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| 1 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 2 | Long-term outcome after additional catheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis(the CaVenT study):a randomised controlled trial显示文摘 | Enden T Haig Y Klw NE | 2012 | Lancet2012，379，9810： | 1 |
| 3 | Azithromycin for the secondary prevention of coronary heart disease events:The WIZARD study:a randomized controlled trial显示文摘 | O'Con nor CM Dun ne M W Pfeffer M A | | 0，，： | 1 |
| 4 | Deciphering synergistic and redundant roles of Hedgehog, Deca pentaplegic and Delta that drive the wave of differentiation in Droso phila eye development显示文摘 | Fu W Baker NE | 2003 | Development2003，130，21： | 1 |
| 5 | Glucocortieoid-induced bone fragility 显示文摘 | Lane NE Yao W | 2010 | Ann N Y Acad Sei2010，1192，： | 1 |
| 6 | Basic fibroblast growth factor forms new trabeculae that physically connect with pre-existing trabeculae, and this new bone is maintained with an anti-resorptive agent and enhanced with an anabolic agent in an osteopenic rat model显示文摘 | Kumer J Yao W | 2003 | Osteoporos Int2003，14，5： | 1 |
| 7 | Changes in cortical thickness during the course of illness in schizophrenia 显示文摘 | van Haren NE Schnack HG Cahn W | 2011 | Arch Gen Psychiatry2011，68，： | 1 |
| 8 | Enhanced neoplastic transformation in an inhomogeneous radiation field:an effect of the presence of heavily damaged cells显示文摘 | Sigg M Crompton NE Burkart W | | 0，，06： | 1 |
| 9 | Catheter-directed ve-nous thrombolysis in acute iliofemoral vein thrombosis-the CaVenT study:rationale and design of a muhicenter,randomized,controlled,clinical trial(NCT00251771)显示文摘 | Enden T Sandvik L Klφw NE | 2007 | Am Heart J2007，154，5： | 1 |
| 10 | Teaching to inhale: better utilization of powder inhalators after counseling and instruction 显示文摘 | Van't Veer NE Lameijer W De Ley M | 2001 | Ned Tijdschr Geneeskd2001，145，5： | 1 |
| 11 | Nonlinear indicial response of complex nonstationary oscillations as pulmonary hypertension responding to step hypoxia显示文摘 | Huang W Shen Z Huang NE | 1999 | Proc Natl Acad Sci USA1999，96，5： | 1 |
| 12 | Long-term outcome after additional catheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis(the CaVenT study):a randomised controlled trial显示文摘 | Enden T Haig Y Kl?w NE | 2012 | Lancet2012，379，9810： | 1 |
| 13 | Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study显示文摘 | Ronenn Roubenoff Helen Parise Hélène A Payette Leslie W Abad Ralph D’Agostino Paul F Jacques Peter W.F Wilson Charles A Dinarello Tamara B Harris | 2003 | The American Journal of Medicine2003，，6： | 1 |
| 14 | Deciphering synergistic and redundant roles of Hedgehog, Deca- pentaplegic and Delta that drive the wave of differentiation in Drosophila eye deve lopment显示文摘 | Fu w Baker NE | 2003 | Development2003，130，21： | 1 |
| 15 | Effects of pravastatin on cardiovascular reactivity to norepinephrine and angiotensin II in patients with hypercholesterolemia and systemic hypertension 显示文摘 | Straznicky NE Howes LG Lam W | 1995 | Am J Cardiol1995，75，8： | 1 |
| 16 | Regulation of T-cen function by endogenously produced angiotensin 11 显示文摘 | Hoch NE Guzik TJ Chen W | 2009 | Am J Physiol Regul Integr Comp Physiol2009，296，2： | 1 |
| 17 | Treat- ment outcomes of AIDS-associated Kaposi's sarcoma un- der a routine antiretroviral therapy program in Lilongwe, Malawi: bleomycin/vincristine compared to vincristine monotherapy 显示文摘 | Mwafongo AA Rosenberg NE Ng'ambi W | 2014 | PLoS One2014，9，91： | 1 |
| 18 | Isoform expression of CD44 adhesion molecules, bcl2, p53 and Ki67 proteinsin lung cancer显示文摘 | Mizera NE Dyszkiewiez W Heider KH | 2000 | Tumor Biol2000，22，1： | 1 |
| 19 | Regu- lation of T - cell function by endogenously pro- dueed angiotensin 11 显示文摘 | Hoeh NE Guzik TJ Chen W | 2009 | Am J Physiol Reg- ul Integr Comp Physiol2009，296，2： | 1 |
| 20 | Astrocytes protect neurons from nitric oxide toxicity by a glutathione dependent mechanism 显示文摘 | Chen Y Vartiainen NE Ying W | 2001 | J Neurochem2001，77，： | 1 |
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