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| 1 | Benign liver tumors in pediatric patients-Review with emphasis on imaging features显示文摘Benign hepatic tumors are commonly observed in adults,but rarely reported in children.The reasons for this remain speculative and the exact data concerning the incidence of these lesions are lacking.Benign hepatic tumors represent a diverse group of epithelial and mesenchymal tumors.In pediatric patients,most benign focal liver lesions are inborn and may grow like the rest of the body.Knowledge of pediatric liver diseases and their imaging appearances is essential in order to make an appropriate differential diagnosis.Selection of the appropriate imaging test is challenging,since it depends on a number of age-related factors.This paper will discuss the most frequently encountered benign liver tumors in children(infantile hepatic hemangioendothelioma,mesenchymal hamartoma,focal nodular hyperplasia,nodular regenerative hyperplasia,and hepatocellular adenoma),as well as a comparison to the current knowledge regarding such tumors in adult patients.The current emphasis is on imaging features,which are helpful not only for the initial diagnosis,but also for pre- and posttreatment evaluation and follow-up.In addition,future perspectives of contrast-enhanced ultrasound(CEUS) in pediatric patients are highlighted,with descriptions of enhancement patterns for each lesion being discussed.The role of advanced imaging tests such as CEUS and magnetic resonance imaging,which allow for non-invasive assessment of liver tumors,is of utmost importance in pediatric patients,especially when repeated imaging tests are needed and radiation exposure should be avoided. | Liliana Chiorean Xin-Wu Cui Andrea Tannapfel Doris Franke Martin Stenzel Wojciech Kosiak Dagmar Schreiber-Dietrich J?rg Jüngert Jian-Min Chang Christoph F Dietrich | 2015 | World Journal of Gastroenterology2015，21，28： | 16 |
| 2 | Endoscopic ultrasound elastography: current status and future perspectives显示文摘Elastography is a new ultrasound modality that provides images and measurements related to tissue stiffness. Endoscopic ultrasound(EUS) has played an important role in the diagnosis and management of numerous abdominal and mediastinal diseases. Elastography by means of EUS examination can assess the elasticity of tumors in the proximity of the digestive tract that are hard to reach with conventional transcutaneous ultrasound probes, such as pancreatic masses and mediastinal or abdominal lymph nodes, thus improving the diagnostic yield of the procedure. Results from previous studies have promised benefits for EUS elastography in the differential diagnosis of lymph nodes, as well as for assessing masses with pancreatic or gastrointestinal(GI) tract locations. It is important to mention that EUS elastography is not considered a modality that can replace biopsy. However, it may be a useful adjunct, improving the accuracy of EUSfine needle aspiration biopsy(EUS-FNAB) by selecting the most suspicious area to be targeted. Even more, it may be useful for guiding further clinical management when EUS-FNAB is negative or inconclusive. In the present paper we will discuss the current knowledge of EUS elastography, including the technical aspects, along with its applications in the differential diagnosis between benign and malignant solid pancreatic masses and lymph nodes, as well as its aid in the differentiation between normal pancreatic tissues and chronic pancreatitis. Moreover, the emergent indication and future perspectives are summarized, such as the benefit of EUS elastography in EUS-guided fine needle aspiration biopsy, and its uses for characterization of lesions in liver, biliary tract, adrenal glands and GI tract. | Xin-Wu Cui Jian-Min Chang Quan-Cheng Kan Liliana Chiorean Andre Ignee Christoph F Dietrich | 2015 | World Journal of Gastroenterology2015，21，47： | 8 |
