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| 1 | Impact of potentially lethal ventricular arrhythmias on long-term outcome in patients with chronic heart failure显示文摘背景潜在地致命的室的心律不齐( PLVA )在尖锐心肌的梗塞以后在幸存者经常发生并且逐渐地在调查的结构的心 diseases.This 学习的另外的形式被认出流行和在有长期的心失败( CHF )的病人的 PLVA 的预示的意义有关人口分布的 .Methods 数据,心失败的病原学, NYHA 功能的班,生物化学的变量, electrocardiographic 和 echocardiographic 调查结果,和医疗是 c 23.4 在病人 45 岁, 27.8 在那些在 45-65 岁之间,并且 33.5 没有 PLVAs.Age ,在病人,有 PLVA 的 65 岁( P=0.033 ) .Patients 比那些在5年的后续期间有更大的 LV 尺寸和更低的喷射部分(两 P 0.01 )和更高的所有原因死亡( P=0.014 )(或 1.041,95 Cl 1.004-1.079 , P=0.03 )并且 LV 结束心脏舒张的尺寸(或 1.068,95 Cl 1.013-1.126 , P=0.015 )独立地预言 PLVAs.And PLVA 的出现是为所有原因死亡的一个独立因素( RR 1.702。 | Liu Ye-hong Su Jing-ying Wang Lin-jie Li Jin-ping Zhou Qing-fen Gan Qian Chai Xi-chen Dai Li-ying Zhang Feng-ru Shen Wei-feng | 2012 | Chinese Medical Journal2012，，4： | 8 |
| 2 | Impacts of different drying strategies on drying characteristics,the retention of bio-active ingredient and colour changes of dried Roselle显示文摘The drying kinetics of Roselle(Hibiscus sabdariffa L) of variety Terengganu(UMKL-1) and the quality attribution of Roselle were studied. The experiments were conducted using four different drying methods, including solar greenhouse drying(SD), solar greenhouse with intermittent heat pump drying(SIHP), hot air drying(HA) and heat pump drying(HP). Among the four drying methods, HP achieved the highest drying rate at a range from0.054 g H_2 O·(g DM)^(-1) ·min^(-1) to 0.212 g H_2 O·(g DM)^(-1)·min^(-1) while SD had the lowest drying rate, measured at 0.042 g H_2 O·(g DM)^(-1)·min^(-1).The analysis on colour kinetics revealed that there is no significant colour loss(p > 0.05) observed from HP's dried Roselle. Greater amount of flavonoid compounds i.e. protocatechuic acid was found in SD and SIHP dried finished product whereas HP's dried Roselle contains higher percentage of catechin as compared to other drying methods. | Thing Chai Tham Mei Xiang Ng Shu Hui Gan Lee Suan Chua Ramlan Aziz Luqman Chuah Abdullah Sze Pheng Ong Nyuk Ling Chin Chung Lim Law | 2018 | Chinese Journal of Chemical Engineering2018，26，2： | 7 |
| 3 | Clinical significance of pain in patients with chronic heart failure显示文摘 | GAN Qian ZHANG Feng-ru ZHOU Qing-fen DAI Li-ying LIUYe-hong CHAI Xi-chen WU Fang SHEN Wei-feng | 2012 | Chinese Medical Journal2012，，18： | 4 |
| 4 | Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance显示文摘Objective: Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma(OSCC), especially in patients with advanced tumors. OSCC development is driven by multiple aberrancies within the cell cycle pathway, including amplification of cyclin D1 and loss of p16. Hence, cell cycle inhibitors of the CDK4/6-cyclin D axis are appealing targets for OSCC treatment. Here, we determined the potency of palbociclib and identified genetic features that are associated with the response of palbociclib in OSCC.Methods: The effect of palbociclib was evaluated in a panel of well-characterized OSCC cell lines by cell proliferation assays and further confirmed by in vivo evaluation in xenograft models. PIK3CA-mutant isogenic cell lines were used to investigate the effect of PIK3CA mutation towards palbociclib response.Results: We demonstrated that 80% of OSCC cell lines are sensitive to palbociclib at sub-micromolar concentrations.Consistently, palbociclib was effective in controlling tumor growth in mice. We identified that palbociclib-resistant cells harbored mutations in PIK3CA. Using isogenic cell lines, we showed that PIK3CA mutant cells are less responsive to palbociclib as compared to wild-type cells with concurrent upregulation of CDK2 and cyclin E1 protein levels. We further demonstrated that the combination of a PI3 K/mTOR inhibitor(PF-04691502) and palbociclib completely controlled tumor growth in mice.Conclusions: This study demonstrated the potency of palbociclib in OSCC models and provides a rationale for the inclusion of PIK3CA testing in the clinical evaluation of CDK4/6 inhibitors and suggests combination approaches for further clinical studies. | Nur Syafinaz Zainal Bernard Kok Bang Lee Zheng Wei Wong Iuan Sheau Chin Pei San Yee Chai Phei Gan Kein Seong Mun Zainal Ariff Abdul Rahman J. Silvio Gutkind Vyomesh Patel Sok Ching Cheong | 2019 | Cancer Biology & Medicine2019，16，2： | 3 |
| 5 | Distribution of polycyclic aromatic hydrocarbons (PAHs) in Henan Reach of the Yellow River, Middle China显示文摘 | Jian-Hui Sun Guo-Liang Wang Yan Chai Gan Zhang Jun Li Jinglan Feng | 2008 | Ecotoxicology and Environmental Safety2008，，5： | 2 |
