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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Aggregate-protected and unprotected organic matter pools in conventional and no-tillage soils 显示文摘 | BEARE M H HENDRIX P F CABRERA M L | 1994 | Soil Science Society of America Journal1994，58，3： | 1 |
| 3 | Aggregate-protected and unprotected organic matter pools in conventional-tillage and no-tillage soils显示文摘 | Beate M H Cabrera M L Hendrix P F | 1994 | Soil Sci Soc Am J1994，58，： | 1 |
| 4 | Aggregate-protected and unprotected organic matter pools in conventional and no-tillage soils显示文摘 | BEAR M H CABRERA M L HENDRIX P F | 1994 | Soil Science Society of America Journal1994，，58： | 1 |
| 5 | Endoscopic treatment of central airway stenosis: five years' experience显示文摘 | Cosano Povedano A Mufioz Cabrera L Cosano Povedano F J | 2005 | Arch Bronconeumol2005，41，6： | 1 |
| 6 | Si diffusion coating on steels by SiH4/H2 treatment for high temperature oxidation protection 显示文摘 | Cabrera A L Kiirner J F | 1990 | J Mater Res1990，5，1： | 1 |
| 7 | Nitrogen mineralizationfrom organic residues 显示文摘 | Cabrera M L Kissel D E Vigil M F | 2005 | Journal of Environmental Quality2005，34，1： | 1 |
| 8 | Surface composition of ordered in-termetallic compounds PtBi and PtPb 显示文摘 | Blasini D R Rochefort D Fachini E Alden L R DiSalvo F J Cabrera C R Abruna H D | 2006 | Surface Science2006，600，13： | 1 |
| 9 | Aggregat Protected and unprotected organic matter Pools in conventional and notillage soils显示文摘 | BEARE M H CABRERA M L HENDRIX P F | 1994 | soil Science Society of AlnericaJoumal1994，58，： | 1 |
| 10 | Heavy metal pollution of soils affected by the Guadiamar toxic flood显示文摘 | CABRERA F CLEMENTE L DfAZ BARRUEBTOS E | 1999 | Science of the Total Environment1999，242，123： | 1 |
| 11 | Swift; Using Distributed DiskStriping to Provide High I/O Data Rates 显示文摘 | Cabrera L F Long D I) E | 1991 | ComputingSystems1991，4，4： | 1 |
| 12 | Aluminium content of drinking waters, fruit juices and soft drinks: contribution to dietary intake 显示文摘 | LOPEZ F F CABRERA C LORENZOM L | 2002 | The Science of the Total Environment2002，292，3： | 1 |
| 13 | The ECCO study显示文摘 | Almagro P López Garcí a F Cabrera F et aL Comorbidity and gender-related differences in patients hospitalized for COPD | 2010 | Respiratory Medicine2010，104，： | 1 |
| 14 | Si diffusion coating on steels by SiH4/H2 treatment for high temperature oxidation protection显示文摘 | Cabrera A L Kirner J F Armor J N | 1990 | Journal of Materials Research1990，6，1： | 1 |
| 15 | The application of genetic algorithm with neural networks to the induction machines modeling显示文摘 | Elbuluk M E Cabrera L A | 1998 | System AnalysisModeling Simulation1998，31，： | 1 |
| 16 | Si diffusion coating on steels by SiH4/H2 treatment for high temperature oxidation protection显示文摘 | KIRNER J F ARMOR J N | 1990 | Journal of Materials Research1990，6，1： | 1 |
| 17 | Activation of the Wnt/p-catenin sig-naling pathway by mechanical ventilation is associatedwith ventilator-induced pulmonary fibrosis in healthylungs显示文摘 | Villar J Cabrera N E Valladares F Casula M FloresC Blanch L | 2011 | PLoS One2011，6，23： | 1 |
| 18 | Influence of growti temperature on cryotolerance and lipid composition of Lactobacillus acidophilus显示文摘 | MURGA M L F CABRERA G M FONT dE V G | 2001 | Applied Microbiology2001，88，： | 1 |
| 19 | Study of Fe-doped rutile TiO2 alloys obtained by mechanical alloying显示文摘 | CABRERA A F RODRIGUEZ TORRES C E ERRICO L | 2006 | Physica B2006，384，： | 1 |
| 20 | Aluminium Content of drinking waters, fruit juices and soft drinks : Contribution to dietary intake 显示文摘 | LOPEZ F F CABRERA C LORENZO M L | 2002 | The Science of the Total Environment2002，292，3： | 1 |
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