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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018,10,9: | 4 |
| 2 | Timing of metamorphosis and estuarine arri-val across the dispersal range of the Japanese eel Anguilla japonica显示文摘 | Cheng P W Tzeng W N | 1996 | Marine Ecology - Progress Series1996,131,13: | 1 |
| 3 | Metabolic monitoring of the electrically stimulated single heart cell within a microfluidic platform显示文摘 | CHENG W KLAUKE N SEDGWICK H | 2006 | Lab on a Chip2006,6,11: | 1 |
| 4 | Expression of PPAR-gamma in human hilar bile duct carcinoma cell line QBC939 and the effects of PPAR-Y activated by its ligand on the growth of QBC939显示文摘 | CHENG W CHENG N S XIONG X Z | 2006 | Journal of Sichuan University (Med- ical Science Edition)2006,37,5: | 1 |
| 5 | Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride显示文摘 | Lee C Y Peng W H Cheng H Y Chen F N Lai M T | 2006 | The American Journal of Chinese Medicine2006,34,3: | 1 |
| 6 | Coronary vasospasm-induced acute coronary syndrome complicated by life-threatening cardiac arrhythmias in patients without hemodynamically significant coronary artery disease显示文摘 | Hung M J Cheng C W Yang N I | 2007 | Int J Cardiol2007,117,1: | 1 |
| 7 | Parallel genetic simulated annealing: a massively parallel SIMD algorithm显示文摘 | Cheng H Flann N S Watson D W | 1998 | IEEE Transactions on Parallel and Distributed Systems1998,9,2: | 1 |
| 8 | Robust stabilization for uncertain discrete singular systems显示文摘 | Xu S Y Cheng W Y Yu G N James Lam | 2001 | Automatica2001,37,5: | 1 |
| 9 | Comparison of the Etest and broth microdilution method for tigecycline susceptibility testing against clinical isolates ofAcinetobacter baumannii from Taiwan显示文摘 | Liu J W Jang T N Cheng Y J | 2010 | Int JAntimicrob Agents2010,35,2: | 1 |
| 10 | Fungicidal effect of am- photericin B in urine: In vitro study to assess feasibility of bladder wash-out for localization of site of candidacies显示文摘 | Fong I W Cheng P C Hinton N A | 2012 | Ani- microbial Agents and Chemotherapy2012,35,9: | 1 |
| 11 | Metabolic monitoring of the electrically stimulated single heart cell within a micrufluidic platform 显示文摘 | CHENG W KLAUKE N SEDGWICK H | 2006 | Lab on a Chip2006,6,11: | 1 |
| 12 | Proteomic analysis of pre-diapause, diapause and post-diapause larvae of the wheat blossom midge, Sitodiplosismosellana ( Diptera : Cecidomyiidae ) 显示文摘 | Cheng W N Li X L Yu F | 2009 | European Journal of Entomology2009,106,1: | 1 |
| 13 | Hepatitis C virus-induced upregulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling显示文摘 | Zhang Y Wei W Cheng N | 2012 | Hepatology2012,56,5: | 1 |
| 14 | The association between birthweight 4 000 g or greater and perinatal outcomes in patients with and without gestational diabetes显示文摘 | Esakoff T F Cheng Y W Sparks T N | 2009 | Am J Obstet Gynecol2009,200,: | 1 |
| 15 | The study of sludge characteristics for one-stage autothermal ther- mophilic aerobic digestion process显示文摘 | Cheng J H Zhang Y Y Zhu N W | 2011 | Adv Mater Res2011,,: | 1 |
| 16 | Extending the Understanding of End User Information Systems Satisfaction Formation: an Equitable Needs Fulfillment Model Approach 显示文摘 | Au N Ngai E W T Cheng T C E | 2008 | MIS Quarterly2008,32,1: | 1 |
| 17 | Exploring the sensitive indicators of uterotrophic assay in immature SD rats exposed to para-nonylphenol显示文摘 | Hunag Y N Cheng W B Xu P Y | 2004 | Sichuan Da Xue Xue Bao Yi Xue Ban2004,35,1: | 1 |
| 18 | Vascular endothelial growth factor in cervical carcinoma显示文摘 | Cheng W F Chen C A Lee C N | | 0,,05: | 1 |
| 19 | Extending the understanding of end user information systems satisfaction formation= An equitable needs fulfillment model approach 显示文摘 | Au N Ngai W T Cheng T C | 2008 | MIS Quarterly2008,32,1: | 1 |
| 20 | Messenger RNAexpression of translationally controlled tumor protein(TCTP) in liver regeneration and cancer显示文摘 | ZHU W L CHENG H X HAN N | 2008 | AnticancerRes2008,28,3: | 1 |