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| 1 | Combined detections of interleukin 27, interferon-γ, and adenosine deaminase in pleural effusion for diagnosis of tuberculous pleurisy显示文摘 | WU Yan-bin YE Zhi-jian QIN Sou-ming WU Cong CHEN Yi-qiang SHI Huan-zhong | 2013 | Chinese Medical Journal2013，，17： | 41 |
| 2 | Efficacy of Different Treatment Regimens for Antiphospholipid Syndrome-related Recurrent Spontaneous Abortion显示文摘 | Sheng-Long Ye Xun-Ke Gu Li-Yuan Tao Ji-Mei Cong Yong-Qing Wang | 2017 | Chinese Medical Journal2017，，12： | 30 |
| 3 | Coesite inclusions in zircon from gneisses identified by laser Raman microspectrometer in ultra-high pressure zone of Dabie Mountains,China显示文摘The mineral inclusions in zircon from gneisses in ultra-high pressure (UHP) zone of the Dabie Mountains were identified by using a laser Raman microspectrometer. Coesite occurs as inclusions in zircons from all types of gneiss. Other important minerals, such as jadeite, omphacite, aragonite, barite, and anhydrite were also found as inclusion minerals. These discoveries indicate that ( i) gneissic country rocks had metamorphosed at the same time as the enclosed eclogites; and (ii) SO4-2 -bearing fluids were presentin the UHP metamorphic process, which is manifested by occurrence of barite and anhydrite coexisting with coesite. | LIU Jingbo YE Kai CONG Bolin Maruyama Shegnori FAN Hongrui | 2001 | Chinese Science Bulletin2001，46，22： | 22 |
| 4 | Cold adaptation in pigs depends on UCP3 in beige adipocytes显示文摘 | Jun Lin Chunwei Cao Cong Tao Rongcai Ye Meng Dong Qiantao Zheng Chao Wang Xiaoxiao Jiang Guosong Qin Changguo Yan Kui Li John R. Speakman Yanfang Wang Wanzhu Jin Jianguo Zhao | 2017 | Journal of Molecular Cell Biology2017，9，5： | 20 |
| 5 | Diagnostic value of FIB-4, aspartate aminotransferaseto-platelet ratio index and liver stiffness measurement in hepatitis B virus-infected patients with persistently normal alanine aminotransferase显示文摘AIM To assess the diagnostic value of FIB-4, aspartate aminotransferase-to-platelet ratio index(APRI), and liver stiffness measurement(LSM) in patients with hepatitis B virus infection who have persistently normal alanine transaminase(PNALT).METHODS We enrolled 245 patients with chronic hepatitis B: 95 in PNALT group, 86 in intermittently elevated alanine transaminase(PIALT1) group [alanine transaminase(ALT) within 1-2 × upper limit of normal value(ULN)], and 64 in PIALT2 group(ALT > 2 × ULN). All the patients received a percutaneous liver biopsy guided by ultrasonography. LSM, biochemical tests, and complete blood cell counts were performed.RESULTS The pathological examination revealed moderate inflammatory necrosis ratios of 16.81%(16/95), 32.56%(28/86), and 45.31%(28/64), and moderate liverfibrosis of 24.2%(23/95), 33.72%(29/86), and 43.75%(28/64) in the PNALT, PIALT1, and PIALT2 groups, respectively. The degrees of inflammation and liver fibrosis were significantly higher in the PIALT groups than in the PNALT group(P < 0.05). No significant difference was found in the areas under the curve(AUCs) between APRI and FIB-4 in the PNALT group; however, significant differences were found between APRI and LSM, and between FIB-4 and LSM in the PNALT group(P < 0.05 for both). In the PIALT1 and PIALT2 groups, no significant difference(P > 0.05) was found in AUCs for all comparisons(P > 0.05 for all). In the overall patients, a significant difference in the AUCs was found only between LSM and APRI(P < 0.05).CONCLUSION APRI and FIB-4 are not the ideal noninvasive hepatic fibrosis markers for PNALT patients. LSM is superior to APRI and FIB-4 in PNALT patients because of the influence of liver inflammation and necrosis. | You-Wen Tan Xing-Bei Zhou Yun Ye Cong He Guo-Hong Ge | 2017 | World Journal of Gastroenterology2017，23，31： | 18 |
