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| 1 | A complete compilation of matrix metalloproteinase expression in human malignant gliomas显示文摘Glioblastomas are characterized by an aggressive local growth pattern, a marked degree of invasiveness and poor prognosis. Tumor invasiveness is facilitated by the increased activity of proteolytic enzymes which are involved in destruction of the extracellular matrix of the surrounding healthy brain tissue. Elevated levels of matrix metalloproteinases(MMPs) were found in glioblastoma(GBM) cell-lines, as well as in GBM biopsies as compared with low-grade astrocytoma(LGA) and normal brain samples, indicating a role in malignant progression. A careful review of the available literature revealed that both the expression and role of several of the 23 human MMP proteins is controversely discussed and for some there are no data available at all. We therefore screened a panel of 15 LGA and 15 GBM biopsy samples for those MMPs for which there is either no, very limited or even contradictory dataavailable. Hence, this is the first complete compilation of the expression pattern of all 23 human MMPs in astrocytic tumors. This study will support a better understanding of the specific expression patterns and interaction of proteolytic enzymes in malignant human glioma and may provide additional starting points for targeted patient therapy. | Carsten Hagemann Jelena Anacker Ralf-Ingo Ernestus Giles H Vince | 2012 | World Journal of Clinical Oncology2012，3，5： | 18 |
| 2 | Not interferon, but interleukin‐6 controls early gene expression in hepatitis B virus infection显示文摘 | Marianna H?sel Maria Quasdorff Katja Wiegmann Dennis Webb Uta Zedler Mathias Broxtermann Raindy Tedjokusumo Knud Esser Silke Arzberger Carsten J. Kirschning Anja Langenkamp Christine Falk Hildegard Büning Stefan Rose‐John Ulrike Protzer | 2009 | Hepatology2009，，6： | 3 |
| 3 | Stepwise approach to substrate modification of ventricular tachycardia after myocardial infarction显示文摘背景最近,(SM ) 底层印射被描述了在心肌的梗塞以后便于稳定、不稳定的室的心悸亢进(vt ) 的导管脱离。然而, SM 与象室的功能或专业版心律不齐的缺陷那样的多重脱离线的潜在的劣势是耗时的。现在的学习的目的是描出 SM 的一条逐步的途径弄短过程时间和限制复杂并发症的可能性。方法 SM 在幸存者们用一个 electroanatomicalmapping 系统(CARTO ) 为 vt 脱离提交了定义梗塞区域的 14 梗塞被执行。为 SM 的一条新逐步的途径如下被设计。起始的脱离地点被步识别 -- 并且在稳定的 vt 的情况下并且由步仅仅在不稳定的 vt 的情况下印射印射的乘火车。基于印射的 CARTO 电压,线性脱离从这个地点被做到疤的中心并且对 thes 汽车的边界或到僧帽形的体环垂直。仅仅当 vt 仍然保持可诱导时,另外的线被执行。3 根脱离线的 Amaximum 在一个过程期间被创造。57 vt 全部的结果 A (21 马厩, 36 不稳定) 在过程期间被导致。vt 在在 2 个病人的第一线性脱离以后不再是可诱导的,在在 6 个病人的第二线性脱离以后并且在在 3 个病人的第三线性脱离以后。vt 或室的纤维性颤动在在 3 个病人的过程的结束仍然是可诱导的。平均的过程时间(291 ± 8 5 ) 分钟,荧光检查时间(10 ± 7 ) 纪录。vt 在 3 个病人复发了。在 2 个病人跟随第二个过程,没有进一步的 vt 复发。总的来说,在 vt 事件有重要减小 3 个月在以后[中部:0,内部方照范围(IQR ) :0-1 ] 与在脱离前的 3 个月相比(中部:25, IQR:16-105, P <
0.01 ) 。结论 SM 的这条逐步的途径在便于稳定、不稳定的 vt 的脱离是有效的。它减少过程和荧光检查预定,并且可以帮助改进 vt 的风险利益比率脱离。 | LI Yi-gang Gerian Groenefeld Carsten Israel LU Shang-biao WANG Qun-shan MENG Shu Stefan H Hohnloser | 2006 | Chinese Medical Journal2006，，14： | 3 |
| 4 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 5 | Hydrogen Isotope Exchange in Palladium Hydride显示文摘 | Carstens D H Encinias P D | 1991 | J Less-Common Met1991，，： | 2 |
