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| 1 | Effects of cannabinoid receptor type 2 on endogenous myocardial regeneration by activating cardiac progenitor cells in mouse infarcted heart显示文摘Cannabinoid receptor type 2(CB2)activation is recently reported to promote proliferation of some types of resident stem cells(e.g.,hematopoietic stem/progenitor cell or neural progenitor cell).Resident cardiac progenitor cell(CPC)activation and proliferation are crucial for endogenous cardiac regeneration and cardiac repair after myocardial infarction(MI).This study aims to explore the role and possible mechanisms of CB2receptor activation in enhancing myocardial repair.Our results revealed that CB2receptor agonist AM1241 can significantly increase CPCs by c-kit and Runx1 staining in ischemic myocardium as well as improve cardiomyocyte proliferation.AM1241 also decreased serum levels of MDA,TNF-αand IL-6 after MI.In addition,AM1241 can ameliorate left ventricular ejection fraction and fractional shortening,and reduce fibrosis.Moreover,AM1241 treatment markedly increased p-Akt and HO-1 expression,and promoted Nrf-2 nuclear translocation.However,PI3K inhibitor wortmannin eliminated these cardioprotective roles of AM1241.In conclusion,AM1241 could induce myocardial regeneration and improve cardiac function,which might be associated with PI3K/Akt/Nrf2 signaling pathway activation.Our findings may provide a promising strategy for cardiac endogenous regeneration after MI. | WANG YaBin MA Sai WANG Qiang HU WenXing WANG DongJuan LI XiuJuan SU Tao QIN Xing ZHANG XiaoTian MA Ke CHEN JiangWei XIONG LiZe CAO Feng | 2014 | Science China(Life Sciences)2014，57，2： | 3 |
| 2 | TAT-Mediated Protein Transduction of Nogo Extracellular Peptide 1-40 and its Biological Activity显示文摘 | Qiang Wang Xingchun Gou Weilin Jin Lize Xiong Lichao Hou Shaoyang Chen Hui Zhang Xiaoling Zhu Lixian Xu | 2009 | Cellular and Molecular Neurobiology2009，，： | 1 |
| 3 | Interpretation of the Spatial Distribution Characteristics of the Co-seismic Landslides Induced by the 1920 Haiyuan M81/2 Earthquake Using Remote Sensing Images显示文摘Analyzing the spatial distribution characteristics of earthquake-induced secondary disasters based on advanced techniques is significantly important,especially in understanding the process of strong earthquakes in the Loess Pateau.Using ArcGIS,this study interprets multi-temporal high-resolution satellite images,field investigation data,and historical seismic records.Major conclusions are obtained as follows:①Landslides induced by the Haiyuan earthquake are mainly distributed in the intersection area of the end of the Haiyuan fault and Liupanshan fault,as indicated by multiple dense distribution centers;②The landslide distribution of the Haiyuan Earthquake is determined by the distance to the fault,topographic relief,slope,lithology,and other factors.In detail,the closer the distance to the fault,the greater the density of the landslide.The greater the slope and relief of the terrain,the greater the density and the smaller the average area of a landslide.Compared with tertiary strata,Quaternary strata has a larger average area,and the density of the landslides is smaller;③The density curve of the death toll in the Haiyuan earthquake can be used as a reference for the distribution of co-seismic landslides.Several Haiyuan co-seismic landslides are distributed in the Tongwei landslide area;however,the major landslides here are induced by the 1718 Tongwei earthquake rather than the 1920 Haiyuan earthquake;④The co-seismic landslides of the Haiyuan earthquake exhibits the“slope effect”in the south-west plate of Haiyuan fault,presenting the dominant sliding direction towards the fault and epicenter;however,the“slope effect”is not evident in the northeast plate of the fault. | ZHANG Weiheng XU Yueren DU Peng LI Wenqiao TIAN Qinjian CHEN Lize | 2020 | Earthquake Research in China2020，34，4： | 1 |
| 4 | Relationship between the Landslides Triggered by the Tongwei M71/2 Earthquake in 1718 AD and the Disappearance of Yongning Ancient Town显示文摘Although China’s historical earthquake documentation is relatively rich,it is not all based on scientific records.Therefore,the verification of the seismic information in historical records can effectively avoid exaggerating or underestimating the damage they produced.In this paper,we analyze the detailed information of the 1718 AD Tongwei M7⅟��earthquake through field surveys,document sorting,and manual visual interpretation of UAV images.Major conclusions are listed as follows:①The low-level terraces of Weihe River between Gangu and Wushan are fully developed with flatted surface,and the residents here are mostly killed by house collapses.In addition,the disappearance of Yongning Ancient Town is not directly related to the earthquakeinduced landslides;②In fact,“Yongning Town is entirely buried by the earthquake”in the historical records describes the phenomenon that loess dust has pervaded the entire Weihe Valley.These dust grains are produced by the sliding of earthquakeinduced landslides.Thus,there is no possibility that large-scale landslides have slipped over Weihe bedrock and buried Yongning Town;③After the earthquake,survivors abandoned the ruins and selected a new site to live.They built a new town named“Pan’an(means always peaceful in the future)”.earthquake-induced landslides may be the reason of burying the residential areas on valley-side slopes,while those locations inside the valley are associated with the amplification effect of ground vibration.On the basis of compiling historical seismic data,scientific methods are used to explore the real meaning of these documents,for the purpose of providing basic data for the risk evaluation of strong historical earthquakes. | XU Yueren DU Peng LI Wenqiao TIAN Qinjian CHEN Lize | 2020 | Earthquake Research in China2020，34，4： | 1 |
