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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | TLR9 agonists oppositely modulate DN repair genes in tumor versus immune cells and enhance chemotherapy effects显示文摘 | Sommariva M De Cecco L De Cesare M | 2011 | Cancer Res2011，71，20： | 1 |
| 3 | The recreational value of coral reefs : A meta-analysis显示文摘 | Brander L M Beukering P V Cesar H SJ | 2007 | Ecological Economics2007，63，1： | 1 |
| 4 | High power density superconducting motor for all-electric aircraft propulsion 显示文摘 | Philippe J M Cesar A L | 2005 | IEEE Transaction on Applied Superconductivity2005，15，2： | 1 |
| 5 | Oxaliplatininduced oxidative stress in nervous system-derived cellular models:could it correlate with in vivo neuropathy?显示文摘 | Di Cesare Mannelli L Zanardelli M Failli P | 2013 | Free Radical Biology and Medicine2013，61，： | 1 |
| 6 | Enzyme stabili- zation by glutaraldehyde crosslinking of adsorbed proteins on aminated supports显示文摘 | Fernando L G Lorena B Cesar M | 2005 | Journal of Biotechnology2005，119，： | 1 |
| 7 | Performance of Drought Indices for Ecological, Agricultural, and Hydrological Applications显示文摘 | Vicente-Serrano Sergio M Beguería Santiago Lorenzo-Lacruz Jorge Camarero Jesús Julio López-Moreno Juan I Azorin-Molina Cesar Revuelto Jesús Morán-Tejeda Enrique Sanchez-Lorenzo Arturo | 2012 | EN2012，，10： | 1 |
| 8 | Improvement of enzymeactivity,stability and selectivity via immobilization techniques显示文摘 | CESAR M TOSE M P GLORIA F L | 2007 | En-zyme and Microbial Technology2007，40，6： | 1 |
| 9 | Polylysine induces changes in membrane electrical properties of K562 cells 显示文摘 | Santini M Cesare C Pietro L | 1997 | Journal of Biomedical Materials Research1997，35，2： | 1 |
| 10 | Oxaliplatin-induced neuropathy:oxidative stress as pathological mechanism显示文摘 | Di Cesare Mannelli L Zanardelli M Failli P | | 0，，03： | 1 |
| 11 | Oxaliplatin-induced neuropathy:oxidative stress as pathological mechanism显示文摘 | Di Cesare Mannelli L Zanardelli M Failli P | | 0，，03： | 1 |
| 12 | Highly efficient dye-sensitized solar cells based on carbon black counter electrodes显示文摘 | MURAKAMI T N ITO S WANG Q NAZEERUDDIN M K BESSHO T CESAR L LISKA P BAKER R H COMTE P PECHY P GRATZEL M | 2006 | Journal of the Electrochemical Society2006，153，12： | 1 |
| 13 | Polylysine induces changes in membrane electrical properties of K562 cells显示文摘 | Santini M Cesare C Pietro L | 1997 | Journal of Biomedical Materials Research1997，35，2： | 1 |
| 14 | Preclinical profile of antitumor activity of a novel hydrophilic camptothecin,ST1968显示文摘 | Pisano C De Cesare M Beretta G L | 2008 | Mol Cancer Ther2008，7，7： | 1 |
| 15 | Modulation of the enantioselectivity of lipases via controlled immobilization and medium engineering: hydrolytic resolution of mandelic acid esters显示文摘 | JOSE M P GLORIA F L CESAR M | 2002 | Enzyme and Microbial Technology2002，31，： | 1 |
| 16 | Realized heritabilities and genetic correlation after dual selection for total weight and shell width in catarina scallop ( Argopecten ventricosus )显示文摘 | Ana M Ibarra Jose L Ramirez Cesar A Ruiz Pedro Cruz Susana Avila | 1999 | Aquaculture1999，，3： | 1 |
| 17 | Optimizationof J3-glucosidase, |3-xylosidase and xylanase produc-tion by colletotrichum graminicoLa under solid-statefermentation and application in raw sugarcane trashsaccharification 显示文摘 | Ana L R L Z Cesar S?Luana P M | 2013 | Int J Mol Sci2013，14，2： | 1 |
| 18 | Sinus Bradycardia as a Predictor of Right Coronary Artery Occlusion in Patients with Inferior Myocardial Infarction 显示文摘 | Serrano C V Bortolotto L A Cesar L M | 1999 | International J Cardiol1999，68，： | 1 |
| 19 | Enzyme stabilization by glutaraldehyde crosslinking of adsorbed proteins on amiinated supports显示文摘 | FERNANDO L G LORENA B CESAR M | 2005 | J Biotechnology2005，119，1： | 1 |
| 20 | Excessive meat consumption in Brazil:diet quality and environmental impacts显示文摘 | DE CARVALHO A M CESAR C L G FISBERG R M | 2013 | Public Health Nutrition2013，16，10： | 1 |
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