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| 1 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Treatment of peri-implant defects with guided bone regeneration:A comparative clinical study with various membranes and bone grafts显示文摘 | Martin L Christof P Clemens K | 1998 | Int J OralMaxillofac Implants1998，13，： | 1 |
| 4 | Stable RNA interference rules for silencing显示文摘 | Christof F Scott W L | 2014 | Nat Cell Biol2014，16，1： | 1 |
| 5 | Keccak und der SHA-2显示文摘 | PAWEL S GERGOR L CHRISTOF P | 2013 | Datenschutz Und Datensicherheit2013，37，11： | 1 |
| 6 | Study of Health in Pomerania (SHIP): A health examination survey in an east German region: Objectives and design显示文摘 | Prof. Dr. Ulrich John Elke Hensel Jan Lüdemann Marion Piek Sybille Sauer Christiane Adam Gabriele Born Dietrich Alte Eberhard Greiser Ursula Haertel Hans-Werner Hense Johannes Haerting Stefan Willich Christof Kessler | 2001 | Sozial - und Pr?ventivmedizin SPM2001，，3： | 1 |
| 7 | Study of Health in Pomerania (SHIP): A health examination survey in an east German region: Objectives and design显示文摘 | Prof. Dr. Ulrich John Elke Hensel Jan Lüdemann Marion Piek Sybille Sauer Christiane Adam Gabriele Born Dietrich Alte Eberhard Greiser Ursula Haertel Hans-Werner Hense Johannes Haerting Stefan Willich Christof Kessler | 2001 | Sozial - und Pr?ventivmedizin SPM2001，，3： | 1 |
| 8 | Intracerebral Mass Bleeding in a Term Neonate: Manifestation of Hereditary Protein S Deficiency with a New Mutation in the PROS1 Gene显示文摘 | Fischer Doris Porto Luciana Stoll Hildegard Geisen Christof Schloesser Rolf L | 2010 | Neonatology2010，，4： | 1 |
| 9 | Investigations of the influence of dicing techniques on the strength properties of thin silicon显示文摘 | STEPHAN S MATTHIAS E CHRISTOF L | | 0，，47： | 1 |
| 10 | Dealing with periodical loads and harmonics in operational modal analysis using time-varying transmissibility functions显示文摘 | Wout W John L Christof D | 2014 | Mechanical Systems and Signal Processing2014，，49： | 1 |
| 11 | Loss of AngiomiR-126 and 130a in Angiogenic Early Outgrowth Cells From Patients With Chronic Heart Failure: Role for Impaired In Vivo Neovascularization and Cardiac Repair Capacity显示文摘 | Philipp Jakob Carola Doerries Sylvie Briand Pavani Mocharla Nicolle Kr?nkel Christian Besler Maja Mueller Costantina Manes Christian Templin Christof Baltes Markus Rudin Heiner Adams Mathias Wolfrum Georg Noll Frank Ruschitzka Thomas F. Lüscher Ulf Landme | 2012 | Circulation2012，，25： | 1 |
| 12 | Associative parametric CAE methods in the aircraft pre-design显示文摘 | CHRISTOF L CLAUS H JORG W Z | 2005 | Aerospace Science and Technology2005，9，7： | 1 |
| 13 | ‘Observations and Modelling of Cold-air Advection over Arctic Sea Ice’显示文摘 | Timo Vihma Christof Lüpkes J?rg Hartmann Hannu Savij?rvi | 2005 | Boundary - Layer Meteorology2005，，2： | 1 |
| 14 | Contracting for major projects: eight business levers for top management显示文摘 | Christof V B Christoph H L | 2004 | International Jour- nal of Project Management2004，22，2： | 1 |
| 15 | Computational fluid dynamics in patients with continuous-flow left ventricular assist device support show hemodynamic alterations in the ascending aorta 显示文摘 | Christof K Sasan P Matthias L | 2014 | J Thorac Cardiovasc Surg2014，147，4： | 1 |
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