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| 1 | Clinical significance of lactate in acute cardiac patients显示文摘Lactate, as a metabolite of easy and quick assessment, has been studied over time in critically ill patients in order to evaluate its prognostic ability. The present review is focused on the prognostic role of lactate levels in acute cardiac patients(that is with acute coronary syndrome, cardiogenic shock, cardiac arrest, non including post cardiac surgery patients). In patients with STelevation myocardial infarction treated with mechanical revascularization, hyperlactatemia identified a subset of patients at higher risk for early death and in-hospital complications, being strictly related mainly to hemodynamic derangement. The prognostic impact of hyperlactatemia on mortality has been documented in patients with cardiogenic shock and in those with cardiac arrest even if there is no cut-off value of lactate to be associated with worse outcome or to guide resuscitation or hemodynamic management. Therapeutic hypothermia seems to affect per se lactate values which have been shown to progressively decrease during hypothermia. The mechanism(s) accounting for lactate levels during hypothemia seem to be multiple ranging from the metabolic effects of reduced temperatures to the hemodynamic effects of hypothermia(i.e., reduced need of vasopressor agents). Serial lactate measurements over time, or lactate clearance, have been reported to be clinically more reliable than lactate absolute value also in acute cardiac patients. Despite differences in study design, timing of lactate measurements and type of acute cardiac conditions(i.e., cardiogenic shock, cardiac arrest, refractory cardiac arrest), available evidence strongly suggests that higher lactate levels can be observed on admission in non-survivors and that higher lactate clearance is associated with better outcome. | Chiara Lazzeri Serafina Valente Marco Chiostri Gian Franco Gensini | 2015 | World Journal of Cardiology2015，7，8： | 10 |
| 2 | Clinical significance of glycated hemoglobin in the acute phase of ST elevation myocardial infarction显示文摘In population-based studies,including diabetic and nondiabetic cohorts,glycated hemoglobin A1c(HbA1c) has been reported as an independent predictor of allcause and cardiovascular disease mortality.Data on the prognostic role of HbA1c in patients with acute myocardial infarction(MI) are not univocal since they stem from studies which mainly differ in patients' selection criteria,therapy(thrombolysis vs mechanical revascularization) and number consistency.The present review is focused on available evidence on the prognostic significance of HbA1c measured in the acute phase in patients with ST-elevation myocardial infarction(STEMI) submitted to primary percutaneous coronary intervention(PCI).We furthermore highlighted the role of HbA1c as a screening tool for glucose intolerance in patients with STEMI.According to available evidence,in contemporary cohorts of STEMI patients submitted to mechanical revascularization,HbA1c does not seem to be associated with short and long term mortality rates.However,HbA1c may represent a screening tool for glucose intolerance from the early phase on in STEMI patients.On a pragmatic ground,an HbA1c testhas several advantages over fasting plasma glucose or an oral glucose tolerance test in an acute setting.The test can be performed in the non-fasting state and reflects average glucose concentration over the preceding 2-3 mo.We therefore proposed an algorithm based on pragmatic grounds which could be applied in STEMI patients without known diabetes in order to detect glucose intolerance abnormalities from the early phase.The main advantage of this algorithm is that it may help in tailoring the follow-up program,by helping in identifying patients at risk for the development of glucose intolerance after MI.Further validation of this algorithm in prospective studies may be required in the contemporary STEMI population to resolve some of these uncertainties around HbA1c screening cutoff points. | Chiara Lazzeri Serafina Valente Marco Chiostri Maria Grazia D'Alfonso Gian Franco Gensini | 2014 | World Journal of Cardiology2014，6，4： | 2 |
