the management of this patient cohort. The evident mortality benefit from clinical trials suggests that catheter ablation for AF should be considered as a therapeutic intervention in all suitable patients with the AF-HF syndrome as these patients may derive the greatest benefit from restoration of sinus rhythm. Further research is needed to refine the evidence base, especially to determine which subgroup of HF patients benefit most from catheter ablation and what is the optimal timing. | Saad Javed Ioanna Koniari David Fox Chris Skene Gregory YH Lip Dhiraj Gupta | 2021 | Journal of Geriatric Cardiology2021，18，4： | 1 |
| 5 | Parental anxiety and quality of life in children with epilepsy显示文摘 | Jane Williams Chris Steel Gregory B Sharp | 2003 | Epilepsy & Behavior2003，4，： | 1 |
| 6 | Life cycle energy and environmental performance of a new university building: modeling challenges and design implications显示文摘 | Chris Scheuer Gregory A Keoleian Peter Reppe | 2003 | Energy & Buildings2003，，10： | 1 |
| 7 | Incisionless revision of post-Roux-en- Y bypass stomal and pouch dilation: multicenter registry results显示文摘 | Santiago Horgan Garth Jacobsen G. Derek Weiss John S. Oldham Peter M. Denk Frank Borao Steven Gorcey Brad Watkins John Mobley Kari Thompson Adam Spivack Dave Voellinger Chris Thompson Lee Swanstrom Paresh Shah Greg Haber Matthew Brengman Gregory Schroder | 2010 | Surgery for Obesity and Related Diseases2010，，3： | 1 |
| 8 | Life cycle energy and environmental performance of a new university building: Modeling challenge sand design implications显示文摘 | Chris Scheuer Gregory A Keoleian Peter Reppe | 2003 | Energy and Buildings2003，35，10： | 1 |
| 9 | Parental anxiety and quality of life in children with epilepsy显示文摘 | JANE W CHRIS S GREGORY BS | 2003 | Epilepsy &Behavior2003，4，： | 1 |
| 10 | Gefitinib Versus Placebo in Completely Resected Non–Small-Cell Lung Cancer: Results of the NCIC CTG BR19 Study显示文摘 | Glenwood D. Goss Chris O’Callaghan Ian Lorimer Ming-Sound Tsao Gregory A. Masters James Jett Martin J. Edelman Rogerio Lilenbaum Hak Choy Fadlo Khuri Katherine Pisters David Gandara Kemp Kernstine Charles Butts Jonathan Noble Thomas A. Hensing Kendrith Ro | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
| 11 | Life cycle energy and environmental performance of a new university building: modeling challenges and design implications 显示文摘 | Chris Scheuer Gregory A Keoleian Peter Reppe | 2007 | Energy and Buildings2007，35，10： | 1 |
| 12 | Hepatotoxicity after Desflurane Anesthesia显示文摘 | Jackie L. Martin David J. Plevak Kathleen D. Flannery Michael Charlton John J. Poterucha Chris E. Humphreys Gregory Derfus Lance R. Pohl | 1995 | Anesthesiology1995，，5： | 1 |
| 13 | Fractures of the Distal Radius and Ulna: Metaphyseal and Physeal Injuries显示文摘 | Chris Stutz Gregory A. Mencio | 2010 | Journal of Pediatric Orthopaedics2010，，： | 1 |
| 14 | Life cycle energy and environmental performance of a new university building: modeling challengers and design implications 显示文摘 | Chris Scheuer Gregory A Keoleian Peter Reppe | 2003 | Energy and Buildings2003，，35： | 1 |
| 15 | A survey of high resolution image processing techniques for cereal crop growth monitoring显示文摘This paper presents a survey of image processing techniques proposed in the literature forextracting key cereal crop growth metrics from high spatial resolution, typically proximalimages. The descriptive crop growth metrics considered are: crop canopy cover, aboveground biomass, leaf area index (including green area index), chlorophyll content, andgrowth stage. The paper includes an overview of relevant fundamental image processingtechniques including camera types, colour spaces, colour indexes, and image segmentation. The descriptive crop growth metrics are defined. Reference methods for groundtruth measurement are described. Image processing methods for metric estimation aredescribed in detail. The performance of the methods is reviewed and compared. The surveyreveals limitations in image processing techniques for cereal crop monitoring such as lackof robustness to lighting conditions, camera position, and self-obstruction. Directions forfuture research to improve performance are identified. | Sanaz Rasti Chris J.Bleakley N.M.Holden Rebecca Whetton David Langton Gregory O’Hare | 2022 | Information Processing in Agriculture2022，9，2： | 1 |
| 16 | Life cycle energy and environmental performance of a new university building:modeling challenges and design implications显示文摘 | Chris Scheuer Gregory A Keoleian Peter Reppe | 2007 | Energy and Buildings2007，35，10： | 1 |
| 17 | Interleukin-18 knockout mice display maladaptive cardiac hypertrophy in response to pressure overload显示文摘 | James T. Colston William H. Boylston Marc D. Feldman Chris P. Jenkinson Sam D. de la Rosa Amanda Barton Rodolfo J. Trevino Gregory L. Freeman Bysani Chandrasekar | 2007 | Biochemical and Biophysical Research Communications2007，，2： | 1 |
| 18 | Life cycleenergy and envi- ronmental performance of a new university building: Model- ing challenge sand design implications显示文摘 | Chris S Gregory A K Peter R | 2003 | Energy and Build- ings2003，35，10： | 1 |
| 19 | Use of the gamma distribution to represent month- ly rainfall in Africa for drought monitoring appli- cations 显示文摘 | Gregory JHusak Joel Michaelsen Chris Funk | 2007 | International Journal of Climatology2007，27，： | 1 |
| 20 | Life cycle energy and en vironmental performance of a new university building: modeling challenges and de sign implications显示文摘 | Chris Scheuer Gregory A Keoleian Peter Reppe | 2003 | Energy and Buildings2003，35，： | 1 |
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