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| 1 | Pancreatic neuroendocrine neoplasms: Magnetic resonance imaging features according to grade and stage显示文摘AIM To describe magnetic resonance(MR) imaging features of pancreatic neuroendocrine neoplasms(Pan NENs) according to their grade and tumor-nodes-metastases stage by comparing them to histopathology and todetermine the accuracy of MR imaging features in predicting their biological behavior.METHODS This study was approved by our institutional review board; requirement for informed patient consent was waived due to the retrospective nature of the study. Preoperative MR examinations of 55 Pan NEN patients(29 men, 26 women; mean age of 57.6 years, range 21-83 years) performed between June 2013 and December 2015 were reviewed. Qualitative and quantitative features were compared between tumor grades and stages determined by histopathological analysis.RESULTS Ill defined margins were more common in G2-3 and stage Ⅲ-Ⅳ PanN ENs than in G1 and low-stage tumors(P < 0.001); this feature had high specificity in the identification of G2-3 and stage Ⅲ-Ⅳ tumors(90.3% and 96%, 95%CI: 73.1-97.5 and 77.7-99.8). The mean apparent diffusion coefficient value was significantly lower in G2-3 and stage Ⅲ-Ⅳ lesions compared to well differentiated and low-stage tumors(1.09 × 10-3 mm2/s vs 1.45 × 10-3 mm2/s and 1.10 × 10-3 mm2/s vs 1.53 × 10-3 mm2/s, P = 0.003 and 0.001). Receiving operator characteristic analysis determined optimal cutoffs of 1.21 and 1.28 × 10-3 mm2/s for the identification of G2-3 and stage Ⅲ-Ⅳ tumors, with sensitivity and specificity values of 70.8/80.7% and 64.5/64%(95%CI: 48.7-86.6/60-92.7 and 45.4-80.2/42.6-81.3).CONCLUSION MR features of PanN ENs vary according to their grade of differentiation and their stage at diagnosis and could predict the biological behavior of these tumors. | Riccardo De Robertis Sara Cingarlini Paolo Tinazzi Martini Silvia Ortolani Giovanni Butturini Luca Landoni Paolo Regi Roberto Girelli Paola Capelli Stefano Gobbo Giampaolo Tortora Aldo Scarpa Paolo Pederzoli Mirko D'Onofrio | 2017 | World Journal of Gastroenterology2017，23，2： | 16 |
| 2 | Comparison of imaging-based and pathological dimensions in pancreatic neuroendocrine tumors显示文摘AIM To establish the ability of magnetic resonance(MR) and computer tomography(CT) to predict pathologic dimensions of pancreatic neuroendocrine tumors(Pan NET) in a caseload of a tertiary referral center.METHODS Patients submitted to surgery for Pan NET at the Surgical Unit of the Pancreas Institute with at least 1 preoperative imaging examination(MR or CT scan) from January 2005 to December 2015 were included and data retrospectively collected. Exclusion criteria were: multifocal lesions, genetic syndromes, microadenomas or mixed tumors, metastatic disease and neoadjuvant therapy. Bland-Altman(BA) and Mountain-Plot(MP) statistics were used to compare size measured by each modality with the pathology size. Passing-Bablok(PB) regression analysis was used to check the agreement between MR and CT.RESULTS Our study population consisted of 292 patients. Seventy-nine(27.1%) were functioning Pan NET. The mean biases were 0.17 ± 7.99 mm, 1 ± 8.51 mm and 0.23 ± 9 mm, 1.2 ± 9.8 mm for MR and CT, considering the overall population and the subgroup of non-functioning-Pan NET, respectively. Limits of agreement(LOA) included the vast majority of observations, indicating a good agreement between imaging and pathology. The MP further confirmed this finding and showed that the two methods are unbiased with respect to each other. Considering ≤ 2 cm non-functioning-Pan NET, no statistical significance was found in the size estimation rate of MR and CT(P = 0.433). PBR analysis did not reveal significant differences between MR, CT and pathology.CONCLUSION MR and CT scan are accurate and interchangeable imaging techniques in predicting pathologic dimensions of Pan NET. | Salvatore Paiella Harmony Impellizzeri Elisabetta Zanolin Giovanni Marchegiani Marco Miotto Anna Malpaga Riccardo De Robertis Mirko D'Onofrio Borislav Rusev Paola Capelli Sara Cingarlini Giovanni Butturini Maria Vittoria Davì Antonio Amodio Claudio BassiAldo Scarpa Roberto Salvia Luca Landoni | 2017 | World Journal of Gastroenterology2017，23，17： | 4 |
