|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 2 | A New Arg54Gly Transthyretin Gene Mutation Associated with Vitreous Amyloidosis in Chinese显示文摘Purpose:To analyse the hereditary features of a Chinese pedigree with familial vitreous amyloidosis in Liaoning Province,China,and to investigate the correlation between the clinical appearance of the disease and transthyretin(TTR)gene mutation,including the locus and type of TTR gene mutation.Methods:Five patients (10 eyes) from one Chinese family were diagnosed with vitreous amyloidosis between July 1996 and April 2009.Family members were followed up subsequently,and peripheral venous blood was obtained from 13 subjects (including 2 patients,and 11 controls without clinical signs of disease).DNA samples were extracted and 4 exons of the TTR gene were amplified by polymerase chain reaction (PCR).The gene fragments were subjected to sequencing analysis.The results were analyzed with DNAMAN Windows 5.2.2.0 and Chromas sequence chart analysis software,TTR gene exons were compared between affected patients and normal controls.Results:Family pedigree analysis revealed that patients were distributed in three generations.Male and female subjects had equal prevalence,and only one parent of affected patients had signs of disease.TTR gene exon sequencing showed that the sequence of patients was identical to that of normal individuals.No TTR gene mutations were noted in 10 unaffected family members.However,a TTR Gly-54 point mutation in the 2nd exon was detected in two patients and 1 unaffected family member (one of the patients' daughters).Vitreous samples in 4 cases (7 eyes) showed positive Congo red staining,suggesting that these family members suffered from familial vitreous amyloidosis.Conclusion:This pedigree affected with familial vitreous amyloidosis was characterized by autosomal dominant inheritance;.a TTR Gly-54 point mutation in the 2nd exon is presumed to be the cause.This Gly-54 point mutation of the TTR gene is a novel mutation in vitreous amyloidosis. | Yining Shi Jing Li Jia Hu Jun Hu Lijun Sun Huijin Li Rui Shi Le Yang Ye Sun Chan Li | 2011 | Eye Science2011，26，4： | 9 |
| 3 | Formal verification of synchronous data-flow program transformations toward certified compilers显示文摘翻译确认被 Pnueli 等在 90 年代发明。作为一种技术到正式验证代码发电机的正确性。而非证明代码生成器或用尽一切地限制它,翻译验证程序试图证实程序转变保存语义。在这个工作,我们采用这条途径正式证实钟语义和数据依赖在信号编译器的编译期间被保存。翻译确认从起始的阶段为每个编译阶段被实现直到可执行的代码被产生的最近的阶段,由证明在编译器的每个阶段的转变保存语义。我们作为分别地被称为钟模型和同步依赖图(SDG ) 的一阶的公式代表钟语义,一个程序的数据依赖和它的转变对应物。我们然后分别地介绍表示钟语义和依赖的保藏的钟精炼和依赖精炼关系,作为钟模型和 SDG 上的一种关系。我们的验证程序不要求编译器,也不任何重写源程序的任何乐器学或修正。 | Van Chan NGO Jean-Pierre TALPIN Thierry GAUTIER Paul Le GUERNIC Loic BESNARD | 2013 | Frontiers of Computer Science2013，7，5： | 7 |
| 4 | Preliminary study of a dot immunogold filtration assay for rapid detection of anti-HCV IgG显示文摘INTRODUCTIONHepatitisCisaworldwideepidemicdiseasestemmingfromthehepatitisCvirus(HCV).HCVisnotonlythepathogenicfactorofhepati... | XIAO Le Yi 1, YAN Xiao Jun 1, MI Ming Ren 2, HAN Feng Chan 1 and HOU Yu 1 | 1999 | World Journal of Gastroenterology1999，5，4： | 7 |
| 5 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 6 | Transverse testicular ectopia detected by MR imaging and MR Venography 显示文摘 | Lam WM Le SD Chan KL | 2002 | Pediatr Radiol2002，32，2： | 1 |
