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| 1 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 2 | 循证医学 误用漏斗图的案例分析显示文摘本文要点应该使用严格的标准对循证医学中使用的方法进行评价用于检验发表偏倚的漏斗图在系统性文献综述中应用广泛漏斗图的不对称性,无论是直观上看到的或统计学检验发现的。 | Joseph Lau John P A Ioannidis Norma Terrin Christopher H Schmid Ingram Olkin 谢朝晖 | 2007 | 英国医学杂志中文版2007，10，3： | 1 |
| 3 | Water resources planning in a strategic context: linking the water sector to the national economy 显示文摘 | CHRISTOPHER H | 1993 | Wat Resour Res1993，29，7： | 1 |
| 4 | Visualization of water buildup in thecathode of a transparent PEM fuel cell显示文摘 | Klaus T David P Christopher H | 2003 | J Power Sources2003，124，2： | 1 |
| 5 | Synthesis,characterization,and catalytic properties of amicroporous/mesoporous material,MMM-1显示文摘 | RAJA H P POLADI R CHRISTOPHER C L | 2002 | J SolidState Chem2002，167，： | 1 |
| 6 | Optimization of Pre-and Post-Dispersion Compensation Schemes for 10-Gbits/s NRZ Links Using Standard and Dispersion Compensating Fibers显示文摘 | CHRISTOPHE P NORBERT H | 2000 | IEEE Photonics Technology Letters2000，12，8： | 1 |
| 7 | Liver cancer in low and middle income countries显示文摘 | Andraw J H Christopher P W | 2003 | BMJ2003，326，： | 1 |
| 8 | Chemi cal recycling of carbon fibre composites using alcohols under subcritical and supercritical conditions显示文摘 | RAUL P H JUAN G S CHRISTOPHER D | 2008 | Journal of Super- critical Fluids2008，46，： | 1 |
| 9 | Assessment of left ventricular parameters using 16-MDCT and new software for endocardial and epicardial border dilineation显示文摘 | Thomas S Konstantin P Christoph U H | 2005 | AJR2005，184，3： | 1 |
| 10 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 11 | Biomechanical analysis of rigid stabilization techniques for three-column injury in the lower cervical spine显示文摘 | Hakan B Christopher P Robert H | 2005 | Spine2005，30，8： | 1 |
| 12 | Endovascular coil embolization of ruptured and unruptured posterior circulation aneurysms:review of a 10-year experience显示文摘 | Aditya S P Christopher K Robert H R | 2007 | Neurosurgery2007，60，4： | 1 |
| 13 | Advances in ultrasound显示文摘 | Christopher J H Kames M P Robert J E | 2002 | Clinical Radiology2002，57，： | 1 |
| 14 | Historical review of air-bearing spacecraft simulators 显示文摘 | Jana L S Mason A P Christopher D H | 2003 | Journal of Guidance Control and Dynamics2003，26，4： | 1 |
| 15 | Synorogenic hydrothermal origin forgiant Hamersley iron oxide ore bodies显示文摘 | Christopher M P Nicholas H S | 1999 | Geology1999，27，2： | 1 |
| 16 | Far posterior subtemporal approach to the dorsolateral brainstem and tentorial ring: technique and clinical experience 显示文摘 | SMITH E R CHRISTOPHER P H OGILVY C S | 2003 | Neurosurgery2003，52，2： | 1 |
| 17 | Bioprotective alkaloids of grass-fungal endophytes symbiosis显示文摘 | Powell P B Heather H W Christopher L S | 1997 | Plant Physiol1997，114，1： | 1 |
| 18 | Assessment of heparanmimetics as novel Alzheimer therapeutics 显示文摘 | Christopher J T Carolyn H Susannah P | 2006 | Alzheimer Dement2006，2，3： | 1 |
| 19 | A knowledge-based approach to the statistical mapping of climate显示文摘 | Christopher D Wayne P G George H T | 2002 | Cli- mate Research2002，22，： | 1 |
| 20 | Critical pathway for management of patients with acute coronary syndromes:an assessment bytheNational Heart Attack Alert Program显示文摘 | CHRISTOPHER P CANNON HAND M H ROALD BAHR | 2002 | American Heart Journal2002，143，5： | 1 |
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