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| 1 | Target Organ Protection from a Novel AngiotensinⅡReceptor (AT1) Vaccine ATR12181 in Spontaneously Hypertensive Rats显示文摘高血压生产为与疾病联系的死亡经常负责的 pathophysiological 变化。overactive 高血压蛋白原酶血管收缩素系统在高血压和与高血压联系的目标机关损坏的发展起一个中央作用,是明显的。我们以前发现了新奇血管收缩素受体(AT1 ) vaccine-ATR12181 在自发地高血压的老鼠(SHR ) 稀释了高血压(BP ) 的发展人的必要高血压的模型。我们的目的是决定高 BP 的这变细是否与由高血压的状态导致的目标机关损坏的预防被联系。SHR 被在联合复杂的 peptide-tetanus-toxoid 的重复下的注射与 Freund 的助手从 AT1A 受体的 extracelluar 部分对肽(编码 ATR12181 ) 使免疫。64 个星期长期的观察被执行。重复种痘导致了 anti-ATR12181 抗体的正式就职。在观察的结束,种牛痘表明的 SHR 降低肾损害的 BP,减少的心脏的肥大和变细。在心和肾的 c-fos 和 c-jun 的 mRNA 层次在种牛痘的 SHR 被减少。因为自我抗原被使用,疫苗的安全被担心。然而,自体免疫的疾病的符号没在心和肾的节被观察。这些数据证明对 AT1 受体的细胞外的部分的域的那重复免疫能对高血压引起一个目标机关保护。对 AT1 受体的活跃免疫可以在高血压的治疗被看作有希望的新策略。 | Feng Zhu Yuhua Liao Liudong Li Min Cheng Fen Wei Yumiao Wei Ming Wang | 2006 | Cellular & Molecular Immunology2006，3，2： | 10 |
| 2 | Chemical characteristics of precipitation at Nanping Mangdang Mountain in eastern China during spring显示文摘To study the characteristics of precipitation in eastern China,an automatic sampler was used to collect rainwater samples from 19 precipitation events at Mangdang Mountain,Nanping City,Fujiang Province,in the spring of 2009.We used ion chromatography to analyze the ionic components and concentrations,and inductively coupled plasma mass spectrometry (ICP-MS) to analyze element compositions and contents.The results demonstrated remarkable acidic characteristics:in more than 80% of precipitation events the pH was less than 5.6,with an average of 4.81.Mass concentration results showed SO 4 2 was the main anionic component (36.2% of the total anion mass),while NH 4+ was the main cationic component (47.7% of the total cation mass) and main ion for acidity neutralization in the rainwater.Organic acid content accounted for 30.9% of total anion mass.The main trace metals were Ca,K,and Na.The SO 4 2/NO 3 ratio was 1.4,indicating that precipitation in this region was influenced by complex air pollution-the product of individual coal-burning combined with vehicle exhaust pollution.Correlation analysis of the chemical composition of the precipitation indicated that acidity in this region was determined by a combination of all acidic and neutralization ions rather than any single ion component.The results also showed that Na+ and Cl contributions were mainly by seawater;Mg 2+ by seawater and crustal materials;the NH 4+,K+,Ca 2+,NO 3 and SO 4 2 by anthropogenic sources;the trace metals were from the Earth's crust;and organic acids were potentially from combustion of biomass. | Yanli Cheng Ying Liu Mingqun Huo Qian Sun Huixiang Wang Zhongming Chen Yuhua Bai | 2011 | Journal of Environmental Sciences2011，23，8： | 8 |
| 3 | External fixation is more suitable for intra-articular fractures of the distal radius in elderly patients显示文摘The purpose of this study was to compare the functional outcomes,psychological impact,and complication rates associated with external fixation and volar or dorsal plating in relation to the functional parameters following treatment of intra-articular fractures of the distal radius(IFDR) in patients older than 65 years.We hypothesized that using volar or dorsal plating would improve functional outcomes,but that it would be associated with more complications and equivalent functional outcomes when compared with the external fixation group.A total of 123 consecutive patients suffering from IFDR were recruited into the study.The patients were measured for clinical,radiological,and psychosocial functioning outcomes and were followed up after 1 week and 3,6 and 12 months.After 3 months,the plating group had better pronation(P=0.001),supination,(P=0.047) and extension(P=0.043) scores.These differences were somewhat attenuated by6 months and disappeared at 1 year.The plating group had a greater occurrence of wound infection(P=0.043),tendonitis,(P=0.024) and additional surgery compared with the external fixation group.The only TNO-AZL Adult Quality of Life scores in the plating group that were lower than those in the external fixation group were in the 'gross motor' category(walking upstairs,bending over,walking 500 yards; P=0.023).Internal fixation was more advantageous than external fixation in the early rehabilitation period; after 1 year the outcomes were similar.The plating group showed significantly higher levels of wound infection and tendonitis and had a greater need for additional surgeries. | Chuang Ma Qiang Deng Hongwei Pu Xinchun Cheng Yuhua Kan Jing Yang Aihemaitijiang Yusufu Li Cao | 2016 | Bone Research2016，4，1： | 7 |