| 6 | The optimization approach for traffic rescue resource dispatch on express- way based on fuzzy programming 显示文摘 | Zhu Canghui Li Xinghua Chai Gan | 2010 | Fuzzy Informa- tion and Engineering2010，78，1： | 1 |
| 7 | ACost-based Study on Highway Traffic Emergency RescueSites Location Using Heuristic Genetic Algorithm 显示文摘 | CHAI Gan FANG Chengwei GAO Xiangyu | 2011 | Journal of Computational Information Systems2011，7，2： | 1 |
| 8 | Hybrid boundary element analysis for surface cracks 显示文摘 | Chai GuoZhong Fang ZhiMin Jiang XianFang Li Gan | 2004 | Computer Methods in Applied Mechanics and Engineering2004，193，2326： | 1 |
| 9 | A genetic-fuzzy control applica-tion to ramp-mainstream joint coordination control of thefreeway 显示文摘 | Chai Gan Xie Yongli | 2012 | Advanced Science Letters2012，7，36： | 1 |
| 10 | Distribution of polycyclic aromatic hydrocarbons (PAHs) in Henan Reach of the Yellow River, Middle China显示文摘 | Jian-Hui Sun Guo-Liang Wang Yan Chai Gan Zhang Jun Li Jinglan Feng | 2008 | Ecotoxicology and Environmental Safety2008，，5： | 1 |
| 11 | Water-saving innovations in Chinese agriculture显示文摘 | Chai Q Gan Y Turner N C | 2014 | Advance in Agronomy2014，126，： | 1 |
| 12 | Study of a bis-furaldehyde Schiff base copper(II) complex as carrier for preparation of highly selective thiocyanate electrodes显示文摘 | Z.-Y. Sun R. Yuan Y.-Q. Chai L. Xu X.-X. Gan W.-J. Xu | 2004 | Analytical and Bioanalytical Chemistry2004，，2： | 1 |
| 13 | 4-(Dimethylamino) butyric acid@PtNPs as enhancer for solid-state electrochemiluminescence aptasensor based on target-induced strand displacement 显示文摘 | Gan X X Yuan R Chai Y Q | 2012 | Biosensors and Bioelectronics2012，34，： | 1 |
| 14 | Adaptive modified function projective lag synchronization of uncertain hyperchaotic dynamical systems with the same or different dimension and structure显示文摘 | Chai Xiu-li Gan Zhi-hua Shi Chun-xiao | 2013 | Mathematical Problems in Engineering2013，2013，28： | 1 |
| 15 | Function Projective Lag Synchronization of Chaotic Systems with Certain Parameters via Adaptive-impulsive Control显示文摘A new method is presented to study the function projective lag synchronization(FPLS) of chaotic systems via adaptive-impulsive control. To achieve synchronization, suitable nonlinear adaptive-impulsive controllers are designed. Based on the Lyapunov stability theory and the impulsive control technology, some effective sufficient conditions are derived to ensure the drive system and the response system can be rapidly lag synchronized up to the given scaling function matrix. Numerical simulations are presented to verify the effectiveness and the feasibility of the analytical results. | Xiu-Li Chai Zhi-Hua Gan | 2019 | International Journal of Automation and computing2019，16，2： | 1 |
| 16 | Antiviral activity of traditional Chinese medicinal plants Dryopteris crassirhizoma and Morus alba against dengue virus显示文摘Dengue virus(DENV) has emerged as a major virus that is spread by mosquitoes. Recently, it has spread to more than a hundred nations but continues to lack specific treatable medication. Many traditional Chinese medicinal(TCM) plants are in practice for dengue fever in dengue endemic regions. These traditional medicines persevere with treatments, which modern medicines lack. The study aims to substantiate the anti-dengue potential of some traditional herbs and make them available for further studies to facilitate TCM users. Twelve TCM plants aqueous extracts were evaluated, which are described as cool herbs used for the diseases with high fever. Lead plants were established through detailed in vitro foci forming unit reduction analysis(FFURA) against all four serotypes and validated through quantitative real-time RT-PCR(q RT-PCR). Four plants potentially inhibited the virus in primary phenotypic in vitro evaluation. Two lead plants Dryopteris crassirhizoma(DC) and Morus alba(MA) were identified with half minimal inhibitory concentration(IC50) 130 and 221 μg m L^-1, respectively, while the selectivity indices(SI) were 4.21 and 4.62, respectively. Lead plants equally inhibited all four serotypes of DENV. Time-of-addition analysis suggested that, DC was active at later stages of viral replication, whereas MA was active during the early stages and even showed some prophylactic activity. Liquid chromatography-mass spectrometry(HPLC/MS) analysis revealed presence of flavonoids. DC and MA are identified as potential anti-dengue plants, active against varied stages of dengue virus replication cycle. These results may serve as the base knowledge for further investigation on their combined treatments or integrative treatment with western medicines, which may improve the overall anti-dengue activity in future. | Maqsood MARYAM Kian Keong TE Fai Chu WONG Tsun Thai CHAI Gary K K LOW Seng Chiew GAN Hui Yee CHEE | 2020 | Journal of Integrative Agriculture2020，19，4： | 1 |