| 6 | CapOX as neoadjuvant chemotherapy for locally advanced operable colon cancer patients: a prospective single-arm phase Ⅱ trial显示文摘Objective: The aim of this prospective, single-arm phase II trial was to confirm the safety and efficacy of neoadjuvant chemotherapy(NAC) using oxaliplatin plus capecitabine(Cap OX) for patients with operable locally advanced colon cancer(CC).Methods: Patients with computed tomography-defined T4 or lymph node-positive CCs were enrolled. After radiological staging, patients were treated with at least 2 cycles of NAC consisting of 130 mg/m2 oxaliplatin on d 1,plus 1,000 mg/m2 capecitabine twice daily for 14 d every 3 weeks, followed by surgery, and then with the rest cycles of adjuvant chemotherapy. Radiological response was evaluated after 2 cycles of NAC. Tumor response, treatment toxicity, and surgical complications were recorded. The pathological response to therapy was evaluated according to the tumor regression grade(TRG) score. The primary endpoint was pathologic tumor response. This trial is registered in Clinical Trials.gov(No: NCT02415829).Results: Forty-seven patients were enrolled in the study. Forty-two patients completed the planned treatments.The total radiological response rate was 68%(32/47), including complete and partial response rates of 2%(1/47)and 66%(31/47), respectively. Stable disease was observed in 32%(15/47) and progressive disease was observed in none. Complete pathologic response, major regression, and at least moderate regression were achieved in 1(2%), 2(4%), and 29(62%) patients, respectively. Four patients developed grade 3 treatment toxicities. One patient with wound infection occurred after operation(1/47, 2%). There was no treatment-related death.Conclusions: Our results suggest that NAC with Cap OX is an effective and safe treatment option for patients with locally advanced CCs. | Fangqi Liu Li Yang Yuchen Wu Cong Li Jiang Zhao Adili Keranmu Hongtu Zheng Dan Huang Lei Wang Tong Tong Junyan Xu Ji Zhu Sanjun Cai Ye Xu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 14 |
| 7 | Arogenate Dehydratase Isoforms Differentially Regulate Anthocyanin Biosynthesis in Arabidopsis thaliana显示文摘Anthocyanins,一组 L 本氨基丙酸(Phe ) 导出 flavonoids,被表明了在在植物和昆虫之间的植物压力抵抗和相互作用起重要作用。尽管 anthocyanin biosynthetic 小径和它的规章的机制广泛地被学习了, Phe 供应的水平是否影响 anthocyanin 生合成,仍然保持不清楚。这里,我们调查了 arogenate dehydratases (ADT ) 的角色,催化 arogenate 的变换进 Phe 的关键酶,在在 Arabidopsis 的导致蔗糖的 anthocyanin 生合成。基因分析证明所有六 ADT isoforms 在 anthocyanin 生合成冗余地工作,但是有微分贡献。ADT2 贡献大多数到 anthocyanin 累积,由 ADT1 和 ADT3 列在后面,并且 ADT4-ADT6。我们发现 anthocyanin 内容断然在幼苗与 Phe 和导致蔗糖的 ADT 抄本的层次被相关。一致地,到媒介的 Phe 的增加能戏剧性地在野类型的植物增加 anthocyanin 内容并且救 adt1 adt3 的显型关于 anthocyanin 累积的两倍异种。而且,转基因的植物 overexpressing ADT4,比 ADT2 的 overexpression 对 Phe 显得是更少敏感, hyperaccumulate Phe 并且生产 anthocyanins 的提高的水平。一起拿,我们的结果建议 Phe 的水平是为支撑 anthocyanin 生合成的一个重要规章的因素。 | Qingbo Chen Cong Man Danning Li Huijuan Tan Ye Xie Jirong Huang | 2016 | Molecular Plant2016，9，12： | 12 |
| 8 | A Crucial Role of GA-Regulated Flavonol Biosynthesis in Root Growth of Arabidopsis显示文摘Flavonols have been demonstrated to play many important roles in plant growth, development, and communication with other organisms. Flavonol biosynthesis is spatiotemporally regulated by the subgroup 7 R2R3-MYB (SG7 MYB) transcription factors including MYB11/MYB12/MYB111. However, whether SG7- MYB activity is subject to post-translational regulation remains unclear. Here, we show that gibberellic acid (GA) inhibits flavonol biosynthesis via DELLA proteins in Arabidopsis. Protein-protein interaction analyses revealed that DELLAs (RGA and GAI) interacted with SG7 MYBs (MYB12 and MYB111) both in vitro