| 4 | 30 GHz GeSn photodetector on SOI substrate for 2 µm wavelength application显示文摘We report the demonstration of a normal-incidence p-i-n germanium-tin(Ge_(0.951)Sn_(0.049))photodetector on silicon-on-insulator substrate for 2μm wavelength application.The DC and RF characteristics of the devices have been characterized.A dark current density under−1 V bias of approximately 125 mA/cm^(2) is achieved at room temperature,and the optical responsivity of 14 mA/W is realized for illumination wavelength of 2μm under−1 V reverse bias.In addition,a 3 dB bandwidth(f_(3dB))of around 30 GHz is achieved at−3 V,which is the highest reported value among all group III–V and group IV photodetectors working in the 2μm wavelength range.This work illustrates that a GeSn photodetector has great prospects in 2μm wavelength optical communication. | Xiuli Li Linzhi Peng Zhi Liu Zhiqi Zhou Jun Zheng Chunlai Xue Yuhua Zuo Baile Chen Buwen Cheng | 2021 | Photonics Research2021，9，4： | 6 |
| 5 | A Heterogeneous Information Fusion Deep Reinforcement Learning for Intelligent Frequency Selection of HF Communication显示文摘The high-frequency(HF) communication is one of essential communication methods for military and emergency application. However, the selection of communication frequency channel is always a difficult problem as the crowded spectrum, the time-varying channels, and the malicious intelligent jamming. The existing frequency hopping, automatic link establishment and some new anti-jamming technologies can not completely solve the above problems. In this article, we adopt deep reinforcement learning to solve this intractable challenge. First, the combination of the spectrum state and the channel gain state is defined as the complex environmental state, and the Markov characteristic of defined state is analyzed and proved. Then, considering that the spectrum state and channel gain state are heterogeneous information, a new deep Q network(DQN) framework is designed, which contains multiple sub-networks to process different kinds of information. Finally, aiming to improve the learning speed and efficiency, the optimization targets of corresponding sub-networks are reasonably designed, and a heterogeneous information fusion deep reinforcement learning(HIF-DRL) algorithm is designed for the specific frequency selection. Simulation results show that the proposed algorithm performs well in channel prediction, jamming avoidance and frequency channel selection. | Xin Liu Yuhua Xu Yunpeng Cheng Yangyang Li Lei Zhao Xiaobo Zhang | 2018 | China Communications2018，15，9： | 6 |
| 6 | Solar fuel generation over nature-inspired recyclable TiO_(2)/g-C_(3)N_(4)S-scheme hierarchical thin-film photocatalyst显示文摘Preparation of efficient photocatalysts with ease of recovery in solar fuel generation is highly desired to achieve carbon neutralization in carbon dioxide(CO_(2))emissions.Inspired from the forest with superior light penetration and fast gas transport,a TiO_(2)/g-C_(3)N_(4)composite nanowire arrays(NAs)film with maximized light utilization is devised.It is achieved by in-situ coating a thin layer of g-C_(3)N_(4)(as the leaf)on the vertically-oriented TiO_(2)arrays(as tree trunks)on Ti foil(as soil).Benefiting from the effective charge separation by S-scheme charge transfer,intimate contact by the in-situ growth as well as the ingenious structure,the composite,readily recyclable,displays exciting performance in photocatalytic CO_(2)reduction.It is beyond doubt that the combination of heterojunction construction and“nature-inspired biomimetic photocatalyst”design promises practical applications and industrial use. | Libo Wang Xingang Fei Liuyang Zhang Jiaguo Yu Bei Cheng Yuhua Ma | 2022 | Journal of Materials Science & Technology2022，，17： | 4 |