| 3 | Serous pancreatic neoplasia, data and review显示文摘AIM To describe the imaging features of serous neoplasms of the pancreas using ultrasound, endoscopic ultrasound, computed tomography and magnetic resonance imaging.METHODS This multicenter international collaboration enhances a literature review to date, reporting features of 287 histologically confirmed cases of serous pancreatic cystic neoplasms(SPN). RESULTS Female predominance is seen with most SPN presenting asymptomatically in the 5th through 7th decade. Mean lesion size was 38.7 mm, 98% were single, 44.2% cystic, 46% mixed cystic and solid, and 94% hypoechoic on B-mode ultrasound. Vascular patterns and contrast-enhancement profiles are described as hypervascular and hyperenhancing.CONCLUSION The described ultrasound features can aid differentiation of SPN from other neoplastic lesions under most circumstances. | Christoph F Dietrich Yi Dong Christian Jenssen Valentina Ciaravino Michael Hocke Wen-Ping Wang Eike Burmester Kathleen Moeller Nathan SS Atkinson Paola Capelli Mirko D’Onofrio | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 4 | Outcomes after resection of locally advanced or borderline resectable pancreatic cancer after neoadjuvant therapy显示文摘 | Giuliano Barugola Stefano Partelli Stefano Crippa Paola Capelli Mirko D’Onofrio Paolo Pederzoli Massimo Falconi | 2012 | The American Journal of Surgery2012，，2： | 2 |
| 5 | Ultrasonography of the pancreas. 4. Contrast-enhanced imaging显示文摘 | M. D'Onofrio G. Zamboni N. Faccioli P. Capelli R. Pozzi Mucelli | 2007 | Abdominal Imaging2007，，2： | 2 |
| 6 | Lipid-Rich Variant of Pancreatic Endocrine Neoplasms显示文摘 | Rajendra Singh Olca Basturk David S Klimstra Giuseppe Zamboni Runjan Chetty Sanaa Hussain Stefano La Rosa Asli Yilmaz Paola Capelli Carlo Capella Jeanette D Cheng N Volkan Adsay | 2006 | The American Journal of Surgical Pathology2006，，2： | 2 |
| 7 | Breast cancer stem cells: an Overview 显示文摘 | Ponti D Zaffaroni N Capelli C | 2006 | Eur J Cancer2006，42，： | 1 |
| 8 | The kinetics and extent of engraftment of chronic myelogenous leukemia cells in nonobese diabetic severe combined immunodeficiency mice reflect the phase of the donor's disease: an in vivo model of chronic myelogenous leukemia biology显示文摘 | Dazzi F Capelli D Hasserjian R | 1998 | Blood1998，92，4： | 1 |
| 9 | Breast cancer stem cells: An overview显示文摘 | Ponti D Zaffaroni N Capelli C | 2006 | Eur J Cancer2006，42，9： | 1 |
| 10 | A comparative and critical evaluation of odour assessment methods on a landfill site 显示文摘 | Capelli L Sironi S Rosso R D | 2008 | Atnospheric Environment2008，，42： | 1 |
| 11 | Energefics of swimming at maximal speed in human显示文摘 | CAPELLI C D R PENDERGAST B TERMIN | 1998 | Eur J Appl Physiol1998，78，： | 1 |
| 12 | Breast cancer stem cell:an overview显示文摘 | Ponti D Zaffaroni N Capelli C | 2006 | Euro J Cancer2006，42，9： | 1 |
| 13 | Synthetic asta-xanthin is significantly inferior to algal-based astax- anthin as an antioxidant and may not be suitable as a human nutraceutical supplement 显示文摘 | CAPELLI B BAGCHI D CYSEWSKI G R | 2013 | Nutrafoods2013，12，4： | 1 |
| 14 | The kinetics and extent of engraftment of chronic myelogenousleukemia ceils in non - obese diabetic/severe combined immunodeficiency mice reflect the phase of the doror's disease : an in vivo model of chronic myelogenous leukemia biolige显示文摘 | Dazzi F Capelli D Hasserjian R | 1998 | Blood1998，92，4： | 1 |
| 15 | Energetics of swimming at maximal speeds in humans显示文摘 | CAPELLI C PENDERGAST D R TERMIN B | 1998 | Eur J Appl Physi- ol1998，78，5： | 1 |
| 16 | Breast cancer :stem cells: an overview 显示文摘 | Ponti D Zaffaroni N Capelli C | 2006 | Eur J Cancer2006，42，9： | 1 |
| 17 | Study of trace elements in organs and tissues of striped dolphins (Stenella coeruleoalba) found dead along the Ligurian coasts (Italy)显示文摘 | Capelli R Drava G Pellegrini R D | 2000 | Advances in Environmental Research2000，4，1： | 1 |
| 18 | Effect of amifostine on mucositis during autologous PBSCT transplantation显示文摘 | Olivieri A Poloni A Capelli D | 1998 | Blood1998，92，101： | 1 |
| 19 | Genetic analysis of the skeletal remains attributed to Francesco Petrarca显示文摘 | Caramelli D Lalueza-Fox C Capelli C | 2007 | Forensic Sci Int2007，173，： | 1 |
| 20 | Long - termhema- tologic reconstitntion after antologous peripheral bloodpro- genitor cell transplantation: acomparison between con - Trolled- ratefreezinganduncon2 - tmlled2ratefreezingat - 80degreec显示文摘 | Montanari M Capelli D Poloni A | 2003 | Transfusion2003，43，1： | 1 |
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