and in vivo, leading to enhanced affinity of MYB binding to the promoter regions of key genes for flavonol biosynthesis and thus increasing their transcriptional levels. We observed that the level of auxin in the root tip was negatively correlated with root flavonol content. Furthermore, genetic assays showed that loss-of-function mutations in MYB 12, which is predominantly expressed in roots, partially rescued the short-root phenotype of the GA-deficient mutant ga1-3 by increasing root meristem size and mature cell size. Consistent with these observations, exogenous application of the flavonol quercetin restored the root meristem size of myb12 ga1-3 to that of ga1-3. Taken together, our data elucidate a molecular mechanism by which GA promotes root growth by directly reducing flavonol biosynthesis. | Huijuan Tan Cong Man Ye Xie Jijun Yan Jinfang Chu Jirong Huang | 2019 | Molecular Plant2019，12，4： | 8 |
| 9 | Photolysis of organic pollutants in wastewater with 206 nm UV irradiation显示文摘新型的紫外轻来源(206 nm ) 第一次在废水为器官的污染物质的降级被探索。triphenyltin 氯化物(TPTCl ) 的降级表演,暗淡乙醇 phthalate (DMP ) ,以及玫瑰精 B (RhB ) 被调查。结果显示了 50 mg/L RhB, 60 mg/L DMP 和 120 mg/L TPTCl 的那移动效率能分别地为 60 min, 50 min 和 75 min 到达 88.6% , 92.5% 和 89.4% 。由移动效率的比较,我们发现 206 nm 比在废水处理紫外的 253.7 nm 优异,暗示分解在废水的器官的污染物质是一种有效、有希望、值得的探索技术。 | Zhao Lian Ye Chang Qing Cao Jin Cong He Ren Xi Zhang Hui Qi Hou | 2009 | Chinese Chemical Letters2009，20，6： | 7 |
| 10 | Rarefaction and Temperature Gradient Effect on the Performance of the Knudsen Pump显示文摘The prediction of the multiscale flow in the Knudsen pump is important for understanding its pumping mechanism.However,there is little research on such interesting multiscale phenomenon in the Knudsen pumps.In this paper,a novel numerical analysis method combining the direct simulation Monte Carlo(DSMC) method with the smoothed particle hydrodynamics(SPH) method is presented for simulating the multiscale flow,which is often encountered in the application of the Knudsen pumps.Validity and accuracy of the new method are given by comparing its results with that of the previous research.Using the coupled multiscale approach,the rarefaction and the temperature drive are studied,which are two main factors on the performance of the Knudsen pumps.To investigate the effect of rarefaction on the performance of the Knudsen pump,various pump operation pressures are compared.The flow characteristics and pumping ability at different rarefaction are analyzed,and the phenomenon of the multiscale flow is also discussed.Several cases with different linear or nonlinear temperature gradients are set to investigate the effect of temperature gradient on the performance of the Knudsen pump.The flow characteristics of the Knudsen pump such as the velocity,pressure increase,and the mass flowrate are presented.A unique phenomenon,the reverse transpiration effect caused by the nonlinear temperature gradient is studied,and the reason of the significant pressure increase in the pump channel is also analyzed.Since the multiscale gas flow is widely encountered in the microflow systems,the above method and its results can also be greatly beneficial and provide significant insights for the design of the MEMS devices. | YE Jianjun YANG Jian ZHENG Jinyang DING Xianting WONG Ieong LI Weizhong CHEN Cong | 2012 | Chinese Journal of Mechanical Engineering2012，25，4： | 6 |