| 7 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 8 | Horizontal GeSn/Ge multi-quantum-well ridge waveguide LEDs on silicon substrates显示文摘A horizontal p-i-n ridge waveguide emitter on a slion(100)substrate with a Gen,g1Sno.c9/Ge multi quantum-well(MQW)active layer was fabricated by molecular beam epitaxy.The device structure was designed to reduce light absorption of metal electrodes and improve injection efficiency.Electroluminescence(EL)at a wavelength of 2160 nm was observed at room temperature.Theoretical calculations indicate that the emission peak corresponds well to the direct bandgap transition(nr-mHr).The light output power was about 2.0μW with an injection current density of 200 kA/cm^2.These results show that the horizontal GeSn/Ge MQW ridge waveguide emiters have great pros-pects for group-IV light sources. | LINZHI PENG Xu LI ZHI LIU XIANGQUAN LIU JUN ZHENG CHUNLAI XUE YUHUA ZUO BUWEN CHENG | 2020 | Photonics Research2020，8，6： | 3 |
| 9 | A glance of technology efforts for design-for-manufacturing in nano-scale CMOS processes显示文摘This paper overviews design for manufacturing (DFM) for IC design in nano-CMOS technologies. Process/device issues relevant to the manufacturability of ICs in advanced CMOS technologies will be presented first before an exploration on process/device modeling for DFM is done. The discussion also covers a brief introduction of DFM-aware of design flow and EDA efforts to better handle the design-manufacturing interface in very large scale IC design environment. | CHENG YuHua | 2008 | Science in China(Series F)2008，51，6： | 3 |
| 10 | Fine-Tuned Expression of Programmed Death 1 Ligands in Mature Dendritic Cells Stimulated by CD40 Ligand is Critical for the Induction of an Efficient Tumor Specific Immune Response显示文摘During maturation,murine myeloid dendritic cells (DCs) upregulated the expressions of CD11c,CD25,CD40,CD80,CD86,MHC Ⅱ and programmed death 1 ligands 1 and 2 (PD-L1 and PD-L2). Differential expression patterns of PD-L1 and PD-L2 were found when DCs were triggered by CD40 ligand and TNF-α. PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40-ligated DCs,whereas TNF-α stimulated DCs kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs. Proliferations of T lymphocytes stimulated by immature DCs were enhanced by blockade of the PD-1 and PD-1 ligand interaction. But inhibitive effects were found in T lymphocytes stimulated by CD40-ligated DCs. With the fine-tuned expressions of PD-L1 and PD-L2,CD40-ligated DCs could sustain a longer activation period and elicit a more efficient T lymphocyte activation. | Tao Gu Yibei Zhu Cheng Chen Min Li Yongjing Chen Gehua Yu Yan Ge Shiyong Zhou Huan Zhou Yong Huang Yuhua Qiu Xueguang Zhang | 2008 | Cellular & Molecular Immunology2008，5，1： | 3 |
| 11 | Growth and characterization ofβ-Ga_(2)O_(3)thin films grown on off-angled Al_(2)O_(3)substrates by metal-organic chemical vapor deposition显示文摘Beta-gallium oxide(β-Ga_(2)O_(3))thin films were deposited on c-plane(0001)sapphire substrates with different mis-cut angles along<>by metal-organic chemical vapor deposition(MOCVD).The structural properties and surface morphology of as-grownβ-Ga_(2)O_(3)thin films were investigated in detail.It was found that by using thin buffer layer and mis-cut substrate technology,the full width at half maximum(FWHM)of the()diffraction peak of theβ-Ga_(2)O_(3)film is decreased from 2°on c-plane(0001)Al_(2)O_(3)substrate to 0.64°on an 8°off-angled c-plane(0001)Al_(2)O_(3)substrate.The surface root-mean-square(RMS)roughness can also be improved greatly and the value is 1.27 nm for 8°off-angled c-plane(0001)Al_(2)O_(3)substrate.Room temper-ature photoluminescence(PL)was observed,which was attributed to the self-trapped excitons formed by oxygen and gallium vacancies in the film.The ultraviolet-blue PL intensity related with oxygen and gallium vacancies is decreased with the increas-ing mis-cut angle,which is in agreement with the improved crystal quality measured by high resolution X-ray diffraction(HR-XRD).The present results provide a route for growing high qualityβ-Ga_(2)O_(3)film on Al_(2)O_(3)substrate. | Yabao Zhang Jun Zheng Peipei Ma Xueyi Zheng Zhi Liu Yuhua Zuo Chuanbo Li Buwen Cheng | 2022 | Journal of Semiconductors2022，43，9： | 3 |
