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| 1 | Driving gene-engineered T cell immunotherapy of cancer显示文摘妄想的抗原受体(汽车) 设计基因的 T 房间治疗保持潜力与终末期癌在病人的生活有有意义的差别。为十年,癌症治疗基于生物物理的参数,与到 debulk 的外科的切除术,由放射和化疗列在后面指向很快成长的肿瘤房间,当时主要 sparing 静止正常纸巾。一突破与 allogeneic 骨头髓发生了与白血病为病人移植,它提供了一有时药品治疗。为稳固的肿瘤的采纳房间治疗的地与发现被建立渗入肿瘤的淋巴细胞能与变形黑瘤被扩展并且使用到对待和甚至痊愈病人。肿瘤特定的 T 房间受体(TCR ) 被识别并且设计了进耐心的外部血淋巴细胞,它也被发现治疗肿瘤。然而,这些被耐心的 HLA 限制限制。紧随来汽车的产生,把抗体的优美识别与一个 T 房间的受动器功能相结合。为与先进 B 房间恶意的多重表格对待病人的指向 CD19 的汽车的来临取得了大成功,与多达 95% 反应率。然而,到稳固的肿瘤的适用的汽车治疗刚开始了,但是已经,某些因素被弄明白:肿瘤目标具有最大的重要性让临床医生不做伤害;并且稳固的肿瘤与 hematologic 相比对汽车治疗不同地作出回应。这里,我们考察临床的设计基因的 T 房间免疫疗法,它的成功,挑战,和未来的状态。 | Laura A Johnson Carl H June | 2017 | Cell Research2017，27，1： | 37 |
| 2 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 3 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 4 | An overview of the latest developments in facial imaging显示文摘Facial imaging is a term used to describe methods that use facial images to assist or facili-tate human identification. This pertains to two craniofacial identification procedures that use skulls and faces—facial approximation and photographic superimposition—as well as face-only methods for age progression/regression, the construction of facial graphics from eye-witness memory (including composites and artistic sketches), facial depiction, face mapping and newly emerging methods of molecular photofitting. Given the breadth of these facial imaging techniques, it is not surprising that a broad array of subject-matter experts partici-pate in and/or contribute to the formulation and implementation of these methods (includ-ing forensic odontologists, forensic artists, police officers, electrical engineers, anatomists, geneticists, medical image specialists, psychologists, computer graphic programmers and software developers). As they are concerned with the physical characteristics of humans, each of these facial imaging areas also falls in the domain of physical anthropology, although not all of them have been traditionally regarded as such. This too offers useful opportunities to adapt established methods in one domain to others more traditionally held to be disciplines within physical anthropology (e.g. facial approximation, craniofacial super-imposition and face photo-comparison). It is important to note that most facial imaging methods are not currently used for identification but serve to assist authorities in narrowing or directing investigations such that other, more potent, methods of identification can be used (e.g. DNA). Few, if any, facial imaging approaches can be considered honed end-stage scientific methods, with major opportunities for physical anthropologists to make meaningful contributions. Some facial imaging methods have considerably stronger scientific underpin-nings than others (e.g. facial approximation versus face mapping), some currently lie entirely within the artistic sphere (facial depiction), and yet others are so aspirational that realistic capacity to obtain their aims has strongly been questioned despite highly advanced tech-nical approaches (molecular photofitting). All this makes for a broad-ranging, dynamic and energetic field that is in a constant state of flux. This manuscript provides a theoretical snap-shot of the purposes of these methods, the state of science as it pertains to them, and their latest research developments. | Carl N.Stephan Jodi M.Caple Pierre Guyomarc'h Peter Claes | 2019 | Forensic Sciences Research2019，4，1： | 3 |
| 5 | Probable involvement of thaxtomins A in pathogenicity of Streptomyces scabies on seedlings显示文摘 | LEINER R H FRY B A CARLING D E | 1996 | Phytopathology1996，86，： | 2 |
| 6 | Information rules: A strategic guide to the network economy 显示文摘 | Carl S Varian H R | 2000 | The Journal of Technology Transfer2000，25，6： | 1 |
| 7 | Surviving sepsis campaign guide lines for management of severe sepsis and septic shock显示文摘 | Dellinger R Carle IMasur H | 2004 | Crit Care Med2004，32，3： | 1 |
| 8 | TGF-β signalling from cell membrane to nucleus through Smad proteins显示文摘 | Carl H H | 1997 | Nature1997，390，： | 1 |
| 9 | Correct formulation of theKappa coefficient of agreement显示文摘 | William D H Carl W R | | 0，，04： | 1 |
| 10 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 11 | New developments in nucleus pulpous replacement technology显示文摘 | CARL A L LEDET E YUAN H | 2004 | Spine2004，4，16： | 1 |
| 12 | Enanti-oselective electrodes:stereose-lective el-ectroreduction of 4-methylbenzopheno-ne and a-cetophenone 显示文摘 | Marion S Susanne P Carl H H | 1999 | Journal of E-lectroanalytical Chemistry1999，461，： | 1 |
| 13 | The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications 显示文摘 | Carl L K Michael S C Lynn A H | 2003 | J Nutr2003，133，： | 1 |
| 14 | Assessment of plantar pressure in forefoot relief shoes of different designs显示文摘 | Carl H D Pfander D Swoboda B | 2006 | Foot Ankle Int2006，27，2： | 1 |
| 15 | On the origin of the maximum in the electromechanical activity in Pb (Zr(x) Ti1-(x))O3 ceramies near the morphotropic phase boundary显示文摘 | CARL K HARDTL K H | 1971 | Physica Status Solidi(a)1971，8，1： | 1 |
| 16 | Health Effects of Nonionizing Radiation 显示文摘 | GEORGE M W CARL H S | 1990 | Environ Med1990，74，5： | 1 |
| 17 | Side effect of endotra- cheal suction in pressure-and volume controlled ventilation显示文摘 | Birgitta A Carl Johan W Erkki H | 2004 | Chest2004，125，3： | 1 |
| 18 | Development in laser trabeculoplasty显示文摘 | Carl H Mark A Joel S | 2000 | Ophthalmic Surg Lasers2000，31，： | 1 |
| 19 | Mild therapeutic hypothermia aftercardiac arrest through continuous dialysis 显示文摘 | Karacan H Valentin A Carl P | 2009 | Ugeskr Laeger2009，171，17： | 1 |
| 20 | Tuberous sclerosis complex and epilepsy: Recent developments and future challenges 显示文摘 | Gregory L H Carl E S The Tuberous Sclerosis Study Group | 2007 | Epilepsia2007，48，4： | 1 |
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