| 11 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 12 | Infective viruses produced from full-length complementary DNA of swine vesicular disease viruses HK/70 strain显示文摘The full-length cDNA clone of swine vesicular disease virus HK/70 strain named pSVOK12 was constructed in order to study the antigenicity, replication, maturation and pathogenicity of swine vesicular disease virus. In vitro transcription RNA from pSVOK12 transfected IBRS-2 cells and the re- covered virus RNA were isolated and sequenced, then indirect hemagglutination test, indirect im- munofluorescence assays, eleectron microscope test, 50% tissue culture infecting dose (TCID50) assays and mouse virulence studies were performed to study the antigenicity and virulence of the recovered virus. The result showed that the infectious clones we ob- tained and the virus derived from pSVOK12 had the same biological properties as the parental strain HK/70. The full-length infectious cDNA clone, pSVOK12, will be very useful in studies of the anti- genicity, virulence, pathogenesis, maturation and replication of SVDV. | ZHENG Haixue LIU Xiangtao SHANG Youiun WU Jinyan BAI Xingwen JIN Ye SUN Shiqi GUO Huichen TIAN Hong FENG Xia YIN Shuanghui GUO Jianhong CONG Guozheng LIU Zaixin CHANG Huiyun MA Junwu XIE Qingge | 2006 | Chinese Science Bulletin2006，51，17： | 6 |
| 13 | Association between Serum Alkaline Phosphatase and Carotid Atherosclerosis in a Chinese Population: A Community-based Cross-sectional Study显示文摘Objective This study aimed to investigate the relationship between alkaline phosphatase(ALP) and common carotid intima media thickness(IMT), carotid plaque, and extracranial carotid artery stenosis(ECAS). Methods A total of 3,237 participants aged ≥ 40 years were recruited from Jidong community in 2013-2014. Participants were divided into five quintile groups based on their serum ALP levels. Carotid atherosclerosis was assessed using ultrasound. Abnormal IMT, carotid plaque, and ECAS were defined as IMT > 0.9 mm, IMT > 1.5 mm, and ≥ 50% stenosis in at least one extracranial carotid artery, respectively. Results Common carotid IMT values and the prevalence of carotid plaque increased across serum ALP quintiles. Higher ALP quintiles were correlated with an increased risk of abnormal IMT [fourth quintile: odds ratio(OR) 1.78, 95% confidence interval(CI) 1.13-2.82, P = 0.0135;fifth quintile: OR = 1.82, 95% CI: 1.15-2.87, P = 0.0110] and ECAS compared to the lowest quintile(fifth quintile: OR = 1.47, 95% CI: 1.09-1.97, P = 0.0106). The association between ALP and prevalence of carotid plaque became insignificant after adjustment for confounders. Conclusion Serum ALP levels were independently associated with abnormal common carotid IMT and ECAS. These conclusions need to be further corroborated in future prospective cohort studies. | YE Yi Cong LIU Hua Min ZHOU Yong ZENG Yong | 2019 | Biomedical and Environmental Sciences2019，32，6： | 5 |
| 14 | Choroidal blood perfusion as a potential“rapid predictive index”for myopia development and progression显示文摘Myopia is the leading cause of visual impairment worldwide.The lack of a“rapid predictive index”for myopia development and progression hinders the clinic management and prevention of myopia.This article reviews the studies describing changes that occur in the choroid during myopia development and proposes that it is possible to detect myopia development at an earlier stage than is currently possible in a clinical setting using choroidal blood perfusion as a“rapid predictive index”of myopia. | Xiangtian Zhou Cong Ye Xiaoyan Wang Weihe Zhou Peter Reinach Jia Qu | 2021 | Eye and Vision2021，8，1： | 5 |
