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| 1 | Genome architecture and tetrasomic inheritance of autotetraploid potato显示文摘Potato(Solanum tuberosum)is the most consumed non-cereal food crop.Most commercial potato cultivars are autotetraploids with highly heterozygous genomes,severely hampering genetic analyses and improvement.By leveraging the state-of-the-art sequencing technologies and polyploid graph binning,we achieved a chromosome-scale,haplotype-resolved genome assembly of a cultivated potato,Cooperation-88(C88).lntra-haplotype comparative analyses revealed extensive sequence and expression differences in this tetraploid genome.We identified haplotype-specific pericentromeres on chromosomes,suggesting a distinct evolutionary trajectory of potato homologous centromeres.Furthermore,we detected double reduction events that are unevenly distributed on haplotypes in 1021 of 1034 selfing progeny,a feature of autopolyploid inheritance.By distinguishing maternal and paternal haplotype sets in C88,we simulated the origin of heterosis in cultivated tetraploid with a survey of 3110 tetra-allelic loci with deleterious mutations,which were masked in the heterozygous condition bytwo parents.This study provides insights into the genomic architecture of autopolyploids and will guide their breeding. | Zhigui Bao Canhui Li Guangcun Li Pei Wang Zhen Peng Lin Cheng Hongbo Li Zhiyang Zhang Yuying Li Wu Huang Mingwang Ye Daofeng Dong Zhukuan Cheng Peter VanderZaag Evert Jacobsen Christian W.B.Bachem Suomeng Dong Chunzhi Zhang Sanwen Huang Qian Zhou | 2022 | Molecular Plant2022，15，7： | 4 |
| 2 | Construction of homozygous diploid potato through maternal haploid induction显示文摘Reinventing the tetraploid potato into a seed-propagated,diploid,hybrid potato would significantly accelerate potato breeding.In this regard,the development of highly homozygous inbred lines is a prerequisite for breeding hybrid potatoes,but self-incompatibility and inbreeding depression present challenges for developing pure inbred lines.To resolve this impediment,we developed a doubled haploid(DH)technology,based on mutagenesis of the potato DOMAIN OF UNKNOWN FUNCTION 679 membrane protein(StDMP)gene.Here,we show that a deficiency in StDMP allows the generation of maternal haploids for generating diploid potato lines.An exercisable protocol,involving hybridization,fluorescent marker screening,molecular and flow cytometric identification,and doubling with colchicine generates nearly 100%homozygous diploid potato lines.This dmp-triggered haploid induction(HI)system greatly shortens the breeding process and offers a robust method for generating diploid potato inbred lines with high purity. | Jinzhe Zhang Jian Yin Jiayi Luo Die Tang Xijian Zhu Jie Wang Zhihong Liu Pei Wang Yu Zhong Chenxu Liu Canhui Li Shaojiang Chen Sanwen Huang | 2022 | aBIOTECH2022，3，3： | 2 |
| 3 | Microstructures and properties of silver-based contact material fabricated by hot extrusion of internal oxidized Ag–Sn–Sb alloy powders显示文摘 | Canhui Xu Danqing Yi Chunping Wu Huiqun Liu Weizhou Li | 2012 | Materials Science & Engineering A2012，，： | 1 |
| 4 | Microstructures and properties of silver-based contact material fabricated by hot extrusion of internal oxidized Ag–Sn–Sb alloy powders显示文摘 | Canhui Xu Danqing Yi Chunping Wu Huiqun Liu Weizhou Li | 2012 | Materials Science & Engineering A2012，，： | 1 |
| 5 | Application of thermal comfort theory in probabilistic safety assessment of a nuclear power plant显示文摘Human factor errors in probabilistic safety assessment(PSA) of a nuclear power plant(NPP) can be prevented using thermal comfort analysis.In this paper,the THERP+HCR model is modified by using PMV (Predicted Mean Vote) and PPD(Predicted Percentage Dissatisfied) index system,so as to obtain the operator cognitive reliability,and to reflect and analyze human perception,thermal comfort status,and cognitive ability in a specific NPP environment.The mechanism of human factors in the PSA is analyzed by operators of skill,rule and knowledge types.The THERP+HCR model modified by thermal comfort theory can reflect the conditions in actual environment,and optimize reliability analysis of human factors.Improving human thermal comfort for different types of operators reduces adverse factors due to human errors,and provides a safe and optimum decision-making for NPPs. | ZHOU Tao SUN Canhui LI Zhenyang WANG Zenghui | 2011 | Nuclear Science and Techniques2011，22，5： | 1 |
