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| 1 | Clinical significance of lactate in acute cardiac patients显示文摘Lactate, as a metabolite of easy and quick assessment, has been studied over time in critically ill patients in order to evaluate its prognostic ability. The present review is focused on the prognostic role of lactate levels in acute cardiac patients(that is with acute coronary syndrome, cardiogenic shock, cardiac arrest, non including post cardiac surgery patients). In patients with STelevation myocardial infarction treated with mechanical revascularization, hyperlactatemia identified a subset of patients at higher risk for early death and in-hospital complications, being strictly related mainly to hemodynamic derangement. The prognostic impact of hyperlactatemia on mortality has been documented in patients with cardiogenic shock and in those with cardiac arrest even if there is no cut-off value of lactate to be associated with worse outcome or to guide resuscitation or hemodynamic management. Therapeutic hypothermia seems to affect per se lactate values which have been shown to progressively decrease during hypothermia. The mechanism(s) accounting for lactate levels during hypothemia seem to be multiple ranging from the metabolic effects of reduced temperatures to the hemodynamic effects of hypothermia(i.e., reduced need of vasopressor agents). Serial lactate measurements over time, or lactate clearance, have been reported to be clinically more reliable than lactate absolute value also in acute cardiac patients. Despite differences in study design, timing of lactate measurements and type of acute cardiac conditions(i.e., cardiogenic shock, cardiac arrest, refractory cardiac arrest), available evidence strongly suggests that higher lactate levels can be observed on admission in non-survivors and that higher lactate clearance is associated with better outcome. | Chiara Lazzeri Serafina Valente Marco Chiostri Gian Franco Gensini | 2015 | World Journal of Cardiology2015，7，8： | 10 |
| 2 | Impact of Platelet Reactivity After Clopidogrel Administration on Drug-Eluting Stent Thrombosis显示文摘 | Piergiovanni Buonamici Rossella Marcucci Angela Migliorini Gian Franco Gensini Alberto Santini Rita Paniccia Guia Moschi Anna Maria Gori Rosanna Abbate David Antoniucci | 2007 | Journal of the American College of Cardiology2007，，： | 2 |
| 3 | Clinical significance of glycated hemoglobin in the acute phase of ST elevation myocardial infarction显示文摘In population-based studies,including diabetic and nondiabetic cohorts,glycated hemoglobin A1c(HbA1c) has been reported as an independent predictor of allcause and cardiovascular disease mortality.Data on the prognostic role of HbA1c in patients with acute myocardial infarction(MI) are not univocal since they stem from studies which mainly differ in patients' selection criteria,therapy(thrombolysis vs mechanical revascularization) and number consistency.The present review is focused on available evidence on the prognostic significance of HbA1c measured in the acute phase in patients with ST-elevation myocardial infarction(STEMI) submitted to primary percutaneous coronary intervention(PCI).We furthermore highlighted the role of HbA1c as a screening tool for glucose intolerance in patients with STEMI.According to available evidence,in contemporary cohorts of STEMI patients submitted to mechanical revascularization,HbA1c does not seem to be associated with short and long term mortality rates.However,HbA1c may represent a screening tool for glucose intolerance from the early phase on in STEMI patients.On a pragmatic ground,an HbA1c testhas several advantages over fasting plasma glucose or an oral glucose tolerance test in an acute setting.The test can be performed in the non-fasting state and reflects average glucose concentration over the preceding 2-3 mo.We therefore proposed an algorithm based on pragmatic grounds which could be applied in STEMI patients without known diabetes in order to detect glucose intolerance abnormalities from the early phase.The main advantage of this algorithm is that it may help in tailoring the follow-up program,by helping in identifying patients at risk for the development of glucose intolerance after MI.Further validation of this algorithm in prospective studies may be required in the contemporary STEMI population to resolve some of these uncertainties around HbA1c screening cutoff points. | Chiara Lazzeri Serafina Valente Marco Chiostri Maria Grazia D'Alfonso Gian Franco Gensini | 2014 | World Journal of Cardiology2014，6，4： | 2 |
| 4 | Hepatitis C virus RNA localization in human carotid plaques显示文摘 | Maria Boddi Rosanna Abbate Benedetta Chellini Betti Giusti Carlo Giannini Giovanni Pratesi Luciana Rossi Carlo Pratesi Gian Franco Gensini Laura Paperetti Anna Linda Zignego | 2009 | Journal of Clinical Virology2009，，1： | 2 |
| 5 | A more meaningful scoring system for determining the severity of coronary heart disease显示文摘 | Gensini GG | 1983 | Am J Cardiol1983，51，3： | 2 |
| 6 | A Reporting System on Patients Evaluated for Coronary Artery Disease显示文摘 | W. GERALD AUSTEN JESSE E. EDWARDS ROBERT L. FRYE GOFFREDO G. GENSINI VINCENT L. GOTT LAWRENCE S. C. GRIFFITH DWIGHT C. MCGOON MARVIN L. MURPHY BENSON B. ROE | 1975 | Circulation1975，，4： | 2 |
| 7 | Lone and secondary nonvalvular atrial fibrillation: role of a genetic suseeptibility显示文摘 | FATINI C STICCHI E GENSINI F | 2007 | Int J Cardiol2007，120，： | 1 |
| 8 | A more meaningful scoring system for deter- mining the severity of coronary heart disease 显示文摘 | Gensini GG | 1983 | Am J Cardiol1983，51，3： | 1 |
| 9 | A more meaningful scoring system for deter- mining the severity of coronary heart disease 显示文摘 | Gensini GG | 1983 | Am J Cardiol1983，51，3： | 1 |
| 10 | A more meaningful scoring system for determining the severity of coronary heart disese显示文摘 | Gensini GG | 1983 | Am J Cardiol1983，51，6： | 1 |
| 11 | A more meaningful scoring system for determining the severity of coronary heart diseases显示文摘 | Gensini GG | 1983 | Am J Cardiol1983，51，3： | 1 |
| 12 | A more meaningful scoring system for determining the severity of coronary heart disease显示文摘 | Gensini CG | 1994 | Am J Cardiol1994，51，： | 1 |
| 13 | Lone and secondary nonvalvular atrial fibrillation:role of a genetic susceptibility显示文摘 | Fatird C Sticehi E Gensini F | 2007 | Int J Cardial2007，120，1： | 1 |
| 14 | Six minute walk test:a simple and useful test to evaluate functional capacity in patients with heart failure显示文摘 | Rostagno C Gensini GF | 2008 | Intern Emerg Med2008，3，3： | 1 |
| 15 | A more meaningful scoring system for determining the severity of coronary heart disease显示文摘 | Gensini GG | 1983 | Am J Cardiol1983，51，3： | 1 |
| 16 | A more meaningful scoring system for determining the severity of coronary heart disease显示文摘 | Gensini GG | 1983 | Am J Cardiol1983，51，3： | 1 |
| 17 | ACE DD genotype: an independent predisposition factor to venous thromboembolism显示文摘 | FATINI C GENSINI F STICCHI E | 2003 | Eur J Clin Invest2003，33，： | 1 |
| 18 | A more meaningful scoring system for determining the severity of coronary heart disease显示文摘 | Gensini GG | 1983 | Am J Cardiol1983，51，5： | 1 |
| 19 | A more meaningful scoring system for determiningthe severity of coronary heart disease显示文摘 | GENSINI GG | 1983 | Am J Cardiol1983，51，3： | 1 |
| 20 | A More meaningful scoring system for determining the severity of coronary heart disease显示文摘 | Gensini GG | 1983 | Am J Cardiol1983，51，： | 1 |
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