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| 1 | Evolution and predictive factors of thyroid disorder due to interferon alpha in the treatment of hepatitis C显示文摘AIM:To study predictive factors of thyroid dysfunction associated with interferon-alpha(IFNα) therapy in chronic hepatitis C(CHC) and to describe its long-term evolution in a large population without previous thyroid dysfunction.METHODS:We performed a follow-up of thyroid function and detection of thyroid antibodies in 301 patients treated for CHC with IFNα from 1999 to 2004.RESULTS:Thyroid disorder developed in 30/301(10%) patients with a mean delay of 6 ± 3.75 mo:13 patients had hyperthyroidism,11 had hypothyroidism,and 6 had biphasic evolution.During a mean follow-up of 41.59 ± 15.39 mo,9 patients with hyperthyroidism,3 with hypothyroidism,and 4 with biphasic evolution normalized thyroid function in 7.88 ± 5.46 mo.Recovery rate of dysthyroidism was not modified by treatment discontinuation,but was better for patients with negative thyroid antibodies before antiviral treatment(P = 0.02).Women had signif icantly more dysthyroidism(P = 0.05).Positive thyroid peroxidase and thyroglobulin antibodies were more frequent before antiviral treatment in patients who developed dysthyroidism(P < 0.0003 and P = 0.0003,respectively).In a multivariate model,low fibrosis was found to be a predictive factor of dysthyroidism(P = 0.039).CONCLUSION:In this monocentric population of CHC,dysthyroidism,especially hyperthyroidism,developed in 10% of patients.Low fibrosis was found to be a predictive factor of dysthyroidism.Thyroid disorder recovered in 16/30 patients(53%) and recovery was better in the non-autoimmune form. | Moana Gelu-Simeon Aurore Burlaud Jacques Young Gilles Pelletier Catherine Buffet | 2009 | World Journal of Gastroenterology2009，15，3： | 8 |
| 2 | Characteristics of patients with dual infection by hepatitis B and C viruses显示文摘 | Jean-Pierre Zarski Benoit Bohn Anne Bastie Jean-Michel Pawlotsky Maryline Baud Frédérique Bost-Bezeaux Jeanne Tran van Nhieu Jean-Marie Seigneurin Catherine Buffet Daniel Dhumeaux | 1998 | Journal of Hepatology1998，，1： | 2 |
| 3 | Biliary obstruction caused by portal cavernoma: a study of 8 cases显示文摘 | Gabriel Perlemuter Hervé Béjanin Jacques Fritsch Frédéric Prat Marianne Gaudric Stanislas Chaussade Catherine Buffet | 1996 | Journal of Hepatology1996，，1： | 2 |
| 4 | Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment显示文摘 | Ariane Vienne Ehlam Hobeika Hervé Gouya Nathanael Lapidus Jacques Fritsch André Daniel Choury Ariane Chryssostalis Marianne Gaudric Gilles Pelletier Catherine Buffet Stanislas Chaussade Frédéric Prat | 2010 | Gastrointestinal Endoscopy2010，，4： | 1 |
| 5 | Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment显示文摘 | Ariane Vienne Ehlam Hobeika Hervé Gouya Nathanael Lapidus Jacques Fritsch André Daniel Choury Ariane Chryssostalis Marianne Gaudric Gilles Pelletier Catherine Buffet Stanislas Chaussade Frédéric Prat | 2010 | Gastrointestinal Endoscopy2010，，4： | 1 |
| 6 | Pancreatic metastases: a multicentric study of 22 patients显示文摘 | Abdallah Moussa Emmanuel Mitry Pascal Hammel Alain Sauvanet Tania Nassif Laurent Palazzo David Malka Jean-Charles Delchier Catherine Buffet Stanislas Chaussade Thomas Aparicio Philippe Lasser Philippe Rougier Gilles Lesur | 2004 | Gastroenterologie Clinique et Biologique2004，，10： | 1 |
| 7 | Visual loss during interferon-alpha therapy in hepatitis C virus infection显示文摘 | Gabriel Perlemuter Bahram Bodaghi Phuc Le Hoang Chaza Izem Catherine Buffet Bertrand Wechsler Jean-Charles Piette Patrice Cacoub | 2002 | Journal of Hepatology2002，，5： | 1 |
| 8 | A randomized trial of endoscopic drainage methods for inoperable malignant strictures of the common bile duct显示文摘 | Frederic Prat Olivier Chapat Beatrice Ducot Thierry Ponchon Gilles Pelletier Jacques Fritsch Andre Daniel Choury Catherine Buffet | 1998 | Gastrointestinal Endoscopy1998，，1： | 1 |
| 9 | Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment显示文摘 | Ariane Vienne Ehlam Hobeika Hervé Gouya Nathanael Lapidus Jacques Fritsch André Daniel Choury Ariane Chryssostalis Marianne Gaudric Gilles Pelletier Catherine Buffet Stanislas Chaussade Frédéric Prat | 2010 | Gastrointestinal Endoscopy2010，，4： | 1 |
| 10 | Treatment of unresectable hepatocellular carcinoma with lipiodol chemoembolization: a multicenter randomized trial显示文摘 | Gilles Pelletier Michel Ducreux France Gay Monique Luboinski Herve Hagège Dao Thong Werner Van Steenbergen Catherine Buffet Philippe Rougier Michael Adler Jean-Pierre Pignon Alain Roche | 1998 | Journal of Hepatology1998，，1： | 1 |
| 11 | High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis显示文摘 | Valerie Paradis Gabriel Perlemuter Franck Bonvoust Delphine Dargere Beatrice Parfait Michel Vidaud Marc Conti Stephane Huet Nathalie Ba Catherine Buffet Pierre Bedossa | 2001 | Hepatology2001，，： | 1 |
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