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| 1 | Caspase-3 activation as a bifurcation point between plasticity and cell death显示文摘Death-mediating proteases such as caspases and caspase-3 in particular,have been implicated in neurodegenerative processes,aging and Alzheimer's disease.However,emerging evidence suggests that in addition to their classical role in cell death,caspases play a key role in modulating synaptic function.It is remarkable that active caspases-3,which can trigger widespread damage and degeneration,aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death.Here,we evaluate this dichotomy,and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling,able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling.We propose that temporal,spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons.This concept has implications for differential roles of caspase-3 activation across the lifespan.Specifically,we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain. | Shikha Snigdha Erica D Smith G Aleph Prieto Carl W Cotman | 2012 | Neuroscience Bulletin2012，28，1： | 91 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | A MyD88-dependent IFNyR-CCR2 signaling circuit is required for mobilization of monocytes and host defense against systemic bacterial challenge显示文摘 | Eric M Pietras Lloyd S Miller Carl T Johnson Ryan M O'Connell Paul W Dempsey Genhong Cheng | 2011 | Cell Research2011，21，7： | 2 |
| 4 | Autoreactive T cell escape clonal deletion in the thymus by a CD24-dependent pathway显示文摘 | Carl J W Jr Liu J Q Joshi P S | 2008 | J Immunol2008，181，1： | 1 |
| 5 | Correct formulation of theKappa coefficient of agreement显示文摘 | William D H Carl W R | | 0，，04： | 1 |
| 6 | Effects of medium composition on the morphology and function of rat hepatocytes cultured as spheroids and monolyers显示文摘 | Geraldine A Carl W Elisabeth G | 2001 | Int Vitro Cell Dev Biol2001，37，： | 1 |
| 7 | Calculation of the roal of coal constituent elements on the enhanced vaporization of silica显示文摘 | NAGELBERG A S MAR R W CARLING R W | 1985 | High Temperature Science1985，19，1： | 1 |
| 8 | The Influence of Source Credibility on Communication Effectiveness 显示文摘 | Hovland Carl I Weiss W | 1952 | Public Opinion Quarterly1952，15，4： | 1 |
| 9 | Advances in modeling the effects of selected parameters on the SLS显示文摘 | John D W Carl R D | 1998 | Rapid Prototyping Journal1998，4，2： | 1 |
| 10 | Social -Ecological Resilience to Coastal Disasters 显示文摘 | Nell Adger W Terry P Hughes Carl Folke | 2005 | Science2005，309，： | 1 |
| 11 | N',2 -diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists Ⅱ显示文摘 | ELLIOTT J M CARLING R W CHICCHI G G | 2006 | Bioorg Med Chem Lett2006，16，22： | 1 |
| 12 | Health Effects of Nonionizing Radiation 显示文摘 | GEORGE M W CARL H S | 1990 | Environ Med1990，74，5： | 1 |
| 13 | Synthesis,structures and ethylene polymerisation behaviour of low valent β-diketiminato chromium complexes显示文摘 | Vernon C G Carl R Gregory A S Andrew J P W David J W | 2001 | Eur J Inorg Chem2001，7，： | 1 |
| 14 | Side effect of endotra- cheal suction in pressure-and volume controlled ventilation显示文摘 | Birgitta A Carl Johan W Erkki H | 2004 | Chest2004，125，3： | 1 |
| 15 | An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties显示文摘 | CHAMBERS M S ATACK Jr CARLING R W | 2004 | J Med Chem2004，47，24： | 1 |
| 16 | Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyl- tmnsferase superfamily显示文摘 | Du Y Carling T Fang W | 2001 | Cancer Res2001，61，22： | 1 |
| 17 | Device-to-device com- munication as an underlay to LTE-advanced networks显示文摘 | KLAUS D MIKA R CARL W | 2009 | IEEE Communications Magazine2009，47，12： | 1 |
| 18 | Formation of composite scales consisting of oxidation of different metals显示文摘 | CARL W | 1956 | Journal of the Electrochemical Society1956，11，： | 1 |
| 19 | Synthesis and mosquito repellent properties of 2,2 - dialkyl and 2 - alky1-4,4 - dimethyl - N - acetyloxazolidines 显示文摘 | Wesley G J Tse W I-I Carl E S | 1996 | Pestic Sci1996，46，： | 1 |
| 20 | Vertebroplasty and kyphoplasty显示文摘 | Lavelle W Carl A Lavelle ED ef al | 2007 | Med Clin N Am2007，91，： | 1 |
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