| 6 | Downregulation of the reduced folate carrier transport activity by Phenobarbital type cytochrome P450 inducers and protein kinase C activators显示文摘 | Sandra H Carsten K Walther H | 2007 | Biochimica et Biophysica Acta (BBA)-Biomembranes2007，3，23： | 1 |
| 7 | The use of adenosine deaminase and interferon-gamma as diagnostic tools for tuberculous pericarditis 显示文摘 | Burgess J Reuter H Carstens ME | 2002 | Chest2002，122，3： | 1 |
| 8 | Solar Energy Assess-ment Using Remote Sensing Technologies显示文摘 | Annette H Detlev H Carsten H | 2003 | Remote Sens-ing of Environment2003，86，3： | 1 |
| 9 | Aerodynamic performance analysis of a hypersonic inlet isolator using computa tion and experiment显示文摘 | Brigit U R Carsten D H Josef B | 2003 | Journal of Propulsion and Power2003，19，5： | 1 |
| 10 | FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex显示文摘 | Marta Muzio Arul M Chinnaiyan Frank C Kischkel Karen O’Rourke Andrej Shevchenko Jian Ni Carsten Scaffidi James D Bretz Mei Zhang Reiner Gentz Matthias Mann Peter H Krammer Marcus E Peter Vishva M Dixit | 1996 | Cell1996，，： | 1 |
| 11 | A novel intronic cis Element,ISE/ISS-3,Regulates rat fibroblast growth factor receptor 2 splicing through activation of an upstream exon and repression of a downstream exon containing a noncanonical branch point sequence显示文摘 | Hovhannisyan R H Carstens R P | 2005 | Mol Cell Biol2005，25，1： | 1 |
| 12 | Novel avilamyein derivatives with improved polarity generated by targeted gene disruption 显示文摘 | Gabriele W Gerd H Carsten H | 2004 | Chemistry & Biology2004，11，10： | 1 |
| 13 | Using Data Envelopment Analysis to Bench- mark Activities 显示文摘 | CARSTEN H | 2001 | International Journal of Production Eco-nomies2001，73，3： | 1 |
| 14 | Preclinical activity of a new platinum analogue, lobaplatin, in cisplatin-sensitive and-resistant human testicular, ovarian, and gastric carcinoma cell lines 显示文摘 | Andreas H Carsten B Martin S | 1993 | Cancer Chemother Pharmacol1993，33，： | 1 |
| 15 | Mammary derived growth inhibitor is not a distinct protein but a mix of heart-type and adipocyte-type fatty acid-binding protein显示文摘 | BERNFRIED S NORBERT B CARSTEN H | 1994 | J Biol Chem1994，271，19： | 1 |
| 16 | Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate 显示文摘 | Deutschman D H Carstens J S Klepper R L | 2003 | Am Heart J2003，146，： | 1 |
| 17 | Reduced antibody responses to vaccinations in children exposed to polychlorinated biphenyls显示文摘 | CARSTEN H PHILIPPE G PA'L W | | 0，，08： | 1 |
| 18 | Serum concentrations of antibodies against vaccine toxoids in children显示文摘 | CARSTEN H ESBEN B J FLEMMING N | | 0，，10： | 1 |
| 19 | Failed res-cue therapy with rapamycin after paraquat intoxication显示文摘 | JOHAN M L EVA S CARSTEN H | 2010 | Clinical Toxicology2010，48，： | 1 |
| 20 | Computed Tomography (CT) perfusion as an early predictive marker or treatment response to neoadjuvant chemotherapy in gastroesophageal junction cancer and gastric cancer-- a prospective study显示文摘 | Martin L H Eva F Carsten L | 2014 | PLoS one2014，9，97： | 1 |
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