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| 1 | In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. | Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 2 | Computer Modeling: an Important Tool in Materials Processing显示文摘The development of techniques to control and use materials, especially metallic materials continues to play a key role in the technological advancement of modem day society. A variety of materials processes have been developed overtime, and are applied to design and fabricate products. Heat treatment of metallic materials has been the method of choice applied to improve mechanical properties such as strength, hardness, and toughness, as well as to improve the homogeneity of properties in materials such as corrosion resistance. The molt significant success stories in the application of materials processes involve the heat-treatment of steel. The reasons for this largely lie in the ease with which steel microstructures can be altered by controlled heating and cooling. The objective of computer modeling of materials processes is to maximize on the beneficial factors while keeping to a minimum the negating effects such as components distortion and residual stresses. Computer modeling is a powerful tool in achieving this objective in the sense that with it, the effect of parameters associated with materials processes can be analyzed systematically in order to optimize them before actual production begins. | L.L Meekisho, X Chen Portland State University, P0 Box 751, Portland, Oregon 97207 USA Automated Analysis Corporation, Peoria, IL USA | 2000 | Journal of Shanghai Jiaotong university(Science)2000，5，1： | 10 |
| 3 | Pretreated quercetin protects gerbil hippocampal CA1 pyramidal neurons from transient cerebral ischemic injury by increasing the expression of antioxidant enzymes显示文摘Quercetin(QE; 3,5,7,3′,4′-pentahydroxyflavone), a well-known flavonoid, has been shown to prevent against neurodegenerative disorders and ischemic insults. However, few studies are reported regarding the neuroprotective mechanisms of QE after ischemic insults. Therefore, in this study, we investigated the effects of QE on ischemic injury and the expression of antioxidant enzymes in the hippocampal CA1 region of gerbils subjected to 5 minutes of transient cerebral ischemia. QE was pre-treated once daily for 15 days before ischemia. Pretreatment with QE protected hippocampal CA1 pyramidal neurons from ischemic injury, which was confirmed by neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B histofluorescence staining. In addition, pretreatment with QE significantly increased the expression levels of endogenous antioxidant enzymes Cu/Zn superoxide dismutase, Mn superoxide dismutase, catalase and glutathione peroxidase in the hippocampal CA1 pyramidal neurons of animals with ischemic injury. These findings demonstrate that pretreated QE displayed strong neuroprotective effects against transient cerebral ischemia by increasing the expression of antioxidant enzymes. | Bai Hui Chen Joon Ha Park Ji Hyeon Ahn Jeong Hwi Cho In Hye Kim Jae Chul Lee Moo-Ho Won Choong-Hyun Lee In Koo Hwang Jong-Dai Kim Il Jun Kang Jun Hwi Cho Bich Na Shin Yang Hee Kim Yun Lyul Lee Seung Min Park | 2017 | Neural Regeneration Research2017，12，2： | 9 |
| 4 | Colorectal neoplasm in asymptomatic Asians: a prospective multinational multicenter colonoscopy survey显示文摘 | Jeong-Sik Byeon Suk-Kyun Yang Tae Il Kim Won Ho Kim James Y.W. Lau Wai-Keung Leung Rikiya Fujita Govind K. Makharia Murdan Abdullah Ida Hilmi Jose Sollano Khay-Guan Yeoh Deng-Chyang Wu Min Hu Chen Pradermchai Kongkam Joseph J.Y. Sung | 2007 | Gastrointestinal Endoscopy2007，，： | 2 |
| 5 | Treatment with high-dose methylprednisolone for hepatic veno-occlusive disease in a child with rhabdomyosarcoma显示文摘 | Chen IL Yang SN Hsiao CC Wu KS Sheen JM | 2008 | Pediatr Neonatol2008，49，4： | 1 |
| 6 | Stability of a biological tissue fixedwitha naturally occurring crosslinking agent (genipin)显示文摘 | Sung HW Liang IL Chen CN | 2001 | J Biomed Mater Res2001，55，： | 1 |
| 7 | Induction of differention in rat C6 glioma cells with Saikosaponins显示文摘 | Tsai YJ Chen IL Horng LY | 2002 | Phytother Res2002，16，2： | 1 |
| 8 | Simultaneous quantification of anti-microbial agents for multidrug-resistant bacterial infections in human plasma by ultra-high-pressure liquid chromatography-tandem mass spectrometry显示文摘 | Tsai IL Sun HY Chen GY | 2013 | Talanta2013，116，： | 1 |
| 9 | Stability of a biological tissue fixed with a naturally occurring crosslinking agent (genipin)显示文摘 | Sung HW Liang IL Chen CN | 2001 | Journal of Biomedical Materials Research Part A2001，55，： | 1 |
| 10 | Coumarins and anti- platelet aggregation constituents from Zanthoxylurn schinfolium 显示文摘 | Chen IS Lin YC Tsai IL | 1995 | Phytochemistry1995，39，5： | 1 |
| 11 | Stability of a biological tissue fixed with a naturally occurring crosslinking agent (genipin) 显示文摘 | Sung HW Liang IL Chen CN | 2001 | Journal of the Biomedical Materials Research2001，55，4： | 1 |
| 12 | Using snowball sampling method with nurses to understand medication administration errors显示文摘 | Sheu SJ Wei IL Chen CH | 2009 | J Clin Nurs2009，18，4： | 1 |
| 13 | Studies on electrochemical behavior of copper in aerated NaBr solution with Schiff base显示文摘 | MA HY CHENS H NU IL | 2001 | Journal of the Electrochemical Society2001，148，5： | 1 |
| 14 | A pivotal role for the multifunctional calcium/calmodulin dependent protein kinase II in T cells: from activation to unresponsiveness 显示文摘 | Lin MY Zal T Chen IL | 2005 | J Immunol2005，9，55： | 1 |
| 15 | Lymphatic absorption of quercetin and rutin in rat and their pharmaeokinetics in systemic plasma显示文摘 | Chen IL Tsai fJ Huang CM | 2010 | J Agric Food Chem2010，58，： | 1 |
| 16 | Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives 显示文摘 | Wang TC Chen IL Lu PJ | 2005 | Bioorg Med Chem2005，13，21： | 1 |
| 17 | Using snowball sampling method with nurses to understand medication administration errors显示文摘 | Sheu SJ Wei IL Chen CH | 2009 | J Cline Uurs2009，18，4： | 1 |
| 18 | Acid-sensing ion channel 3,but not capsaicin receptor TRPV1,plays a protective role in isoproterenol-induced myocardial ischemia in mice显示文摘 | Cheng CF Chen IL Cheng MH | 2011 | Circ J2011，75，1： | 1 |
| 19 | Synthesis,antiproliferative,and antiplatelet activities of oxime-and methyloxime-containing flavone and isoflavone derivatives显示文摘 | Wang TC Chen IL Lu PJ | 2005 | Bioorg Med Chem2005，13，21： | 1 |
| 20 | Systemic administration of a water-soluble hexasulfonated C60(FC~4)reduces cerebral ischemia- induced infarct volume in gerbils 显示文摘 | Yang Dy Wang MF Chen IL | 2001 | Neurosci Lett2001，311，2： | 1 |
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