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| 1 | Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy显示文摘Primary ovarian insufficiency(POI)is an ovarian dysfunction that affects more than 1%of women and is characterized by hormone imbalances that afflict women before the age of 40.The typical perimenopausal symptoms result from abnormal levels of sex hormones,especially estrogen.The most prevalent treatment is hormone replacement therapy(HRT),which can relieve symptoms and improve quality of life.However,HRT cannot restore ovarian functions,including secretion,ovulation,and fertility.Recently,as part of a developing field of regenerative medicine,stem cell therapy has been proposed for the treatment of POI.Thus,we recapitulate the literature focusing on the use of stem cells and biomaterials for POI treatment,and sum up the underlying mechanisms of action.A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies. | Sichen Zhang Dashuai Zhu Xuan Mei Zhenhua Li Junlang Li Mengjie Xie Halle Jiang Williams Lutz Shaowei Wang Ke Cheng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 2 | The determinant representation of the gauge transformation for the discrete KP hierarchy显示文摘A successive gauge transformation operator Tn+k for the discrete KP(dKP) hierarchy is defined,which is involved with two types of gauge transformations operators.The determinant representation of the Tn+k is established and it is used to get a new τ function τ(n+k) of the dKP hierarchy from an initial τ.In this process,we introduce a generalized discrete Wronskian determinant and some useful properties of discrete difference operators. | Liu ShaoWei Cheng Yi He JingSong | 2010 | Science China Mathematics2010，53，5： | 6 |
| 3 | Discovery of Early Paleozoic Garnet Amphibolite in the Wenquan Complex,Northern Margin of the Yili Block,NW China显示文摘Objective High-pressure(HP)and ultrahigh-pressure(UHP)minerals tend to be preserved in mafic and ultramafic metamorphic rocks(e.g.eclogites and garnet amphibolite)rather than felsic rocks.Generally,HP and UHP rocks are thought to be formed as a result of the tectonic burial or subduction of oceanic crust or thicked continental lithosphere to depths corresponding to the eclogite facies metamorphism,followed by fast uplift(Ernst et al.,2007). | CHEN Youxin CHENG Kaikai PEI Xianzhi WANG Meng ZHAO Shaowei LI Zuochen LI Ruibao PEI Lei GAO feng | 2021 | Acta Geologica Sinica(English Edition)2021，95，2： | 3 |
| 4 | Syntheses and Insecticidal Activity of Spirocyclic Tetronic Acid Derivatives Containing Oxime Ether Moiety显示文摘In order to develop novel spirocyclic tetronic acid lead compounds,a series of new spirocyclic tetronic acid derivatives containing oxime ether moiety was synthesized and bioassayed.The stmctures of 16 target compounds were characterized by lH NMR spectra,13C NMR spectra and high-resolution mass spectrometer(HRMS).Preliminary bioassays indicated that most of the title compounds displayed excellent insecticidal activity against Aphis fabae and Nilapmyata lugens at 100 mg/L.In particular,compound 6k showed the similar activity(LC50=6.87 mg/L)against A.fabae as the spirotetramat(LC50=4.56 mg/L)and had better efIects(LC50=l.64 mg/L)against N.lugens in comparison with spirotetramat(LC5o=7.90 mg/L).The study showed that compound 6k exhibited more promising and broad-spectrum insecticide activity and may serve as a new insecticidal agent for sucking pests. | ZHAO Yang CHENG Jingli XIE Zhengang FANG Shaowei ZHAO Jinhao | 2020 | Chemical Research in Chinese Universities2020，36，5： | 3 |
| 5 | Statistical investigation on resistance spot welding quality using a two-state,sliding-level experiment显示文摘 | Cheng Shaowei Jack Hu S | 2001 | Journal of Manufacturing Science and Engineering2001，123，3： | 1 |
| 6 | Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design显示文摘Varicella-zoster virus(VZV)is a highly infectious agent responsible for both varicella and herpes zoster disease.Despite high efficacy,there remain safety and accessibility concerns with the licensed vaccines.Here,we sought to produce a VZV g E immunogen using an E.coli expression system.We found that the soluble expression and yield of g E protein could be enhanced via C-terminal truncations to the protein,thereby facilitating a robust and scalable purification process for the purpose of vaccine manufacturing.The lead truncated g E(aa 31–358),hereafter referred to as tg E,was a homogenous monomer in solution and showed excellent antigenicity.Finally,we assessed and compared the immunogenicity of tg E with commercial v Oka LAV and Shingrix vaccine.We found that aluminum-adjuvanted tg E was immunogenic as compared with v Oka LAV.When adjuvanted with AS01B,a two-dose immunization of tg E showed comparable or better potency in antibody responses and cell-mediated immunity with those of the Shingrix vaccine at the same dosage,especially in terms of the proportion of IFN-γ-expressing CD4^(+)T cells.In conclusion,this method of E.coli-mediate tg E expression offers a cost-effective and scalable strategy to generate an ideal VZV g E immunogen for the development of both varicella and zoster vaccines. | Tingting Chen Jie Sun Sibo Zhang Tingting Li Liqin Liu Wenhui Xue Lizhi Zhou Siting Liang Zhili Yu Qingbing Zheng Hai Yu Tong Cheng Jun Zhang Ying Gu Shaowei Li Ningshao Xia | 2023 | Science China(Life Sciences)2023，66，4： | 1 |
| 7 | Research on the Production Efficiency andUtilizing Rate of Potassium Fertilizer for Rape in Yunnan Province 显示文摘 | Minglian FU Genze U Xiaoyan YUAN Derong CHENG Xuan ZHU Shengguang WEI Hongyan LJ Shi PENG Yuankuan LEI Bin HE Heming WEN Shaowei YU | 2011 | Agricultural Science & Technology2011，12，14： | 1 |