| 3 | Ultrasonographic imaging of inflammatory bowel disease in pediatric patients显示文摘Inflammatory bowel disease(IBD) is one of the most common chronic gastrointestinal diseases in pediatric patients.Choosing the optimal imaging modality for the assessment of gastrointestinal disease in pediatric patients can be challenging.The invasiveness and patient acceptance,the radiation exposure and the quality performance of the diagnostic test need to be considered.By reviewing the literature regarding imaging in inflammatory bowel disease the value of ultrasound in the clinical management of pediatric patients is highlighted.Transabdominal ultrasound is a useful,noninvasive method for the initial diagnosis of IBD in children;it also provides guidance for therapeutic decisions and helps to characterize and predict the course of the disease in individual patients.Ultrasound techniques including color Doppler imaging and contrast-enhanced ultrasound are promising imaging tools to determine disease activity and complications.Comparative studies between different imaging methods are needed. | Liliana Chiorean Dagmar Schreiber-Dietrich Barbara Braden Xin-Wu Cui Reiner Buchhorn Jian-Min Chang Christoph F Dietrich | 2015 | World Journal of Gastroenterology2015，21，17： | 7 |
| 4 | A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma显示文摘 | Gregory L. Beatty Drew A. Torigian E. Gabriela Chiorean Babak Saboury Alex Brothers Abass Alavi Andrea B. Troxel Weijing Sun Ursina R. Teitelbaum Robert H. Vonderheide Peter J. O’Dwyer | 2013 | Clinical Cancer Research2013，，22： | 6 |
| 5 | Complications Associated With Double Balloon Enteroscopy at Nine US Centers显示文摘 | Lauren B. Gerson Jeffrey Tokar Michael Chiorean Simon Lo G. Anton Decker David Cave Doumit BouHaidar Daniel Mishkin Charles Dye Oleh Haluszka Jonathan A. Leighton Alvin Zfass Carol Semrad | 2009 | Clinical Gastroenterology and Hepatology2009，，11： | 2 |
| 6 | Spontaneous regression ofcolonic lymphoma following infliximab and azathioprinewithdrawal in patients with Crohn's disease显示文摘 | Flynn AD Azar JM Chiorean MV | 2013 | Inflamm Bowel Dis2013，19，5： | 1 |
| 7 | Radiologic in- vestigations complement and add diagnostic information to capsule endoscopy of small-bowel diseases 显示文摘 | Maglinte DD Sandrasegaran K Chiorean M | 2007 | Am J Roentgenol2007，189，： | 1 |
| 8 | Complications Associated With Double Balloon Enteroscopy at Nine US Centers显示文摘 | Lauren B. Gerson Jeffrey Tokar Michael Chiorean Simon Lo G. Anton Decker David Cave Doumit BouHaidar Daniel Mishkin Charles Dye Oleh Haluszka Jonathan A. Leighton Alvin Zfass Carol Semrad | 2009 | Clinical Gastroenterology and Hepatology2009，，11： | 1 |
| 9 | Trastuzumab and inter- leukin-2 in HER2-positive metastatic breast cancer:a pilot study 显示文摘 | Repka T Chiorean EG Gay J | 2003 | Clin Cancer Res2003，9，7： | 1 |
| 10 | Neuroendocrine tumor of gallbladder with liver and retroperitoneal, metastases and a good response to the chemotherapeutical treatment显示文摘 | Chiorean L Bartos A Pelau D | 2015 | J Med Ultra- son2015，42，2： | 1 |
| 11 | A prospective evaluation of comput- erized tomographyic (CT)scanning as a screening modality for esophageal varices显示文摘 | Kim E Chiorean M V Fidler J L | 2008 | Hepatology2008，47，5： | 1 |
| 12 | A prospective evaluation of computerized tomographic (CT) scanning as a screening modality for esophageal varices显示文摘 | Perri RE Chiorean MV Fidler JL | 2008 | Hepatology2008，47，5： | 1 |
| 13 | CD40 ag-onists alter tumor stroma and show efficacy against pancre-atic carcinoma in mice and humans显示文摘 | Beatty G L Chiorean E G Fishman M P | 2011 | Science2011，331，6024： | 1 |
| 14 | Imatinib mesylate induces apoptosis in human cholangiocarcinoma ceils 显示文摘 | Chiorean M V Guicciardi M E Yoon J H | 2004 | Liver Int2004，24，6： | 1 |
| 15 | The biology of natural killer cells anti implication for therapy of human disease 显示文摘 | Chiorean EG Miller JS | 2002 | J Hematother Stem Cell Res2002，10，4： | 1 |
| 16 | Locally advanced pancreatic cancer:current therapeutic approach显示文摘 | Cardenes HR Chiorean EG Dewitt J | 2006 | Oncologist2006，11，6： | 1 |
| 17 | CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans显示文摘 | Beatty GL Chiorean EG Fishman MP | 2011 | Science2011，331，6024： | 1 |
| 18 | Prognostic factors of survival in a randomized phase Ill trial (MPACT) of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone in pa- tients with metastatic pancreatic cancer显示文摘 | Tabernero J Chiorean EG Infante JR | 2015 | Oncologist2015，20，2： | 1 |
| 19 | A prospective evaluation of computerized tomographic(CT)scanning as a screening modal ity for oesophageal varices 显示文摘 | Perri RE Chiorean MV Fidler JL | 2008 | Hepatology2008，47，5： | 1 |
| 20 | Trastuzumab and interleukin-2 in HER2-positive metastatic breast cancer: A pilot study显示文摘 | Repka T Chiorean E G Gay J | 2003 | Clin Cancer Res2003，9，7： | 1 |
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