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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Restoration of pedicle screw fixation with an in situ setting calcium phosphate cement 显示文摘 | Moore DC Maitra RS arjo LA t al | 1997 | Spine1997，22，： | 2 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Comparative analysis of T-cell receptor gene rearrangements at diagnosis and T-cell acute lymphoblastic leukemia (T-ALL) shows high stability of clonal markers for monitoring of minimal residual disease,and reveals the occurrence of second T-ALl,显示文摘 | Szczepanski T van der Velden VH Raft T Jacobs DC van Wering ER Bruggemann M | 2003 | leukemia2003，17，11： | 1 |
| 5 | Molecular and immunological characterization of Mycobacterium tuberculosis CFP-10, an immunodiagnostic antigen missing in Mycobacterium boris BCG显示文摘 | Dillon DC Alderson MR Day CH Bement T Campos Neto A Skeiky YA Vedvick T Badaro R Reed SG Houghton R | 2000 | J Clin Microbiol2000，38，9： | 1 |
| 6 | Microvascular structure after embolic focal cerebral ischemia in the rat显示文摘 | Yeich T Khalighi MM | 2003 | Brain Res2003，972，： | 1 |
| 7 | Mechanisms of ischemic preconditioning显示文摘 | Yarimizu K Gute DC | 1997 | Shock1997，8，： | 1 |
| 8 | Combined analysis of risk factors for SUDEP显示文摘 | Hesdorffer DC Tomson T Benn E | 2011 | Epilepsia2011，52，： | 1 |
| 9 | Expression of VEGF and angiopoietins-1 and -2 during ischemia-induced coronary angiogenesis显示文摘 | Matsunaga T Warhier DC Tessmer J etal | 2003 | Am J Physiol Heart Circ Physiol2003，285，1： | 1 |
| 10 | Line bisection and unilateral visual neglect in patientswith neurologic impairment显示文摘 | Bradford DC Ajax ET | 1980 | Neurology1980，30，： | 1 |
| 11 | Viral myocarditis identification of five differentially expressed gene in coxasaki virus B3 infected mouse heart显示文摘 | Yang DC Yu T Lous ZS | 1999 | Circ Res1999，84，6： | 1 |
| 12 | Physician staffing patterns and clinical outcomes in critically illpatients:a systematic review显示文摘 | Pronovost PJ Angus DC Dorman T | 2002 | JAMA2002，288，17： | 1 |
| 13 | Hypoxia is a majorstimulator of osteoclast formation and bone resorption显示文摘 | Arnett TR Gibbon DC Utting JCe t al | | J Cell Physiol0，3196，1： | 1 |
| 14 | The prefusogenic intermediate of HIV-1 gp41 contains exposed C-peptide regions显示文摘 | KOSHIBA T CHAN DC | 2003 | J Biol Chem2003，278，9： | 1 |
| 15 | Testis-sparingsurgery versus radical orchiectomy in patients with Leydigcell tumors 显示文摘 | Loeser A Vergho DC Katzenberger T | 2009 | Urology2009，74，2： | 1 |
| 16 | Minimal treatment approaches for concerned significant othersof problem gamblers: a randomized controlled trial 显示文摘 | Hodgins DC Toneatto T Makarchuk K | 2007 | Journal of Gambling Studies2007，23，2： | 1 |
| 17 | Severe sepsis and septic shock显示文摘 | ANGUS DC VAN DER POLL T | 2013 | The New England journal of medicine2013，369，21： | 1 |
| 18 | Determinant s of plasma levels of brain natriuretic peptide after acute ischemic strok or TIA显示文摘 | Emanuele DA Stefano DC Danilo T | 2007 | J Neurol Sci2007，260，： | 1 |
| 19 | Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer显示文摘 | Bianco T Chenevix-Trench G Walsh DC | 2000 | Carcinogenesis2000，21，2： | 1 |
| 20 | Multiparametric 3T MR approch to the assessment of cerebral gliomas: tumor extent and malignancy显示文摘 | Alfonso DC Tommaso S Francesca T | 2006 | Neuroradiology2006，48，9： | 1 |
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