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| 1 | Large-sized bone defect repair by combining a decalcified bone matrix framework and bone regeneration units based on photo-crosslinkable osteogenic microgels显示文摘Physiological repair of large-sized bone defects is great challenging in clinic due to a lack of ideal grafts suitable for bone regeneration.Decalcified bone matrix(DBM)is considered as an ideal bone regeneration scaffold,but low cell seeding efficiency and a poor osteoinductive microenvironment greatly restrict its application in large-sized bone regeneration.To address these problems,we proposed a novel strategy of bone regeneration units(BRUs)based on microgels produced by photo-crosslinkable and microfluidic techniques,containing both the osteogenic ingredient DBM and vascular endothelial growth factor(VEGF)for accurate biomimic of an osteoinductive microenvironment.The physicochemical properties of microgels could be precisely controlled and the microgels effectively promoted adhesion,proliferation,and osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in vitro.BRUs were successfully constructed by seeding BMSCs onto microgels,which achieved reliable bone regeneration in vivo.Finally,by integrating the advantages of BRUs in bone regeneration and the advantages of DBM scaffolds in 3D morphology and mechanical strength,a BRU-loaded DBM framework successfully regenerated bone tissue with the desired 3D morphology and effectively repaired a large-sized bone defect of rabbit tibia.The current study developed an ideal bone biomimetic microcarrier and provided a novel strategy for bone regeneration and large-sized bone defect repair. | Junxiang Hao Baoshuai Bai Zheng Ci Jincheng Tang Guanhuai Hu Chengxiang Dai Mengyuan Yu Meng Li Wei Zhang Yixin Zhang Wenjie Ren Yujie Hua Guangdong Zhou | 2022 | Bioactive Materials2022，7，8： | 2 |
| 2 | The growth of private hospitals and their health workforce in Chi- na: a comparison with public hospitals 显示文摘 | Tang Chengxiang Zhang Yucheng Chen Lieping | 2014 | Health Policy Plan2014，，29： | 1 |
| 3 | The growth of private hospitals and their health workforce in China:a comparison with public hospitals显示文摘 | Tang Chengxiang Zhang Yucheng Chen Lieping | 2014 | Health Policy Plan2014，29，： | 1 |
| 4 | The growth of private hospitals and their health workforce in China: a comparison with public hospitals 显示文摘 | Chengxiang Tang Yucheng Zhang Lieping Chcn ct al | 2014 | Health Policy and Planning2014，29，： | 1 |
| 5 | Overexpression ofGbERF confers alteration of ethylene-responsive gene expression and enhanced resistance toPseudomonas syringae in transgenic tobacco显示文摘 | Jie Qin Kaijing Zuo Jingya Zhao Hua Ling Youfang Cao Chengxiang Qiu Fupeng Li Xiaofen Sun Kexuan Tang | 2006 | Journal of Biosciences2006，，2： | 1 |
| 6 | The AKT-independent MET–V-ATPase–MTOR axis suppresses liver cancer vaccination显示文摘Despite recent progress in hepatitis treatment,there have been no significant advances in the development of liver cancer vaccines in recent years.In this study,we investigated the regulatory effect and potential mechanism of hepatocyte growth factor receptor(MET,also known as HGFR)on tumor vaccinations for liver cancer in mice.Herein,we demonstrate that MET expression is significantly associated with the immunogenicity of liver cancer in mice and humans,and that MET depletion dramatically enhances the protective efficacy of chemotherapy-based anti-liver cancer vaccination.Mechanistically,MET repressed liver cancer immunogenicity independent of the traditional PI3K–AKT cascade,and MET interacted with vacuolar ATP synthase(V-ATPase)and mediated the activation of mammalian target of rapamycin(MTOR),thus suppressing liver cancer immunogenicity.The efficacy of chemotherapy-based liver cancer vaccination was markedly enhanced by targeting the MET–V-ATPase–MTOR axis,highlighting a translational strategy for identifying MET-associated drug candidates for cancer prevention. | Xing Huang Xingyuan Xu Xun Wang Tianyu Tang Enliang Li Xiaozhen Zhang Jian Xu Hang Shen Chengxiang Guo Tao Xu Jianhong Ren Xueli Bai Tingbo Liang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 7 | Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer’s disease:a phaseⅠ/Ⅱclinical trial显示文摘Background There have been no effective treatments for slowing or reversing Alzheimer’s disease(AD)until now.Growing preclinical evidence,including this study,suggests that mesenchymal stem cells-secreted exosomes(MSCs-Exos)have the potential to cure AD.Aims The first three-arm,drug-intervention,phase I/II clinical trial was conducted to explore the safety and efficacy of allogenic human adipose MSCs-Exos(ahaMSCs-Exos)in patients with mild to moderate AD.Methods The eligible subjects were assigned to one of three dosage groups,intranasally administrated with ahaMSCs-Exos two times per week for 12 weeks,and underwent follow-up visits at weeks 16,24,36 and 48.Results No adverse events were reported.In the medium-dose arm,Alzheimer’s Disease Assessment Scale–Cognitive section(ADAS-cog)scores decreased by 2.33(1.19)and the basic version of Montreal Cognitive Assessment scores increased by 2.38(0.58)at week 12 compared with baseline levels,indicating improved cognitive function.Moreover,the ADAS-cog scores in the medium-dose arm decreased continuously by 3.98 points until week 36.There were no significant differences in altered amyloid or tau deposition among the three arms,but hippocampal volume shrank less in the medium-dose arm to some extent.Conclusions Intranasal administration of ahaMSCs-Exos was safe and well tolerated,and a dose of at least 4×10^(8)particles could be selected for further clinical trials. | Xinyi Xie Qingxiang Song Chengxiang Dai Shishuang Cui Ran Tang Suke Li Jing Chang Ping Li Jintao Wang Jianping Li Chao Gao Hongzhuan Chen Shengdi Chen Rujing Ren Xiaoling Gao Gang Wang | 2023 | General Psychiatry2023，36，5： | 0 |
| 8 | E3泛素连接酶SINAT通过光信号调控BR转录因子BES1的蛋白稳定性显示文摘文章简介油菜素甾醇(BRs)是一类促进植物生长的类固醇激素,可以调控植物多方面的生长发育过程。已有的研究表明,BES1/BZR1的活性和功能主要取决于对其磷酸化状态和蛋白稳定性的调控,但对于BES1/BZR1的调控机制尤其是降解机制,仍需进一步探究。 | Mengran Yang Chengxiang Li Zhenying Cai Yinmeng Hu Trevor Nolan Feifei Yu Yanhai Yin Qi Xie Guiliang Tang 王学路 | 2018 | 科学新闻2018，0，4： | 0 |
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