| 5 | The Calculation Method for the Volume of Landslides and Dammed Lake Sediments Triggered by a Strong Historical Earthquake in the Loess Plateau:A Case Study of Qiuzigou, Gansu Province, Northwest China显示文摘The quantitative calculation of the volume of large earthquake-triggered landslides and related dammed lake sediments is of great significance in the study of secondary disasters and focal parameters of strong historical earthquakes.In this study,the dammed lake induced by Qishan M7 earthquake(Lingtai County,Gansu Province,Northwest China)is selected as the research object.Based on the information collected from the 4 boreholes in the dammed lake area,we further take advantage of the lowlevel Unmanned Aerial Vehicle(UAV)photogrammetry and the morphology recovery method,to calculate the volume of the dammed lake and landslides,respectively.Finally,major conclusions are obtained as follows:①the AMS-14C age at the bottom of the Qiuzigou Dammed Lake sediments is 2890±30 BP,which coincides with the 780 BC Qishan earthquake;furthermore,the Qiuzigou Landslides seem to have been triggered by the earthquake,forming an enclosed dammed lake deposition environment after the upstream sediments accumulate;②the Qiuzigou landslides are opposite-sliding landslides that have blocked the river valley;in detail,landslide volumes at the right and left banks are 235×104 m3 and 229×104 m3,respectively.The length of the dammed lake is 2.6 km,with a thickness of approximately 43 m near the landslides,and the total sedimentary volume is 573×104 m3;③the erosion rate of Qiuzigou Landslide Dammed Lake is 0.44 mm/a,the accumulation rate is 15.05 mm/a,and the soil erosion modulus is 593 t/(km2/a),characterized as slight erosion.Quantitative research on the formation of landslides and dammed lakes from strong historical earthquakes is vital for increasing our understanding of the vibrational characteristics and surface action processes of these types of earthquakes. | DU Peng XU Yueren LI Wenqiao TIAN Qinjian CHEN Lize | 2020 | Earthquake Research in China2020，34，4： | 1 |
| 6 | The Volume Calculation Method of Rock Collapses and Loess Landslides Triggered by the 1556 AD Huaxian M81/2 Earthquake in Shaanxi Province, China显示文摘Accurate volume calculation of each individual landslide triggered by strong historical earthquakes can help understand the characteristics of the typical earthquake-induced landslides,thus providing significant information for the modification of the focal parameters of historical earthquakes.In this study,we select one rock fall and three loess landslides triggered by the 1556 AD Huaxian M8⅟��earthquake,compute their volumes using the low-altitude high-precision Unmanned Aerial Vehicle(UAV)photogrammetry and landslide profile restoration methods.The results show that:①the whole influencing area of the Huangjiagou Rock Fall is approximately 3.03×105 m2 and the area of the collapsed rock accumulated at the slope foot is 3.33×104 m2,accounting for approximately 10%of the entire influencing range.However,the estimated volume of the collapsed rock is only 0.699×106 m3,indicating a rock fall with large influencing range but limited collapsed rock;②the geological form of thethree loess landslides are preserved intactly,with volumes of 0.283×108 m3,0.074×108 m3,and 0.377×108 m3.These important geological hazard relics reflect the strong vibrations and severe casualties in the meizoseismal area;③loess landslides are the key reason of the serious death toll in the hilly-gully loess area.Our new method can be used to estimate the influencing area and the actual volume of each individual landslide,and rationally evaluate the role of earthquake landslides in the disaster.In addition,quantitative research on secondary disasters triggered by strong historical earthquakes is beneficial for understanding the surface process and focal parameters of the earthquakes. | ZHANG Yanbo XU Yueren DU Peng LI Wenqiao CHEN Lize TIAN Qinjian | 2020 | Earthquake Research in China2020，34，4： | 1 |
| 7 | PROTECTIVE EFFECTS OF HYDROGEN GAS ON MURINE POLYMICROBIAL SEPSIS VIA REDUCING OXIDATIVE STRESS AND HMGB1 RELEASE显示文摘 | Keliang Xie Yonghao Yu Yuping Pei Lichao Hou Shaoyang Chen Lize Xiong Guolin Wang | 2010 | Shock2010，，1： | 1 |
| 8 | Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADNRI)显示文摘The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic burdens.Abnormal metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβantibodies.Nonetheless,the cognitive benefits of the current treatments are limited.The etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive impairment.Hence,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve cognition.To attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2)identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD patients.The Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat AD.The aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline. | Jie Liu Heleen van Beusekom Xian-Le Bu Gong Chen Paulo Henrique Rosado de Castro Xiaochun Chen Xiaowei Chen Andrew N.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia Jukka Jolkkonen Woojin Scott Kim Paula Korhonen Shen Li Yajie Liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja Malm Xiaobo Mao Joaquim Miguel Oliveira Mike M.Modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao Wu Lize Xiong Yi Yang Keqiang Ye Jin-Tai Yu Xin-Fu Zhou Marietta Zille Colin L.Masters Piotr Walczak Boltze Johannes Xunming Ji Yan-Jiang Wang | 2023 | Neuroprotection2023，1，2： | 0 |
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