| 15 | Combining Ability and Genetic Effects of Germination Traits of Brassica napus L.Under Waterlogging Stress Condition显示文摘Cross combinations from six rapeseed cultivars and lines were evaluated under waterlogging stress condition in order to understand the genetic mechanism of waterlogging tolerance of Brassica napus L.and provide reasonable improvement programs.There were six germination traits investigated on combining ability and heritability using complete diallel crossing method designed for 30 combinations from those six cultivars and lines.The traits included relative root length,stem length,fresh weight per plant,survival rate,electrical conductivity,and vigor index.After flooding treatment,the six traits of parents and F1 were analyzed.The general combining ability(GCA) and special combining ability(SCA) of germination traits were analyzed using Griffing I method.Among 30 cross combinations,the GCA was significantly different among six waterlogging resistance traits.The SCA of these traits was significantly different except the SCA of electrical conductivity.As a representative trait of waterlogging tolerance in rapeseed,relative vigor index had the highest narrow heritability and relatively low broad heritability.The cultivars Zhongshuang 9 and P79 had higher tolerance potential to waterlogging stress.It can be concluded that combining ability and genetic effects of relative vigor index during germination stage could be used to identify the waterlogging tolerance of rapeseed in breeding program. | CHENG Yong GU Min CONG Ye ZOU Chong-shun ZHANG Xue-kun WANG Han-zhong | 2010 | Agricultural Sciences in China2010，9，7： | 5 |
| 16 | An all-round AI-Chemist with a scientific mind显示文摘The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI)laboratory.Several AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains challenging.Here,we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research.Based on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly.It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations,including synthesis,characterization and performance tests.The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be proposed.The competence of the AI-Chemist has been scrutinized by three different chemical tasks.In the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory. | Qing Zhu Fei Zhang Yan Huang Hengyu Xiao LuYuan Zhao XuChun Zhang Tao Song XinSheng Tang Xiang Li Guo He BaoChen Chong JunYi Zhou YiHan Zhang Baicheng Zhang JiaQi Cao Man Luo Song Wang GuiLin Ye WanJun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou WeiWei Shang Jun Jiang Yi Luo | 2022 | National Science Review2022，9，10： | 5 |
| 17 | CFD-Based Optimization of Hot Primary-Air Pipe Networks in Power Plant Milling Systems显示文摘A hot primary-air pipe system is the bridge connecting an air-preheater with a coal mill in power generation stations.The effective geometrical configuration of the pipe network greatly affects the air flow distribution and consequently influences the safe and economic operation of milling systems in power stations.In order to improve the properties of the air flow,in the present work the SIMPLEC method is used to simulate numerically the flow field for the original layout of the system.As a result,the internal mechanisms influencing the uneven pressure drop in each branch are explored and three optimization schemes are proposed accordingly.The numerical results indicate that,for the original layout,the local pressure drop of the tee section accounts for approximately 74%of the total drop of the system,with other pressure drops depending on the specific branch considered.It is shown that after optimization,a roughly balanced flow resistance and flow rate can be obtained.Compared with the original layout,the pressure drop relating to different branches is significantly reduced. | Qingyun Yan You Li Yuanhong Zhu Kui Cheng Xueli Huang Cong Qi Xuemin Ye | 2020 | Fluid Dynamics & Materials Processing2020，16，3： | 4 |