| 3 | Postprocedural hyperglycemia in ST elevation myocardial infarction submitted to percutaneous coronary intervention:a prognostic indicator and a marker of metabolic derangement显示文摘 | Lazzeri C Chiostri M Sori a | 2010 | J Cardiovasc Med(Hagerstown)2010，，11： | 1 |
| 4 | Correlates of acute insulin resistance in the early phase of non-diabetic ST-elevation myocardial infarction显示文摘 | Lazzeri C Valente S Chiostri M | 2011 | Diab Vase Dis Res2011，8，1： | 1 |
| 5 | Uric acid in the early risk strat- ification of ST - elevation myocardial infarction 显示文摘 | Lazzeri C Valente S Chiostri M | 2012 | Intern Emerg Med2012，7，1： | 1 |
| 6 | uric aciu in me acute phase of ST elevation myocardial infarction submitted to primary PCI: its prognostic role and relation with inflammatory markers: a single center experience 显示文摘 | Lazzeri C Yalente S Chiostri M | 2010 | Int J Cardiol2010，138，2： | 1 |
| 7 | Prior and new onset anemia in ST-elevation myocardial infarction: a different prognostic role显示文摘 | VALENTE S LAZZERI C CHIOSTRI M | 2011 | Intern Emerg Med2011，6，： | 1 |
| 8 | Uric acid in the acute phase of ST elevation myocardial infarction submitted to primary PCI:its prognostic role and relation with inflammatory markers:a single center experience显示文摘 | Lazzeri C Valente S Chiostri M | | 0，，： | 1 |
| 9 | Usefulness of Hyponatremia in the acute phase of ST-elevation myocardial infartion asc a marker of severity显示文摘 | Lazzeri C Valente S Chiostri M | 2012 | Am J Cardiol2012，110，10： | 1 |
| 10 | Evaluation of acid–base balance in ST-elevation myocardial infarction in the early phase: a prognostic tool?显示文摘 | Chiara Lazzeri Serafina Valente Marco Chiostri Claudio Picariello Gian Franco Gensini | 2010 | Coronary Artery Disease2010，，5： | 1 |
| 11 | Acid–base imbalance in uncomplicated ST-elevation myocardial infarction: the clinical role of tissue acidosis显示文摘 | Chiara Lazzeri Serafina Valente Marco Chiostri Claudio Picariello Gian Franco Gensini | 2010 | Internal and Emergency Medicine2010，，1： | 1 |
| 12 | The glucose dysmetabolism in the acute phase of non-diabetic ST-elevation myocardial infarction: from insulin resistance to hyperglycemia显示文摘 | Chiara Lazzeri Serafina Valente Marco Chiostri Paola Attanà Claudio Picariello Gian Franco Gensini | 2013 | Acta Diabetologica2013，，3： | 1 |
| 13 | Effects of two different treatments with continuous renal replacement therapy in patients with chronic renal dysfunction submitted to coronary invasive procedures显示文摘 | Spini V Cecchi E Chiostri M | 2013 | J Invasive Cardiol2013，25，： | 1 |
| 14 | NT-proBNP on admission for early risk stratification in STEMI patients submitted to PCI. Relation with extension of STEMI and inflammatory markers显示文摘 | Serafina Valente Chiara Lazzeri Marco Chiostri Cristina Giglioli Andrea Sori Sabrina Tigli Gian Franco Gensini | 2007 | International Journal of Cardiology2007，，1： | 1 |
| 15 | Effects of two different treatments with continuous renal replacement therapy in patients with chronic renal dysfunction submitted to coronary invasive procedures显示文摘 | Spini V Cecchi E Chiostri M | 2013 | J Invasive Cardiol2013，25，2： | 1 |
| 16 | Impact of hypertension on short- and long-term prognoses in patients with ST elevation myocardial infarction and without previously known diabetes显示文摘 | Chiara Lazzeri Serafina Valente Marco Chiostri Paola Attanà Claudio Picariello Gian Gensini | 2012 | Heart and Vessels2012，，4： | 1 |
| 17 | Evaluation of acid- base balance in ST-elevation myocardial infarction in the early phase: a prognostic tool显示文摘 | Lazzeri C Valente S Chiostri M | 2010 | Coron Artery Dis2010，56，5： | 1 |
| 18 | Lactate clearance in cardio- genic shock following ST elevation myocardial infarction : a pilot study 显示文摘 | Attan6 P Lazzeri C Chiostri M | 2012 | Acute Card Care2012，14，： | 1 |
| 19 | Trends in mortality rates in elderly ST elevation myocardial infarction patients submitted to primary percutaneous coronary intervention: a 7-year single-center experience 显示文摘 | Lazzeri C Valente S Chiostri M | 2013 | Geriatr Gerontol Int2013，13，3： | 1 |
| 20 | Kinetic of procalcitonin in patients with cardiogenic shock following acute myocardial in- farction: preliminary data显示文摘 | Picariello C Lazzeri C Chiostri M | 2010 | HSR Proc Intensive Care Cardio- vasc Anesth2010，2，3： | 1 |
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