| 6 | Seven facts and five initiatives for gut microbiome research显示文摘The gut microbiome has attracted increasing attention over the past 15 years.Along with the fast-growing body of research literature and media reports,the public's opinions on the gut microbiome have begun to appear polarized.Some believe that the gut microbiome is at the core of human health and is related to every single disease.To the opposite,some people question the scientific basis of gut microbiome studies and criticize that many of them are farfetched;there is even a joke spreading in the biomedical research field—'keeping gut microbiome in mind,no mechanism is hard to find'. | Danyi Li Chunhui Gao Faming Zhang Ruifu Yang Canhui Lan Yonghui Ma Jun Wang | 2020 | Protein & Cell2020，11，6： | 1 |
| 7 | Electrochemical quartz crystal microbalance study on growth and property of the polymer deposit at gold electrodes during oxidation of dopamine in aqueous solutions显示文摘 | Yunlong Li Meiling Liu Canhui Xiang Qingji Xie Shouzhuo Yao | 2005 | Thin Solid Films2005，，1： | 1 |
| 8 | Electrochemical quartz crystal microbalance study on growth and property of the polymer deposit at gold electrodes during oxidation of dopamine in aqueous solutions显示文摘 | Yunlong Li Meiling Liu Canhui Xiang Qingji Xie Shouzhuo Yao | 2005 | Thin Solid Films2005，，1： | 1 |
| 9 | Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction显示文摘Ginsenoside Rb1 shows a strong antioxidant effect and has potential activation effects on Akt.The aim of the present study was to investigate the protective effect of Rb1 on age-related ovarian granulosa cell injury.Ovarian granulosa cells(GCs)were obtained from 50 young women(≤30 years)and 50 aged women(≥38 years)at an IVF center.Young and aged ICR mice were administered with or without Rb1(10 mg kg^(-1),i.p.)for 2 weeks.The protective effects of Rb1 were investigated and the role of Rb1 on the modulation of Akt-FoxO1 interaction was determined with immunofluorescence,Western blotting,immunoprecipitation,si RNA silencing and pharmacological inhibitor.Rb1 effectively decreased LDH and MDA,and reversed the apoptotic-related protein levels in h GL cells from old patients.Similar results were found in mice.In addition,the mitochondrial membrane potential was restored and the overaccumulation of ROS was reversed by Rb1.Rb1 preserved peroxide-impaired Akt activation,to some extent,by increasing phosphorylation at Ser473.Rb1 also facilitated p-Akt binding to FoxO1 and promoted the phosphorylation of FoxO1.Si RNA silencing of Akt,Akt inhibitor LY294002,and FoxO1 inhibitor AS1842856 attenuated the effects of Rb1.Ginsenoside Rb1 inhibits age-related GCs oxidative damage by activating Akt phosphorylation at Ser473 and by further interaction with FoxO1. | Ping Zhou Feng Deng Zi Yang Canhui Cao Hongcui Zhao Fenting Liu Ke Zhong Lin Fu Tianliu Peng Di Sun Hui Liu Rong Li Yang Yu | 2022 | Science China(Life Sciences)2022，65，11： | 1 |
| 10 | The DELLA-ABI4-HY5 module integrates light and gibberellin signals to regulate hypocotyl elongation显示文摘Plant growth is coordinately controlled by various environmental and hormonal signals,of which light and gibberellin(GA)signals are two critical factors with opposite effects on hypocotyl elongation.Although interactions between the light and GA signaling pathways have been studied extensively,the detailed regulatory mechanism of their direct crosstalk in hypocotyl elongation remains to be fully clarified.Previously,we reported that ABA INSENSITIVE 4(ABI4)controls hypocotyl elongation through its regulation of cellelongation-related genes,but whether it is also involved in GA signaling to promote hypocotyl elongation is unknown.In this study,we showthat promotion of hypocotyl elongation by GA is dependent on ABI4 activation.DELLAs interact directly with ABI4 and inhibit its DNA-binding activity.In turn,ABI4 combined with ELONGATED HYPOCOTYL 5(HY5),a key positive factor in light signaling,feedback regulates the expression of the GA2ox GA catabolism genes and thus modulates GA levels.Taken together,our results suggest that the DELLA-ABI4-HY5 module may serve as a molecular link that integrates GA and light signals to control hypocotyl elongation. | Haibo Xiong Dandan Lu Zhiyuan Li Jianghao Wu Xin Ning Weijun Lin Zechen Bai Canhui Zheng Yang Sun Wei Chi Lixin Zhang Xiumei Xu | 2023 | Plant Communications2023，4，5： | 0 |