| 18 | A low power global shutter pixel with extended FD voltage swing range for large format high speed CMOS image sensor显示文摘A low power 8T global shutter pixel with extended FD voltage swing range is proposed for large format high speed CMOS image sensor. The pixel has a negative threshold reset transistor, two in-pixel source followers, and a sample-and-hold circuit. The in-pixel first source follower is employed for reducing the pixel average current and maximum transient current. The negative threshold reset transistor is applied to extend the voltage swing of FD. Using pixel level sample-and-hold circuit, the k TC noise on FD node can be effectively nullified by correlated double sampling operation. A high speed 1000 fps 256×256 CMOS image sensor is implemented in 0.18 μm CMOS process. Two 10-bit cyclic ADC arrays are integrated in this prototype sensor chip. The active area of the chip is 10 mm×7 mm with a pixel size of 14 μm×14 μm. The developed sensor achieves an average current of 23 n A per pixel, a maximum transit current per pixel as low as 1113 n A, and a large FD voltage swing of 1.78 V. The sensor temporal noise level is 103 e-and full well capacity has 27000 e-which results in 48.3 d B signal dynamic range. | ZHOU YangFan CAO ZhongXiang HAN Ye LI QuanLiang SHI Cong DOU RunJiang QIN Qi LIU Jian WU NanJian | 2015 | Science China(Information Sciences)2015，58，4： | 4 |
| 19 | A New Enolate Furostanoside from Asparagus Filicinus显示文摘A new enolate derivative of furostanol glycoside, named asparagusin A, was isolated from the roots of Asparagus filicinus and established as 3 - O- 6 - D- xylopyranosyl (l →4)- β - Dglucopyranosyl (25S)-furost-20(22)-ene-3β, 26-diol 26-O-0-D-glucopyranoside (l) by spectroscopic and chemical methods. Asparagusin A (l) exhibited a cytotoxic activity effect on PC12 cells. | Xiao Dong CONG Wen Cai YE Chun Tao CHE Department of Pharmacohnosy China Pharmaceutical University Nanjing 210009 Department of Phytochemistry China Pharmaceutical University Nanjing 210009 School of Chinese Medicine The Chinese University of Hong Kon | 2000 | Chinese Chemical Letters2000，11，9： | 4 |
| 20 | Genome and transcriptome of Papaver somniferum Chinese landrace CHM indicates that massive genome expansion contributes to high benzylisoquinoline alkaloid biosynthesis显示文摘Opium poppy(Papaver somniferum)is a source of morphine,codeine,and semisynthetic derivatives,including oxycodone and naltrexone.Here,we report the de novo assembly and genomic analysis of P.somniferum traditional landrace‘Chinese Herbal Medicine’.Variations between the 2.62 Gb CHM genome and that of the previously sequenced high noscapine 1(HN1)variety were also explored.Among 79,668 protein-coding genes,we functionally annotated 88.9%,compared to 68.8%reported in the HN1 genome.Gene family and 4DTv comparative analyses with three other Papaveraceae species revealed that opium poppy underwent two whole-genome duplication(WGD)events.The first of these,in ancestral Ranunculales,expanded gene families related to characteristic secondary metabolite production and disease resistance.The more recent species-specific WGD mediated by transposable elements resulted in massive genome expansion.Genes carrying structural variations and large-effect variants associated with agronomically different phenotypes between CHM and HN1 that were identified through our transcriptomic comparison of multiple organs and developmental stages can enable the development of new varieties.These genomic and transcriptomic analyses will provide a valuable resource that informs future basic and agricultural studies of the opium poppy. | Li Pei Baishi Wang Jian Ye Xiaodi Hu Lihong Fu Kui Li Zhiyu Ni Zhenlong Wang Yujie Wei Luye Shi Ying Zhang Xue Bai Mengwan Jiang Shuhui Wang Chunling Ma Shujin Li Kaihui Liu Wanshui Li Bin Cong | 2021 | Horticulture Research2021，8，1： | 4 |
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