| 12 | Auditory characteristics of noise-exposed memberscrossing age-related groups显示文摘Objective: To report audiological characteristics in a group of noise-exposed crew members on board ships.Methods and materials: Clinical and audiological measurements including pure-tone thresholds, acoustic immittance results and tinnitus questionnaires were collected from both the ship crew members(study subjects) and their land based colleagues(controls).Results: 1) Noise exposed crew members showed not only high frequency, but also low frequency hearing loss; 2) Hearing impairment increased with age, with 65.5% of crew members younger than 50 years showing normal hearing while only 14.9% of those older than 50 years had normal hearing; 3)hearing loss gradually increased with the extension of on board career time; and 4) Most study subjects reported high pitch tinnitus, significantly more than the control group although not significantly different among different age groups.Conclusion: Noise induced hearing impairment from working on board ships shows specific frequency and age characteristics. Understanding these characteristics is important for advancing relevant studies and for effective prevention of noise-induced hearing loss in ship crew members. | Liu Chenqing Ding Daxiong Zhu Yuhua Wang Hongyang Cheng Xiaoting Zhao Zhenhua Cao Juyang Zhai Suoqiang Yu Ning | 2018 | Journal of Otology2018，13，2： | 3 |
| 13 | Constructing a Genetic Linkage Map Using an F1 Population of Non-inbred Parents in Cassava (Manihot esculenta Crantz)显示文摘 | Xin Chen Zhiqiang Xia Yuhua Fu Cheng Lu Wenquan Wang | 2010 | Plant Molecular Biology Reporter2010，，4： | 2 |
| 14 | A low power and small area all digital delay-locked loop based on ring oscillator architecture显示文摘A 133-500 MHz,5.2 mW @500 MHz,0.021 mm2 all digital delay-locked loop(ADDLL)is presented.The power and area reduction of the proposed ADDLL are achieved by implementing a high frequency ring oscillator(ROSC)to count the reference clocks such that the one-clock cycle delay chain and the phase detector in a conventional Master block are no longer needed.The proposed ADDLL has better immunity to PVT(process,voltage,and temperature)than most conventional DLLs,which do not update the control word signals after the locking process,since the control signals for slave delay line are updated in every 256 reference cycles.Fabricated in 0.13 um CMOS process,the measured RMS jitter is 10.83 ps at 500 MHz while the RMS jitter of the input signal is 9.97 ps. | ZHENG JiaPeng LI Wei LU XueQing CHENG YuHua WANG YangYuan | 2012 | Science China(Information Sciences)2012，55，2： | 2 |
| 15 | Role of hydrogen peroxide in stress-induced programmed cell death during somatic embryogenesis in Fraxinus mandshurica显示文摘We examined how reactive oxygen species, in the form of hydrogen peroxide (H2O2), affect osmotic stress–induced programmed cell death during somatic embryogenesis from cotyledon explants of Manchurian ash (Fraxinus mandshurica Rupr.). We found that substantial osmotic stress was essential for Manchurian ash somatic cells to obtain embryogenic competence. The explant cells displayed hallmarks of programmed cell death, chromatin condensation, and DNA fragmentation to oligonucleotides during somatic embryogenesis. Increasing concentrations of plant growth regulators and sucrose in the medium increased osmotic stress thereby inducing H2O2 accumulation in the explant cells. We found that H2O2 concentration was significantly decreased in explant cells when the induction medium was modified, i.e., when reducing the concentration of sucrose, which reduces the osmotic pressure of the medium, or by withdrawing plant growth regulators at mid-culture. These treatments also decreased the proportion of explant cells undergoing programmed cell death. Accordingly, a decreased rate of somatic embryo induction was observed. These results show that PCD occurred during tissue browning and death of some explant cells during somatic embryogenesis in F. mandshurica. The ROS contributed to PCD in abiotic stress stimulated F. mandshurica cells. | Ling Yang Cheng Wei Chao Huang Hongnan Liu Dongyan Zhang Hailong Shen Yuhua Li | 2019 | Journal of Forestry Research2019，30，3： | 2 |