| 8 | Fabrication of catalytically active Au/Pt/Pd trimetallic nanoparticles by rapid injection of NaBH4显示文摘 | Haijun Zhang Lilin Lu Yingnan Cao Shuang Du Zhong Cheng Shaowei Zhang | 2014 | Materials Research Bulletin2014，49，1： | 1 |
| 9 | A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse显示文摘Current contraceptive methods come with a number of drawbacks,including low efficacy,in the case of commercial contraceptive gels,and a reduction in the quality of sexual intercourse,in the case of condoms.Adding pharmacologically-active agents to contraceptive gels holds the potential to improve sexual experience,and hardbor safety and hygiene.In this study,we fabricated a carbomer-based contraceptive gel consisting of three agents:tenofovir,gossypol acetate,and nitroglycerin(TGN),with pH adjusted to 4.5(to be compatible with the vagina).In vitro,the gossypol component of the contraceptive gel proved to be an effective spermicide.When the concentration of gossypol acetate was 10 mg/ml,the spermicidal ability reached 100%after 30 s.In addition,tenofovir in the gel significantly inhibited lentiviral transfection efficiency in cell-containing media.In 6 pairs of rats,the gel successfully prevented all females from conceiving after successful mating.Moreover,increased sexual frequency and enhanced erection,which were promoted by the nitroglycerin in the components,were observed in male rats that had the gel applied to their penises.This novel TGN contraceptive gel yielded a higher contraceptive success rate than that of the commercial contraceptive gel(Contragel®).In addition,it has the added benefits to prevent sexually transmitted diseases and improve male libido and erectile function during sexual intercourse.Combining three FDA-approved and marketed agents together,our trifunctional TGN gel has a great potential for further translation and commercialization. | Mengjie Xie Junlang Li Sichen Zhang Dashuai Zhu Xuan Mei Zhenzhen Wang Xiao Cheng Zhenhua Li Shaowei Wang Ke Cheng | 2021 | Bioactive Materials2021，6，6： | 1 |
| 10 | Research on the Scientific and Technological Innovation of Research University and Its Strategic Measures显示文摘 | Yongbo Cheng Shaowei Ge | 2005 | 美中教育评论2005，2，3： | 0 |
| 11 | Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD显示文摘Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or vaccination.The rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus strain.Here,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron subvariants.Cryo-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric clashing.Bispecific antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant XBB.1.5.Together,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines. | Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia | 2024 | Protein & Cell2024，15，2： | 0 |
| 12 | Cloning and expression of aequorin genes from jellyfish Aequorea and characterization of aequorins activities显示文摘Two new aequorin genes,aeqxm and aeqxxm,were isolated from jellyfish Aequorea macrodactyla and Aequorea parva respectively,which are commonly found in the warmer waters on the coastal region of the East China Sea.The DNA sequences of the two genes have no introns and each one contains an ORF of 585 bp in full-length encoding a 195-aa protein.The two genes of aeqxm and aeqxxm share nucleotide homologies of 80.7% and 85.1% with AEVAQ440X respectively,and the corresponding proteins share amino acid homologies of 84.7% and 84.2% with AEVAQ440X.High amino acid homology was found between apoaeqxm and apoaeqxxm.The two genes were cloned into expression vector pTO -T7 respectively,and the expression yields amounted to 40% of the total protein in E.coli BL21.The activities of the two photoproteins were reconstituted by incubating the expressed apoproteins with coelenterazine f.In the presence of Ca ion,both of the regenerated aeqxm and aeqxxm exhibited an emission peak at the wave length of 470 nm. | Luo Wenxin(罗文新) Zhang Jun(张军) Li Shaowei(李少伟) Cheng Tong(程通) Chen Min(陈敏) Li Shaojing(李少菁) Xia Ningshao(夏宁邵) | 2002 | Acta Oceanologica Sinica2002，21，4： | 0 |
| 13 | Improvement of hydrogen permeation barrier performance by iron sulphide surface films显示文摘Fe–S compounds with hexagonal crystal structure are potential hydrogen permeation barrier during H2S corrosion. Hexagonal system Fe–S films were prepared on carbon steel through corrosion and CVD deposition, and the barrier effect of different Fe–S films on hydrogen permeation was tested using electrochemical hydrogen permeation method. After that, the electrical properties of Fe–S compound during phase transformation were measured using thermoelectric measurement system. Results show that the mackinawite has no obvious barrier effect on hydrogen penetration, as a p-type semiconductor, and pyrrhotite (including troilite) has obvious barrier effect on hydrogen penetration,as an n-type semiconductor. Hydrogen permeation tests showed peak permeation performance when the surface was deposited with a continuous film of pyrrhotite (Fe_(1–x)S) and troilite. The FeS compounds suppressed hydrogen permeation by the promotion of the hydrogen evolution reaction, semiconducting inversion from p-to n-type, and the migration of ions at the interface. | Pengpeng Bai Shaowei Li Jie Cheng Xiangli Wen Shuqi Zheng Changfeng Chen Yu Tian | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，9： | 0 |
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