| 17 | Distribution of Epstein-Barr virus antigenic sites on the carboxyl terminal end of ribonucleotide re- ductase against nasopharyngeal carcinoma serum antibodies using an immunoabsorption method显示文摘 | Gan YY Hu R Chai D | 1999 | J Med Virol1999，59，2： | 1 |
| 18 | Electrical and thermal transport properties of kagome metals AV3Sb5(A=K,Rb,Cs)显示文摘The interplay between lattice geometry,band topology and electronic correlations in the newly discovered kagome compounds AV3Sb5(A=K,Rb,Cs) makes this family a novel playground to investigate emergent quantum phenomena,such as unconventional superconductivity,chiral charge density wave and electronic nematicity.These exotic quantum phases naturally leave nontrivial fingerprints in transport properties of AV3Sb5,both in electrical and thermal channels,which are prominent probes to uncover the underlying mechanisms.In this brief review,we highlight the unusual electrical and thermal transport properties observed in the unconventional charge ordered state of A V3Sb5,including giant anomalous Hall,anomalous Nernst,ambipolar Nernst and anomalous thermal Hall effects.Connections of these anomalous transport properties to time-reversal symmetry breaking,topological and multiband fermiology,as well as electronic nematicity,are also discussed.Finally,a perspective together with challenges of this rapid growing field are given. | Xin-Run Mi Kun-Ya Yang Yu-Han Gan Long Zhang Ai-Feng Wang Yi-Sheng Chai Xiao-Yuan Zhou Ming-Quan He | 2023 | Tungsten2023，5，3： | 1 |
| 19 | Spatio-temporal heuristic method:a trajectory planning for automatic parking considering obstacle behavior显示文摘Purpose–The purpose of this paper is to develop a real-time trajectory planner with optimal maneuver for autonomous vehicles to deal with dynamic obstacles during parallel parking.Design/methodology/approach–To deal with dynamic obstacles for autonomous vehicles during parking,a long-and short-term mixed trajectory planning algorithm is proposed in this paper.In long term,considering obstacle behavior,A-star algorithm was improved by RS curve and potential function via spatio-temporal map to obtain a safe and efficient initial trajectory.In short term,this paper proposes a nonlinear model predictive control trajectory optimizer to smooth and adjust the trajectory online based on the vehicle kinematic model.Moreover,the proposed method is simulated and verified in four common dynamic parking scenarios by ACADO Toolkit and QPOASE solver.Findings–Compared with the spline optimization method,the results show that the proposed method can generate efficient obstacle avoidance strategies,safe parking trajectories and control parameters such as the front wheel angle and velocity in high-efficient central processing units.Originality/value–It is aimed at improving the robustness of automatic parking system and providing a reference for decision-making in a dynamic environment. | Nianfei Gan Miaomiao Zhang Bing Zhou Tian Chai Xiaojian Wu Yougang Bian | 2022 | Journal of Intelligent and Connected Vehicles2022，5，3： | 0 |
| 20 | Prevalence and risk assessment of antibiotics in riverine estuarine waters of Larut and Sangga Besar River, Perak显示文摘Antibiotics released into the environment through anthropogenic activities exert selective pressure,driving bacteria towards increasing antimicrobial resistance.The prevalence of antibiotics and the ecological risks posed in the riverine estuarine of Larut River and Sangga Besar River,which included wastewater effl uents from hospital,zoo,and poultry slaughterhouse sources were investigated.Solid phase extraction(SPE)followed by high-performance liquid chromatography tandem mass chromatography(HPLC-MS/MS)were used to extract and quantify the antibiotic residues from 22 antibiotics belonging to six major antibiotic classes(sulfonamide,macrolide,fl uoroquinolone,phenicol,trimethoprim,and tetracycline).Sixteen antibiotic residues were detected with concentrations ranging from limit of detection(LOD)to 1262.3 ng/L.Fluoroquinolones and macrolides were the most frequently detected compounds.Erythromycin,clarithromycin,and ofl oxacin detected in hospital and zoo effl uents posed a high risk to algae while tetracycline had low to medium ecological risks toward all the relevant organisms from aquatic environments(algae,invertebrate Daphnia magna,and fi sh). | Kyleyoung LOW Layching CHAI Choonweng LEE Gan ZHANG Ruijie ZHANG Vaezzadeh VAHAB Chuiwei BONG | 2021 | Journal of Oceanology and Limnology2021，39，1： | 0 |
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