| 16 | Studies of benzyl hydroxamic acid/calcium lignosulphonate addition order in the flotation separation of smithsonite from calcite显示文摘Flotation separation of smithsonite from calcite is difficult due to their similar surface properties.In the present study,a reagent scheme of depressant calcium lignosulphonate(CLS) and collector benzyl hydroxamic acid(BHA) was introduced in the flotation of smithsonite from calcite.Microflotation tests revealed that the efficient flotation of smithsonite from calcite could only be obtained with the addition order of BHA before CLS,which was opposite to the widely-used order that adding depressant prior to the collector.The zeta potential measurements indicated that BHA selectively adsorbed onto smithsonite surface,then not allowed the CLS adsorption onto the smithsonite surface rather than calcite surface because of the steric hindrance,thereby the smithsonite surface remained hydrophobic while calcite surface became more hydrophilic after the addition of CLS.As a result,the calcite flotation was completely depressed while the smithsonite flotation recovery was still in high value,leading to the optimal flotation separation performance. | Cheng Liu Yuhua Zhu Kaihua Huang Siyuan Yang Zhian Liang | 2021 | International Journal of Mining Science and Technology2021，31，6： | 2 |
| 17 | A new method for quantitatively characterizing atmospheric oxidation capacity显示文摘Based on atmospheric chemical kinetics, the rate constant of overall pseudo-first order oxidation re-moval of gaseous pollutants (Kpor,T) is proposed to characterize the atmospheric oxidation capacity in troposphere. Being a quantitative parameter, Kpor,T can be used to address the issues related to at-mospheric oxidation capacity. By applying this method, the regional oxidation capacity of the atmos-phere in Pearl River Delta (PRD) is numerically simulated based on CBM-IV chemical mechanism. Re-sults show the significant spatio-temporal variation of the atmospheric oxidation capacity in PRD. It is found that OH initiated oxidations, heterogeneous oxidation of SO2, and photolysis of aldehydes are the three most important oxidation processes influencing the atmospheric oxidation capacity in PRD. | CHENG YanLi WANG XueSong LIU ZhaoRong BAI YuHua LI JinLong | 2008 | Science China Chemistry2008，51，11： | 2 |
| 18 | Myosin Specific-T Lymphocytes Mediated Myocardial Inflammation in Adoptive Transferred Rats显示文摘Myosin specific-T lymphocytes might mediate myocardial inflammation and remodeling after AMI. Myosin- activated or unactivated T lymphocytes in vitro were transferred into na?ve syngeneic rats, respectively. T lymphocyte infiltration and myocyte apoptosis were explored by the H&E and TUNNEL. Proteins and mRNA levels of cytokines (IL-1β, IL-6 and TNF-α) in myocardium were determined by RT-PCR and immunohisto- chemistry. T lymphocyte infiltration was evidently observed after one week of activated T cell transfer. The expressions of cytokines were elevated markedly one week later. The myocyte apoptosis occurred after T lymphocyte infiltration in myocardium. Our findings suggest that cardiac myosin activated-T lymphocytes may mediate myocardial inflammation and remodeling. | Jin Zhang Yuhua Liao Xiang Cheng Jing Chen Peng Chen Xiang Gao Zhengjenny Zhang | 2006 | Cellular & Molecular Immunology2006，3，6： | 2 |
| 19 | Design and optimization of an integrated MEMS gas chamber with high transmissivity显示文摘Non-Dispersive InfraRed(NDIR)gas sensor is widely used for gas detection in collieries and the gas chemical industry,etc.The performance of the NDIR gas sensor depends on the volume,optical length and transmittance of the gas chamber.However,the existing gas sensor products have problems of large volume,high cost and incapable of integration,which need to develop towards the miniaturized sensor.This paper first presents the theoretical background of the NDIR gas sensor and the novel structure of a fully integrated infrared gas sensor and its micro-machined gas chamber structure.Then,the light structure and the gas flow of the gas chamber are optimized on Tracepro software and Ansys workbench,respectively,and the technological process for preparing the Micro-Electro-Mechanical System(MEMS)gas chamber is designed.Finally,we produce a gas chamber with a small volume and good transmissivity,which would be the most important part of producing the miniaturized NDIR gas sensor. | Yang Jing Cheng Yuhua Yuan Yupeng Li Xiaofei Zhang Zuwei Xu Ming Wang Dengpan Mu Jiangdong Mei Yong Zhang Yuzhe | 2021 | Digital Communications and Networks2021，7，1： | 2 |
| 20 | Tumor Necrosis Factor-α-Converting Enzyme (ADAM17) Mediates GPIbα Shedding From Platelets In Vitro and In Vivo显示文摘 | Wolfgang Bergmeier Crystal L. Piffath Guiying Cheng Vandana S. Dole Yuhua Zhang Ulrich H. von Andrian Denisa D. Wagner | 2004 | Circulation Research2004，，7： | 2 |
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