| 7 | Radiation dose reduction in pediatric cranial CT显示文摘 | Chan CY Wang YC Chau LE | 1999 | Pediatr Radiol1999，29，： | 1 |
| 8 | Dendritic atrophy in children with Down's syndrome显示文摘 | Becker LE Armstrong DL Chan F | 1986 | Ann Neurol1986，20，4： | 1 |
| 9 | Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis 显示文摘 | Cheng LE Chan FK Cado D | 1997 | EMBO J1997，16，8： | 1 |
| 10 | The influ- ence of greening the suppliers and green innovation on environ- mental performance and competitive advantage in Taiwan 显示文摘 | CHIOU T Y CHAN H K LE'ITICE F | 2011 | Transportation Research Part E2011，47，6： | 1 |
| 11 | Radiaion dose reduction in pedia rivivranial CT显示文摘 | Chan CY Wang Y C Chau LE | 1999 | Pediar Radio1999，29，： | 1 |
| 12 | Understanding the Determinants of Program Organization for Construc- tion Megaproject Success: Case Study of the Shanghai Expo Construction显示文摘 | HU Y CHAN A P C LE Y | 2015 | Journal of Management in En- gineering2015，31，5： | 1 |
| 13 | Safety of zoster vaccine in elderly adults following documented herpes zoster 显示文摘 | Morrison VA Oxman MN Levin MJ Schmader KE Guatelli JC Betts RF Gelb LD Pachucki CT Keay SK Menzies B Griffin MR Kauffman CA Marques AR Toney JF Simberkoff MS Serrao R Arbeit RD Gnann JW Greenberg RN Holodniy M Keitel WA Yeh SS Davis LE Crawford GE Neuzil KM Johnson GR ZhangJH Harbecke R Chan IS Keller PM Williams HM Boardman KD Silber JL Annunziato PW Shingles Prevention Study Group | 2013 | J Infect Dis2013，208，4： | 1 |
| 14 | Identification of cardiacspecific myosin light chain kinase显示文摘 | Chan JY Takeda M Briggs LE | 2008 | Circ Res2008，102，5： | 1 |
| 15 | A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults 显示文摘 | Oxman MN Levin MJ Johnson GR Schmader KE Straus SE Gelb LD Arbeit RD Simberkoff MS Gershon AA Davis LE Weinberg A Boardman KD Williams HM Zhang JH Peduzzi PN Beisel CE Morrison VA Guatelli JC Brooks PA Kauffman CA Pachucki CT Neuzil KM Betts RF Wright PF Griffin MR Brunell P Soto NE Marques AR Keay SK Goodman RP Cotton DJ Gnann JW Jr Loutit J Holodniy M Keitel WA Crawford GE Yeh SS Lobo Z Toney JF Greenberg RN Keller PM Harbecke R Hayward AR Irwin MR Kyriakides TC Chan CY Chan IS Wang WW Annunziato PW Silber JL Shingles Prevention Study Group | 2005 | New Engl J Med2005，352，22： | 1 |
| 16 | Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial显示文摘 | Nancy Y Lee Qiang Zhang David G Pfister John Kim Adam S Garden James Mechalakos Kenneth Hu Quynh T Le A Dimitrios Colevas Bonnie S Glisson Anthony TC Chan K Kian Ang | 2012 | Lancet Oncology2012，，2： | 1 |
| 17 | Identification of cardiac-specific myosin light chain kinase显示文摘 | Chan JY Takeda M Briggs LE | 2008 | Circ Res2008，102，5： | 1 |
| 18 | Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines显示文摘 | Soriano AF Helfrich B Chan DC Heasley LE Bunn PA Jr Chou TC | 1999 | Cancer Res1999，59，24： | 1 |
| 19 | Functional redundancy of the Nur77and Nor-1 orphan steroid receptors in T-cell apoptosis 显示文摘 | Cheng LE Chan FK Cado D | 1997 | EMBO J1997，16，8： | 1 |
| 20 | Hormone replace-ment therapy and cognition : systematic review and meta-anal-ysis显示文摘 | Le Blanc E S Janowsky J Chan B K | 2001 | JAMA2001，285，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员