| 11 | Basic characteristics of key interfaces in Upper Ordovician Wufeng Formation – Lower Silurian Longmaxi Formation in Sichuan Basin and its periphery,SW China显示文摘Based on anatomy of key areas and data points and analysis of typical features of shell layer in Guanyinqiao Member, basic characteristics of key interfaces, mainly bentonite layers, in the Upper Ordovician Wufeng Formation-Lower Silurian Longmaxi Formation in the Sichuan Basin and its surrounding areas and the relationship between these key interfaces with the deposition of organic-rich shale have been examined systematically. The Wufeng Formation-Longmaxi Formation has four types of marker beds with interface attributes, namely, the characteristic graptolite belt, Guanyinqiao Member shell layer, section with dense bentonite layers, and concretion section, which can be taken as key interfaces for stratigraphic division and correlation of the graptolite shale. The shell layer in Guanyinqiao Member is the most standard key interface in Wufeng Formation-Longmaxi Formation, and can also be regarded as an important indicator for judging the depositional scale of organic-rich shale in key areas. There are 8 dense bentonite sections of two types mainly occurring in 7 graptolite belts in these formations. They have similar interface characteristics with the shell layer in Guanyinqiao Member in thickness and natural gamma response, and belong to tectonic interfaces(i.e., event deposits). They have three kinds of distribution scales: whole region, large part of the region, and local part, and can be the third, fourth and fifth order sequence interfaces, and have a differential control effect on organic-rich shale deposits. The horizon the characteristic graptolite belt occurs first is the isochronous interface, which is not directly related to the deposition of organic-rich shale. Concretions only appear in local areas, and show poor stability in vertical and horizontal directions, and have no obvious relationship with the deposition of the organic-rich shale. | WANG Yuman WANG Hongyan QIU Zhen SHEN Junjun ZHANG Qin ZHANG Leifu WANG Canhui LI Xinjing | 2022 | Petroleum Exploration and Development2022，49，1： | 0 |
| 12 | HSCA-Net: A Hybrid Spatial-Channel Attention Network in Multiscale Feature Pyramid for Document Layout Analysis显示文摘Document images often contain various page components and complex logical structures,which make document layout analysis task challenging.For most deep learning-based document layout analysis methods,convolutional neural networks(CNNs)are adopted as the feature extraction networks.In this paper,a hybrid spatial-channel attention network(HSCA-Net)is proposed to improve feature extraction capability by introducing attention mechanism to explore more salient properties within document pages.The HSCA-Net consists of spatial attention module(SAM),channel attention module(CAM),and designed lateral attention connection.CAM adaptively adjusts channel feature responses by emphasizing selective information,which depends on the contribution of the features of each channel.SAM guides CNNs to focus on the informative contents and capture global context information among page objects.The lateral attention connection incorporates SAM and CAM into multiscale feature pyramid network,and thus retains original feature information.The effectiveness and adaptability of HSCA-Net are evaluated through multiple experiments on publicly available datasets such as PubLayNet,ICDAR-POD,and Article Regions.Experimental results demonstrate that HSCA-Net achieves state-of-the-art performance on document layout analysis task. | Honghong Zhang Canhui Xu Cao Shi Henyue Bi Yuteng Li Sami Mian | 2023 | Journal of Artificial Intelligence and Technology2023，3，1： | 0 |
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